Download or read book Innate Immune Modulation and Pathogenic Basis for Porcine Reproductive and Respiratory Syndrome Virus written by Hanzhong Ke and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Basis of Porcine Reproductive and Respiratory Syndrome Virus mediated Innate Immune Suppression written by and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Interactions of Porcine Reproductive and Respiratory Syndrome Virus with Innate Immune Responses written by Sang-Myeong Lee and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: North American field isolates of PRRSV differed in their type I IFN response with respect to induction, sensitivity and suppression. Furthermore, one PRRSV isolate strongly enhanced polyI:C - induced IFN-[alpha] production in PAM cultures and this priming effect was suppressed by other PRRSV isolates. PRRSV activates NF-[kappa]B which is a critical regulator of innate and adaptive immune function. NF-[kappa]B activation was dependent on virus replication and I[kappa]B[alpha] degradation. ROS production was involved in NF-[kappa]B activation by PRRSV. NF-[kappa]B dependent expression of MMP-2 and MMP-9 suggested a possible role of the NF-[kappa]B pathway in PRRSV pathogenesis and the immune response. PRRSV infection induced both intrinsic and extrinsic apoptosis pathways and linked these two pathways via Bid cleavage by caspase-8. While apoptosis was significantly suppressed by caspase inhibitors, the same inhibitors did not affect PRRSV replication. This study also provided evidence of a possible involvement of NF-[kappa]B and ROS in apoptosis induced by PRRSV.
Download or read book Veterinary Vaccines written by R. Pandey and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccines have historically been considered to be the most cost-effective method for preventing communicable diseases. It was a vaccine that enabled global eradication of the dreaded disease smallpox. Mass immunization of children forms the anchor of the strategy of the World Health Organization (WHO) to attain "health for all" status by the year 2000. Vaccinology is undergoing a dimensional change with the advances that have taken place in immunology and genetic engineering. Vaccines that confer short or inadequate immunity or that have side effects are being replaced by better vaccines. New vaccines are being developed for a variety of maladies. Monoclonal antibodies and T cell clones have been employed to delineate the immunodeterminants on microbes, an approach elegantly complemented by computer graphics and molecular imaging techniques. Possibilities have opened for obtaining hitherto scarce antigens of parasites by the DNA recombinant route. Better appreciation of the idiotypic network has aroused research on anti idiotypic vaccines. Solid-phase synthesis of peptides is leading to an array of synthetic vaccines, an approach that is expected to attain its full potential once the sequences activating suppressor cells are discovered and the rules for presentation of antigens to T and B cells are better worked out. A new breed of vaccines is on the horizon that seeks to control fertility. Originally conceived to intercept a step in the reproductive process, they are conceptual models for developing approaches to regulate the body's internal processes.
Download or read book Polymicrobial Diseases written by Kim A. Brogden and published by . This book was released on 2002 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymicrobial diseases, those involving more than one etiologic agent, are more common than is generally realized and include respiratory diseases, gastroenteritis, conjunctivitis, keratitis, hepatitis, periodontal diseases, multiple sclerosis, genital infections, intra -- abdominal infections, and pertussis.
Download or read book Chimpanzees in Biomedical and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 2011-12-05 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: For many years, experiments using chimpanzees have been instrumental in advancing scientific knowledge and have led to new medicines to prevent life-threatening and debilitating diseases. However, recent advances in alternate research tools have rendered chimpanzees largely unnecessary as research subjects. The Institute of Medicine, in collaboration with the National Research Council, conducted an in-depth analysis of the scientific necessity for chimpanzees in NIH-funded biomedical and behavioral research. The committee concludes that while the chimpanzee has been a valuable animal model in the past, most current biomedical research use of chimpanzees is not necessary, though noted that it is impossible to predict whether research on emerging or new diseases may necessitate chimpanzees in the future.
Download or read book Porcine Viruses written by Hovakim Zakaryan and published by . This book was released on 2019 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive review of the current knowledge written by prominent scientists.
Download or read book Proteostasis and Disease written by Rosa Barrio and published by Springer Nature. This book was released on 2020-04-09 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.
Download or read book Recoding Expansion of Decoding Rules Enriches Gene Expression written by John F. Atkins and published by Springer Science & Business Media. This book was released on 2010-03-10 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: The literature on recoding is scattered, so this superb book ?lls a need by prov- ing up-to-date, comprehensive, authoritative reviews of the many kinds of recoding phenomena. Between 1961 and 1966 my colleagues and I deciphered the genetic code in Escherichia coli and showed that the genetic code is the same in E. coli, Xenopus laevis, and guinea pig tissues. These results showed that the code has been c- served during evolution and strongly suggested that the code appeared very early during biological evolution, that all forms of life on earth descended from a c- mon ancestor, and thus that all forms of life on this planet are related to one another. The problem of biological time was solved by encoding information in DNA and retrieving the information for each new generation, for it is easier to make a new organism than it is to repair an aging, malfunctioning one. Subsequently, small modi?cations of the standard genetic code were found in certain organisms and in mitochondria. Mitochondrial DNA only encodes about 10–13 proteins, so some modi?cations of the genetic code are tolerated that pr- ably would be lethal if applied to the thousands of kinds of proteins encoded by genomic DNA.
Download or read book Antiviral Strategies written by Hans-Georg Kräusslich and published by Springer Science & Business Media. This book was released on 2008-12-02 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: A crucial issue for antiviral therapy is the fact that all antiviral substances rapidly select for resistance; thus, monitoring and overcoming resistance has become a most important clinical paradigm of antiviral therapy. This calls for cautious use of antiviral drugs and implementation of combination therapies. In parallel, efforts in drug discovery have to be continued to develop compounds with novel mode-of-action and activity against resistant strains. This book reviews the current status of antiviral therapy, from the roads to development of new compounds to their clinical use and cost effectiveness. Individual chapters address in more detail all available drug classes and outline new approaches currently under development.
Download or read book The Nidoviruses written by Stanley Perlman and published by Springer. This book was released on 2010-11-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is based on the 10th International Nidovirus Symposium: Towards Control of SARS and other Nidovirus Diseases. The volume includes articles by all of the major contributors to this burgeoning area of research which summarize the work presented at the meeting. This represents the only comprehensive book to cover this field in the last five years.
Download or read book Animal Influenza written by David E. Swayne and published by John Wiley & Sons. This book was released on 2016-10-14 with total page 755 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal Influenza, Second Edition is a comprehensive text on animal influenza. Organized by species, coverage includes avian, swine, equine and mammals, with each section including data on influenza viruses, the infection and disease they cause, and strategies used in control. Covers the full range of topics within avian, swine, equine and mammalian influenzas in one comprehensive and authoritative text Provides a summarization of peer-reviewed and empirical data on influenza viruses, the infection, and diseases they cause Discusses strategies used in control of the disease Leading experts are drawn together to provide an international and multi-disciplinary perspective Fuses latest developments in basic scientific research with practical guidance on management of the disease
Download or read book MRCOG Part One written by Alison Fiander and published by Cambridge University Press. This book was released on 2016-10-13 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fully updated and illustrated handbook providing comprehensive coverage of all curriculum areas covered by the MRCOG Part 1 examination.
Download or read book Pathologic Basis of Veterinary Disease E BOOK written by James F. Zachary and published by Elsevier Health Sciences. This book was released on 2021-12-15 with total page 2165 pages. Available in PDF, EPUB and Kindle. Book excerpt: **Selected for Doody's Core Titles® 2024 in Veterinary Medicine** Use the veterinarian's #1 reference on general pathology and the pathology of organ systems! Pathologic Basis of Veterinary Disease, 7th Edition helps you understand and diagnose diseases of domestic animals by using the latest scientific and medical research. Focusing on dogs, cats horses, cattle, sheep, goats, and pigs, this reference describes and vividly illustrates and explores the pathogeneses of animal diseases, how cells and tissues respond to injury, and the morphology (lesions) of this injury. New to this edition is basic coverage of tumor, inflammatory, and microbial cytology. Edited by veterinary pathologist James F. Zachary and a team of expert veterinary pathologists, this book includes access to an enhanced eBook with every new print purchase, featuring a fully searchable version of the entire text, an image collection, and much more – and available on a variety of devices. - Clear, up-to-date illustrations and explanations of the macroscopic (gross) and microscopic lesions resulting from diseases occurring in domestic animals - Complete coverage of both general pathology and the pathology of organ systems that includes the latest research, practice, and diagnostic information on disease mechanisms, pathogenesis, and lesions. - Clear explanations of disease mechanisms that describe cell, tissue, and organ system responses to injury and infection. - Easy-to-follow organization for each systemic disease chapter including a brief review of the study of diseases that occur in specific tissues, organs, and organ systems, with basic principles related to anatomy, structure, and function, followed by congenital and functional abnormalities and discussions of infectious disease responses, helping students apply principles to veterinary practice. - More than 2,100 full-color illustrations featuring color photographs, schematics, flow charts, and diagrammatic representations of disease processes as well as summary tables and boxes, making it easier to understand difficult concepts. - Content on cellular and organ system pathology updated throughout the book, with expanded coverage of genetics and disease. - Key Readings Index in each chapter with page numbers for key topics. - Essential Concept boxes in each General Pathology chapter break down complicated topics that are critical to understanding lesions and pathogeneses. - More than 20 recognized experts deliver the most relevant information for the practitioner, student, or individual preparing for the American College of Veterinary Pathologists' board examination. - An enhanced eBook is included with new print purchase, featuring the complete, fully searchable text plus an image collection; the text, tables, and boxes linked to the website that are cited throughout the book; ten new appendices that focus on veterinary diagnostic pathology, postmortem examination, interpretation of lesions, and more; plus an established appendix of photographic techniques used in veterinary diagnostic pathology.
Download or read book Mucosal Vaccines written by Hiroshi Kiyono and published by Elsevier. This book was released on 1996-10-23 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive, authoritative treatise covers all aspects of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology. - Provides the latest views on mucosal vaccines - Applies basic principles to the development of new vaccines - Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases - Unique and user-friendly organization
Download or read book Pathologic Basis of Veterinary Disease Expert Consult E BOOK written by James F. Zachary and published by Elsevier Health Sciences. This book was released on 2016-05-23 with total page 1837 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diagnose and manage diseases using the newest information and research! Pathologic Basis of Veterinary Disease – Expert Consult, 6th Edition provides complete, illustrated coverage of both general pathology and the pathology of organ systems of domestic animals. Addressing species from dogs and cats to pigs and cattle — and many more — this reference describes the lesions and pathogeneses of diseases, how cells and tissues respond to injury, and the interplay of host defense mechanisms with microbes and injurious agents. Updates include the latest scientific advances and diagnostic information. Written by a team of expert contributors, this book includes an Expert Consult website with access to the complete digital book plus thousands of images and guidelines for sample acquisition and for performing a complete necropsy. - Complete coverage of both general pathology and pathology of organ systems is provided in one convenient resource, and includes the latest information available. - Over 20 recognized experts deliver the most relevant information for the practitioner, student, or individual preparing for the American College of Veterinary Pathology board examination. - UPDATED content on cellular and organ system pathology includes the latest insights into the science of inflammation, healing, and molecular carcinogenesis, as well as expanded coverage of genetics and disease. - Over 2,100 full-color illustrations include color schematics, flow charts, and diagrammatic representations of disease processes as well as summary tables and boxes, making it easier to understand difficult concepts. - Clear, up-to-date explanations of disease mechanisms describe cell, tissue, and organ response to injury and infection. - Easy-to-follow organization for each systemic disease chapter includes a brief review of basic principles related to anatomy, structure, and function, followed by congenital and functional abnormalities and discussions of infectious disease responses, helping you apply principles to veterinary practice. - Expert Consult website provides the reader with the complete digital text plus: An image collection; guidelines for performing a complete, systematic necropsy and appropriate sample acquisition for all organ systems; a comprehensive glossary; and an appendix of photographic techniques in veterinary pathology. - NEW line drawings and schematic diagrams depict current concepts about pathogeneses and lesions of veterinary diseases. - NEW! Essential Concept boxes in each basic pathology chapter break down long and complicated topics, making it easier to understand lesions and pathogeneses in the 'organ system' chapters. - NEW! Key Readings Index at the beginning of each chapter includes page numbers, making important information easy to locate.
Download or read book Pathogenetic mechanism and therapeutic target for inflammation in autoimmune disease written by Jing Tian and published by Frontiers Media SA. This book was released on 2024-03-13 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
