Download or read book Information Approach To Mitochondrial Dysfunction An Extending Swerdlow s Hypothesis written by Rodrick Wallace and published by World Scientific. This book was released on 2015-02-13 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: The monograph applies sophisticated topological symmetry tools to biological applications of information theory, along with a Black-Scholes model invocation of the Data Rate Theorem which links information and control theories. The focus is on statistical mechanics and other models that explore pathological phase transitions — driven by changes in available rates of mitochondrial free energy — in physiological functions, a cutting-edge topic in the study of chronic disease. One of the key focuses is Alzheimer's disease — a relatively simple canonical example.
Download or read book Mitochondrial Dysfunction written by Lawrence H. Lash and published by Elsevier. This book was released on 2013-10-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.
Download or read book Philosophy And Methodology Of Information The Study Of Information In The Transdisciplinary Perspective written by Gordana Dodig-crnkovic and published by World Scientific. This book was released on 2019-04-22 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book gives up-to-date, multi-aspect exposition of the philosophy and methodology of information, and related areas within the nascent field of the study of information. It presents the most recent achievements, ideas and opinions of leading researchers in this domain, as well as from physicists, biologists and social scientists. Collaboration of researchers from different areas and fields opens new perspectives for the understanding of information essential in the innovative development of science, technology and society.The book is meant for readers conducting research into any aspect of information, information society and information technology. The ideas presented give new insights for those who develop or implement scientific, technological or social applications. They are especially for those who are participating in setting the goals for science in general and sciences of information in particular.
Download or read book Information And Complexity written by Mark Burgin and published by World Scientific. This book was released on 2016-11-28 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book is a collection of papers of experts in the fields of information and complexity. Information is a basic structure of the world, while complexity is a fundamental property of systems and processes. There are intrinsic relations between information and complexity.The research in information theory, the theory of complexity and their interrelations is very active. The book will expand knowledge on information, complexity and their relations representing the most recent and advanced studies and achievements in this area.The goal of the book is to present the topic from different perspectives — mathematical, informational, philosophical, methodological, etc.
Download or read book Information Studies And The Quest For Transdisciplinarity Unity Through Diversity written by Mark Burgin and published by World Scientific. This book was released on 2017-03-27 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the second volume of a two-volume edition based on the International Society for Information Studies Summit Vienna 2015 on 'The Information Society at the Crossroads. Response and Responsibility of the Sciences of Information' (see summit.is4is.org).The book gives an up-to-date multiaspect exposition of contemporary studies in the field of information and related areas. It presents most recent achievements, ideas and opinions of leading researchers in this domain reflecting their quest for advancing information science and technology. With the goal of building a better society, in which social and technological innovations help make information key to the flourishing of humanity, we dispense with the bleak view of the dark side of information society.It is aimed at readers that conduct research into any aspect of information, information society and information technology, who develop or implement social or technological applications. It is also for those who have an interest in participating in setting the goals for the sciences of information and the social applications of technological achievements and the scientific results.
Download or read book Computational Psychiatry written by Rodrick Wallace and published by Springer. This book was released on 2017-04-20 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores mental disorders from a uniquely evolutionary perspective. Although there have been many attempts to mathematically model neural processes and, to some extent, their dysfunction, there is very little literature that models mental function within a sociocultural, socioeconomic, and environmental context. Addressing this gap in the extant literature, this book explores essential aspects of mental disorders, recognizing the ubiquitous role played by the exaptation of crosstalk between cognitive modules at many different scales and levels of organization, the missing heritability of complex diseases, and cultural epigenetics. Further, it introduces readers to valuable control theory tools that permit the exploration of the environmental induction of neurodevelopmental disorders, as well as the study of the synergism between culture, psychopathology and sleep disorders, offering a distinctively unique resource.
Download or read book Theoretical Information Studies Information In The World written by Mark Burgin and published by World Scientific. This book was released on 2020-03-24 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first attempt to delineate the synthetic field of the theoretical study of information, treating information as the basic phenomenon on the fundamental level of the world, encompassing nature, technology, individuals and society. The exploration of information is done within Info-computational approaches, to natural and social phenomena such as Bioinformatics, Information Physics, Informational Chemistry, Computational Physics, Cognitive and Social sciences, with special emphasis on interdisciplinary, crossdisciplinary and transdisciplinary knowledge.The book presents results of collaboration across research fields within info-computational and info-structural frameworks, in attempt to better theoretically and conceptually capture the phenomenon of information and its dynamics (such as computation and communication), as they appear on different levels of organization, on different scales and in different contexts.
Download or read book Carl von Clausewitz the Fog of War and the AI Revolution written by Rodrick Wallace and published by Springer. This book was released on 2018-01-21 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: The language of business is the language of dreams, but the language of war is the language of nightmare made real. Yet business dreams of driverless cars on intelligent roads, and of other real-time critical systems under the control of algorithmic entities, have much of war about them. Such systems, including military institutions at the tactical, operational and strategic scales, act on rapidly-shifting roadway topologies whose ‘traffic rules’ can rapidly change. War is never without both casualty and collateral damage, and realtime critical systems of any nature will inevitably partake of fog-of-war and frictional challenges almost exactly similar to those that have made warfare intractable for modern states. Into the world of Carl von Clausewitz, John Boyd, Mao Tse-Tung, Vo Nguyen Giap and Genghis Khan, come the brash, bright-eyed techies of Alphabet, Microsoft, Amazon, and Uber who forthrightly step in where a phalanx of angels has not feared to tread, but treaded badly indeed. In this book we use cutting-edge tools from information and control theories to examine canonical and idiosyncratic failure modes of real-time cognitive systems facing fog-of-war and frictional constraints. In sum, nobody ever navigates, or can navigate, the landscapes of Carl von Clausewitz unscathed.
Download or read book Future Information Society The Social And Technological Problems written by Wolfgang Hofkirchner and published by World Scientific. This book was released on 2017-01-24 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first volume of a two-volume edition based on the International Society for Information Studies Summit Vienna 2015 on 'The Information Society at the Crossroads. Response and Responsibility of the Sciences of Information' (see summit.is4is.org).The book represents a trans-disciplinary endeavor of the leading experts in the field of information studies posing the question for a better society, in which social and technological innovations help make information key to the flourishing of humanity and dispense with the bleak view of the dark side of information society.It is aimed at readers that conduct research into any aspect of information, information society and information technology, who develop or implement social or technological applications. It is also for those who have an interest in participating in setting the goals for sciences of information and social applications of technological achievements and scientific results.
Download or read book Neoliberal Ebola written by Robert G. Wallace and published by Springer. This book was released on 2016-08-29 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume compiles five papers modeling the effects of neoliberal economics on the emergence of Ebola and its aftermath. Neoliberalism is currently the world’s primary economic philosophy. It centers international relations around globalizing laissez-faire economics for multinational companies, promoting free trade, deregulating economic markets, and shifting state expenditures in favor of private property. The multidisciplinary teams represented here place both Ebola Makona, the Zaire Ebola virus variant that has infected 28,000 in West Africa, and Ebola Reston, which is currently emerging in industrial hog farms in the Philippines and China, within a multi-plank modeling framework. Using a stochastic extinction model that one group spatializes, environmental stochasticity across the ecologies in which Ebola evolves is treated as an ecosystemic prophylaxis. An agroecological logic gate is developed for epidemic control. A Black-Scholes model explicitly links economic margins across agricultural systems to success in biocontrol. This new control theory is further developed around the data-rate and rate-distortion theorems, a turbulence model, and cognitive symmetry breaking. Lastly, a model of pandemic penetrance is used to explore the domino effects of serious outbreaks amplifying through the cascades of disasters that can follow deadly pandemics. All the models presented are contextualized by socioeonomic geographies specific to outbreak locales.Together the models suggest shifts in regional agroeconomics under the neoliberal doctrine, driving deforestation and monoculture production, destroying the ecosystemic “friction” with which local forests typically disrupt Ebola transmission. The resulting collapse in such an ecological function accelerates pathogen spillover and propagation across the remaining host populations. The failure on the part of current control efforts to assimilate such a structural context may render even an efficacious vaccine dysfunctional. The authors propose an alternate science of disease and an adjunct program of interventions useful to researchers and public health officials alike.
Download or read book Psychiatry written by Emil Kraepelin and published by . This book was released on 1990 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Information Theory Models Of Instabilities In Critical Systems written by Rodrick Wallace and published by World Scientific. This book was released on 2016-08-18 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book is a unique exploration of a spectrum of unexpected analogs to psychopathologies likely to afflict real-time critical systems, written by a specialist in the epidemiology of mental disorders. The purpose of this book is to develop a set of information-theoretic statistical tools for analyzing the instabilities of real-time cognitive systems at those varying scales and levels of organization, with special focus on high level machine function.The book should be of particular interest to both industry and academic scientists, and government regulators, concerned with driverless cars on intelligent roads. Many of the same concerns also afflict high-end automated weapons systems. The book should appeal to students, researchers, and industrial and governmental administrators facing the design, operation, and maintenance of real time critical systems ranging across manufacturing facilities, transportation, finance, and military operations.
Download or read book Canonical Instabilities of Autonomous Vehicle Systems written by Rodrick Wallace and published by Springer. This book was released on 2017-10-31 with total page 53 pages. Available in PDF, EPUB and Kindle. Book excerpt: The asymptotic limit theorems of control and information theories make it possible to explore the dynamics of collapse likely to afflict large-scale systems of autonomous ground vehicles that communicate with each other and with an embedding intelligent roadway. Any vehicle/road system is inherently unstable in the control theory sense as a consequence of the basic irregularities of the traffic stream, the road network, and their interactions, placing it in the realm of the Data Rate Theorem that mandates a minimum necessary rate of control information for stability. It appears that large-scale V2V/V2I systems will experience correspondingly large-scale failures analogous to the vast, propagating fronts of power network blackouts, and possibly less benign but more subtle patterns of individual vehicle, platoon, and mesoscale dysfunction. The central matter is the synergism between poorly-understood traffic flow dynamics and similarly cryptic multisource information network dynamics, leading to highly punctuated phase transition analogs.
Download or read book Alzheimer s Disease written by Thimmaiah Govindaraju and published by Royal Society of Chemistry. This book was released on 2022-01-04 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer’s disease is an increasingly common form of dementia and despite rising interest in discovery of novel treatments and investigation into aetiology, there are no currently approved treatments that directly tackle the causes of the condition. Due to its multifactorial pathogenesis, current treatments are directed against symptoms and even precise diagnosis remains difficult as the majority of cases are diagnosed symptomatically and usually confirmed only by autopsy. Alzheimer’s Disease: Recent Findings in Pathophysiology, Diagnostic and Therapeutic Modalities provides a comprehensive overview from aetiology and neurochemistry to diagnosis, evaluation and management of Alzheimer's disease, and latest therapeutic approaches. Intended to provide an introduction to all aspects of the disease and latest developments, this book is ideal for students, postgraduates and researchers in neurochemistry, neurological drug discovery and Alzheimer’s disease.
Download or read book Aging and Age Related Disorders written by Stephen Bondy and published by Springer Science & Business Media. This book was released on 2010-09-02 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Features that characterize the aging process include the gradual accumulation of cell damage after prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to the accretion of lesions, the intrinsic levels of pro-oxidant and aberrant immune responses are elevated with age. These adverse events are often further enhanced by the chronic and slow progressing diseases that characterize the senescent brain and cardiovascular system. The incidence of some disorders such as Alzheimer's disease and vascular diseases are sufficiently prevalent in the extreme elderly that these disorders can arguably be considered "normal". Aging and Aging-Related Disorders examines the interface between normal and pathological aging, and illustrates how this border can sometimes be diffuse. It explores and illustrates the processes underlying the means by which aging becomes increasingly associated with inappropriate levels of free radical activity and how this can serve as a platform for the progression of age-related diseases. The book provides chapters that examine the interactive relationship between systems in the body that can enhance or sometimes even limit cellular longevity. In addition, specific redox mechanisms in cells are discussed. Another important aspect for aging discussed here is the close relationship between the systems of the body and exposure to environmental influences of oxidative stress that can affect both cellular senescence and a cell’s nuclear DNA. What may be even more interesting to note is that these external stressors are not simply confined to illnesses usually associated with aging, but can be evident in maturing and young individuals. A broad range of internationally recognized experts have contributed to this book. Their aim is to successfully highlight emerging knowledge and therapy for the understanding of the basis and development of aging–related disorders.
Download or read book Mitochondrial Dysfunction in Neurodegenerative Disorders written by Amy Katherine Reeve and published by Springer Science & Business Media. This book was released on 2011-11-15 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: As age related diseases increase in prevalence and impact more significantly on medical resources it is imperative to understand these diseases and the mechanisms behind their progression. New research has stimulated a growing interest in mitochondrial involvement in neurodegenerative disorders such as Parkinson’s disease, Alzheimer’s disease and multiple sclerosis and the mechanisms which lead from mitochondrial dysfunction to neurodegeneration. Mitochondrial Dysfunction in Neurodegenerative Disorders brings together contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of these diseases, guiding the reader through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, to the consequences of this dysfunction on neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets. Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research.
Download or read book Polyglutamine Disorders written by Clévio Nóbrega and published by Springer. This book was released on 2018-02-09 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies’ development and progression, and (2) the therapeutic strategies that are currently being explored to stop or delay disease progression. Polyglutamine (polyQ) disorders are a group of inherited neurodegenerative diseases with a fatal outcome that are caused by an abnormal expansion of a coding trinucleotide repeat (CAG), which is then translated in an abnormal protein with an elongated glutamine tract (Q). To date, nine polyQ disorders have been identified and described: dentatorubral-pallidoluysian atrophy (DRPLA); Huntington’s disease (HD); spinal–bulbar muscular atrophy (SBMA); and six spinocerebellar ataxias (SCA 1, 2, 3, 6, 7, and 17). The genetic basis of polyQ disorders is well established and described, and despite important advances that have opened up the possibility of generating genetic models of the disease, the mechanisms that cause neuronal degeneration are still largely unknown and there is currently no treatment available for these disorders. Further, it is believed that the different polyQ may share some mechanisms and pathways contributing to neurodegeneration and disease progression.
