Download or read book In Vitro Studies on the Anticoagulant Properties of Russell s Viper Venom written by Gottfried Härtel and published by . This book was released on 1963 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Snake Venoms written by C.-Y. Lee and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 1162 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past decade has been a period of explosion of knowledge on the chemistry and pharmacology of snake toxins. Thanks to the development of protein chemistry, nearly a hundred snake toxins have been purified and sequenced, representing one of the largest families of sequenced proteins. Moreover, the mode of action of these toxins has been largely elucidated by the concerted efforts of pharmacologists, electro physiologists, and biochemists. As a result of these studies, some of the snake toxins, e.g., a-bungarotoxin and cobra neurotoxins, have been extensively used as specific markers in the study of the acetylcholine receptors. Indeed, without the discovery of these snake toxins, our knowledge of the structure and function of nicotinic acetylcholine receptors would not have advanced so rapidly. The contribution of snake venom research to the biomedical sciences is not limited to the study of cholinergic receptors. Being one of the most concentrated enzyme sources in nature, snake venoms are also valuable tools in biochemical research. Venom phosphodiesterase, for example, has been widely used for structural studies of nucleic acids; proteinase, for the sequence studies of proteins and pep tides ; phospholipase A , for lipid research; and L-amino acid oxidase for identifying optical z isomers of amino acids. Furthermore, snake venoms have proven to be useful agents for clarifying some basic concepts on blood coagulation and some venom enzymes, e.g., thrombin-like enzymes and pro coagulants have been used as therapeutic agents.
Download or read book Cerebrovascular Bibliography written by and published by . This book was released on 1975-04 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Snake Venoms written by P. Gopalakrishnakone and published by Springer. This book was released on 2017-02-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively.
Download or read book Blood written by Walter S. Root and published by Elsevier. This book was released on 2013-10-22 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physiological Pharmacology, Volume V: Blood describes the interrelationships between pharmacology and blood. This volume is organized into five parts encompassing 16 chapters that consider the effect of therapeutic agents on the physiology of blood, whether it be coagulation, the white cells, red cells, or platelets. The opening part deals first with the physiology of blood coagulation and the mode of action of anticoagulants. This part also covers the mechanism of thrombogenesis and thrombolysis, as well as the in vivo actions of thrombolytic agents. The subsequent parts initially examine the biochemistry and physiology of platelets, hematopoietic stem cells, and white cells. These topics are followed by discussions of the mechanism of thrombocytosis and clinical manifestations of thrombocythemia, as well as the mechanisms of immunologic drug effect on blood cells. These parts also explore the effects of drugs on myelopoiesis and the physiological and immunological activities of lymphocytes. The closing part reviews the iron, vitamin B12, folic acid, erythropoietin, and transferrin components of red blood cells. This part also examines the mechanism of erythropoietic cellular proliferation and the initiation of hyperoxia. This book is intended primarily to physiological pharmacologists, hematologists, and researchers.
Download or read book Vasculitis written by Gene V. Ball and published by . This book was released on 2008 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a new edition of the successful textbook providing updated, detailed information on clinical, epidemiologic, pathophysiologic and therapeutic aspects of common and rare forms of vasculitis. New chapters include pathology of vasculitis, autoantibodies, animal models of vasculitis and PET scanning. Separate sections are devoted to basic science, clinical manifestations commonly seen in vasculitis, imaging and perpcutaneous interventions, individual diseases and syndromes as well as conditions which can mimic vasculitis. Subsumed under clinical manifestations are chapters, some new, which deal with skin, oral ulcers, eyes, cardiopulmonary system, nervous system, the gastrointestinal track, kidney and digital ischemia and Raynaud's phenomenon. Other chapters address diagnostic approaches to adults and to children with suspected vasculitis, as well as assessment of disease activity and damage. Individual chapters are written by authorities from throughout the world.
Download or read book Proceedings of the Congress written by European Society of Haematology and published by . This book was released on 1965 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book AnticoagulantsPhysiologic Pathologic and Pharmacologic written by David Green and published by CRC Press. This book was released on 1994-06-06 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anticoagulants provides authoritative reviews of proteins C and S, antithrombin III, and the recently described tissue factor pathway inhibitor. There are extensive discussions of pathologic anticoagulants, such as those found in patients with congenital clotting factor deficiencies or those that arise de novo in previously well individuals. Detailed clinical advice is presented for the management of patients with these inhibitors. A chapter on "lupus" anticoagulants provides a comprehensive review of the pathophysiology of these intriguing antibodies. Current guidelines are offered for the use of heparin, warfarin, and thrombolytic agents. The biochemistry, physiology, and clinical applications of the new, low molecular weight heparins are explored.
Download or read book Venomous Animals and Their Venoms written by Wolfgang Bücherl and published by Elsevier. This book was released on 2013-09-17 with total page 732 pages. Available in PDF, EPUB and Kindle. Book excerpt: Venomous Animals and their Venoms focuses on the comprehensive presentation of the entire field of the venomous members of the animal kingdom, chemistry and biochemistry of venoms, and pharmacological actions and their antigenic properties. The selection first offers information on the development of knowledge about venoms and the platypus (Ornithorhynchus anatinus) and its venomous characteristics, including biology, venom apparatus, properties of venom, and significance of venom apparatus in Ornithorhynchus. The text then elaborates on the classification, biology, and description of the venom apparatus of insectivores of the genera Solenodon, Neomys, and Blarina and the chemistry and pharmacology of insectivore venoms. The publication takes a look at karyotypes, sex chromosomes, and chromosomal evolution in snakes and coagulant, proteolytic, and hemolytic properties of some snake venoms. Topics include hemolytic property, karyotypes of South American snakes, sex chromosomes, methods for the study of chromosomes of reptiles, and chromosomal evolution. The selection is a vital source of data for readers interested in venomous animals and their venoms.
Download or read book The Big Four Snakes of India written by Ashis K. Mukherjee and published by Springer Nature. This book was released on 2021-08-26 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides detailed and updated knowledge about medically important ‘Big Four’ venomous snakes of India (Indian spectacled cobra, Indian common krait, Indian Russell’s viper, and Indian saw-scaled viper). This book essentially covers the snakebite problem in the world with particular reference to Asia and India. It discusses the evolution and systematics of venomous snakes, emphasizing ‘Big Four’ venomous snakes of India; the evolution and composition of venoms determined by traditional biochemical and modern proteomic analyses. It also describes the pharmacological properties of enzymatic and non-enzymatic toxins of ‘Big Four’ venomous snakes of India. Different chapters discuss exciting topics such as species-specific and geographical differences in venom composition and its impact on pathophysiology and clinical manifestations of snakebite envenomation in India, biomedical application of Indian snake venom toxins; production and quality assessment of commercial antivenom, prevention, and treatment of snakebite in India, adverse effects of antivenom including strategies to combat antivenom reactions inpatient. This book caters to toxinologists, pharmacologists, zoologists, antivenom manufacturers, biochemists, clinicians, evolutionary biologists, herpetologists, and informed non-specialists interested to know about the Indian snake venoms.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1996 with total page 1340 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Venoms and Toxins of Reptiles written by Stephen P. Mackessy and published by CRC Press. This book was released on 2021-05-24 with total page 912 pages. Available in PDF, EPUB and Kindle. Book excerpt: A decade after publication of the first edition, Handbook of Venoms and Toxins of Reptiles responds to extensive changes in the field of toxinology to endure as the most comprehensive review of reptile venoms on the market. The six sections of this new edition, which has nearly doubled in size, complement the original handbook by presenting current information from many of the leading researchers and physicians in toxinology, with topics ranging from functional morphology, evolution and ecology to crystallography, -omics technologies, drug discovery and more. With the recent recognition by the World Health Organization of snakebite as a neglected tropical disease, the section on snakebite has been expanded and includes several chapters dealing with the problem broadly and with new technologies and the promises these new approaches may hold to counter the deleterious effects of envenomation. This greatly expanded handbook offers a unique resource for biologists, biochemists, toxicologists, physicians, clinicians, and epidemiologists, as well as informed laypersons interested in the biology of venomous reptiles, the biochemistry and molecular biology of venoms, and the effects and treatment of human envenomation.
Download or read book Fibrinogen Thrombosis Coagulation and Fibrinolysis written by Chung Yuan Liu and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Scientific Symposium on Fibrinogen, Thrombosis, Coagulation, and Fibrinolysis was held in Academia Sinica, Taipei, Taiwan, Republic of China, on August 30 - September 1, 1989. This Symposium has provided a forum for the free exchange of information in this important and rapidly advancing research field. This proceedings volume provides a published record of 46 papers presented at the Symposium. The sponsors have exerted no influence on the scientific opinions or positions of the participants in the Symposium. It is hoped that this Symposium will stimulate further worldwide cooperation and collaboration in these vital fields for the benefit of all human kind. This volume is composed of four parts. The first part consists of 8 papers on Fibrinogen and Fibrin: Biochemistry, Molecular Biology, and Physiology. The second part contains 16 papers on Coagulation and Fibrinolysis: Biochemistry, Molecular Biology, and Physiology. The third part has 10 papers on Cardiovascular Cell Biology: Biochemistry, Molecular Biology, and Physiology. The fourth part comprises 12 papers on Clinical Studies of the Cardiovascular System: Thrombotic and Bleeding Disorders and Thrombolytic Therapy. The Author Index with addresses of all contributors and the Subject Index of all 46 papers are arranged at the end of this volume.
Download or read book Consultative Hemostasis and Thrombosis E Book written by Craig S. Kitchens and published by Elsevier Health Sciences. This book was released on 2018-07-20 with total page 932 pages. Available in PDF, EPUB and Kindle. Book excerpt: With authoritative coverage of rare and common hemostatic disorders, Consultative Hemostasis and Thrombosis, 4th Edition, keeps you both up to date with all that's new in this fast-moving field as well as reviewing background and development and citing pertinent classical literature. Broad differential diagnoses are provided, underscoring the editors' position that correct treatment begins with correct diagnosis. This trusted resource by Drs. Craig S. Kitchens, Craig M. Kessler, Barbara A. Konkle, Michael B. Streiff, and David A. Garcia is designed for rapid reference and critical decision making at the point of care. - Emphasizes real-world problems and solutions, with quick access to concise descriptions of each condition, associated symptoms, laboratory findings, differential diagnosis, and treatment. - Features a user-friendly design, full-color format, abundant laboratory protocols, and at-a-glance tables and charts throughout. - Provides thorough updates on core information on hemostasis and thrombosis, including deep venous thrombosis (DVT), pulmonary embolisms, hypercoagulability, thrombocytopenia, von Willenbrand disease, and more. - Covers new treatment information on hemophilia A and B. - Contains new chapters on hereditary hemorrhagic telangiectasia, hemolytic uremic syndrome, and paroxymal nocturnal hemoglobinuria. - Two new editors, Dr. Michael B. Streiff and Dr. David A. Garcia, offer fresh perspectives and valuable experience. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Download or read book The Antiphospholipid Syndrome written by Ronald A. Asherson and published by CRC Press. This book was released on 2018-05-04 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the foremost researchers in the field, this book gathers together in a single source the many important clinical associations of antiphospholipid antibodies. Antibody-related clotting mechanisms and their relationship to conditions such as recurrent strokes, chorea, multi infarct dementias, a variety of spinal syndromes, Addison's Disease, recurrent miscarriages, and many more are discussed in depth. The importance of these antibodies in 'Primary,' 'Secondary,' and 'Catastrophic' Antiphospholipid Syndrome is highlighted. Each chapter is devoted to a specific internal system and the clinical effects this syndrome has on that system. This authoritative book is an essential addition to medical libraries as well as an invaluable reference for general physicians, internists, rheumatologists, neurologists, cardiologists, nephrologists, endocrinologists, gastroenterologists, pulmonologists, dermatologists, and obstetricians.
Download or read book Clinical Toxinology in Asia Pacific and Africa written by P. Gopalakrishnakone and published by Springer. This book was released on 2015-03-12 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical toxinologic conditions are becoming increasingly frequent, more so than is generally recognized. The conditions comprise of clinical aspects such as the diagnosis, management, and prevention of snakebite envenoming, scorpion sting, mushroom toxins, plant toxins, and other natural toxins. Clinical toxinology also deals with the ecology, epidemiology, regional differences, and varieties of fauna accounting for different envenoming manifestations. This handbook includes 30 chapters addressing various topics on clinical toxinology such as the epidemiology and management of snakebites in different Asian and African countries, disability following snakebite, effect of snake venoms on hemostasis, socioeconomic aspects of snakebites, therapeutic application of snake venom, scorpion sting in the Middle East, jellyfish sting, etc. These titles are written by experts currently working in the subspecialty, many of whom have first-hand experience in the relevant research fields. In virtually all the topics, appropriate illustrations are provided to simplify comprehension including tables, figures and pictures. This reference work on Clinical Toxinology in Asia Pacific and Africa, in the Toxinology handbook series, is designed to keep readers abreast with new knowledge and experience in toxinology regionally and globally. Toxinologists, researchers, scientists, and experts in this field from various working areas considered it necessary to collect all the aspects of clinical toxinology in a single, handy handbook. This can be used by medical students, postgraduate students, general practitioners, specialists in internal medicine, critical care physicians, emergency physicians, and anesthetists worldwide.
Download or read book Hematologic Agents Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hematologic Agents—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Hematologic Agents. The editors have built Hematologic Agents—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Hematologic Agents in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Hematologic Agents—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
