Download or read book Image Processing for Phase Sensitive Optical Coherence Tomography written by Bettina Heise and published by Sudwestdeutscher Verlag Fur Hochschulschriften AG. This book was released on 2010-11 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phase-sensitive imaging techniques, suitable for investigating structures in the micron range, are discussed in this book with a focus on optical coherence tomography (OCT). The probed samples are mostly of technical nature, but the methods in general are not restricted to technical applications. Moreover, several imaging aspects, originating from biological applications, recently have been transferred to technical material sciences. OCT imaging is presented here mainly by its phase-sensitive modifications: polarization-sensitive OCT (PS-OCT) and differential phase contrast OCT (DPC-OCT). The comparison to quantitative imaging in phase contrast microscopy techniques has been drawn to illustrate the similarities, differences, and limitations of both techniques. The potential for appropriate image processing is demonstrated in this context to obtain improved quantitative and localized information about specimens and material behavior. The book connects the field of optics, mathematics, and image processing from an interdisciplinary point of view.
Download or read book Optical Coherence Tomography written by Wolfgang Drexler and published by Springer Science & Business Media. This book was released on 2008-12-10 with total page 1346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is the optical analog of ultrasound imaging and is emerging as a powerful imaging technique that enables non-invasive, in vivo, high resolution, cross-sectional imaging in biological tissue. This book introduces OCT technology and applications not only from an optical and technological viewpoint, but also from biomedical and clinical perspectives. The chapters are written by leading research groups, in a style comprehensible to a broad audience.
Download or read book High Resolution Imaging in Microscopy and Ophthalmology written by Josef F. Bille and published by Springer. This book was released on 2019-08-13 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.
Download or read book Application of Polarization Sensitive Optical Coherence Tomography PS OCT and Phase Sensitive Optical Coherence Tomography PhS OCT for Retinal Diagnostics written by Amit Shrikant Paranjape and published by . This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: An Enhanced Polarization-Sensitive Swept Source Optical Coherence Tomography (EPS-SS-OCT) instrument for high sensitivity cross-sectional imaging of Retinal Nerve Fiber Layer (RNFL) has been designed, constructed, and verified. The instrument is capable of measuring the thickness and birefringence of the RNFL. Birefringence change of the RNFL could serve as an early indicator of glaucoma. The associated image processing methods for completely automated, time efficient algorithm to segment the RNFL in images of the human retina recorded by the EPS-SS-OCT. Detected RNFL boundaries are used to compute peripapillary thickness maps. Numerical algorithms to compute the birefringence of the detected RNFL layer are presented along with the associated phase retardation and birefringence peripapillary maps. Glaucoma affects the vitality of retinal ganglion cell axons in the retinal nerve fiber layer (RNFL) and may be clinically detected through a change in RNFL birefringence. Comprehensive peripapillary maps of healthy and glaucoma suspect human RNFL birefringence were constructed using EPS-SS-OCT. Presence of macrophages is a hallmark of several retinal diseases such as drusen and age related macular degeneration. Application of photothermal Optical Coherence Tomography (OCT) to detect macrophages in ex vivo arteries which have engulfed nanoclusters of gold coated iron oxide (nanorose) is reported. Nanorose engulfed by macrophages in arteries absorb incident laser (800nm) energy and cause optical pathlength (OP) variation which is measured using photothermal OCT. OP variation in polydimethyl siloxane tissue phantoms containing varying concentrations of nanorose match values predicted from nanoparticle and material properties. Measurement of OP variation in arteries in response to laser excitation provides an estimate of nanorose concentration in arteries 2.5x109 particles/ml. OP variation in nanoparticle containing artery sections and tissue phantoms taking up nanorose has a different magnitude and profile from that observed in control aorta and phantoms without macrophages and is consistent with macrophage presence as identified with RAM-11 histology staining. Our results suggest that tissue regions with macrophages taking up nanorose can be detected using photothermal OCT.
Download or read book Development and Application of Optical Coherence Tomography OCT written by Michael Pircher and published by MDPI. This book was released on 2018-03-23 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Development and Application of Optical Coherence Tomography (OCT)" that was published in Applied Sciences
Download or read book Image Processing in Optical Coherence Tomography Using Matlab written by Robert Koprowski and published by Robert Koprowski. This book was released on 2011 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the results of the creation of methods for ophthalmologists support in OCT images automated analysis. These methods, like the application developed on their basis, are used during routine examinations carried out in hospital. The monograph comprises proposals of new and also of known algorithms, modified by authors, for image analysis and processing, presented on the basis of example of Matlab environment with Image Processing tools. The results are not only obtained fully automatically, but also repeatable, providing doctors with quantitative information on the degree of pathology occurring in the patient. In this case the anterior and posterior eye segment is analysed, e.g. the measurement of the filtration angle or individual layers thickness. To introduce the Readers to subtleties related to the implementation of selected fragments of algorithms, the notation of some of them in the Matlab environment has been given. The presented source code is shown only in the form of example of implementable selected algorithm. In no way we impose here the method of resolution on the Reader and we only provide the confirmation of a possibility of its practical implementation.
Download or read book Optical Coherence Tomography for Retinal Diagnostics written by Biwei Yin and published by . This book was released on 2013 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Tomography (OCT) is a non-invasive three-dimensional imaging technique. OCT synthesizes a cross-sectional image from a series of lateral adjacent depth scans, and with a two-dimensional scanning scheme, three-dimensional intensity image of sample can be constructed. Due to its non-invasive capability, OCT has been widely applied in ophthalmology, cardiology and dermatology; and in addition to three-dimensional intensity image construction, various functional OCT imaging techniques have been developed for clinical application. My research is focused on developing functional OCT systems for application in ophthalmology, including polarization-sensitive optical coherence tomography (PS-OCT) for retinal nerve fiber layer (RNFL) birefringence measurement and dual-wavelength photothermal optical coherence tomography (DWP-OCT) for microvasculature blood oxygen saturation (SO2) measurement. In the study, a single-mode-fiber based polarization-sensitive swept-source OCT (PS-SS-OCT) with polarization modulator, polarization-sensitive bulk-optics balanced detection module is constructed and polarization processing methods based on Stokes vectors are applied to determine birefringence. PS-OCT is able to provide human subject's RNFL thickness, phase retardation, and birefringence information. Degradation in the degree of polarization (DOP) along depth is investigated and its difference between four quadrants of RNFL (superior, temporal, inferior and nasal) indicates the structural property difference. DWP-OCT is a novel functional OCT system consisting of a phase-sensitive optical coherence tomography system (PhS-OCT) and two photothermal excitation lasers. PhS-OCT is based on a swept-source laser operating in the 1060 nm wavelength range; the two photothermal excitation lasers with wavelength 770 nm and 800 nm are intensity modulated at different frequencies. PhS-OCT probe beam and two photothermal excitation beams are combined and incident on the sample, optical pathlength (op) change on the sample introduced by two photothermal excitation beams are measured and used for blood SO2 estimation. A polarization microscope is proposed for future study. The polarization microscope is an imaging technique providing molecular structure and orientation based on probe light's polarization state information. The polarization microscope uses a wavelength tunable light source, and can achieve any incident polarization state by a retarder-rotator combination. Specimen's birefringence can be determined based on the changing of detected light amplitude.
Download or read book Optical Coherence Tomography and Its Non medical Applications written by Michael Wang and published by BoD – Books on Demand. This book was released on 2020-05-27 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is a promising non-invasive non-contact 3D imaging technique that can be used to evaluate and inspect material surfaces, multilayer polymer films, fiber coils, and coatings. OCT can be used for the examination of cultural heritage objects and 3D imaging of microstructures. With subsurface 3D fingerprint imaging capability, OCT could be a valuable tool for enhancing security in biometric applications. OCT can also be used for the evaluation of fastener flushness for improving aerodynamic performance of high-speed aircraft. More and more OCT non-medical applications are emerging. In this book, we present some recent advancements in OCT technology and non-medical applications.
Download or read book Optical Coherence Tomography written by Mark E. Brezinski and published by Elsevier. This book was released on 2006-08-25 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Tomography gives a broad treatment of the subject which will include 1)the optics, science, and physics needed to understand the technology 2) a description of applications with a critical look at how the technology will successfully address actual clinical need, and 3) a discussion of delivery of OCT to the patient, FDA approval and comparisons with available competing technologies. The required mathematical rigor will be present where needed but be presented in such a way that it will not prevent non-scientists and non-engineers from gaining a basic understanding of OCT and the applications as well as the issues of bringing the technology to the market. - Optical Coherence Tomography is a new medical high-resolution imaging technology which offers distinct advantages over current medical imaging technologies and is attracting a large number of researchers. - Provides non-scientists and non-engineers basic understanding of Optical Coherence Tomography applications and issues.
Download or read book Optical Coherence Tomography written by Masanori Kawasaki and published by BoD – Books on Demand. This book was released on 2013-03-06 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is an imaging technology that provides high resolution cross-sectional images in many fields of medicine and engineering. OCT images are constructed by measuring the intensity of reflected or back scattered light that is scanned across the tissue and material. This book aims to provide readers with comprehensive information of OCT in ophthalmology, oncology, atherosclerosis and engineering.
Download or read book Retinal Optical Coherence Tomography Image Analysis written by Xinjian Chen and published by Springer. This book was released on 2019-07-05 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the latest optical coherence tomography (OCT) imaging and computerized automatic image analysis techniques, and their applications in the diagnosis and treatment of retinal diseases. Discussing the basic principles and the clinical applications of OCT imaging, OCT image preprocessing, as well as the automatic detection and quantitative analysis of retinal anatomy and pathology, it includes a wealth of clinical OCT images, and state-of-the-art research that applies novel image processing, pattern recognition and machine learning methods to real clinical data. It is a valuable resource for researchers in both medical image processing and ophthalmic imaging.
Download or read book Development and Application of Polarization Sensitive Optical Coherence Tomography written by Peijun Tang and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT), a three-dimensional optical imaging technique based on low coherence interferometry, can be extended to measure the functional property of the biological sample. As a functional extension of OCT, polarization sensitive optical coherence tomography (PSOCT) enables 3D imaging of the anisotropic biological samples, such as scar, tendon, muscle, collagen, and nerve fiber bundles. This thesis focuses on the development and application of PSOCT. This goal includes four specific aims. The first aim is to develop a single input PSOCT imaging system with an improved image contrast. To achieve this aim, the polarization state is utilized as the imaging parameter and visualized using the Stokes parameters-based color-encoded algorithm. The second aim is to develop an algorithm that can derive depth-resolved polarization parameters with the single input PSOCT system. Towards this aim, a PSOCT-based polarization state transmission model is proposed. Based on this model, a novel method that utilizes discrete differential geometry (DDG) combined with a series of 3D rotations is developed to derive the local axis orientation and phase retardation. The third aim is to use the developed DDG-based PST method to extract the collagen organization embedded within the soft biological tissues. To achieve this aim, the proposed method is utilized to image the local axis orientation of the collagen fibers of the rodent heart and human facial skin. The fourth aim is to use the multiparameter provided by the PSOCT to detect and characterize the white spot lesions in the enamel of the tooth. Towards this aim, multiple parameters in the PSOCT: scattering, attenuation, degree of polarization (DOP), local axis orientation, and local phase retardation of the sample are provided simultaneously for the comprehensive investigation of the location, depth, and severity of the white spot lesions.
Download or read book Optical Coherence Tomography in Dentistry written by Anderson S. L. Gomes and published by CRC Press. This book was released on 2023-08-08 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Tomography (OCT), a method to "see inside of things" without destroying them, has been applied to subjects ranging from materials science to medicine. This book focuses on the biomedical application of OCT in dentistry, covering topics from dental materials to clinical practice. Since the introduction of the OCT method in ophthalmology in 1991, and then dentistry in 1998, developments in OCT methods, particularly in biomedical areas, have led to its dissemination worldwide. The chapters of this book cover the basics and recent global advances of OCT in dentistry, including an overview of the method and its use in cariology, restorative dentistry, dental materials, endodontics, pediatric dentistry, orthodontics, prosthodontics, soft oral tissues and nanodentistry. This book will be of interest to both newcomers in the field as well as those already working in OCT, either in research and/or the clinic. It will be of great use in courses on optical imaging applied to biomedical areas, particularly where it can provide real-life examples of the application of OCT.
Download or read book Clinical Applications of Ultra high Resolution and Phase sensitive Optical Coherence Tomography written by Joseph Boadi and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Parallel Processing for Adaptive Optics Optical Coherence Tomography AO OCT Image Registration Using GPU written by Nhan Hieu Do and published by . This book was released on 2016 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adaptive Optics Optical Coherence Tomography (AO-OCT) is a high-speed, high-resolution ophthalmic imaging technique offering detailed 3D analysis of retina structure in vivo. However, AO-OCT volume images are sensitive to involuntary eye movements that occur even during steady fixation and include tremor, drifts, and micro-saccades. To correct eye motion artifacts within a volume and to stabilize a sequence of volumes acquired of the same retina area, we propose a stripe-wise 3D image registration algorithm with phase correlation. In addition, using several ideas such as coarse-to-fine approach, spike noise filtering, pre-computation caching, and parallel processing on a GPU, our approach can register a volume of size 512 x 512 x 512 in less than 6 seconds, which is a 33x speedup as compared to an equivalent CPU version in MATLAB. Moreover, our 3D registration approach is reliable even in the presence of large motions (micro-saccades) that distort the volumes. Such motion was an obstacle for a previous en face approach based on 2D projected images. The thesis also investigates GPU implementations for 3D phase correlation and 2D normalized cross-correlation, which could be useful for other image processing algorithms.
Download or read book Handbook of Full Field Optical Coherence Microscopy written by Arnaud Dubois and published by CRC Press. This book was released on 2016-10-14 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: Full-field optical coherence microscopy (FF-OCM) is an imaging technique that provides cross-sectional views of the subsurface microstructure of semitransparent objects. The technology is based on low-coherence interference microscopy, which uses an area camera for en face imaging of the full-field illuminated object. FF-OCM benefits from the lateral imaging resolution of optical microscopy along with the capacity of optical axial sectioning at micrometer-scale resolution. The technique can be employed in diverse applications, in particular for non-invasive examination of biological tissues. This handbook is the first to be entirely devoted to FF-OCM. It is organized into four parts with a total of 21 chapters written by recognized experts and major contributors to the field. After a general introduction to FF-OCM, the fundamental characteristics of the technology are analyzed and discussed theoretically. The main technological developments of FF-OCM for improving the image acquisition speed and for endoscopic imaging are presented in part II. Extensions of FF-OCM for image contrast enhancement or functional imaging are reported in part III. The last part of the book provides an overview of possible applications of FF-OCM in medicine, biology, and materials science. A comprehensive compilation of self-contained chapters written by leading experts, this handbook is a definitive guide to the theoretical analyses, technological developments, and applications of FF-OCM. Using the rich information the book is replete with, a wide range of readers, from scientists and physicists to engineers as well as clinicians and biomedical researchers, can get a handle on the latest major advances in FF-OCM.
Download or read book Mechanobiology of Cell Cell and Cell Matrix Interactions written by A. Wagoner Johnson and published by Springer Science & Business Media. This book was released on 2011-02-21 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanobiology of Cell-Matrix Interactions focuses on characterization and modeling of interactions between cells and their local extracellular environment, exploring how these interactions may mediate cell behavior. Studies of cell-matrix interactions rely on integrating engineering, (molecular and cellular) biology, and imaging disciplines. Recent advances in the field have begun to unravel our understanding of how cells gather information from their surrounding environment, and how they interrogate such information during the cell fate decision making process. Topics include adhesive and integrin-ligand interactions; extracellular influences on cell biology and behavior; cooperative mechanisms of cell-cell and cell-matrix interactions; the mechanobiology of pathological processes; (multi-scale) modeling approaches to describe the complexity or cell-matrix interactions; and quantitative methods required for such experimental and modeling studies.
