Download or read book Human Red Cell Metabolism written by A. J. Grimes and published by . This book was released on 1980 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Red Cell Metabolism and Function written by George Brewer and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last six years, a remarkable series of stUdies have demonstrated an intimate relationship between red cell metabolism and the function of the cell as an organ of gas transport. First came the demonstration of binding of organic phosphocompounds of the red cell to hemoglobin; this was followed by studies that demonstrated modification of hemoglobin oxygen affinity by such binding. At present we are in an exhilirating phase of accrual of data showing that the levels of these phosphorylated inter mediates can be rapidly altered in the red cell to modulate hemo globin function. At one time it was said that the red cell was an inert bag full of hemoglobin. Now we know not only that the cell has an active metabolism crucial to its viability, but that this metabolism is just as crucial to the whole organism in the proper adjustment of oxygen transport. On October first, second and third, 1969, red cell biochemists, general biochemists, geneticists, cardio-pulmonary physiologists, exercise physiologists, experts in blood storage, and represen tatives from many other disciplines met in the Towsley Center for Continuing Medical Education at the University of Michigan, Ann Arbor, to present recent findings and discuss developments in this new interdisciplinary field. The meeting was dedicated to Dr. Alfred Chanutin, Professor Emeritus of the University of Virginia, to honor his retirement in 1967 and in recognition of his great contributions to the studies outlined in the first paragraph of this preface.
Download or read book Red Cell Metabolism written by Ernest Beutler and published by . This book was released on 1975 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Hemoglobin and Red Cell Structure and Function written by George Brewer and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hemoglobin and the red cell have continued to set a dizzying pace as the objects of research in the two and one-half year interval since the First International Conference on Red Cell Metabolism and Function. Most exciting perhaps, is a beginning molecular attack on sickle cell disease. The story of the inter action of red cell metabolism and oxygen transport has continued to unfold, and we can now infer that patients with hypoxia usually utilize red cell metabolic adjustments to improve oxygenation. This puts the red cell squarely in the center of medical practice, since much of medicine-heart, pulmonary, and blood disease- deals with inadequate oxygenation. On April 27th through the 29th, 1972, crystallographers, chemists, biochemists, physiologists, geneticists, and physi cians from many medical disciplines met in the Towsley Center for Continuing Medical Education at the University of Michigan, Ann Arbor to present new data, to review recent developments, and to try to piece together additional features of the red cell puzzle. The meeting was dedicated to Dr. Francis John Worsley Roughton, Professor Emeritus of Colloid Science, University of Cambridge, England, in recognition of his numerous excellent contributions to the understanding of hemoglobin and red cell function. The program got off to a good start with a paper from M. F. Perutz, Nobel Laureate, on the structure of hemoglobin. Dr.
Download or read book The Red Blood Cell written by Douglas Surgenor and published by Elsevier. This book was released on 2012-12-02 with total page 629 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Red Blood Cell, Second Edition, Volume I provides information pertinent to red blood cells, which is the most intensely studied human tissue. This book reviews the basic biomedical knowledge about the circulating, red blood cells. Organized into 13 chapters, this edition starts with an overview of the discovery of red blood cells, which results in the growth of knowledge in the areas of clinical disease and therapeutic efforts. This book then discusses the significant functions of the red blood cells, which exists basically to transport the respiratory gases. Other chapters examine the red blood cell’s capacity for protein synthesis and its ability to diversify its function. This book discusses as well the progress in the structural analysis of lipids. The final chapter deals with the capacity to store red blood cells frozen for long periods with high yield of viable physiological functional cells after post-thaw processing. Scientists, physicians, teachers, researchers, and students will find this book extremely useful.
Download or read book E Cell System written by Satya Nanda Vel Arjunan and published by Springer Science & Business Media. This book was released on 2013-05-13 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interdisciplinary field of molecular systems biology aims to understand the behavior and mechanisms of biological processes composed of individual molecular components. As we gain more qualitative and quantitative information of complex intracellular processes, biochemical modeling and simulation become indispensable not only to uncover the molecular mechanisms of the processes, but to perform useful predictions. To this end, the E‐Cell System, a multi‐algorithm, multi‐timescale object‐oriented simulation platform, can be used to construct predictive virtual biological systems. Gene regulatory and biochemical networks that constitute a sub‐ or a whole cellular system can be constructed using the E‐Cell System to perform qualitative and quantitative analyses. The purpose of E‐Cell System: Basic Concepts and Applications is to provide a comprehensive guide for the E‐Cell System version 3 in terms of the software features and its usage. While the publicly available E‐Cell Simulation Environment version 3 User's Manual provides the technical details of model building and scripting, it does not describe some of the underlying concepts of the E‐Cell System. The first part of the book addresses this issue by providing the basic concepts of modeling and simulation with the E‐Cell System.
Download or read book A Model of the Human Red Blood Cell Metabolism written by Neema Jamshidi and published by . This book was released on 2000 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Systems Biology of Red Cell Metabolism written by James T Yurkovich and published by . This book was released on 2018 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human red blood cell (RBC) is a logical starting point for the development and application of systems biology methods because of its simplicity, intrinsic experimental accessibility, and importance in human health. New "-omics" technologies have been used to study the biochemical and morphological changes that occur in red blood cells during cold storage, collectively referred to as the "storage lesion." Here, we extend these previous efforts by using systems biology to examine the metabolic physiology of RBCs under storage conditions. We first characterized the temperature dependence of the storage process using previously identified storage-age biomarkers as a representation of systems-level trends, showing that the metabolic state of the RBC is conserved but accelerated with increasing temperature. We then questioned whether these biomarkers--which had been shown to be excellent qualitative markers of systemic behavior--held any potential to provide quantitative information about the system. Using simple linear statistical models, we showed that a subset of the biomarkers could be used to predict the quantitative concentration profiles of other metabolites in the RBC network. We expanded these efforts by integrating network structural information into these statistical models to forecast future values of these concentration profiles after measurements made during only the first eight days of storage. Next, we used multiple first principles modeling approaches to understand the underlying mechanisms and temporal dynamics of the observed behaviors and developed a method for the integration of metabolomics data into cell-scale mathematical models. Finally, we developed a method for the integration of quantitative proteomics data into cell-scale models using Escherichia coli as a test case. Collectively, these results provide empirical proof that the RBC metabolome can be represented in a low-dimensional space and offer the starting point for a whole-cell model of the RBC. More broadly, we detail the development and use of systems biology methods on the human RBC, providing a starting point from which we can expand these efforts to other, more complicated cellular systems.
Download or read book The Red Blood Cell written by Douglas MacN. Surgenor and published by Academic Press. This book was released on 2013-10-22 with total page 783 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Red Blood Cell, Second Edition, Volume II provides a comprehensive treatment and review of basic biomedical knowledge about the circulating, adult red blood cell. This book discusses the transport through red cell membranes; carrier-mediated glucose transport across human red cell membranes; and metabolism of methemoglobin in human erythrocytes. The interaction of oxygen and carbon dioxide with hemoglobin at the molecular level; physiological role of the oxyhemoglobin dissociation curve; hemoglobinopathies; and thalassemia syndromes are also deliberated. This publication likewise covers the red cell genetic polymorphisms; biological life of the red cell; clinical indications for red cells and blood; and biophysical behavior of red cells in suspensions. Other topics include the electrokinetic behavior of red cells; erythrocyte as a biopsy tissue in the evaluation of nutritional status; and knowledge of red cell purine and pyrimidine metabolism coming from the study of human disease. This volume is recommended for students, researchers, teachers, and physicians aiming to acquire knowledge of the red blood cell.
Download or read book The Red Cell written by George J. Brewer and published by . This book was released on 1981 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metabolism in Human Red Blood Cells written by Ta-Chen Ni and published by . This book was released on 1994 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of Tissue Oxygenation Second Edition written by Roland N. Pittman and published by Biota Publishing. This book was released on 2016-08-18 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.
Download or read book Red Cell Metabolism written by Ernest Beutler and published by . This book was released on 1986 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of Phosphate and Mineral Metabolism written by Shaul G. Massry and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: We are pleased to present to our readers the Proceedings of the Fifth International Workshop on Phosphate and Other Minerals which was held in New York City, New York, U.S.A during September 23-27,1981. It was hosted by Joseph M. Letteri, M.D., Professor of Medicine at the State University of New York at Stonybrook School of Medicine, and Chief, Division of Nephrology, Nassau County Medical Center. As in the previous Workshops, this meeting provided an oppor tunity for interested scientists from interrelated fields, including nephrology, endocrinology, physiology, biochemistry and nutrition, to get together and discuss the recent advances in the field of phosphate and mineral metabolism. There were 29 invited presenta tions by leading scientists and 40 oral and 90 poster presentations selected from over 250 abstracts submitted to the Organizing Committee. The Workshop was attended by 250 scientists from 14 countries including Austria, Australia, Canada, Denmark, England, France, Germany, Holland, Israel, Italy, Japan, Sweden, and the United States of America. The Sixth International Workshop on Phosphate and Other Minerals will be held during June 24-26, 1983 in Verona, Italy. It will be hosted by Professor Giuseppe Maschio, Director, Division of Nephrology, Istituti Ospitalieri, Verona, Italy. The theme of this coming Workshop will continue to focus on the pathophysiology of phosphate homeostasis and the metabolism of other minerals.
Download or read book The Relationship of the Metabolism of the Human Red Blood Cell and Its Ability to Concentrate Potassium written by Roberta R. Coffin and published by . This book was released on 1959 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Red Cell written by John William Harris and published by Harvard University Press. This book was released on 1970 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every chapter in this classic on hematology has been entirely updated. Beginning at the molecular level, the book gives a detailed description of the way a red blood cell is produced, its metabolic processes, and how it is destroyed. Data and examples drawn from experiments illustrate current knowledge of the subject and substantiate conclusions. Although the work is clinically oriented, the text emphasizes the experimental approach to seeking the pathophysiology and mechanisms of disease resulting from alterations in the life processes of the red cell. Nearly 100 illustrations accompany the text.
