Download or read book Handbook of Oxidative Stress in Cancer Therapeutic Aspects written by Sajal Chakraborti and published by Springer Nature. This book was released on 2022-09-28 with total page 4078 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy.
Download or read book Handbook of Oxidative Stress in Cancer Mechanistic Aspects written by Sajal Chakraborti and published by Springer. This book was released on 2022-02-01 with total page 2675 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive, up-to-date reference work compiles the scientific research on the relationship between various forms of cancer and reactive oxygen species (ROS). It is well known that ROS play a key role in the various steps leading to malignancy, this includes increase in DNA mutation rates. The book brings together exciting reviews, written by leading experts all over the world. The book is divided into four broad sections. Each section describes the role of oxidative stress and underlying mechanisms and pathways, at various stages of cancer, including its role in carcinogenesis, cancer progression and metastasis. Further, the book describes how the reactive oxygen species (ROS) modulate gene expression and signal transduction pathways in cancer. The book discusses the ways to interfere with the cancer progression, and design of anti-cancer drugs. The book provides an integrated approach for better understanding of the development phases of oxidative stress-induced cancers, and mainly the current perspectives about mechanistic aspects of cancer initiation, progression and metastasis. It is a highly resourceful book and would be extremely important to clinicians, students and researchers in the field of cancer genetics, therapeutics and oncology.
Download or read book Oxidative Stress in Cancer Biology and Therapy written by Douglas R. Spitz and published by Springer Science & Business Media. This book was released on 2011-11-25 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last 30 years it has become clearly evident that oxidative stress and free radical biology play key roles in carcinogenesis, cancer progression, cancer therapy, and normal tissue damage that limits treatment efficacy during cancer therapy. These mechanistic observations have led to the realization that free radical biology and cancer biology are two integrally related fields of investigation that can greatly benefit from cross fertilization of theoretical constructs. The current volume of scientific papers was assembled under the heading of Oxidative Stress in Cancer Biology and Therapy in order to stimulate the discussion of how the knowledge gained in the emerging field of oxidative stress in cancer biology can be utilized to more effectively design interventions to enhance therapeutic responses while causing fewer treatment limiting complications. The chapters contained in this volume provide highly informative emerging perspectives on how that selective enhancement of oxidative stress in cancerous tissues can be used as a target for enhancing therapeutic outcomes as well as how selective inhibition of oxidative stress could spare normal tissue damage and inhibit carcinogenesis. In this regard, the book represents an outstanding resource for both basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy.
Download or read book Handbook of Oxidative Stress and Cancer written by Sajal Chakraborti and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Arsenic Toxicology written by Swaran Jeet Singh Flora and published by Academic Press. This book was released on 2023-02-21 with total page 988 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Arsenic Toxicology, Second Edition presents the latest findings on arsenic, including its chemistry, sources and effects on the environment and human health. The book discusses both acute and chronic effects, discussing many aspects of arsenic, from physical and chemical properties, exposure, epidemiology, organ toxicity, diagnosis, prevention and treatment. Fully updated and revised, this new edition includes new topics on risk assessment, molecular mechanisms of arsenic, advances in the integrated approach to testing, assessment and development, evaluation and application of high content predictive models, and new alternative methods (NAMS) in the context of Adverse Outcome Pathways (AOPs) to assess toxicology. This comprehensive resource allows readers to effectively assess the risks related to arsenic, providing them with all they need to know on arsenic exposure, toxicity and toxicity prevention. - Brings together current findings on the effects of arsenic on the environment and human health - Includes state-of-the-art techniques in arsenic toxicokinetics, speciation and molecular mechanisms - Provides all the information needed for effective risk assessment, prevention and countermeasures
Download or read book Handbook on Oxidative Stress written by Adolfo M. Reyes and published by Nova Science Publishers. This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents new research in the study of oxidative stress. Topics discussed include pharmacological treatments in myocardial ischemia-reperfusion injury; oxidative stress in neurodenegerative disorders, hyptertension, and the cardiovascular system; the role of antioxidant supplementation in ischemic stroke; mitochondria at the crossroads of cancer and oxidative stress; and the influence of aerobic exercise training on post-prandial oxidative stress.
Download or read book Analytical Methods for Heat Transfer and Fluid Flow Problems written by Bernhard Weigand and published by Springer. This book was released on 2015-05-05 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes useful analytical methods by applying them to real-world problems rather than solving the usual over-simplified classroom problems. The book demonstrates the applicability of analytical methods even for complex problems and guides the reader to a more intuitive understanding of approaches and solutions. Although the solution of Partial Differential Equations by numerical methods is the standard practice in industries, analytical methods are still important for the critical assessment of results derived from advanced computer simulations and the improvement of the underlying numerical techniques. Literature devoted to analytical methods, however, often focuses on theoretical and mathematical aspects and is therefore useless to most engineers. Analytical Methods for Heat Transfer and Fluid Flow Problems addresses engineers and engineering students. The second edition has been updated, the chapters on non-linear problems and on axial heat conduction problems were extended. And worked out examples were included.
Download or read book Biochemistry of Oxidative Stress written by Ricardo Jorge Gelpi and published by Springer. This book was released on 2018-07-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The strongest point of this book titled “Biochemistry of Oxidative Stress: Physiopathology and Clinical Aspects”, is that the academic and scientific background of the authors/editors guarantee the authorship of a book comprising all aspects of oxidative stress, ranging from very molecular aspects, to clinical application, including the antioxidant therapy. Of particular importance is the fact that the aforementioned aspects are described in the book in a general section and in three different and important pathologies, such as cardiovascular diseases, neurodegenerative diseases, and cancer. The importance of these pathologies lays in the fact that, taken separately or together, they represent by far the leading cause of death in the world. Finally, all the chapters have been written by highly recognized authorities in the field of their investigations. At least to our knowledge, this is the first book with this characteristics in the field of oxidative stress.
Download or read book Analytical Elements of Mechanisms written by Dan B. Marghitu and published by Cambridge University Press. This book was released on 2001-06-18 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes methods and algorithms for the analysis and design of kinematic systems.
Download or read book Corrosion Inhibitors Principles and Recent Applications written by Mahmood Aliofkhazraei and published by BoD – Books on Demand. This book was released on 2018-04-04 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: To protect metals or alloys from corrosion, some methods can be used such as isolating the structure from the aggressive media or compensating the loss of electrons from the corroded structure. The use of corrosion inhibitors may include organic and inorganic compounds that adsorb on the metallic structure to isolate it from its surrounding media to decrease oxidation-reduction processes. This book collects new developments about corrosion inhibitors and their recent applications.
Download or read book Aging Mechanisms written by Nozomu Mori and published by Springer. This book was released on 2015-11-26 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together the most up-to-date information on recent research results of leading laboratories on aging science in East Asia, particularly in Japan, Korea, and Hong Kong. Starting with a comprehensive overview of various hypotheses on biological mechanisms of aging by Dr. Sataro Goto, each chapter covers broad aspects of the most recent findings in aging-related topics: centenarian studies and genome analysis of progeria, metabolic biochemistry and neurobiology, longevity controls in yeast and nematodes, oxidative stress and calorie restriction, and neurodegeneration mechanisms in Alzheimer’s and Huntington’s diseases, with further potential therapeutic approaches to these age-related neurodegenerative diseases. Also included, in part, is a summary and the outcomes of a scientific discussion forum called the Asian Aging Core for Longevity (AACL) that has been held annually alternating between Japan and Korea during the last decade. This book can serve as a useful resource for finding appropriate collaborators in the areas it covers. The target readership is made up of graduate students and researchers at universities, medical and/or life-science schools, and biomedical and pharmaceutical institutes. Why does aging exist? How do we age? How is each organism’s lifespan determined? These are fundamental questions in the field. We may be still far from achieving a complete view of aging mechanisms, but this book, Aging Mechanisms, offers an excellent opportunity to become familiar with the most updated progress in the biomedical research of aging in Japan and Korea, the two leading nations for human longevity.
Download or read book Handbook of Biologically Active Peptides written by Abba Kastin and published by Elsevier. This book was released on 2011-04-28 with total page 1682 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbook of Biologically Active Peptides presents, for the first time, this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. The Handbook of Biologically Active Peptides is a definitive, all-encompassing reference that will be indispensable for individuals ranging from peptide researchers, to biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and to endocrinologists. Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas with which they would not ordinarily be familiar.*Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas that they would not ordinarily be familiar.*Fascinating relationships described in the book include the presence of some peptides originally found in frog skin that persist in the human human and brain where they can affect food intake and obesity.
Download or read book Ascorbate Glutathione Pathway and Stress Tolerance in Plants written by Naser A. Anjum and published by Springer Science & Business Media. This book was released on 2010-08-20 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants are sessile organisms that live under a constant barrage of biotic and abiotic insults. Both biotic and abiotic stress factors have been shown to affect various aspects of plant system including the acceleration in the formation of reactive oxygen species (ROS). The ascorbate (AsA)-glutathione (GSH) pathway is a key part of the network of reactions involving enzymes and metabolites with redox properties for the detoxification of ROS, and thus to avert the ROS-accrued oxidative damage in plants. The present book mainly deals with the information gained through the cross-talks and inter-relationship studies on the physiological, biochemical and molecular aspects of the cumulative response of various components of AsA-GSH pathway to stress factors and their significance in plant stress tolerance.
Download or read book Fluids Under Pressure written by Tomáš Bodnár and published by Springer Nature. This book was released on 2020-04-30 with total page 647 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed volume is based on talks given at the August 2016 summer school “Fluids Under Pressure,” held in Prague as part of the “Prague-Sum” series. Written by experts in their respective fields, chapters explore the complex role that pressure plays in physics, mathematical modeling, and fluid flow analysis. Specific topics covered include: Oceanic and atmospheric dynamics Incompressible flows Viscous compressible flows Well-posedness of the Navier-Stokes equations Weak solutions to the Navier-Stokes equations Fluids Under Pressure will be a valuable resource for graduate students and researchers studying fluid flow dynamics.
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Download or read book Herbal Medicine written by Iris F. F. Benzie and published by CRC Press. This book was released on 2011-03-28 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: The global popularity of herbal supplements and the promise they hold in treating various disease states has caused an unprecedented interest in understanding the molecular basis of the biological activity of traditional remedies. Herbal Medicine: Biomolecular and Clinical Aspects focuses on presenting current scientific evidence of biomolecular ef
Download or read book Encyclopedia of Metalloproteins written by Robert H. Kretsinger and published by Springer. This book was released on 2013-05-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In biochemistry, a metalloprotein is a generic term for a protein that contains a metal cofactor. The metal may be an isolated ion or may be coordinated with a nonprotein organic compound, such as the porphyrin found in hemoproteins. In some cases, the metal is co-coordinated with a side chain of the protein and an inorganic nonmetallic ion. This kind of protein-metal-nonmetal structure is seen in iron-sulfur clusters Metalloproteins deals with all aspects related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The biological roles of metal cations and metal-binding proteins are endless. They are involved in all crucial cellular activities. Many pathological conditions are related to the problematic metal metabolism. Research in metalloprotein-related topics is therefore rapidly growing, and different aspects of metal-binding proteins progressively enter curricula at Universities and even at the High School level on occasion. However, no key resource providing basic, but comprehensible knowledge on this rapidly expanding field exists. The Encyclopedia of Metalloproteins aims to bridge this gap, and will attempt to cover various aspects of metalloprotein/metalloproteomics and will deal with the different issues related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The goal is to cover exhaustively all catalytically and biologically crucial metal ions and to find at least one interacting protein for other metal ions. The Encyclopedia of Metalloproteins will provide a key resource for advanced undergraduate and graduate students, researchers, instructors, and professors interested in protein science, biochemistry, cell biology, and genetics.
