Download or read book Handbook of Chronic Myeloid Leukemia written by Timothy P Hughes and published by Springer. This book was released on 2014-11-06 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise, clinically focused pocket handbook assembles and synthesizes the latest developments and trends in the diagnosis and treatment of CML and provides an authoritative and convenient summary of the latest progress in TKI trials, the molecular monitoring of CML responses, and the development of new therapies to overcome resistance and improve patient care. Chronic myeloid leukemia (CML) is a rare type of leukemia (1–2 per 100,000 people) but is the most common chronic myeloproliferative neoplasm. CML remains a key model for the improved understanding of the pathophysiology of a malignancy at a molecular level; CML was the first cancer to be associated with a recurring chromosome abnormality, which generates the Philadelphia (Ph) chromosome and its associated fusion gene BCR-ABL1. The clinical outcome for patients with CML has changed dramatically in the past 15 years and this has been due to the development of tyrosine kinase inhibitors (TKIs), compounds that inhibit the activity of the oncogenic BCR-ABL1 protein. A number of first-, second- and third-generation TKIs are now available for the treatment of CML, although a number of treatment challenges remain, not least the development of treatment-resistant CML. Parallel to the development of specific drugs for treating CML, major advances have been made in the field of disease monitoring and standardization of response criteria.
Download or read book Chronic Myeloid Leukemia written by Tariq I. Mughal and published by CRC Press. This book was released on 2013-04-25 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highly Commended, BMA Medical Book Awards 2014 Chronic myeloid leukemia is a clonal disease that results from an acquired genetic change in a single pluripotential hemopoietic stem cell. Efforts to confront this disease have been assisted by advances in cellular and molecular biology and the speed at which these findings have transformed the therapeutic algorithm. Nevertheless, there is some uncertainty with regards to how best to assess efficacy of treatment, especially with regards to the most appropriate surrogate markers for overall survival. From the standpoint of biology and clinical management, this handbook provides an authoritative state-of-the-art review of current and developing progress.
Download or read book Chronic Myeloid Leukemia written by Rüdiger Hehlmann and published by Springer. This book was released on 2016-08-17 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides state-of-the-art reviews of key issues and recent developments relating to chronic myeloid leukemia (CML), acquainting the reader with advances in research, treatment, and promotion of public health. Among the management topics addressed are the choices, advantages, and pitfalls of first-, second-, and third-line treatments; the European LeukemiaNet recommendations; management of adverse effects of tyrosine kinase inhibitors (TKI); management of CML blast crisis; management of pregnancy in the context of CML; the role of hematopoietic cell transplantation; the current experience with TKI discontinuation; and the value of interferon α in improving the outcome of TKI treatment. Various aspects of relevance to treatment outcome are discussed, including prognostic scores, molecular monitoring (principles and interlaboratory standardization), and response-related predictors of survival. Furthermore, updates are provided on the increasing prevalence of CML and its implications and on the changing cost of care for CML, taking into account the forthcoming impact of availability of generic imatinib.
Download or read book Molecular Pathogenesis and Treatment of Chronic Myelogenous Leukemia written by Masahiro Kizaki and published by Springer. This book was released on 2015-11-05 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Pathogenesis and Treatment of Chronic Myelogenous Leukemia provides a comprehensive understanding of the recent molecular genetics of Chronic Myelogenous Leukemia (CML) and a characterization of the molecular targets for drug development. Included are therapeutic implications, diagnosis, and prognosis for understanding and facilitating daily practice in the management of patients with CML. Understanding of the pathogenesis and therapy of hematological malignancies such as CML has grown significantly in recent years. This development owe much to the progress in molecular biology and now makes a major contribution to diagnosis and to treatment that pharmacologically targets the molecular events of CML. Molecular targeting therapy with newly developed agents such as small molecules and antibodies for hematological malignancies are being discovered after years of research. Some of these, including tyrosine kinase inhibitors such as imatinib, nilotinib, and dasatinib, lead to increased survival rates and improved therapies. With the opinion leaders of basic and clinical research in the field as authors, this book reviews recent advances in the biology of CML.
Download or read book Chronic Myeloid Leukemia New Insights for the Healthcare Professional 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-07-22 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic Myeloid Leukemia: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Genetics. The editors have built Chronic Myeloid Leukemia: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Genetics in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Chronic Myeloid Leukemia: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book The CML Guide written by Leukemia & Lymphoma Society of America and published by . This book was released on 2012 with total page 35 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Acute Leukemia written by Wolfgang Hiddemann and published by Springer. This book was released on 2016-11-14 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of the key developments in both acute lymphocytic leukemia and acute myeloid leukemia with a comprehensive guide to the epidemiology, pathogenesis, etiology, clinical manifestations, classification, diagnosis, and staging as well as the most recent developments in the therapeutic landscape for acute leukemia. The Handbook of Acute Leukemia offers readers a key resource into the future outlook for patients with leukemia and is edited and authored by internationally renowned experts in the field. Leukemia is cancer of the white blood cells and acute leukemia means the condition progresses rapidly and aggressively, requiring immediate treatment. Acute leukemia is classified according to the type of white blood cells that are affected: either lymphocytes and myeloid cells.
Download or read book Chronic Myeloid Leukemia New Insights for the Healthcare Professional 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic Myeloid Leukemia: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Chronic Myeloid Leukemia. The editors have built Chronic Myeloid Leukemia: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Chronic Myeloid Leukemia in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Chronic Myeloid Leukemia: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book NCCN Guidelines for Patients Chronic Myeloid Leukemia written by National Comprehensive Cancer Network® (NCCN®) and published by . This book was released on 2020-02-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: [OFFICIAL CURRENT VERSION] From the National Comprehensive Cancer Network® (NCCN®), comes this essential guide to Chronic Myeloid Leukemia. Adapted from clinical treatment guidelines used by physicians and oncology professionals around the world, these NCCN Guidelines for Patients help prepare patients and caregivers to talk with their doctors and make treatment decisions. Topics include: CML basics, testing for CML, treatment options, chronic phase CML, advanced phase, and making treatment decisions. Let this authoritative handbook be your guide!
Download or read book Chronic Myeloid Leukemia written by Uday R. Popat and published by Nova Science Publishers. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted therapy has revolutionised modern oncology practice and has completely changed the outcome of once universally fatal diseases like chronic myeloid leukaemia (CML). The last decade has witnessed significant advances in the management of CML, which has become more like a chronic disease. Written by experts in the field, this volume nicely describes the current knowledge of the pathophysiology, clinical features, and management of CML. It covers not only clinical topics but also the basic science underlying these practices. It will be of help to clinicians and basic scientists alike. In addition to the state of the art treatment of CML, this book also covers many uncommon but very important special topics like management of CML in pregnancy or with children, management of resistance to new tyrosine kinases and treatment of the advanced phase of the disease. Written to be easily digestible, patients will also be able to access important and universally useful information on CML (eg: diagnosis, symptoms and signs, and treatment). Some themes especially, including drug and food interactions of tyrosine kinase inhibitors (TKIs), CML treatment during pregnancy, advantages/disadvantages of the most commonly used TKIs, and bone marrow transplantation indications, will be of popular concern. This extensively referenced book therefore should be of great help to both novices and experts in the field.
Download or read book Handbook of Leukemia written by Dylan Hill and published by . This book was released on 2019-06-07 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leukemia is a group of cancer, which occurs in the bone marrow and results in abnormal growth of white blood cells. Such cells are called blasts or leukemia cells. Bleeding and bruising, fever, tiredness and increased infections are some of the symptoms of leukemia. It can be classified as chronic lymphocytic leukemia, acute lymphoblastic leukemia, acute myeloid leukemia and chronic myeloid leukemia. The diagnosis of leukemia is usually determined by blood tests or though a bone marrow biopsy. A variety of factors may contribute to its incidence, among which are smoking, genetics, chemical exposure, etc. Leukemia is treated with a multi-drug chemotherapy regimen, pharmaceutical medication or with radiation therapy. A bone marrow transplant is also an important strategy to treat such a cancer. This book provides comprehensive insights into leukemia. It consists of contributions made by international experts. Coherent flow of topics, student-friendly language and extensive use of examples make this book an invaluable source of knowledge.
Download or read book Oxford Specialist Handbook Myeloproliferative Neoplasms written by Tariq I. Mughal and published by Oxford University Press, USA. This book was released on 2020-08-06 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of myeloproliferative neoplasms (MPN) disorders has grown considerably over the past four decades. Myeloproliferative Neoplasms offers a detailed evidence-based guide to MPNs in an easily accessible format, structure to facilitate learning specialist information presenting core information in 'bite size' chunks.
Download or read book Chronic Myeloid Leukemia New Insights for the Healthcare Professional 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-10 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic Myeloid Leukemia: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Chronic Myeloid Leukemia. The editors have built Chronic Myeloid Leukemia: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Chronic Myeloid Leukemia in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Chronic Myeloid Leukemia: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book CML Chronic Myeloid Leukemia written by Dr Bhratri Bhushan and published by Independently Published. This book was released on 2021-08-12 with total page 66 pages. Available in PDF, EPUB and Kindle. Book excerpt: CML (chronic myeloid leukemia) is one of the most treatable cancers. With the advent of new diagnostic and therapeutic modalities, the management landscape of CML has dramatically changed, especially so in the past decade. In this book, together we will explore the subject of CML. This will help you understand the disease better. It is overwhelming to know that either you or your loved one has been diagnosed with CML and it may sound unrealistic that at this trying time you should pick up a book and understand the disease biology and management strategies but believe me, it is important. Today all of the decision making in medicine, especially in oncology, is "shared" decision making. What it means is that the team treating you is just one part of the decision making process, the other part is you and your family. An informed decision is a good decision and to make an informed decision, you must have reasonably enough knowledge of the subject. The goal of this book is in no way to be an all encompassing, comprehensive reference for all of your questions; but to provide you all of the useful information, without unnecessarily burdening you with confusing facts and figures. I have constructed this book in an interactive format, i.e., questions and answers. Most of these question I have picked up by my daily encounters with patients and their families and some I have constructed myself to bridge the gaps between the topics. I hope you will find this book helpful. I wish you and your loved ones long, healthy and prosperous lives.
Download or read book Leukemias written by Stefan Faderl and published by John Wiley & Sons. This book was released on 2011-09-14 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by experts from one of the world’s largest leukemia centers, this book provides information on the biology of the variety of leukemic disorders, up-to-date diagnostic testing and many new developments in therapy. Chapters covering new treatments present an outlook for the future and explain the rationale for ongoing clinical trials. Topics include: Targeted therapy, e.g. tyrosine kinase inhibitors (Flt3, Aurora kinase inhibitors, kit inhibitors, BCR-ABL inhibitors) Ras inhibitors Epigenetic therapy (hypomethylaters and histone deacetylase inhibitors) Lenalidomide analogs New chemotherapy drugs, e.g. clofarabine, cloretazine, sapacitabine, forodesine Combinations of chemotherapy with kinase inhibitors (e.g. ALL induction protocols in combination with dasatinib or imatinib) New monoclonal antibodies (lumiliximab, humaxCD20, anti-CD40) Thrombopoietic agents Leukemias: Principles and Practice of Therapy Includes practical information to guide you in challenging situations, such as treatment of elderly patients, pregnancy, relapsed and refractory disease Incorporates chapters on supportive care and pharmacologic information about the most frequently used drugs in this area
Download or read book Myeloproliferative Disorders written by J.V. Melo and published by Springer Science & Business Media. This book was released on 2007-03-06 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains a series of contributions from internationally renowned academics with special expertise in one or other diseases which collectively are grouped under the heading myeloproliferative disorders. There have been many recent developments in understanding the pathophysiology and a number therapeutic innovations in this area. A feature of this book is the speed with which it has been produced – an important factor in this rapidly moving field.
Download or read book The EBMT Handbook written by Nicolaus Kröger and published by . This book was released on 2020-10-08 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
