Download or read book Genetic Variants in Periodontal Health and Disease written by Alexandrina L Dumitrescu and published by Springer. This book was released on 2009-10-26 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: Periodontitis is a complex, multifactorial disease and its susceptibility is genetically determined. The present book systematically reviews the evidence of the association between the genetic variants and periodontitis progression and/or treatment outcomes. Genetic syndromes known to be associated with periodontal disease, the candidate gene polymorphisms investigated in relation to periodontitis, the heritability of chronic and aggressive periodontitis, as well as common guidelines for association studies are described. This growing understanding of the role of genetic variation in inflammation and periodontal chronic disease presents opportunities to identify healthy persons who are at increased risk of disease and to potentially modify the trajectory of disease to prolong healthy aging. The book represents a new concept in periodontology with its pronounced focus on understanding through knowledge rather than presenting the presently valid answers. Connections between genetics and periodontology are systematically reviewed and covered in detail.
Download or read book Pathogenesis of Periodontal Diseases written by Nagihan Bostanci and published by Springer. This book was released on 2017-09-25 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to provide clinicians with a refined understanding of the biology that underlies periodontal diseases, thereby offering a sound basis for improved clinical decision making with regard to prevention strategies, diagnosis, and therapy. All significant aspects of periodontal pathogenesis are covered, including the roles played by the oral microbiome and biofilms, bacterial virulence factors, cells of the immune system, matrix metalloproteinases, proinflammatory and osteolytic cytokines, genetic factors, and antimicrobial peptides. Periodontal diseases are among the most common infectious diseases in humans, and the primary cause of tooth loss in adults. The functional and esthetic problems associated with these diseases compromise quality of life, and their treatment imposes large financial burdens on national health systems and private patients. Up-to-date knowledge of periodontal pathogenesis is therefore essential for the contemporary clinician. This book, written by experts from Europe and the Americas, delivers such knowledge in an accessible, clinician-friendly way.
Download or read book Polymicrobial Diseases written by Kim A. Brogden and published by . This book was released on 2002 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymicrobial diseases, those involving more than one etiologic agent, are more common than is generally realized and include respiratory diseases, gastroenteritis, conjunctivitis, keratitis, hepatitis, periodontal diseases, multiple sclerosis, genital infections, intra -- abdominal infections, and pertussis.
Download or read book Exploring the Genetic Correlation between Periodontal and Respiratory Diseases written by Pooja Singh and published by Cambridge Scholars Publishing. This book was released on 2024-03-21 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: Delve into the intricate genetic ties between periodontitis and respiratory disease in this illuminating book. Synthesizing current research, it elucidates shared genetic risk factors and pathways, enriching our understanding of their complex interconnection. Providing insights for practitioners, it enables personalized treatment strategies, leveraging genetic insights for improved patient outcomes. Recognizing the evolving research landscape and challenges in unraveling gene-environment interactions, it underscores the necessity for targeted interventions and individualized therapies. With its comprehensive overview, this book empowers researchers and healthcare professionals, paving the way for advanced approaches to prevention, diagnosis, and treatment in this vital field.
Download or read book The Resolution of Inflammation written by Adriano Rossi and published by Springer Science & Business Media. This book was released on 2008-03-17 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.
Download or read book Periodontology written by and published by BoD – Books on Demand. This book was released on 2022-02-16 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Edited Volume Periodontology - Fundamentals and Clinical Features is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the field. The book comprises single chapters authored by various researchers and edited by an expert active in the dental medicine research area. All chapters are complete in themselves but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors in periodontology, and opening new possible research paths for further novel developments.
Download or read book Genetics and Periodontal Disease written by Santo Grace Umesh and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A branch of Biology which deals with the science of hereditary influences on living organisms is termed as Genetics. There has been a broad study related to hereditary influence on human tissue linking to health and disease conditions. A vital role is played by genetics in the proper functioning, adaptive repair, regeneration and remodelling of hard and soft tissue. A major segment of genes are related to periodontal disease. Periodontal disease, being multifactorial in origin is directly or indirectly known to be caused by genetic factors also. A study on human and animals validates the concept that genetics could have influenced periodontal disorders and also plays a key role in the predisposition and progressiveness of the condition. The role played by genetics to damage the inflammatory and immune response system of the host tissues during periodontal conditions has been proved and this section will give a clear insight on the influence of genetics in this condition.
Download or read book Periodontal Disease written by and published by BoD – Books on Demand. This book was released on 2020-02-05 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to provide readers with the latest updates and an informative overview of the most successful diagnostic aids for periodontal diseases. This book is divided into three sections. Section 1 discusses the periodontal disease pathogenesis and how the disease develops and the contributing factors in disease development. Section 2 includes three chapters that focus mainly on the most common and recent biomarkers that aid in diagnosis of periodontal diseases. Section 3 includes one chapter and discusses a non-surgical treatment modality that could provide definite improvement in the mild to moderate conditions in periodontal diseases.
Download or read book GENETIC RISKS OF PERIODONTAL D written by Ying Zheng and published by Open Dissertation Press. This book was released on 2017-01-26 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Genetic Risks of Periodontal Disease" by Ying, Zheng, 鄭穎, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract GENETIC RISKS OF PERIODONTAL DISEASE By ZHENG YING For the Degree of Doctor of Philosophy at the University of Hong Kong Sep 2016 Periodontitis is a common dental noncommunicable disease. Numerous risk indicators are reported to be associated with chronic periodontitis (CP), including genetic susceptibility. The aim of this study was to investigate the genetic risk indicators of periodontitis in southern Chinese by candidate-gene and genome- wide association study approaches. Materials and methods In the first part of the study, the association of T helper 2 cell (Th2) regulatory and effector molecules' genetic polymorphisms with periodontitis in non-smokers was investigated. Th2 cells have been suggested to play an important role in periodontitis pathogenesis for decades, but the genetic background has not been thoroughly studied. 141 non-smoking CP patients and 163 periodontitis-free controls diagnosed clinically as well as characterized via radiograph assessment of alveolar bone loss were recruited. Genomic DNA from whole blood samples was collected and genotyped using Sequenom iPlex assays upon 129 SNPs of eleven IV Th2 cell regulatory or effector molecules genes (CD28, CTLA4, IL4, IL5, IL6, IL9, IL10, IL13, IL4R, GATA3, STAT6) and rs1537415, a recently reported SNPs related to aggressive periodontitis. In the second part of the study, 1,213 Southern Chinese were clinically examined and diagnosed based on the CDC/AAP classification of periodontitis and mean clinical attachment level (mCAL). A whole-genome association study (GWAS) was conducted to identify the genetic indicator for periodontitis in this Chinese cohort using HumanOmniZhongHua-8 BeadChip (Illumina), consisting of 814,285 SNPs after quality control. Single-marker, gene-based and pathway analysis were performed after imputation with the adjustment of age, gender, smoking, diabetes and plaque percentage. Results In the candidate gene study, three SNPs (rs4553808, rs16840252 and rs5742909) located in the promoter region of CTLA4 were identified to be closely inter- linked, and they were significantly associated with CP (pIn the GWAS, after single marker analysis with the mCAL-phenotype, four SNPs (rs78946930, rs77514260, rs78931888 and rs78399198) in the intron of the gene of Src homology domain containing 4A (SH2D4A) were found to be significantly V -8 associated with CP (p=1.32 2.5810 ). Gene-based analysis with mCAL- phenotype confirmed the significant association of SH2D4A with CP -7 (p=5.7410 ). Conclusion The candidate-gene study showed that SNPs in the region of CTLA4 was associated with CP in non-smoking Chinese. As CTLA4 was not exclusively expressed on Th2 cells, there was yet insufficient evidence to support the influence of Th2 cells on CP pathogenesis. The GWAS result suggested that SH2D4A was significantly associated with CP in Southern Chinese. Replication study and functional studies were underway to validate such observation. Word count: 452 VI Subjects: Periodontitis - Genetic aspects
Download or read book Glossary of Periodontal Terms written by and published by . This book was released on 1992 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Influence of Cooperative Bacteria on Animal Host Biology written by Margaret J. McFall Ngai and published by Cambridge University Press. This book was released on 2005-08-22 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Broad-ranging and cross-disciplinary overview of the evolution and mechanisms of beneficial host-pathogen interactions.
Download or read book Periodontitis written by Pachiappan Arjunan and published by BoD – Books on Demand. This book was released on 2017-11-15 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Periodontitis - A Useful Reference is a comprehensive book compiled by a team of experts with the objective of providing an overview of the basic pathology of "periodontitis" and its implication on oral health and general systemic health. Periodontitis has become a global health burden in recent days. It is noteworthy that oral health is being considered as the mirror of general health and the study of oral-systemic health connections has advanced among scientists, clinicians, and the public as well. We wish the array of chapters that highlights the importance and impact of periodontal health could be a useful guide for the community of public, students, and clinicians.
Download or read book Genetic Basis of Oral Health Conditions written by Alexandre Rezende Vieira and published by Springer Nature. This book was released on 2019-11-28 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains the genetic basis of a wide range of dental disorders, including dental caries, periodontitis, congenital anomalies, malocclusions, orofacial pain, dental implant failure, and cancer. Such conditions are typically multifactorial or complex, with involvement of more than one gene as well as environmental influences. A sound grasp of this framework is ever more important, given the emergence of consumer genomics, including direct-to-consumer genetic testing. Dental professionals now need to understand why one person is susceptible to a particular oral health condition while a first-degree relative either does not develop the condition or does so in a less severe form. Knowledge of how genes operate in the susceptible host is essential if patients are to be offered accurate advice about their risks. The information provided in this book will assist in the delivery of effective personalized dental care through optimization of preventive strategies. It will enable the practitioner to explain the extent to which a patient’s condition is pure "bad luck", whether that bad luck can be changed by behavioral choices, and how many of our behaviors are influenced by genes.
Download or read book A Life Course Perspective on Health Trajectories and Transitions written by Claudine Burton-Jeangros and published by Springer. This book was released on 2015-08-11 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book examines health trajectories and health transitions at different stages of the life course, including childhood, adulthood and later life. It provides findings that assess the role of biological and social transitions on health status over time. The essays examine a wide range of health issues, including the consequences of military service on body mass index, childhood obesity and cardiovascular health, socio-economic inequalities in preventive health care use, depression and anxiety during the child rearing period, health trajectories and transitions in people with cystic fibrosis and oral health over the life course. The book addresses theoretical, empirical and methodological issues as well as examines different national contexts, which help to identify factors of vulnerability and potential resources that support resilience available for specific groups and/or populations. Health reflects the ability of individuals to adapt to their social environment. This book analyzes health as a dynamic experience. It examines how different aspects of individual health unfold over time as a result of aging but also in relation to changing socioeconomic conditions. It also offers readers potential insights into public policies that affect the health status of a population.
Download or read book Lipid Mediators written by Fiona M. Cunningham and published by . This book was released on 1994 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an overview of lipid mediators from synthesis to inhibition. It addresses the immune system and its diseases from a pharmacological viewpoint and combines clinical aspects with basic science.
Download or read book The Human Microbiota and Chronic Disease written by Luigi Nibali and published by John Wiley & Sons. This book was released on 2016-10-03 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbiota-associated pathology can be a direct result of changes in general bacterial composition, such as might be found in periodontitis and bacterial vaginosis, and/or as the result of colonization and/or overgrowth of so called keystone species. The disruption in the composition of the normal human microbiota, or dysbiosis, plays an integral role in human health and human disease. The Human Microbiota and Human Chronic Disease: Dysbioses as a Cause of Human Pathology discusses the role of the microbiota in maintaining human health. The text introduces the reader to the biology of microbial dysbiosis and its potential role in both bacterial disease and in idiopathic chronic disease states. Divided into five sections, the text delineates the concept of the human bacterial microbiota with particular attention being paid to the microbiotae of the gut, oral cavity and skin. A key methodology for exploring the microbiota, metagenomics, is also described. The book then shows the reader the cellular, molecular and genetic complexities of the bacterial microbiota, its myriad connections with the host and how these can maintain tissue homeostasis. Chapters then consider the role of dysbioses in human disease states, dealing with two of the commonest bacterial diseases of humanity – periodontitis and bacterial vaginosis. The composition of some, if not all microbiotas can be controlled by the diet and this is also dealt with in this section. The discussion moves on to the major ‘idiopathic’ diseases afflicting humans, and the potential role that dysbiosis could play in their induction and chronicity. The book then concludes with the therapeutic potential of manipulating the microbiota, introducing the concepts of probiotics, prebiotics and the administration of healthy human faeces (faecal microbiota transplantation), and then hypothesizes as to the future of medical treatment viewed from a microbiota-centric position. Provides an introduction to dysbiosis, or a disruption in the composition of the normal human microbiota Explains how microbiota-associated pathology and other chronic diseases can result from changes in general bacterial composition Explores the relationship humans have with their microbiota, and its significance in human health and disease Covers host genetic variants and their role in the composition of human microbial biofilms, integral to the relationship between human health and human disease Authored and edited by leaders in the field, The Human Microbiota and Human Chronic Disease will be an invaluable resource for clinicians, pathologists, immunologists, cell and molecular biologists, biochemists, and system biologists studying cellular and molecular bases of human diseases.
Download or read book Translational Systems Medicine and Oral Disease written by Stephen Sonis and published by Academic Press. This book was released on 2019-09-14 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease specific chapters detail systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease, and autoimmune disease, among others. In addition, the book emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology and primary care. Presents the work of leading international researchers and clinicians who speak on the clinical applications of genomics, proteomics, metabolomics, microbiomics, and epigenetics, as well as analytic methods and functional omics in oral medicine Provides full-color, richly illustrated chapters that examine systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease and autoimmune diseases Includes clinical case studies that illustrate examples of oral disease diagnostics and management, highlighting points of key importance for the reader Emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers, and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology, and primary care
