Download or read book Gene Expression and Spinal Cord Injury written by Jason Brant Carmel and published by . This book was released on 2003 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Injury Responses in the Spinal Cord written by Catriona Helen Hay and published by . This book was released on 1996 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Gene Expression Analysis of Neurotrophins Trk Receptors and Associated Regulatory Molecules After Contusive Spinal Cord Injury written by Matthew Tyler Hougland and published by . This book was released on 2013 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic spinal cord injury (SCI) results in changes to the anatomical, neurochemical, and physiological properties of cells in the central and peripheral nervous system. Neurotrophins, acting by binding to their cognate Trk receptors on target cell membranes, contribute to modulation of anatomical, neurochemical, and physiological properties of neurons in sensorimotor circuits in both the intact and injured spinal cord. Neurotrophin signaling is associated with many post-SCI changes including maladaptive plasticity leading to pain and autonomic dysreflexia, but also therapeutic approaches such as training-induced locomotor improvement. Here we characterize expression of mRNA for neurotrophins and Trk receptors in lumbar dorsal root ganglia (DRG) and spinal cord after two different severities of mid-thoracic injury and at 6 and 12 weeks post-SCI. There was complex regulation that differed with tissue, injury severity, and survival time, including reversals of regulation between 6 and 12 weeks, and the data suggest that natural regulation of neurotrophins in the spinal cord may continue for months after birth. Our assessments determined that a coordination of gene expression emerged at the 12 week post-SCI time point and bioinformatic analyses address possible mechanisms. Additionally, we sought to determine if the regulatory patterns we observed were perhaps due to an inflammatory molecule that mediated the coordinated expression pattern that we observed at 12 weeks post injury, and identified the chemokine CCL2 as a potential candidate gene.

Download or read book Cellular Molecular Physiological and Behavioral Aspects of Spinal Cord Injury written by Rajkumar Rajendram and published by Academic Press. This book was released on 2022-05-10 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spinal injury affects about 10 million people annually worldwide, impacting on the family unit and causing lifelong disabilities, with varied symptoms including paresthesia, spasticity, loss of motor control, and often severe pain. Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury will enhance readers' understanding of the biological and psychological effects of spinal cord injury. Featuring chapters on gene expression, metabolic effects, and behavior, this volume discusses in detail the impact of spinal cord injury to better understand the underlying pathways and processes. The book has applicability for neuroscientists, neurologists, clinicians, and anyone working to better understand these injuries. - Summarizes the neuroscience of spinal cord injury, including cellular and molecular biology - Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding - Features chapters on signaling and hormonal events - Includes plasticity and gene expression - Examines health and stress behaviors after spinal cord injury

Download or read book The Effects of Spinal Cord Injury on Expression of Pain Relevant Genes in the Colon written by Noelle McKearney and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Neurobiology of Spinal Cord Injury written by Robert G. Kalb and published by Springer Science & Business Media. This book was released on 1999-10-22 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: Distinguished researchers review the latest scientific understanding of spinal cord injury (SCI), focusing on the mechanisms causing paralysis after spinal cord trauma, the molecular determinants of neural regeneration, and methods for improving damaged function. The authors examine the role of intracellular Ca2+ in neuronal death, the possibility of spinal learning, growth-promoting molecules for regenerating neurons, and the biochemistry and cell biology of microtubules. Among the treatment possibilities discussed are cell transplantation strategies beyond the use of fetal spinal cord tissue, remyelination in spinal cord demyelination models, high steroid therapy immediately after SCI, and the mixed use of anti- and proinflammatories. Comprehensive and highly promising, Neurobiology of Spinal Cord Injury summarizes and integrates the great progress that has been made in understanding and combating the paralysis that follows spinal cord injury.

Download or read book Bone Morphogenetic Proteins Bmps Mediate Cellular Response and Regulate Neural Stem Cell Differentiation After Acute Spinal Cord Injury in the Adult Mice written by Qi Xiao and published by . This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Bone Morphogenetic Proteins (BMPS) Mediate Cellular Response and Regulate Neural Stem Cell Differentiation After Acute Spinal Cord Injury in the Adult Mice" by Qi, Xiao, 肖琦, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. DOI: 10.5353/th_b4129044 Subjects: Bone morphogenetic proteins Gene expression Stem cells Spinal cord - Wounds and injuries Mice

Download or read book Therapeutic Strategies to Spinal Cord Injury written by Pavla Jendelova and published by MDPI. This book was released on 2018-11-29 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Therapeutic Strategies to Spinal Cord Injury" that was published in IJMS

Download or read book Regeneration associated Gene Expression in Hamster Rubrospinal Motoneurons Following Partial Spinal Cord Injury written by Paul David Storer and published by . This book was released on 2001 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Neuroscience of Spinal Cord Injury written by Rajkumar Rajendram and published by Academic Press. This book was released on 2022-05-27 with total page 1186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diagnosis and Treatment of Spinal Cord Injury will enhance readers' understanding of the complexities of the diagnosis and management of spinal cord injuries. Featuring chapters on drug delivery, exercise, and rehabilitation, this volume discusses in detail the impact of the clinical features, diagnosis, management, and long-term prognosis of spinal cord injuries on the lives of those affected. The book has applicability for neuroscientists, neurologists, clinicians, and anyone working to better understand spinal cord injuries. Spinal injury affects about 10 million people annually worldwide, impacting on the family unit and causing lifelong disabilities, with varied symptoms including paresthesia, spasticity, loss of motor control, and often severe pain. Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury will enhance readers' understanding of the biological and psychological effects of spinal cord injury. Featuring chapters on gene expression, metabolic effects, and behavior, this volume discusses in detail the impact of spinal cord injury to better understand the underlying pathways and processes. The book has applicability for neuroscientists, neurologists, clinicians, and anyone working to better understand these injuries. Diagnosis and Treatment of Spinal Cord Injury: - Covers both the diagnosis and treatment of spinal cord injury - Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding - Features chapters on epidemiology and pain - Includes MRI usage, biomarkers, and stem cell and gene therapy for management of spinal cord injury - Discusses pain reduction, drug delivery, and rehabilitation Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury: - Summarizes the neuroscience of spinal cord injury, including cellular and molecular biology - Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding - Features chapters on signaling and hormonal events - Includes plasticity and gene expression - Examines health and stress behaviors after spinal cord injury

Download or read book Model Organisms in Spinal Cord Regeneration written by Catherina G. Becker and published by John Wiley & Sons. This book was released on 2007-03-30 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook provides a comprehensive overview for students, clinicians and researchers planning to enter the field of neural regeneration, combining the latest knowledge with an understanding of all important model organisms in one handy volume. By covering the strengths and weaknesses as well as possible applications of different models it saves researchers both time and resources in their choice of the appropriate model organism. An equally valuable introduction for the novice planning to enter the field.

Download or read book The Effect of Tissue Damage and Inflammation on Gene Expression in Sensory Neurons written by Sean Anthony Trusty and published by . This book was released on 2011 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study examined the effects of tissue damage and inflammation on the expression in sensory neurons of P2X3, a gene that has a role in nociception and sensing bladder distension, which is regulated by nerve injury. Tissue damage induces expression of ATF3, an indicator of injury, in sensory neurons. Animals were exposed to different types of tissue damage including single and repeated skin incision, bladder incision and a spinal cord injury with bladder inflammation. P2X3 was regulated differentially between conditions of single and repeated skin incision. One condition that involves repeated tissue damage and alteration of bladder function is spinal cord injury. In a small study of SCI and bladder inflammation we found no change in P2X3 expression in sensory neurons. Changes in expression of genes like P2X3 could have implications for bladder dysfunction and altered nociception.

Download or read book Gene Therapy for the Central and Peripheral Nervous System written by Andrew P. Tosolini and published by Frontiers Media SA. This book was released on 2018-05-10 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene therapy is at the forefront of current techniques that aim to re-establish functional connectivity, after an insult to the brain, spinal cord or peripheral nerves. Gene therapy makes the most of the existing cellular machinery and anatomical networks to facilitate molecular changes in DNA, RNA and proteins aiming to repair these disrupted connections. For instance, gene therapy is currently being used to target genes in conditions including spinal cord injury, amyotrophic lateral sclerosis, spinal muscular atrophy, stroke and multiple sclerosis, amongst others. The various delivery routes include viral-vectors, genetically modified cellular implants, naked DNA/RNA, liposomes, Cre-Lox recombination, optogenetics and nanoparticles. In particular, gene therapy aims to restore function by augmenting the expression of neuroprotective/axonal growth-promoting neurotrophic factors (e.g., BDNF, CNTF, NGF and GDNF, etc.). Furthermore, the downstream intracellular signalling pathways after receptor activation can also be targeted (e.g., mTor, MAPK, etc.). On the other hand, gene therapy can also be used to downregulate and/or remove faulty mutated genes, such as those contributing to disease progression or that inhibit axonal regeneration (e.g., SOD-1, TDP-43, Nogo-A, MAG, OmGP, etc.). Depending on the methodology, these genes, for instance, can be silenced, removed or replaced to alleviate the underlying pathology. As such, gene therapy can transform a largely toxic and inhibitory milieu surrounding a neuronal/axonal insult into a growth-permissive environment that will ultimately aid neuronal survival and functional regeneration. Moreover, gene therapy has the capacity to target non-neuronal cells and can be even used for neuroanatomical tract tracing. Ultimately, the principal outcome of gene therapy is to functionally restore damaged neuronal and/or axonal connections irrespective of the system it is being introduced in to. This Research Topic is devoted to work using gene therapy for the both the central and/or peripheral nervous system.

Download or read book A Novel Role of Lactosylceramide in Inductible Nitric Oxide Synthase Gene Expression and Astrogliosis in Spinal Cord Injury induced Inflammatory Disease written by Ravinder Pannu and published by . This book was released on 2004 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Spinal Cord Injury New Insights for the Healthcare Professional 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-10 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spinal Cord Injury: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Spinal Cord Injury in a concise format. The editors have built Spinal Cord Injury: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Spinal Cord Injury in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Spinal Cord Injury: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book The Regulation of Immediate Early Gene and Opioid Expression Following Exciotoxic Spinal Cord Injury written by Karen E. Abraham and published by . This book was released on 2000 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Spinal Cord Injury Pain written by International Association for the Study of Pain. Research Symposium and published by Progress in Pain Research and. This book was released on 2002 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: