Download or read book Functional Biomaterials Design Synthesis and Applications written by Manjie Zhang and published by Frontiers Media SA. This book was released on 2024-08-21 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early diagnosis of cancer is still a major challenge in cancer therapy. In recent years, the development of multifunctional nanomaterials has provided a new diagnosis and treatment platform to combat cancer. Polymer-inorganic nanomaterials with novel structures such as bowl-shaped/Janus/core-shell have drawn much attention owing to their diversity in composition or asymmetry in structure. More importantly, imparting unique optical, electrical, and magnetic properties to these nanocomposites can further extend their function repertoire. However, to fulfill this vision, fundamental understandings regarding strategies of precise synthesis, mechanisms of structure formation, in vivo synergistic effects in bioapplications, and biosafety of these materials are needed. Besides, nanomaterials with novel structures are well positioned for imaging-guided cancer theranostic. On one hand, nanomaterials themselves are suitable for imaging because of their intrinsic properties such as fluorescent or magnetic properties. On the other hand, nanomaterials can serve as functional platforms that integrate various therapeutic modalities including photothermal therapy, chemodynamic/ion-interference therapy, photodynamic therapy, and cuproptosis to efficiently kill cancer cells. This Research Topic aims at collecting works about synthesis, and biomedical applications of polymer/mesoporous inorganic nanomaterials, especially in the aspect of novel synthetic approaches for fabricating nanomaterials with unique structures. Additionally, we hope that in-depth research articles on this topic can provide insights into the mechanism of nanomaterials acting in cancer diagnosis and therapy. These include the mechanisms of customized drug load/release and synergistic effects in theranostics of these materials. Meanwhile, elucidations of key proteins’ roles in cancer development are also anticipated. Lastly, we hope that this topic can brew new ideas for the adaption of nanomaterials as platforms that allow for multimodal therapeutic modalities. The current Research Topic centers on the design, precise synthesis, and biomedical applications of nanomaterials. It aims to cover novel and promising research trends in nanomaterials with different morphology for cancer theranostics. Manuscripts from the following aspects, but not limited to, are welcomed: • Tailoring of asymmetrically structured (bowl-shaped, Janus, Yin Yang-like) polymer-inorganic nanomaterials; • Inorganic functional nanocrystals and functionalized mesoporous nanomaterials; • Design and synthesis of functional biomaterials, including lipids, polymers, and 2D materials • Non-viral DNA/mRNA delivery or drug/molecular inhibitor delivery; • Synthesizing biomaterials with novel nanostructures such as bowl-shaped, core-shell, spherical, Janus, and quantum dots; • Conquering drug resistance issues, tumor metastasis, and recurrence, as well as designing combination nanomedicines; • Dissecting the role of menin in prostate cancer and breast cancer: crosstalk between menin and AR signaling; • Multi-stimulus-responsive drug release and biological molecules.

Download or read book Functional Biomaterials written by Tamilselvan Mohan and published by John Wiley & Sons. This book was released on 2023-02-09 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: A succinct handbook explaining interdisciplinary processing, methods, and applications of bio-based materials This book merges the two most important trends in biomaterials: functionalization and renewable chemistry. It covers a variety of biopolymers and various approaches for the transformation of these biopolymers into functional units. Sample topics covered by the two well-qualified authors include: Fundamental knowledge of biopolymers–natural ones, such as cellulose and other polysaccharides, and synthetic ones, such as polyethylene The origin, classifications, chemical nature, and isolation methods of specific biopolymers The different classical and modern approaches for the transformation of biopolymers into different shapes, ranging from thin films (model surfaces), to nanoparticles, to nanofibers, all the way to 3D scaffolds The morphology, structure, shape, thermal, electrical, and surface properties of biomaterials This all-inclusive reference guide, which covers fundamentals, methods, and applications alike, is a key resource for both students and practicing scientists involved in programs of study or disciplines that intersect with the field of biomaterials.

Download or read book Functional Biomaterials written by Anuj Kumar and published by CRC Press. This book was released on 2023-09-22 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses design chemistry, modification, and processing of biomaterials Describes the efficacy of biomaterials at various scales for biological response and drug delivery Demonstrates technological advances from conventional to additive manufacturing Covers future of biofabrication and customized medical devices

Download or read book Self assembling Biomaterials written by Helena S. Azevedo and published by Woodhead Publishing. This book was released on 2018-04-17 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: Self-assembling biomaterials: molecular design, characterization and application in biology and medicine provides a comprehensive coverage on an emerging area of biomaterials science, spanning from conceptual designs to advanced characterization tools and applications of self-assembling biomaterials, and compiling the recent developments in the field. Molecular self-assembly, the autonomous organization of molecules, is ubiquitous in living organisms and intrinsic to biological structures and function. Not surprisingly, the exciting field of engineering artificial self-assembling biomaterials often finds inspiration in Biology. More important, materials that self-assemble speak the language of life and can be designed to seamlessly integrate with the biological environment, offering unique engineering opportunities in bionanotechnology. The book is divided in five parts, comprising design of molecular building blocks for self-assembly; exclusive features of self-assembling biomaterials; specific methods and techniques to predict, investigate and characterize self-assembly and formed assemblies; different approaches for controlling self-assembly across multiple length scales and the nano/micro/macroscopic properties of biomaterials; diverse range of applications in biomedicine, including drug delivery, theranostics, cell culture and tissue regeneration. Written by researchers working in self-assembling biomaterials, it addresses a specific need within the Biomaterials scientific community. Explores both theoretical and practical aspects of self-assembly in biomaterials Includes a dedicated section on characterization techniques, specific for self-assembling biomaterials Examines the use of dynamic self-assembling biomaterials

Download or read book Biomaterials in Orthopaedics and Bone Regeneration written by Preetkanwal Singh Bains and published by Springer Nature. This book was released on 2019-09-09 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the recent advances in the field of orthopaedic biomaterials, with a particular emphasis on their design and fabrication. Biomimetic materials, having similar properties and functions to that of the natural tissue, are becoming a popular choice for making customized orthopaedic implants and bone scaffolds. The acceptability of these materials in the human body depends on the right balance between their mechanical and biological properties. This book provides a comprehensive overview of the state-of-the-art research in this rapidly evolving field. The chapters cover different aspects of multi-functional biomaterials design, and cutting-edge methods for the synthesis and processing of these materials. Advanced manufacturing techniques, like additive manufacturing, used for developing new biomimetic materials are highlighted in the book. This book is a valuable reference for students and researchers interested in biomaterials for orthopaedic applications.

Download or read book Functional Biomaterials written by Anuj Kumar and published by CRC Press. This book was released on 2023-09-22 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the emergence of additive manufacturing, mass customization of biomaterials for complex tissue regeneration and targeted drug delivery applications is possible. This book emphasizes the fundamental concepts of biomaterials science, their structure–property relationships and processing methods, and biological responses in biomedical engineering. It focuses on recent advancements in biomedical applications, such as tissue engineering, wound healing, drug delivery, cancer treatments, bioimaging, and theranostics. This book: Discusses design chemistry, modification, and processing of biomaterials Describes the efficacy of biomaterials at various scales for biological response and drug delivery Demonstrates technological advances from conventional to additive manufacturing Covers future of biofabrication and customized medical devices This volume serves as a go-to reference on functional biomaterials and is ideal for multi-disciplinary communities such as students and research professionals in materials science, biomedical engineering, healthcare, and medical fields.

Download or read book Synthesis of Functional Biomaterials from Natural Building Blocks written by Hiromitsu Urakami and published by . This book was released on 2010 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation describes the syntheses of functional polymeric biomaterials from natural monomeric building blocks for application specific to vectors for gene delivery. Chapter 1 of this dissertation introduces and discusses the various chemical and biological challenges of synthetic polymeric vectors for gene delivery. In particular, Chapter 1 examines various barriers at the cellular level for efficient gene transfer. In addition, chemical strategies to overcome such biological barriers are also discussed. Finally, a variety of synthetic vectors with various design and chemical diversities are presented. In particular, incorporation of an environmentally responsive bond into synthetic vectors is introduced as one of the main design characteristics necessary for overcoming multiple biological challenges. Overall, the introductory chapter attempts to illustrate the sensitive balances and complexities observed in the field of gene delivery. Chapter 2 of this dissertation describes the influence of structural modifications on saccharide-peptide hybrid copolymer (SPHC) as a synthetic vector for plasmid DNA and short interfering RNA delivery. SPHCs with various cationic charge densities, buffering capabilities, and cross-linking densities were prepared and consequences of these modifications on SPHCs are discussed. Chapter 3 of this dissertation describes the surfactant-free synthesis of bioreducible and biocompatible cationic nanogels intended for siRNA delivery. Nanogels were prepared by cross-linking the linear polymeric precursors in combination with polar and non-polar organic solvents without the addition of surfactants. The presence of amine side chains off the polymer backbone were determined to be crucial for efficient siRNA complexation. Our results (size, stability, environment responsiveness, and toxicity profile) clearly reveal the potential of this nanogel to be applied as a nano-colloidal drug carrier. Chapter 4 describes an efficient living ring-opening polymerization (ROP) of a permethoxylated-caprolactone [(OMe)CL] catalyzed by yttrium(III) isopropoxide for development of degradable protein-resistant polymers [P(OMe)CL]. The lactone monomer was efficiently prepared from a reduced sugar, D-dulcitol. A series of block copolymers consisting of permethoxylated lactone and [varepsilon]-caprolactone [P(OMe)CL-b-PCL] were synthesized and characterized. Finally, surface plasmon resonance (SPR) sensorgrams demonstrated that both P(OMe)CL and the P(OMe)CL-b-PCL block copolymers exhibit excellent resistance to protein adsorption.

Download or read book Hybrid Nanomaterials written by Weibo Cai and published by CRC Press. This book was released on 2017-05-25 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decade, an unprecedented expansion in the field of nanomedicine has resulted in the development of new nanomaterials for diagnosis and therapy of various diseases such as cancer. This book covers the design, synthesis and applications of various functionally-hybridized nanomaterials for biomedical applications. It includes strategies for design and synthesis of hybrid nanomaterials, surface engineering of various nanoparticle-based hybrid nanosystems for cancer imaging and therapy, toxicity aspects of nanomaterials and the challenges in translation research of hybrid nanomaterials.

Download or read book Hydrogels written by Thakur Raghu Raj Singh and published by CRC Press. This book was released on 2018-02-28 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hydrogels are crosslinked, macromolecular polymeric materials arranged in a three-dimensional network, which can absorb and retain large amounts of water. Hydrogels are commonly used in clinical practice and experimental medicine for a wide range of applications, including drug delivery, tissue engineering and regenerative medicine, diagnostics, cellular immobilization, separation of biomolecules or cells, and barrier materials to regulate biological adhesions. This book elucidates the underlying concepts and emerging applications of hydrogels and will provide key case studies and critical analysis of the existing research.

Download or read book Novel Biomaterials for Tissue Engineering 2018 written by Emmanuel Stratakis and published by MDPI. This book was released on 2019-02-05 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Novel Biomaterials for Tissue Engineering 2018" that was published in IJMS

Download or read book Engineered Biomaterials written by Rishabha Malviya and published by Springer Nature. This book was released on 2023-12-28 with total page 623 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights recent advances focusing on the synthesis methods of engineered biomaterials and their applications. The book discusses recent applications of various approaches and technology in improving the functional properties and biological activities of biopolymers. It includes two major sections: the first section introduces a range of methods which lead to materials with enhanced properties for a range of practical applications, along with the positives and limitations of the techniques. The second section covers recent trends and advances in application of engineered biomaterials that assist materials scientists and researchers in mapping out the future of these new improved materials through value addition in order to enhance their use. Contributions in the book are done by prominent researchers from industry, academia, and government/private research laboratories across the globe. The book summarizes in a fairly comprehensive manner many of the recent technical advancements in the area of biopolymers. The book is intended to serve as a reference resource in the area of polymers science.

Download or read book Functional Biomaterials written by Sougata Jana and published by Springer Nature. This book was released on 2022-03-29 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores in depth a wide range of functional biomaterials-based systems for drug, gene delivery, and biomedical aspects. The chapters cover newer technologies such as polymeric micelle, pH-responsive biomaterials, stimuli-responsive hydrogels, silk fibroin, inorganic biomaterials, synthetic biomaterials, 3D printed biomaterials, metallic biomaterials, ceramic and hybrid biomaterials. It also describes the theranostic approaches for cancer therapy, the biomaterials-based nanofibers scaffolds in tissue engineering, as well as the strategies applications of metallic biomaterials for the medical and dental prosthetic field. This newer and updated approach will be attractive for biomedical engineering students working on materials science in the development of novel drug delivery strategies. The book will be an important reference for researchers and professionals working on biomaterial research in the pharmaceutical and medical fields.

Download or read book Peptide based Biomaterials written by Mustafa O. Guler and published by Royal Society of Chemistry. This book was released on 2020-11-18 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research and new tools in biomaterials development by using peptides are currently growing, as more functional and versatile building blocks are used to design a host of functional biomaterials via chemical modifications for health care applications. It is a field that is attracting researchers from across soft matter science, molecular engineering and biomaterials science. Covering the fundamental concepts of self-assembly, design and synthesis of peptides, this book will provide a solid introduction to the field for those interested in developing functional biomaterials by using peptide derivatives. The bioactive nature of the peptides and their physical properties are discussed in various applications in biomedicine. This book will help researchers and students working in biomaterials and biomedicine fields and help their understanding of modulating biological processes for disease diagnosis and treatments.

Download or read book Methodology of Citric Acid Based Functional Biomaterial Development and Application written by Yi Zhang and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials play critical roles in modern strategies of biomedical applications, such as tissue engineering, and theranostic therapy. Attempts to design ideal biomaterials for each specific application have led to an enormous increase in the number of polymeric biomaterials. Different biomedical applications require specific functionality of biomaterials. Unfortunately, the limited versatility of currently available biodegradable polymers fails to meet the wide range of requirement for biomedical applications. Therefore, a methodology of functional biomaterials development would be beneficial to the biomaterial field. It has been proved that citric acid can be utilized as a key element in the development of novel biodegradable polymers. This work presents the methodology of three citric acid based functional biomaterials design and application to meet the multifaceted needs of tissue engineering and theranostic therapy. Firstly, urethane doped biodegradable polyester with dual crosslinking mechanism is developed as scaffold materials to fulfill the wide range of mechanical properties of soft tissue engineering. We hypothesize that doping of urethane bond can greatly increase the mechanical strength and elasticity, and dual crosslinking mechanism confers parameters to manipulate mechanical properties over a wide range. Secondly, novel family of biodegradable photoluminescent polymers (BPLPs) is developed meet the increasing needs of marriage between biodegradable polymers and bioimaging. We hypothesize that the intrinsic strong fluorescence of BPLPs can be exploited as theranostic probes, and provide possibility of real-time monitoring for implants. Lastly, BPLPs are doped with urethane bond (UBPLPs) to achieve an ultra strong elastomer with strong fluorescence. We hypothesize that the greatly increased mechanical strength makes UBPLPs suitable for engineering cardiovascular tissue. It also can improve the stability of nanoparticles for theranostic application. To test these hypotheses, we first developed the methodology of all three functional biodegradable polymers. The synthesis, characterization, fabrication, and application of those polymers were discussed. The relationship between materials chemistry and phenomenon were devoted to the understanding of basic biomaterials science. The results presented in this work show that all three functional polymers succeed to fulfill the requirements of specific biomedical applications. The designing strategies can serve as a guide for developing of new citric acid based biodegradable polymers. These enabling new biodegradable polymers are able to address many of the existing challenges in tissue engineering, and theranostic applications.

Download or read book New Functional Biomaterials for Medicine and Healthcare written by Elena P. Ivanova and published by Woodhead Publishing. This book was released on 2014-02-13 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Functional Biomaterials for Medicine and Healthcare provides a concise summary of the latest developments in key types of biomaterials. The book begins with an overview of the use of biomaterials in contemporary healthcare and the process of developing novel biomaterials; the key issues and challenges associated with the design of complex implantable systems are also highlighted. The book then reviews the main materials used in functional biomaterials, particularly their properties and applications. Individual chapters focus on both natural and synthetic polymers, metallic biomaterials, and bio-inert and bioactive ceramics. Advances in processing technologies and our understanding of materials and their properties have made it possible for scientists and engineers to develop more sophisticated biomaterials with more targeted functionality. New Functional Biomaterials for Medicine and Healthcare provides an ideal one-volume summary of this important field that represents essential reading for scientists, engineers, and clinicians, and a useful reference text for undergraduate and postgraduate students. Provides a concise summary of the latest developments in key types of biomaterials Highlights key issues and challenges associated with the design of complex implantable systems Chapters focus on both natural and synthetic polymers, metallic biomaterials, and bio-inert and bioactive ceramics

Download or read book Functional Bio based Materials for Regenerative Medicine From Bench to Bedside Part 1 written by Mohd Fauzi Mh Busra and published by Bentham Science Publishers. This book was released on 2023-07-25 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional Bio-based Materials for Regenerative Medicine: From Bench to Bedside explores the use of bio-based materials for the regeneration of tissues and organs. The book presents an edited collection of 28 topics in 2 parts focused on the translation of these materials from laboratory research (the bench) to practical applications in clinical settings (the bedside). Chapter authors highlight the significance of bio-based materials, such as hydrogels, scaffolds, and nanoparticles, in promoting tissue regeneration and wound healing. Topics included in the book include: - the properties of bio-based materials, including biocompatibility, biodegradability, and the ability to mimic the native extracellular matrix. - fabrication techniques and approaches for functional bio-based material design with desired characteristics like mechanical strength and porosity to promote cellular attachment, proliferation, and differentiation - the incorporation of bioactive molecules, such as growth factors, into bio-based materials to enhance their regenerative potential. - strategies for the controlled release of molecules to create a favorable microenvironment for tissue regeneration. - the challenges and considerations involved in scaling up the production of bio-based materials, ensuring their safety and efficacy, and obtaining regulatory approval for clinical use Part 1 covers techniques for tissue engineering, wound healing and skin engineering. It also presents reviews on techniques such as acellular synthesis and 3D bioprinting. Materials highlighted in this part include chitosan-based nanoparticles, nanocollagen-based materials and plant based composites. Functional Bio-based Materials for Regenerative Medicine: From Bench to Bedside is a valuable reference for researchers in biomedical engineering, cell biology, and regenerative medicine who want to update their knowledge on current developments in the synthesis and application of functional biomaterials.

Download or read book Functional and Smart Materials written by Chander Prakash and published by CRC Press. This book was released on 2020-10-25 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a comprehensive and broad-spectrum picture of the state-of-the-art research, development, and commercial prospective of various discoveries conducted in the real world of functional and smart materials. This book presents various synthesis and fabrication routes of function and smart materials for universal applications such as material science, mechanical engineering, manufacturing, metrology, nanotechnology, physics, biology, chemistry, civil engineering, and food science. The content of this book opens various scientific horizons proved to be beneficial for uplifting the standards of day-to-day practices in the biomedical domain. Myriad innovations in the materials science and engineering are transforming our everyday lives in extraordinary ways. This book captures the emerging areas of materials science and advanced manufacturing engineering and presents recent trends in research for researchers, field engineers, and academic professionals.