Download or read book Forkhead FOXO Transcription Factors in Development and Disease written by and published by Academic Press. This book was released on 2018-02-07 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forkhead FOXO Transcription Factors in Development and Disease, Volume 127, the latest release in the Current Topics in Developmental Biology series, provides a comprehensive set of reviews on transcription factors FOXO and their various functions in health and disease. Each chapter is contributed by a leading expert in the field, with specific sections covering Exceptional Longevity: Insights from Hydra to Humans, FOXO in neural cells and diseases of the nervous system, maintaining the equilibrium for better or for worse, and The Role of FoxOs in Bone Health and Disease, amongst other topics. This compilation provides a unique, up-to-date view of this enigmatic, highly evolutionary conserved family of transcription factors with a diverse array of functions in aging and longevity, cancer, and metabolism. Provides the authority and expertise of leading contributors Includes sections on the regulation of FOXO factors and stem cells Presents a unique view of this highly evolutionary family of transcription factors

Download or read book Forkhead Transcription Factors written by Kenneth Maiese and published by Springer Science & Business Media. This book was released on 2010-07-29 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forkhead Transcription Factors: Vital Elements in Biology and Medicine provides a unique platform for the presentation of novel work and new insights into the vital role that forkhead transcription factors play in multiple systems throughout the body. Leading international authorities provide their knowledge and insights to offer a novel perspective for translational medicine that highlights the role of forkhead genes and proteins that may have the greatest impact for the development of new strategies for a broad array of disorders. Equally important, Forkhead Transcription Factors: Vital Elements in Biology and Medicine clearly sets a precedent for the necessity to understand the diverse and complex nature of forkhead proteins since this family of transcription factors can limit as well as foster disease progression depending upon the cellular environment. The presentation and discussion of innovative studies and especially those that examine previously unexplored pathways that may influence clinical survival and longevity offer an exciting approach to address the potential of forkhead transcription factors for new therapeutic avenues in multiple disciplines.

Download or read book Encyclopedia of Signaling Molecules written by Sangdun Choi and published by Springer. This book was released on 2017-12-15 with total page 6330 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this encyclopedia presents over 400 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities.

Download or read book Hormones Metabolism and the Benefits of Exercise written by Bruce Spiegelman and published by Springer. This book was released on 2018-03-07 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.

Download or read book Lymphocyte Updates written by Gheorghita Isvoranu and published by BoD – Books on Demand. This book was released on 2017-07-12 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents a synergic effort of an international team of specialists in immunology to expand the scientific achievements in the field of lymphocytes. It offers important and specific updated information to researchers, students, teachers, and medical professionals. Moreover, considering the remarkable dynamics of immunology and immunotherapy, this book "Lymphocyte Updates - Cancer, Autoimmunity, and Infection" aims to represent a significant source of concise scientific data and advancement of knowledge in this field. The chapters offer new insights into the latest scientific progress on lymphocyte roles in protective immunity, as well as their involvement in pathogenesis of various disorders.

Download or read book FOXO Transcription Factors written by Wolfgang Link and published by Humana Press. This book was released on 2018-11-10 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an overview of experimental procedures and state-of art methods to investigate FOXOs. Chapters guide readers through biochemical and molecular methods, imaging approaches to monitor the subcellular localization of FOXO factors, omics and bioinformatics approaches, different animal models used in FOXO research, and human studies to investigate the role of FOXO factors in human disease and longevity. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge FOXO Transcription Factors: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Download or read book FOXO Transcription Factors written by Wolfgang Link and published by Humana. This book was released on 2019-12-10 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an overview of experimental procedures and state-of art methods to investigate FOXOs. Chapters guide readers through biochemical and molecular methods, imaging approaches to monitor the subcellular localization of FOXO factors, omics and bioinformatics approaches, different animal models used in FOXO research, and human studies to investigate the role of FOXO factors in human disease and longevity. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge FOXO Transcription Factors: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Download or read book Gonadotropins From Bench Side to Bedside written by Rajendra T. Kumar and published by Academic Press. This book was released on 2016-09-30 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gonadotropins: From Bench Side to Bedside, the latest volume in the Progress in Molecular Biology and Translational Science series, focuses on all aspects of gonadotropins, from research to treatment. Contains contributions from leading authorities on the topic Publishes cutting-edge reviews in molecular biology Informs and updates on all the latest developments available regarding the research of gonadotropins

Download or read book Genetics of Human Infertility written by P.H. Vogt and published by Karger Medical and Scientific Publishers. This book was released on 2017-09-12 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infertility affects more than one in ten couples worldwide and is related to highly heterogeneous pathologies sometimes only discernible in the germ line. Its complex etiology often, but not always, includes genetic factors besides anatomical defects, immunological interference, and environmental aspects. Nearly 30% of infertility cases are probably caused only by genetic defects. Thereby experimental animal knockout models convincingly show that infertility can be caused by single or multiple gene defects. Translating those basic research findings into clinical studies is challenging, leaving genetic causes for the vast majority of infertility patients unexplained. Nevertheless, a large number of candidate genes have been revealed by sophisticated molecular methods. This book provides a comprehensive overview on the subject of infertility written by the leading authorities in this field. It covers topics including basic biological, cytological, and molecular studies, as well as common and uncommon syndromes. It is a must-read for human geneticists, endocrinologists, epidemiologists, zoologists, and counsellors in human genetics, infertility, and assisted reproduction.

Download or read book Signal Transduction in Cancer written by David A. Frank and published by Springer Science & Business Media. This book was released on 2002-12-31 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."

Download or read book Poly ADP Ribosyl ation written by Alexander Bürkle and published by Springer Science & Business Media. This book was released on 2008-01-11 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the most comprehensive, up-to-date reference on this post-translational modification of proteins, which is intimately linked with DNA repair, maintenance of genomic stability, transcriptional regulation, cell death and a variety of other cellular phenomena as well as with a variety of pathophysiological conditions, including ischemia-reperfusion damage, Parkinson’s disease, Type I diabetes mellitus, hemorrhagic and septic shock and other inflammatory conditions. Richly illustrated, it offers 19 chapters written by international experts.

Download or read book Vertebrate Skeletal Development written by and published by Academic Press. This book was released on 2019-03-20 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vertebrate Skeletal Development, Volume 133, the latest release in the Current Topics in Developmental Biology series, presents interesting chapters on a variety of topics, with this edition focusing on Craniofacial skeletal development, Regulatory mechanism of jawbone and tooth development, Development of the axial skeleton and intervertebral discs, Stem and progenitor cells in skeletal development, Origin, functioning and morphogenetic activity of limb synovial joint, ECM signaling in cartilage development and endochondral ossification, Sox genes in skeletal development, Wnt-Signaling in Skeletal Development, Gαs signaling in skeletal development and diseases, FGF signaling in skeletal development, Bone morphogenetic growth factors in bone development, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series Includes the latest information on Vertebrate Skeletal Development

Download or read book Sertoli Cell Biology written by Michael K. Skinner and published by Elsevier. This book was released on 2004-11-23 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sertoli cells assist in the production of sperm in the male reproductive system. This book provides a state-of-the-art update on the topic of sertoli cells and male reproduction. It addresses such highly topical areas as stem cells, genomics, and molecular genetics, as well as provides historical information on the discovery of this type of cell, and the pathophysiology of male infertility. * Presents the state-of-the-art research on topics such as stem cell research, transplantation and genomics* Includes contributions from leaders in the field, including several members of the National Academy of Science

Download or read book Forkhead Transcription Factors in Mammalian Development written by Margit Mahlapuu and published by . This book was released on 2001 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Epigenetics of Cancer Prevention written by Anupam Bishayee and published by Academic Press. This book was released on 2018-11-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics of Cancer Prevention, Volume Ten is the first to look at epigenetics and chemoprevention together. Although there is numerous scientific data available on how epigenetics can lead to cancer and how chemoprevention can be beneficial in the treatment of, or improvement of quality of life, together they will set an advanced understanding for the reader in this upcoming field of chemoprevention influencing epigenetics. This book discusses molecular epigenetic targets of natural products, such as green tea polyphenols, curcumin and resveratrol, and organ specific epigenetic targets related to diverse types of cancer, for example prostate, colorectal, breast, lung and skin cancers. Additionally, it encompasses a discussion on research methods and limitations to study epigenetics and epigenomics of chemopreventive drugs and personalized cancer treatment with phytochemicals. The book is ideal for cancer researchers, health care professionals and all individuals who are interested in cancer prevention research and its clinical applications, especially in natural remedies.

Download or read book Chemical Modulation of the Forkhead Box M1 Transcription Factor written by Seyed Amirhossein Tabatabaei Dakhili and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thousands of transcription factors control the process of gene expression and protein synthesis in the human body. These nuclear proteins are fundamental for healthy organ development, cellular function, immunity and body response to diseases and stress. Mutated, overexpressed, or dysregulated transcription factors are linked to cancer, neurological disorders, metabolic, and autoimmunity diseases. Forkhead Box M1 (FOXM1) is a transcription factor required for the normal progression of the cell cycle as well as tissue regeneration, homeostasis, and DNA repair. However, in many types of cancer, its expression is dysregulated. As the "master regulator of the cell cycle", its overexpression leads to tumorigenesis, angiogenesis, metastasis and poor patient prognosis. Accumulating evidence suggests that inhibition of FOXM1 as the Achilles heel of cancer could be the master key for the cancer-treatment lock. However, direct targeting of the FOXM1 transcription factor is a challenging task due to the lack of binding pocket and ligand-binding site. In the past decade, several small molecules have been introduced with the ability to decrease the FOXM1 expression with a different and distinct mechanism. Most-recently it is found that compounds thiostrepton (previously found to inhibit FOXM1 indirectly through proteasome inhibition) and Forkhead Domain Inhibitor-6 (FDI-6) can directly bind to the FOXM1 DNA binding domain (DBD) and suppress its activity. However, the exact mechanism of binding of these agents to the FOXM1-DBD is not reported. Since the fundamental of designing inhibitors for any target is an extensive structural analysis of the target, we used a series of molecular dynamics (MD) simulations to understand the mechanism of FOXM1-DBD/DNA recognition. Next, using different approaches, we identified a binding pocket on the DNA recognition helix of FOXM1-DBD. Furthermore, using molecular modeling and docking techniques, we found a mutual binding mode for known FOXM1 inhibitors, thiostrepton, FDI-6, and troglitazone. We found that these compounds form a complex with the FOXM1-DBD mainly through a strong pi-sulfur interaction with His287 of FOXM1-DBD. Additionally, we reported that FDI-6 forms an additional strong halogen bonding with Arg297 by its 4-fluorophenyl ring. To provide evidence regarding the existence of halogen bonding, we chemically modified the structure of FDI-6. Then, using protein immunoblot and EMSA of recombinant human FOXM1-DBD, we proved that only those derivatives carrying halogen atoms at positions 3 and 4 are active. To validate the hypothesis of pi-sulfur interaction, we used two different pathways, chemical and biological. First, we exchanged the sulfur atom in the structure of FDI-6 and confirmed that the sulfur atom is essential for its FOXM1 inhibitory activity. Next, using site-directed mutagenesis, we mutated the His287 of recombinant FOXM1-DBD to a simple and non-aromatic amino acid (alanine) and also to an aromatic amino acid (phenylalanine). Using EMSA, we confirmed that FDI-6 was unable to bind to the alanine mutated FOXM1-DBD, while its binding was unaffected by phenylalanine mutation. These results point to the probability that the theoretical binding site we identified using molecular modeling of the FOXM1-DBD is valid. Based on the gained knowledge of binding sites as well as the structural requirements necessary for a small molecule to inhibit this oncogenic transcription factor, we designed a series of compounds based on the structure of thiazolidinediones (troglitazone) capable of suppressing the FOXM1 transcriptional program. Among them, compound TFI-10 was able to target and decrease the cellular level of FOXM1 without affecting FOXM1's closely related family members and key tumor suppressors, FOXO1, and FOXO3a. We also showed that the currently known selective FOXO1 inhibitor, AS1842856, could also target FOXM1 and decrease its protein level as well as its target genes by a mechanism other than direct binding to the DBD. We demonstrated that FOXM1b could promote the expression of FOXO1 while the other FOXM1 isoform, FOXM1c, negatively regulates the level of FOXO1. We also presented using colony formation assay and gene silencing techniques that dual inhibition of FOXM1 and FOXO1 can dramatically decrease the ability of breast cancer cells to proliferate and form colonies.

Download or read book The Amazing World of IDPs in Human Diseases written by Simona Maria Monti and published by . This book was released on 2021 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is now clearly established that some proteins or protein regions are devoid of any stable secondary and/or tertiary structure under physiological conditions, but still possess fundamental biological functions. These intrinsically disordered proteins (IDPs) or regions (IDRs) have peculiar features due to their plasticity such as the capacity to bind their biological targets with high specificity and low affinity, and the possibility of interaction with numerous partners. A correlation between intrinsic disorder and various human diseases such as cancer, diabetes, amyloidoses and neurodegenerative diseases is now evident, highlighting the great importance of the topic. In this volume, we have collected recent high-quality research about IDPs and human diseases. We have selected nine papers which deal with a wide range of topics, from neurodegenerative disease to cancer, from IDR-mediated interactions to bioinformatics tools, all related to IDP peculiar features. Recent advances in the IDPs/IDRs issue are here presented, contributing to the progress of knowledge of the intrinsic disorder field in human disease.