Download or read book Establishment of MITF and TAZ as Major Determinants of Uveal Melanoma written by Grace B. Phelps and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Uveal melanoma (UM) is a cancer that arises from transformed melanocytes that exist in the uvea of the eye. Although UM is relatively rare, it is extremely deadly, due to the lack of treatment options for the metastatic disease. In contrast, cutaneous melanoma (CM), which is derived from transformed skin melanocytes, has multiple approved therapies, which have not worked in UM patients. Thus, there is great need to gain a deeper understanding of UM, and how it differs from CM, to inform effective therapeutic strategies. The vast majority of UM patients present with activating mutations in the GNAQ/11 pathway, which signals through PLC[beta]4-MAPK and YAP, whereas CM is primarily driven by activation of the MAPK pathway. It has been well established that CM tumors are dependent on MITF, the master melanocyte transcription factor. Here, in stark contrast, we establish that MITF serves as a tumor suppressor in an oncogenic GNAQ/11 UM zebrafish model. Moreover, we show that resulting MITF-deficient tumors are more de-differentiated and down-regulate PLC[beta]4-MAPK signaling, but retain active YAP. Furthermore, we establish that YAP, and not PLC[beta]4, is sufficient to drive MITF-wildtype tumorigenesis. Thus, our data de-emphasize the role of the PLC[beta]4-MAPK pathway in UM. We further show that YAP is surprisingly wholly dispensable for oncogenic GNAQ tumorigenesis in an autochthonous zebrafish model, but resulting tumors display active TAZ, a YAP paralog. Moreover, we establish that TAZ is an extremely potent oncogene in UM using autochthonous zebrafish models, even moreso than YAP. Furthermore, we show that higher TAZ expression, but not YAP expression, significantly correlates with decreased UM patient survival. Thus, this suggests that the role of TAZ does not entirely mirror that of YAP in UM. Lastly, we provide molecular characterization of the MITF-deficient s tate, and develop a system in which to screen UM therapies in vivo. Overall, our work establishes a tumor suppressor role for MITF, de-emphasizes the role of the MAPK pathway, and further underscores the importance of YAP/TAZ signaling in UM.
Download or read book Tumor Microenvironments in Organs written by Alexander Birbrair and published by Springer Nature. This book was released on 2020-02-06 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the tumor microenvironment in over thirty human organs, including the parathyroid gland, heart, intestine, testicles, and more. Taken alongside its companion volumes, these books update us on what we know about the different aspects of the tumor microenvironments in distinct organs as well as future directions. Tumor Microenvironments in Organs: From the Brain to the Skin – Part A is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
Download or read book Experimental Metastasis Modeling and Analysis written by Anastasia Malek and published by Springer Science & Business Media. This book was released on 2013-12-02 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metastatic dissemination of cancer is a main cause of cancer related deaths, therefore biological mechanisms implicated in metastatic process presents an essential object of cancer research. This research requires creation and utilization of adequate laboratory models. The book describes main approaches to model processes of metastatic cancer dissemination and metastases development. The book is structured in according with various metastatic pathways reflecting molecular specificity of metastatic process as well as anatomical specificity of aria of dissemination. Each chapter is introduced by short discussion of clinical aspects of certain metastatic pathway. Especial attention is paid for methods of visualization, quantification and analysis of the modeled metastases. Additional chapter is devoted to methods of mathematic modeling of tumor spread. The data presented in the book may be helpful for cancer researchers and oncologists.
Download or read book Oncogenomics written by Franco Dammacco and published by Academic Press. This book was released on 2018-10-30 with total page 722 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oncogenomics: From Basic Research to Precision Medicine offers a thorough survey of precision medicine and its diagnostic and therapeutic applications in oncology. Gathering contributions from leading international researchers in the field, chapters examine recent translational advances in oncogenomic methods and technologies, detailing novel molecular classifications of tumors as well as diagnostic and prognostic biomarkers for various types of cancers including pancreatic, gastrointestinal, breast, hematological, lung, osteotropic, genitourinary, and skin cancers. This book provides a foundation for clinical oncologists, human geneticists, and physicians to develop new targeted cancer treatments and incorporate genomic medicine into clinical practice, with particular attention paid to noninvasive diagnostic techniques such as the liquid biopsy and molecular characterization of solid malignancies. - Provides clinical oncologists, human geneticists, physicians, and students with a thorough understanding of current diagnostic and prognostic applications of genomic methods and technologies to a variety of solid malignancies - Employs current knowledge in oncogenomics towards developing therapeutic interventions for various cancer types - Features a team of internationally recognized researchers and physicians in clinical oncology, oncogenomics and precision medicine
Download or read book Sunlight Vitamin D and Skin Cancer written by Jörg Reichrath and published by Springer Nature. This book was released on 2020-09-11 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third edition is a comprehensive and updated overview of positive and negative effects of UV-exposure, with a focus on Vitamin D and skin cancer. Researchers, oncologists,and students will be provided with the most significant and timely information related to topics such as the epidemiology of skin cancer, the immune system and skin cancer, ultraviolet damage, DNA repair and Vitamin D in Nonmelanoma skin cancer and malignant melanoma. There have been a number of new, scientific findings in this fast moving field that necessitated a thoroughly updated and revised edition including new Vitamin D metabolites and skin cancer, new findings on the beneficial effects of UV and solar UV and skin cancer, adverse effects of sun protection and sunscreens, sun exposure and mortality, and more. The book will summarize essential, up-to-date information for every clinician or scientist interested in how to balance the positive and negative effects of UV‐exposure to minimize the risks of developing vitamin D deficiency and skin cancer.
Download or read book Skin Cancer Pathogenesis and Diagnosis written by Ashish Dwivedi and published by Springer Nature. This book was released on 2021-08-02 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the molecular and cellular mechanisms involved in the initiation and progression of skin cancer. It also explains the role of the environment in skin cancer development and explores the potential of microbiome in the diagnosis, prevention and treatment of skin cancer. The book also presents potential biomarkers for early detection of skin cancer and discusses recent advances in skin cancer prevention and treatment using photodynamic therapy. Lastly, it summarizes the applications of biomedical engineering, non-coding and nanotechnology in the diagnosis and therapeutics in skin cancer. It is a valuable resource for investigators in the field of skin cancer, including pathologists, medical and surgical oncologists, and dermatologists.
Download or read book Atlas of Metabolic Diseases Second edition written by William Nyhan and published by CRC Press. This book was released on 2005-08-26 with total page 801 pages. Available in PDF, EPUB and Kindle. Book excerpt: In a field where even experts may find that years have elapsed since they last encountered a child with a given disorder, it is essential for the clinician to have a comprehensive source of practical and highly illustrated information covering the whole spectrum of metabolic disease to refer to. The second edition of this highly regarded book, auth
Download or read book Ethnic Skin and Hair and Other Cultural Considerations written by Becky S. Li and published by Springer Nature. This book was released on 2021-03-03 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is written to help educate dermatologists and general physicians of the challenges involved in treating those with darker skin tones in culturally appropriate ways. Distinctly broken up into three sections for ease of use, the reader enters the text through a series of chapters meant to introduce the physician to the anatomical structure and makeup of patient with skin of color as well as the evolution basic concepts for understanding and treatment. The second and longest section looks at diseases and cosmetic concerns covering some of the most common issues for patients with skin of color. The last section offers cultural considerations to treatment and care. Socially conscious and comprehensive, Ethnic Skin and Hair is written by some of the leading names in dermatological treatment of skin of color, and functions as a concise and thorough tool for dermatologists at every stage in their career.
Download or read book Pathology of Childhood and Adolescence written by Consolato M. Sergi and published by Springer Nature. This book was released on 2020-10-28 with total page 1617 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the full range of pathologic conditions encountered during childhood and youth, including tumors and tumor-like conditions of all organ systems, with direct links to developmental biology pathways and genetics. It provides a user-friendly road map to the main diagnostic criteria and combines an organ-related approach with an explanation of the diagnostic approaches to various specific diseases and syndromes, including sequential segmental analysis of congenital heart disease. More than 500 new full-color macro- and microphotographs using more than 500 multi-photographic panels are included to provide a realistic basis for comparison macroscopically and under the lens, and summarizing tables highlight key information in the concise form required for at-a-glance review. Pathologists will find the book very helpful when signing out complex and challenging cases, and it will also prove invaluable for exam preparation and continuing medical education.
Download or read book Dento Oro Craniofacial Anomalies and Genetics written by Agnes Bloch-Zupan and published by Elsevier. This book was released on 2012-03-21 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dental defects may be the physical expression of genetic defects, and so they can often be seen in a variety of syndromes associated with malformations of organs. However, dental defects are often not recognized, identified, nor characterised despite representing a possible diagnostic sign for an undiagnosed condition. This book addresses this gap by providing an understanding of dental genetics and its developmental biology counterpart. With approximately seventy well-illustrated examples, the authors present the clinical oro-facial manifestations accompanying various syndromes, providing the necessary knowledge for diagnostic purposes, as well as giving insight into recent development for each specific condition. The clarity and format of this book make it an ideal support guide both in the clinic and while conducting research. Comprehensive examination of dento/oro/craniofacial anomalies Well-illustrated examples Presented in a compact, easy to use format
Download or read book Cancer Stem Cells written by Federica Papaccio and published by Springer Nature. This book was released on with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book From Melanocytes to Melanoma written by Vincent J. Hearing and published by Springer Science & Business Media. This book was released on 2007-11-05 with total page 673 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading researchers and clinicians join forces to explain how malignant melanoma develops from its benign precursor cell type. The authors focus on the molecular mechanisms involved in melanogenesis, in the malignant transformation of melanocytes, and in the further progression of primary melanomas into invasive and metastatic melanomas. They also review recent advances in our understanding of the basic biology of melanocytes and the development, migration, and differentiation of melanoblasts into melanocytes. The book provides an up-to-date understanding of the progressive mechanisms of oncological development in malignant melanoma, a likely model of malignant progress for other types of cancer, and the ongoing development of novel therapeutics.
Download or read book Neural Crest Induction and Differentiation written by Jean-Pierre Saint-Jeannet and published by Springer Science & Business Media. This book was released on 2006-08-28 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by an international panel of recognized leaders in the field, Neural Crest Induction and Differentiation discusses all aspects of modern neural crest biology from its evolutionary significance to its specification, migration, plasticity and contribution to multiple lineages of the vertebrate body, to the pathologies associated with abnormal neural crest development and function. Abundant color figures enhance the text providing clear and attractive illustrations of central issues and concepts.
Download or read book Enzinger and Weiss s Soft Tissue Tumors E Book written by John R. Goldblum and published by Elsevier Health Sciences. This book was released on 2013-10-11 with total page 1173 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzinger and Weiss's Soft Tissue Tumors is your essential medical reference on the diagnosis of tumors of the skeletal muscles, connective tissue, fat, and related structures. No other source matches Enzinger and Weiss’s scope and depth of coverage in this complex and challenging area of surgical pathology, and no other text contains as much practical information on differential diagnosis. Microscopic findings are correlated with the latest developments in molecular biology, cytogenetics, and immunohistochemistry, providing you with a comprehensive and integrated approach to the evaluation of soft tissue specimens. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compare what you see under the microscope to nearly 2,000 superb images that capture the appearance of a complete range of pathological entities and help you relate their characteristics to their specific classifications. Apply the latest knowledge on FNA biopsy, molecular biology, and cytogenetics. Make rapid and effective decisions with the aid of extensive algorithms, and access information at a glance with abundant tables and graphs. Take advantage of all of the essential clinical and prognostic data on soft tissue tumors that are necessary to formulate complete sign-out reports. Navigate through the book quickly thanks to summary outlines at the beginning of each chapter, a color-coded page design, and a consistent approach to every entity. Apply the latest advances in surgical pathology thanks to major updates on recently identified pathological entities such as soft tissue angiofibroma and CIC-related sarcomas; coverage of the newest molecular diagnostic techniques and immunohistochemical and molecular genetic features of soft tissue tumors; new chapters on GIST and soft tissue tumors showing melanocytic differentiation; and more. Effortlessly find the information you need with a chapter organization based on the newest surgical pathology concepts and classifications of soft tissue tumors.
Download or read book Ophthalmic Oncology written by Bita Esmaeli and published by Springer Science & Business Media. This book was released on 2011-01-06 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the unique aspects of oncologic ophthalmology as a medical and surgical discipline practiced at a comprehensive cancer center. Multi-disciplinary management of ocular, orbital and adnexal cancers are highlighted using simple and tried-and-true algorithms. In addition, ocular problems caused as a direct result of cancer treatment are reviewed using illustrative photographs and case presentations. The content is provided by full-time ophthalmology faculty and fellows at M. D. Anderson Cancer Center. Experts in complementary disciplines such as ophthalmic pathology, dermatopathology, radiation oncology, radiology, and other surgical subspecialties have brought their unique perspective to each chapter. The book is abundant with clinical photographs as well as interesting case presentations that will help the clinician correctly diagnose cancers of the orbit, eye, and adnexal structures, initiate appropriate management, as well as recognize and treat common ocular complications of cancer therapy.
Download or read book Dermatology Essentials E Book written by Jean L. Bolognia and published by Elsevier Health Sciences. This book was released on 2021-11-30 with total page 1577 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by world authorities Drs. Jean L. Bolognia, Julie V. Schaffer, Karynne O. Duncan, and Christine J. Ko, Dermatology Essentials, 2nd Edition, provides the fast answers you need on every important aspect of dermatology and guidance on their application in your day-to-day practice. Derived from the renowned authoritative reference work Dermatology, 4th Edition, this on-the-go reference distills the essential information needed to quickly diagnose and manage a wide range of dermatologic disorders—without the need for any additional resources. It's an ideal reference for family medicine and internal medicine physicians, nurse practitioners, physician assistants, and other health care professionals who diagnose, treat, and refer patients with dermatological conditions. - Features a highly user-friendly, "easy-in-easy-out" format and a wealth of tables and schematics for instant visual comprehension. - Helps you visualize more of the conditions you see in practice with over 1,800 typical clinical images, illustrations, and line drawings. - Includes numerous practical tables, intuitive artworks, and logical algorithms to help you avoid diagnostic pitfalls. - Expedites decision making with easily recognizable DDx and Rx sections that provide rapid, direct reference to current guidance and treatment recommendations. Downloadable worksheets are also available. - Features unique introductory chapters that cover the basic principles of dermatology, bedside diagnostics, and clinical approach to a fever and rash—extremely helpful information for the beginner.
Download or read book Reproductive Genetics written by Sean Kehoe and published by RCOG. This book was released on 2009-11 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the findings of the RCOG Study Group findings on genetics underlying reproductive function.
