Download or read book Enantiomer Separation written by Fumio Toda and published by Springer Science & Business Media. This book was released on 2007-11-04 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: In spite of important advances in asymmetric synthesis, chiral compounds cannot all be obtained in a pure state by asymmetric synthesis. As a result, enantiomer separation remains an important technique for obtaining optically active materials. Although asymmetric synthesis is a once-only procedure, an enantiomer separation process can be repeated until the optically pure sample is obtained. This book discusses several new enantiomer separation methods using modern techniques developed by experts in the field. These methods consist mainly of the following three types: 1) Enantiomer separation by inclusion complexation with a chiral host compound 2) Enantiomer separation using biological methods 3) Enantiomer separation by HPLC chromatography using a column containing a chiral stationary phase. Separation of a racemic compound has been called “optical resolution” or simply “resolution”. Nowadays, the descriptions “enantiomer resolution” or “enantiomer separation” are also commonly used. Accordingly, “Enantiomer Separation” is used in the title of this book. The editor and all chapter contributors hope that this book is helpful for scientists and engineers working in this field.
Download or read book Differentiation of Enantiomers I written by Volker Schurig and published by Springer. This book was released on 2013-12-16 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.
Download or read book Enantiomers Racemates and Resolutions written by Jean Jacques and published by . This book was released on 1994 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Differentiation of Enantiomers II written by Volker Schurig and published by Springer. This book was released on 2014-07-08 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chiral Derivatizing Agents, Macrocycles, Metal Complexes and Liquid Crystals for Enantiomer Differentiation in NMR Spectroscopy: Thomas J. Wenzel. Chiral NMR Solvating Additives for Differentiation of Enantiomers: Gloria Uccello-Barretta and Federica Balzano. Chiral Sensor Devices for Differentiation of Enantiomers: Kyriaki Manoli, Maria Magliulo and Luisa Torsi. Enantiopure supramolecular cages: synthesis and chiral recognition properties: Thierry Brotin, Laure Guy, Alexandre Martinez, Jean-Pierre Dutasta. Interconversion of Stereochemically Labile Enantiomers (Enantiomerization) : Oliver Trapp. Anisotropy Spectra for Enantiomeric Differentiation of Biomolecular Building Blocks: A.C. Evans, C. Meinert, J.H. Bredehöft, C. Giri, N.C. Jones, S.V. Hoffmann, U.J. Meierhenrich. Self-disproportionation of Enantiomers of Enantiomerically Enriched Compounds: Alexander E. Sorochinsky and Vadim A. Soloshonok.
Download or read book Stereochemistry of Organic Compounds written by Ernest L. Eliel and published by John Wiley & Sons. This book was released on 1994-09-28 with total page 1296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stereochemistry of Organic Compounds The first fully referenced, comprehensive book on this subject in more than thirty years, Stereochemistry of Organic Compounds contains up-to-date coverage and insightful exposition of all important new concepts, developments, and tools in the rapidly advancing field of stereochemistry, including: * Asymmetric and diastereoselective synthesis * Conformational analysis * Properties of enantiomers and racemates * Separation and analysis of enantiomers and diastereoisomers * Developments in spectroscopy (including NMR), chromatography, and molecular mechanics as applied to stereochemistry * Prostereoisomerism * Conceptual foundations of stereochemistry, including terminology and symmetry concepts * Chiroptical properties Written by the leading authorities in the field, the text includes more than 4,000 references, 1,000 illustrations, and a glossary of stereochemical terms.
Download or read book Pharmacokinetics of enantiomers of profens written by Dr.G.SANDHYARANI and published by Lulu.com. This book was released on 2014-02-05 with total page 49 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enantiomers are optically active compounds with one or more chiralcenters and have identical physicochemical properties except the rotation of plane polarized light. Approximately 1 in 4 therapeutic agents are marketed as racemates; the individual enantiomers frequently differ in both their pharmacokinetic and pharmacodynamic profiles.
Download or read book Enantioselective Synthesis Enantiomeric Separations and Chiral Recognition written by Maria Elizabeth Tiritan and published by MDPI. This book was released on 2020-11-13 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book includes both fundamental studies and applications in a multidisciplinary research field involving a high diversity of chiral compounds, including commercial substances with industrial applications, pharmaceuticals, and new chiral compounds with promising biological activities.
Download or read book Separation of Enantiomers written by Matthew H. Todd and published by John Wiley & Sons. This book was released on 2014-05-06 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: In one handy volume this handbook summarizes the most common synthetic methods for the separation of racemic mixtures, allowing an easy comparison of the different strategies described in the literature. Alongside classical methods, the authors also consider kinetic resolutions, dynamic kinetic resolutions, divergent reactions of a racemic mixture, and a number of "neglected" cases not covered elsewhere, such as the use of circularly polarized light, polymerizations, "ripening" processes, dynamic combinatorial chemistry, and several thermodynamic processes. The result is a thorough introduction to the field plus a long-needed, up-to-date overview of the chemical, biological, and physical methods and their applications. Newcomers to the field, students as well as experienced synthetic chemists will benefit from the highly didactic presentation: Every method is presented in detail, from relatively simple separation problems to advanced complex resolution methods.
Download or read book Basic Concepts in Medicinal Chemistry written by Marc Harrold and published by ASHP. This book was released on 2013-01-18 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal chemistry is a complex topic. Written in an easy to follow and conversational style, Basic Concepts in Medicinal Chemistry focuses on the fundamental concepts that govern the discipline of medicinal chemistry as well as how and why these concepts are essential to therapeutic decisions. The book emphasizes functional group analysis and the basics of drug structure evaluation. In a systematic fashion, learn how to identify and evaluate the functional groups that comprise the structure of a drug molecule and their influences on solubility, absorption, acid/base character, binding interactions, and stereochemical orientation. Relevant Phase I and Phase II metabolic transformations are also discussed for each functional group. Key features include: • Discussions on the roles and characteristics of organic functional groups, including the identification of acidic and basic functional groups. • How to solve problems involving pH, pKa, and ionization; salts and solubility; drug binding interactions; stereochemistry; and drug metabolism. • Numerous examples and expanded discussions for complex concepts. • Therapeutic examples that link the importance of medicinal chemistry to pharmacy and healthcare practice. • An overview of structure activity relationships (SARs) and concepts that govern drug design. • Review questions and practice problems at the end of each chapter that allow readers to test their understanding, with the answers provided in an appendix. Whether you are just starting your education toward a career in a healthcare field or need to brush up on your organic chemistry concepts, this book is here to help you navigate medicinal chemistry. About the Authors Marc W. Harrold, BS, Pharm, PhD, is Professor of Medicinal Chemistry at the Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA. Professor Harrold is the 2011 winner of the Omicron Delta Kappa "Teacher of the Year" award at Duquesne University. He is also the two-time winner of the "TOPS" (Teacher of the Pharmacy School) award at the Mylan School of Pharmacy. Robin M. Zavod, PhD, is Associate Professor for Pharmaceutical Sciences at the Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, where she was awarded the 2012 Outstanding Faculty of the Year award. Professor Zavod also serves on the adjunct faculty for Elmhurst College and the Illinois Institute of Technology. She currently serves as Editor-in-Chief of the journal Currents in Pharmacy Teaching and Learning.
Download or read book Organic Chemistry Transition from High School to College written by Dipak K. Mandal and published by Allied Publishers. This book was released on 2024-01-25 with total page 852 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic Chemistry: Transition from High School to College is a comprehensive textbook on foundational organic chemistry which aims to provide a seamless link between the higher secondary and the undergraduate level. The book has been organized logically to provide an excellent coverage on the structure, reactions and synthesis of organic compounds. Advanced high school students and beginning undergraduates will find this book invaluable for their academic progression and also for competitive entrance examinations. Also students in pharmaceutics, polymer science and medicinal chemistry will find this book very useful. Key Features • Clear explanations of basic principles of organic chemistry. • Logical approaches from structure to reactions to synthesis of organic molecules. • Inclusion of spectroscopy and retrosynthesis as advanced topics. • Introduction to polymers and biomolecules as special topics. • Inclusion of in-chapter problems with detailed answers and end-of-chapter supplementary problems for practice.
Download or read book Chirotechnology written by Roger A. Sheldon and published by CRC Press. This book was released on 1993-05-27 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference provides an introduction to the phenomenon of chirality and its importance in conjunction with biological activity and offers an easy-to-read examination of practical, industrially relevant methods for the synthesis of optically active compounds.;Furnishing hands-on guidelines for the development of economically viable synthetic compounds, Chirotechnology: explains optical isomerism and stereochemistry; gives a general overview of various methods of synthesis; supplies detailed explications of specific techniques, including fermentation, crystallization, the chirality pool, enzymatic methods, and catalytic asymmetric synthesis; illustrates and compares approaches with examples taken directly from industry such as the synthesis of pharmaceuticals, agrochemicals, flavours, and fragrances; and clarifies the importance of determining which approach to use for the synthesis of particular molecules.;With over 1100 literature citations, tables and figures, Chirotechnology is a reference for chemical engineers; industrial, organic and medicinal chemists; and bioprocess technologists, as well as a text for upper-level undergraduate, graduate and continuing-education students in these disciplines.
Download or read book Stereochemical Aspects of Drug Action and Disposition written by Michel F. Eichelbaum and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to guide and inspire drug researchers as they enter the 21st century. Stereochemistry is an essential dimension in pharmacology and should be understood as such by all drug researchers whatever their background. When used as probes or medicines, stereoisomeric drugs offer invaluable insights or innovative therapeutic strategies. The book spans the subject from the molecular to the clinical. The first section on chemical aspects contains chapters on chemical synthesis, analysis, natural products, chiral stability (racemezation) and physical properties. The second section is on experimental pharmacology, with chapters on drug-receptor interactions, chiral recognition, ion channels, and molecular toxicology. The third section focuses on drug disposition, with chapters on absorption, distribution, protein binding, metabolism and elimination. The final section is dedicated to regulatory and clinical aspects.
Download or read book Chiral Separation Methods for Pharmaceutical and Biotechnological Products written by Satinder Ahuja and published by John Wiley & Sons. This book was released on 2011-03-31 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses chiral separations and offers guidance for selecting the optimum method for desired results Chiral separations represent the most intriguing and, by some measures, most difficultseparations of chemical compounds. This book provides researchers and students an under-standing of chiral separations and offers a convenient route to selecting the best separation method, saving considerable time and cost in product development. Considering chiral separations in the biotechnological and pharmaceutical industries, as well as for food applications, Dr. Ahuja provides insights into a broad range of topics. Opening with a broad overview of chiral separations, regulatory considerations in drug product development, and basic issues in method development, the book: Covers a variety of modern methods such as gas chromatography, high performance liquid chromatography, supercritical fluid chromatography, and capillary electrophoresis Deals with the impact of chirality on the biological activity of small and large molecules Provides detailed information on useful chiral stationary phases (CSPs) for HPLC Includes handy information on selection of an appropriate CSP, including mechanistic studies Offers strategies for fast method development with HPLC, SFC, and CE Discusses preparatory methods utilized in the pharmaceutical industry With in-depth discussions of the current state of the field as well as suggestions to assist future developments, Chiral Separation Methods for Pharmaceutical and Biotechnological Products is an essential text for laboratory investigators, managers, and regulators who are involved in chiral separations in the pharmaceutical industry, as well as students preparing for careers in these fields.
Download or read book Preclinical Development Handbook written by Shayne Cox Gad and published by John Wiley & Sons. This book was released on 2008-03-21 with total page 1075 pages. Available in PDF, EPUB and Kindle. Book excerpt: A clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic,comprehensive reference to prioritizing and optimizing leads, toxicity, pharmacogenomics, modeling, and regulations. This single definitive, easy-to-use resource discusses all the issues that need consideration and provides detailed instructions for current methods and techniques. Each chapter was written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor, with more than thirty years' experience working with pharmaceutical and biotechnology companies, carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear. Among the key topics covered are: * In vitro mammalian cytogenetics tests * Phototoxicity * Carcinogenicity studies * The pharmacogenomics of personalized medicine * Bridging studies * Toxicogenomics and toxicoproteomics Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage. This is a hands-on guide for pharmaceutical scientists involved in preclinical testing,enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin.
Download or read book Smith and Williams Introduction to the Principles of Drug Design and Action written by H. Jphn Smith and published by CRC Press. This book was released on 2005-10-10 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in knowledge and technology have revolutionized the process of drug development, making it possible to design drugs for a given target or disease. Building on the foundation laid by the previous three editions, Smith and Williams Introduction to the Principles of Drug Design and Action, Fourth Edition includes the latest informatio
Download or read book Essentials of Organic Chemistry written by Paul M. Dewick and published by John Wiley & Sons. This book was released on 2013-03-20 with total page 711 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essentials of Organic Chemistry is an accessible introduction to the subject for students of Pharmacy, Medicinal Chemistry and Biological Chemistry. Designed to provide a thorough grounding in fundamental chemical principles, the book focuses on key elements of organic chemistry and carefully chosen material is illustrated with the extensive use of pharmaceutical and biochemical examples. In order to establish links and similarities the book places prominence on principles and deductive reasoning with cross-referencing. This informal text also places the main emphasis on understanding and predicting reactivity rather than synthetic methodology as well as utilising a mechanism based layout and featuring annotated schemes to reduce the need for textual explanations. * tailored specifically to the needs of students of Pharmacy Medical Chemistry and Biological Chemistry * numerous pharmaceutical and biochemical examples * mechanism based layout * focus on principles and deductive reasoning This will be an invaluable reference for students of Pharmacy Medicinal and Biological Chemistry.
Download or read book Identification and Quantification of Drugs Metabolites Drug Metabolizing Enzymes and Transporters written by Shuguang Ma and published by Elsevier. This book was released on 2020-07-09 with total page 710 pages. Available in PDF, EPUB and Kindle. Book excerpt: Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade's numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism. - Four sections in the book with 24 chapters give readers an overview of state-of-the-art techniques for identifying and quantifying drugs, metabolites and biomarkers, including a chapter on new approaches for quantification of enzymes and transporters in different tissues - Focuses on the role of drug metabolism enzymes, transporters in disposition and drug-drug interactions, as well as strategies for evaluating drug metabolism and safety using advanced liver and kidney models. Discussions on immunogenicity risks of biologics and their evaluation methods have been included - Includes several chapters on advanced translational sciences to predict human dosage, pharmacokinetics and efficacy for small molecules and biotherapeutics - All chapters are written by experts with a wide range of practical experience from the industry and academia
