Download or read book Effects of Dietary Fish Oil Supplementation on the Skeletal Muscle Blood Flow Response to Submaximal Treadmill Exercise written by and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Dietary supplementation with omega-3 polyunsaturated fatty acids (PUFAs) containing docosahexaenoic (DHA) and eicosapentaenoic acid (EPA) has been demonstrated to produce advantageous effects on vascular function. Specifically, PUFA supplementation has resulted in enhanced brachial artery blood flow (Q), dilation, and vascular conductance (VC) during rhythmic handgrip exercise. The effects of fish oils (FO) on skeletal muscle blood flow (Qm) during dynamic whole body exercise, however, remain unknown. PURPOSE: To test our hypothesis that 6 weeks of dietary FO supplementation with DHA and EPA enhances regional Qm and VC to the hindlimb musculature during submaximal treadmill exercise. METHODS: Following 6 weeks of dietary supplementation with safflower oil (SO) (control; n = 9) or FO (n = 8), heart rate (HR), mean arterial pressure (MAP), and Q[subscript]m to the hindlimb were measured at rest and during submaximal treadmill exercise (20 m/min, 10%, ~65% VO[subscript]2max) via radiolabeled microspheres in adult male Sprague-Dawley rats. RESULTS: HR and MAP were not different between SO and FO at rest or exercise (P

Download or read book Effects of Dietary Fish Oil on Skeletal Muscle Vascular Control in Chronic Heart Failure Rats written by Clark T. Holdsworth and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Impaired vasomotor control in chronic heart failure (CHF) limits the delivery of O2 to skeletal muscle during exercise. Previous results demonstrate significant increases in skeletal muscle blood flow (BF) during exercise with omega-3 polyunsaturated fatty acid (PUFA) supplementation via fish oil (FO) versus safflower oil (SO) in healthy rats (Stebbins CL et al., Int J Sport Nutr Exerc Metab 20:475-86, 2010). Whether PUFA supplementation with FO will improve vasomotor control in CHF and skeletal muscle BF during exercise remains to be determined. This investigation tested the hypothesis that PUFA supplementation with FO would augment the skeletal muscle BF response to exercise in rats with CHF when compared to SO. CHF was induced in male Sprague-Dawley rats by myocardial infarction produced via left coronary artery ligation. Rats were then randomized to dietary FO (20% docosahexaenoic acid and 30% eicosapentaenoic acid, n = 8) or SO (5% safflower, n = 6) supplementation for 6 weeks. Rats remained on their respective diets until final experiments were conducted. Following acute instrumentation and recovery (> 1 hour), mean arterial pressure (MAP), skeletal muscle BF to the total hindlimb and individual muscles (via radiolabeled microspheres), and blood lactate concentration were determined during rest, submaximal treadmill exercise and exercise+LNAME (20 m · min−1, 5% incline). Left ventricular end-diastolic pressure (LVEDP) measured in the SO and FO groups during instrumentation were similar and demonstrated moderate CHF (LVEDP; SO: 14 ± 2; FO: 11 ± 1 mmHg, P>0.05). During submaximal exercise, MAP (SO: 128 ± 3; FO: 132 ± 3 mmHg) and blood lactate (SO: 3.8 ± 0.4; FO: 4.6 ± 0.5 mmol · 1−1) were similar (P>0.05) between groups. Exercising hindlimb skeletal muscle BF was higher in SO compared to FO (SO: 120 ± 11; FO: 93 ± 4 ml · min−1 · 100 g−1). Specifically, 17 of 28 individual hindlimb muscle BF's were higher (P

Download or read book Effects of Dietary Intake of Fish Oils on Cardiovascular Function During Exercise in Humans written by Milton Wesley Walser and published by . This book was released on 2007 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Effects of Dietary Fish Oil Supplementation on Substrate Utilization at Rest and During Submaximal Exercise written by Martha C. Stein and published by . This book was released on 1995 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Metabolic Responses to Submaximal and Maximal Exercise Following Three Weeks of Dietary Fish Oil Supplementation written by Michael Bizeau and published by . This book was released on 1993 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Effects of Chronic Omega 3 Fatty Acid Supplementation on Erythrocyte Deformability and Muscle Microvascular Oxygenation in Endurance Trained Cyclists written by Allison J. Campbell and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability to perform endurance exercise is dependent on the transport of oxygen to the active skeletal muscles. For oxygen to perfuse into the skeletal muscle, flexibility of red blood cells is crucial in determining the passage through narrow capillaries, thus the erythrocytes must deform to increase regional blood flow through the microvasculature. It has been shown at submaximal exercise and in conditions of acute hypoxia, erythrocyte deformability is decreased, however supplementation of omega-3 polyunsaturated fatty acids (PUFAs) has been shown to increase erythrocyte deformability. PURPOSE: The purpose of this study is to determine the effects of chronic omega-3 fatty acid supplementation on erythrocyte deformability and tissue oxygenation in highly trained cyclists during submaximal exercise in both normoxic and hypoxic conditions.

Download or read book Effect of Dietary Fish Oil and Eicosapentaenoic Acid Supplementation on Fatty Acid Oxidation in Rat Skeletal Muscle written by Brian L. Johnson and published by . This book was released on 2001 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Fish Oil written by Joseph C. Maroon and published by Basic Health Publications, Inc.. This book was released on 2006 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic inflammation can cause chronic pain, a breakdown of cartilage and muscle, increased blood clotting, and may cause genetic changes leading to various cancers. This book discusses a method of mitigating the effects of chronic inflammation through the power of fish oil.

Download or read book The Potential Role of Fish Oil Supplementation in Overcoming Sarcopenia written by Torkamol Kamolrat and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fish oil supplementation (containing eicosapentaenoic acid; EPA and docosahexaenoic acid; DHA) may have a potential role in overcoming the age-related decline in skeletal muscle mass and function, termed sarcopenia. The aim of this thesis was to determine whether fish oil supplementation can enhance anabolic signalling, muscle strength, protein metabolism and functional abilities in ageing skeletal muscle. In ageing rats (aged 13 months) the effect of 8-week fish oil (2.5 g/day, consisting of 240 mg EPA and 245 mg DHA) supplementation on skeletal muscle anabolic signalling pathways and changes in lean body mass was determined. The data revealed fish oil supplementation tended (P=0.09) to preserve total lean mass loss and increased whole-body glucose flux and phosphorylation of the PI3K-PDK1-p70s6k pathway in type II glycolytic muscle fibres. There was no effect of supplementation on markers of inflammation. In C2C12 myotubes, the distinct effects of EPA and DHA on protein synthesis, protein breakdown and signalling pathways, information previously unknown, was examined. Data showed that EPA (50 μM) augmented L-leucine stimulated protein synthesis and anabolic signalling. EPA also reduced protein breakdown and catabolic signalling. DHA (50 μM) increased anabolic signalling (specifically p70s6k phosphorylation) but had no effect on any other measures. In healthy older women (aged> 65 years) the effect of fish oil supplementation, 4 g/day fish oil (containing 1.7 g EPA and 0.4 g DHA) daily for 12 weeks, on adaptations in skeletal muscle function in response to resistance training was examined. The data revealed that fish oil supplementation enhanced adaptations in isometric strength, gait speed, and also decreased markers of insulin resistance.

Download or read book The Effect of Dietary Fish Oil Supplementation on High Intensity Exercise Performance in Competitive Runners written by Brady Powell and published by . This book was released on 2006 with total page 22 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study examined the effect of dietary fish oil supplementation on high intensity exercise performance in competitive runners. Twelve human subjects (7 males and 5 females) who run a minimum of 20 miles per week were randomly divided into two groups. The experimental group too 4800 mg of fish oil daily for four weeks while the control group took a placebo for four weeks.

Download or read book Submaximal and Maximal Exercise Response to Fish Oil Consumption written by Richard Clarke Bullough and published by . This book was released on 1989 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Effects of Omega 3 Supplementation on Whole Body and Skeletal Muscle Energy Metabolism in Humans written by Sebastian Jannas-Vela and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In humans, evidence regarding the effects of (omega-3) n-3 supplementation on whole body resting metabolic rate (RMR) and fatty acid (FA) oxidation is limited and controversial. In the first study of this thesis, supplementing with a high dose of fish oil (FO) containing 2 g/d eicosapentaenoic acid (EPA) and 1 g/d docosahexaenoic acid (DHA) for 12 weeks, in healthy young males did not affect RMR and substrate oxidation. However, FA oxidation was increased (36%) with a concomitant decrease (34%) in carbohydrate (CHO) oxidation, during the winter season, independent of supplementation. These data demonstrate that RMR and substrate oxidation were unaffected by n-3 supplementation in healthy young males, and that substrate utilization may be affected by changes in external temperature. The second study of the present thesis investigated whether supplementing with purified EPA or DHA would influence whole body RMR and substrate oxidation, in healthy young females and males. Supplementing with olive oil (OO), EPA or DHA had no effect on RMR and substrate oxidation, in males. However, in females, supplementing with DHA decreased (-7%) RMR with no effect on substrate oxidation, whereas OO and EPA, had no effect on these measurements. These data confirmed previous studies reporting small effects of n-3s in RMR and substrate oxidation in females and males. A previous study, in healthy older females, reported a significant increase in resting oxygen consumption (14%) and fat oxidation (19%), after a 12-week period of FO supplementation. Therefore, we examined the effects of FO on RMR, substrate oxidation and skeletal muscle Na+/K+ ATPase (NKA) and sarcoplasmic reticulum Ca2+ ATPase (SERCA) activity in healthy older adults. There was no effect on RMR, substrate oxidation, and skeletal muscle NKA and SERCA activity and protein content, after a 12-week supplementation period with OO or FO. However, there was a decrease in NKA pump sensitivity to Na+, after FO supplementation. These data suggest, that in healthy older adults, n-3s have no effect on whole body and skeletal muscle resting energy metabolism. Altogether, this thesis supports recent evidence, arguing that the necessity to supplement with EPA and DHA, in healthy individuals has been overemphasized.

Download or read book The Effect of EPA and DHA on Skeletal Muscle Physiology and Energy Balance written by Saeed Jebor Ghnaimawi and published by . This book was released on 2020 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA) supplementation commonly suggested during pregnancy confers many health benefits on offspring and more recently improves fetal BAT development and induces myoblast trans-differentiation into adiopocytes through activating PPARs expression. Embryonic myoblast is a highly flexible cell showing great capacity to change its phenotype into adipocyte in response to EPA and DHA supplementation in many in vitro models. However, a little is known about the identity of derived adipocytes, whether, they change into brown or white adipocyte, and in vivo evidence is still missing. Given that the myogeneis process is initiated at the mid of gestation and fetal BAT development is formed at the late stage of pregnancy, we sought to investigate the effect of EPA and DHA supplementation on fetal muscle growth and energy regulation. To achieve our goal, the study was mapped in two patterns: three in vitro experiments, devoted to test the effect of combined and isolated EPA and DHA on C2C12 undergoing differentiation into white and brown adipocytes, and in vivo experiment devoted to investigate the effect of maternal ingestion of EPA and DHA enriched diet on muscle growth, BAT activity, lipid metabolism regulation in liver, and browning of sWAT. C2C12 cell have frequently been used as a representative model of myoblasts in preclinical trials. In vitro, Cells were induced to differentiate into white or brown adipocytes using hormonal cocktail in the absence (CON) or presence of (50 æm) EPA and (50 æm) DHA in combination or separately. The results suggested that EPA and DHA treatments potentiate the route of C2C12 trans-differentiation into white- like adipocytes with a greater potency of DHA in compared to EPA. The effect was mediated via inhibiting myogenesis and mitochondrial biogenesis processes and up-regulating the expression of WAT signature genes and impairing the aquistion of brown adipocyte phenotype. Changing genes profile was concurrent with increasing lipid droplets formation and impairing mitochondrial function. In vivo, mice were fed a diet containing (3.05%) fish oil (FA) enriched with EPA and DHA or diet devoid of fish oil (CON) throughout the entire period of gestation and lactation. The results showed partial inconsistency with in vitro trials where transient increase in myogenesis regulating genes and MHC4 without increasing muscle mass were observed in FA treated group. An increasing intramuscular fat infiltration as a result of stimulating the expression of adipogenesis regulating genes was predominant in FA treated group at day 1 and 21 post-parturition. Also, maternal EPA/ DHA intake induced up-regulation the expression of fatty acids catabolism regulating genes in liver. Stimulating BAT development and activity and browning of subcutaneous white adipose tissue were demonstrated in FA treated group in weaned mice. Taken together, EPA and DHA supplementation is associated with ectopic lipid accumulation in skeletal muscle but not on the expense of myoblasts, and it can be suggested as an excellent therapeutic option to combat childhood obesity as a result of their potential role in stimulating energy expenditure transcriptional program.

Download or read book Effects of High Dose Fish Oil Supplementation on Delayed Onset Muscle Soreness DOMS and Inflammatory Markers written by Robert Standley and published by . This book was released on 2009 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: Delayed muscle soreness (DOMS) is caused, in part, by muscle damage associated with the eccentric component of exercise and this muscle damage can result in an inflammatory response by the body. Fish oil rich in eicosapaetonic acid (EPA) and docosahexeoric acid (DHA) have been shown to have anti-inflammatory properties.

Download or read book The Effects of Chronic Heart Failure on Skeletal Muscle Blood Flow Across the Rest to exercise Transition written by Troy E. Richardson and published by . This book was released on 2001 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Effects of Omega 3 Supplementation on Human Skeletal Muscle Sarcolemmal and Mitochondrial Membrane Fatty Acid Composition and Whole Body Substrate Oxidation written by Christopher Gerling and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The effects of Blue Calorad supplementation on exercise performance and skeletal muscle metabolic potential written by Emma Galbraith and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Résumé en anglais