Download or read book Quantitative Physiology written by Shangbin Chen and published by Springer Nature. This book was released on 2021-02-09 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stephen Hawking says that the 21st century will be the century of complexity and indeed now systems biology or medicine means dealing with complexity. Both the genome and physiome have emerged in studying complex physiological systems. Computational and mathematical modeling has been regarded as an efficient tool to boost the understanding about living systems in normal or pathophysiological states. Covering applied methodology, basic case studies and complex applications, this volume provides researchers with an overview of modeling and computational studies of physiology (i.e. quantitative physiology), which is becoming an increasingly important branch of systems biology. This book aims to build multi-scale models to investigate functions in living systems and explain how biomolecules, cells, organs, organ systems and organisms carry out the chemical or physical functions. Some of the models addressed are related to gene expression, calcium signalling, neural activity, blood dynamics and bone mechanics. Combining theory and practice, with extensive use of MATLAB, this book is designed to establish a paradigm for quantitative physiology by integrating biology, mathematics, physics and informatics etc. To benefit from this book, the readers are expected to have a background in general physiology and mathematics

Download or read book Plant Microbe Interactions written by B.B. Biswas and published by Springer Science & Business Media. This book was released on 1998-04-30 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have seen tremendous progress in unraveling the molecular basis of different plant-microbe interactions. Knowledge has accumulated on the mecha nisms of the microbial infection of plants, which can lead to either disease or resistance. The mechanisms developed by plants to interact with microbes, whether viruses, bacteria, or fungi, involve events that can lead to symbiotic association or to disease or tumor formation. Cell death caused by pathogen infection has been of great interest for many years because of its association with plant resistance. There appear to be two types of plant cell death associated with pathogen infection, a rapid hypersensitive cell death localized at the site of infection during an incompatible interaction between a resistant plant and an avirulent pathogen, and a slow, normosensitive plant cell death that spreads beyond the site of infection during some compatible interactions involving a susceptible plant and a virulent, necrogenic pathogen. Plants possess a number of defense mechanisms against infection, such as (i) production of phytoalexin, (ii) formation of hydrolases, (iii) accumulation of hydroxyproline-rich glycoprotein and lignin deposition, (iv) production of pathogen-related proteins, (v) produc tion of oligosaccharides, jasmonic acid, and various other phenolic substances, and (vi) production of toxin-metabolizing enzymes. Based on these observations, insertion of a single suitable gene in a particular plant has yielded promising results in imparting resistance against specific infection or disease. It appears that a signal received after microbe infection triggers different signal transduction pathways.

Download or read book Genomic Control Process written by Isabelle S. Peter and published by Academic Press. This book was released on 2015-01-21 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic Control Process explores the biological phenomena around genomic regulatory systems that control and shape animal development processes, and which determine the nature of evolutionary processes that affect body plan. Unifying and simplifying the descriptions of development and evolution by focusing on the causality in these processes, it provides a comprehensive method of considering genomic control across diverse biological processes. This book is essential for graduate researchers in genomics, systems biology and molecular biology seeking to understand deep biological processes which regulate the structure of animals during development. - Covers a vast area of current biological research to produce a genome oriented regulatory bioscience of animal life - Places gene regulation, embryonic and postembryonic development, and evolution of the body plan in a unified conceptual framework - Provides the conceptual keys to interpret a broad developmental and evolutionary landscape with precise experimental illustrations drawn from contemporary literature - Includes a range of material, from developmental phenomenology to quantitative and logic models, from phylogenetics to the molecular biology of gene regulation, from animal models of all kinds to evidence of every relevant type - Demonstrates the causal power of system-level understanding of genomic control process - Conceptually organizes a constellation of complex and diverse biological phenomena - Investigates fundamental developmental control system logic in diverse circumstances and expresses these in conceptual models - Explores mechanistic evolutionary processes, illuminating the evolutionary consequences of developmental control systems as they are encoded in the genome

Download or read book Gene Network Inference written by Alberto Fuente and published by Springer Science & Business Media. This book was released on 2014-01-03 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents recent methods for Systems Genetics (SG) data analysis, applying them to a suite of simulated SG benchmark datasets. Each of the chapter authors received the same datasets to evaluate the performance of their method to better understand which algorithms are most useful for obtaining reliable models from SG datasets. The knowledge gained from this benchmarking study will ultimately allow these algorithms to be used with confidence for SG studies e.g. of complex human diseases or food crop improvement. The book is primarily intended for researchers with a background in the life sciences, not for computer scientists or statisticians.

Download or read book Computational Modeling of Gene Regulatory Networks written by Hamid Bolouri and published by Imperial College Press. This book was released on 2008 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book serves as an introduction to the myriad computational approaches to gene regulatory modeling and analysis, and is written specifically with experimental biologists in mind. Mathematical jargon is avoided and explanations are given in intuitive terms. In cases where equations are unavoidable, they are derived from first principles or, at the very least, an intuitive description is provided. Extensive examples and a large number of model descriptions are provided for use in both classroom exercises as well as self-guided exploration and learning. As such, the book is ideal for self-learning and also as the basis of a semester-long course for undergraduate and graduate students in molecular biology, bioengineering, genome sciences, or systems biology.

Download or read book The Regulatory Genome written by Eric H. Davidson and published by Elsevier. This book was released on 2010-07-19 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene regulatory networks are the most complex, extensive control systems found in nature. The interaction between biology and evolution has been the subject of great interest in recent years. The author, Eric Davidson, has been instrumental in elucidating this relationship. He is a world renowned scientist and a major contributor to the field of developmental biology. The Regulatory Genome beautifully explains the control of animal development in terms of structure/function relations of inherited regulatory DNA sequence, and the emergent properties of the gene regulatory networks composed of these sequences. New insights into the mechanisms of body plan evolution are derived from considerations of the consequences of change in developmental gene regulatory networks. Examples of crucial evidence underscore each major concept. The clear writing style explains regulatory causality without requiring a sophisticated background in descriptive developmental biology. This unique text supersedes anything currently available in the market. - The only book in the market that is solely devoted to the genomic regulatory code for animal development - Written at a conceptual level, including many novel synthetic concepts that ultimately simplify understanding - Presents a comprehensive treatment of molecular control elements that determine the function of genes - Provides a comparative treatment of development, based on principles rather than description of developmental processes - Considers the evolutionary processes in terms of the structural properties of gene regulatory networks - Includes 42 full-color descriptive figures and diagrams

Download or read book Probabilistic Boolean Networks written by Ilya Shmulevich and published by SIAM. This book was released on 2010-01-21 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first comprehensive treatment of probabilistic Boolean networks, unifying different strands of current research and addressing emerging issues.

Download or read book Fuzzy Models for Pattern Recognition written by James C. Bezdek and published by Institute of Electrical & Electronics Engineers(IEEE). This book was released on 1992 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Genomic Regulatory Systems written by Eric H. Davidson and published by Elsevier. This book was released on 2001-01-24 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interaction between biology and evolution has been the subject of great interest in recent years. Because evolution is such a highly debated topic, a biologically oriented discussion will appeal not only to scientists and biologists but also to the interested lay person. This topic will always be a subject of controversy and therefore any breaking information regarding it is of great interest.The author is a recognized expert in the field of developmental biology and has been instrumental in elucidating the relationship between biology and evolution. The study of evolution is of interest to many different kinds of people and Genomic Regulatory Systems: In Development and Evolution is written at a level that is very easy to read and understand even for the nonscientist.* Contents Include* Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and Its Causal Role in Development and Evolution * Inside the Cis-Regulatory Module: Control Logic and How the Regulatory Environment Is Transduced into Spatial Patterns of Gene Expression* Regulation of Direct Cell-Type Specification in Early Development* The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts* Changes That Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans

Download or read book Echinoderms Part B written by and published by Academic Press. This book was released on 2019-04-02 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: Echinoderms, Volume 151, the latest release in the Methods in Cell Biology series, highlights advances in the field, with this update presenting chapters on Echinoderm Genome Databases, analysis of gene regulatory networks, using ATAC-seq and RNA-seq to increase resolution in GRN connectivity, multiplex cis-regulatory analysis, experimental approaches GRN/signal pathways, BACs, analysis of chromatin accessibility using ATAC-seq, analysis of sea urchin proteins /Click IT, CRISPR/Cas9-mediated genome editing in sea urchins, super-resolution and in toto imaging of echinoderm embryos, and methods for analysis of intracellular ion signals in sperm, eggs and embryos. - Presents clear, concise protocols provided by experts who have established the echinoderms as a model systems - Highlights new advances in the field, with this update presenting interesting chapters on echinoderms

Download or read book Advances in Neural Information Processing Systems 12 written by Sara A. Solla and published by MIT Press. This book was released on 2000 with total page 1124 pages. Available in PDF, EPUB and Kindle. Book excerpt: The annual conference on Neural Information Processing Systems (NIPS) is the flagship conference on neural computation. It draws preeminent academic researchers from around the world and is widely considered to be a showcase conference for new developments in network algorithms and architectures. The broad range of interdisciplinary research areas represented includes computer science, neuroscience, statistics, physics, cognitive science, and many branches of engineering, including signal processing and control theory. Only about 30 percent of the papers submitted are accepted for presentation at NIPS, so the quality is exceptionally high. These proceedings contain all of the papers that were presented.

Download or read book Handbook of Systems Biology written by Marian Walhout and published by Academic Press. This book was released on 2012-12-31 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics. - 2013 Honorable Mention for Single Volume Reference in Science from the Association of American Publishers' PROSE Awards - Emphasizes the interdisciplinary nature of systems biology with contributions from leaders in a variety of disciplines - Includes the latest research developments in human and animal models to assist with translational research - Presents biological and computational aspects of the science side-by-side to facilitate collaboration between computational and biological researchers

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Origins of Order written by Stuart A. Kauffman and published by Oxford University Press. This book was released on 1993-06-10 with total page 958 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stuart Kauffman here presents a brilliant new paradigm for evolutionary biology, one that extends the basic concepts of Darwinian evolution to accommodate recent findings and perspectives from the fields of biology, physics, chemistry and mathematics. The book drives to the heart of the exciting debate on the origins of life and maintenance of order in complex biological systems. It focuses on the concept of self-organization: the spontaneous emergence of order that is widely observed throughout nature Kauffman argues that self-organization plays an important role in the Darwinian process of natural selection. Yet until now no systematic effort has been made to incorporate the concept of self-organization into evolutionary theory. The construction requirements which permit complex systems to adapt are poorly understood, as is the extent to which selection itself can yield systems able to adapt more successfully. This book explores these themes. It shows how complex systems, contrary to expectations, can spontaneously exhibit stunning degrees of order, and how this order, in turn, is essential for understanding the emergence and development of life on Earth. Topics include the new biotechnology of applied molecular evolution, with its important implications for developing new drugs and vaccines; the balance between order and chaos observed in many naturally occurring systems; new insights concerning the predictive power of statistical mechanics in biology; and other major issues. Indeed, the approaches investigated here may prove to be the new center around which biological science itself will evolve. The work is written for all those interested in the cutting edge of research in the life sciences.

Download or read book Caenorhabditis Elegans written by and published by Academic Press. This book was released on 2011 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Systems Immunology Landscaping Immune Regulatory Networks written by Aridaman Pandit and published by Frontiers Media SA. This book was released on 2022-03-31 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Topology of Chaos written by Robert Gilmore and published by John Wiley & Sons. This book was released on 2012-09-19 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: A highly valued resource for those who wish to move from the introductory and preliminary understandings and the measurement of chaotic behavior to a more sophisticated and precise understanding of chaotic systems. The authors provide a deep understanding of the structure of strange attractors, how they are classified, and how the information required to identify and classify a strange attractor can be extracted from experimental data. In its first edition, the Topology of Chaos has been a valuable resource for physicist and mathematicians interested in the topological analysis of dynamical systems. Since its publication in 2002, important theoretical and experimental advances have put the topological analysis program on a firmer basis. This second edition includes relevant results and connects the material to other recent developments. Following significant improvements will be included: * A gentler introduction to the topological analysis of chaotic systems for the non expert which introduces the problems and questions that one commonly encounters when observing a chaotic dynamics and which are well addressed by a topological approach: existence of unstable periodic orbits, bifurcation sequences, multistability etc. * A new chapter is devoted to bounding tori which are essential for achieving generality as well as for understanding the influence of boundary conditions. * The new edition also reflects the progress which had been made towards extending topological analysis to higher-dimensional systems by proposing a new formalism where evolving triangulations replace braids. * There has also been much progress in the understanding of what is a good representation of a chaotic system, and therefore a new chapter is devoted to embeddings. * The chapter on topological analysis program will be expanded to cover traditional measures of chaos. This will help to connect those readers who are familiar with those measures and tests to the more sophisticated methodologies discussed in detail in this book. * The addition of the Appendix with both frequently asked and open questions with answers gathers the most essential points readers should keep in mind and guides to corresponding sections in the book. This will be of great help to those who want to selectively dive into the book and its treatments rather than reading it cover to cover. What makes this book special is its attempt to classify real physical systems (e.g. lasers) using topological techniques applied to real date (e.g. time series). Hence it has become the experimenter?s guidebook to reliable and sophisticated studies of experimental data for comparison with candidate relevant theoretical models, inevitable to physicists, mathematicians, and engineers studying low-dimensional chaotic systems.