Download or read book Development and Validation of Differential Spectrophotometric Method for Assay of Enrofloxacin in Bulk and Tablet Formulation written by M. Patel and published by GRIN Verlag. This book was released on 2023-12-12 with total page 19 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research Paper (postgraduate) from the year 2019 in the subject Medicine - Pharmacology, Pharmacy, , course: M pharmacy, language: English, abstract: A simple, precise and accurate spectrophotometric method have been developed and validated for the estimation of Enrofloxacin in bulk as well as tablet formulation. The UV spectra of Enrofloxacin was obtained in 0.1N HCl and 0.1N NaOH, and the overlain spectra showed maximum absorbance at 271.0 nm (maxima) and 276.5 nm (minima) in 0.1N NaOH and HCl respectively. The drug follows linearity in the range of 5-30 μg/ml (R2= 0.988). Both intra- and inter-day precision showed % RSD˂ 2 while LOD and LOQ were 0.320 and 0.971 respectively. The method was validated as per ICH guidelines. Enrofloxacin or [1-cyclopropyl-6-fluoro-7-(4-ethyl-1-piperazinyl)-1,4-dihydro-4-oxo-3 quinoline carboxylic acid]. The chemical structure of the drug is given in. It is a synthetic antibacterial agent from the class of the fluroquinolone carboxylic acid derivatives. It has antibacterial activity against a broad spectrum of Gram negative and Gram positive bacteria. Enrofloxacin is used for the treatment of individual pets and domestic animals. Literature survey shows that several analytical methods for the determination of Enrofloxacin include RP-HPLC, HPLC, RP-LC, LC and dissolution study have been reported. Many pharmaceutical products have been assayed by this method. But Differential UV spectrophotometric method of Enrofloxacin was not reported as so far. So an attempt was made to develop a novel, simple, accurate spectrophotometric method for the determination of Enrofloxacin in tablet formulation.
Download or read book Novel Spectrophotometric and HPLC Method Development and Validation written by Pratik Mehta and published by LAP Lambert Academic Publishing. This book was released on 2013-01 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug manufacturing control requires high level and intensive analytical and chemical support of all stages to ensure the drug's quality and safety. Highly specific and sensitive analytical techniques hold the key to the design, development, standardization and quality control of medicinal products. The book is focussed on development and validation of RP-HPLC method for simultaneous estimation of bromhexine HCl, dextromethorphan HBr, and guaiphenesin, colorimetric method for estimation of ferrous fumarate and zinc sulphate, and UV spectrophotometric method for simultaneous estimation of ambroxol HCl, cetirizine HCl, and dextromethorphan HBr, form their combined dosage form. The analysis should be useful to some pharmaceutical companies, students of pharmacy field or anyone else seeking knowledge in the respective field.
Download or read book Development and Validation of Anti tussive Drugs in Dosage Form written by Mukesh C. Sharma and published by LAP Lambert Academic Publishing. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analytical methods development and validation play important roles in the discovery, development, and manufacture of pharmaceuticals. The official test methods that result from these processes are used by quality control laboratories to ensure the identity, purity, potency, and performance of drug products. The method is found to be linear and accurate in the specified range. These newer methods for separating and determining chemical species are known collectively as instrumental methods of analysis.
Download or read book Development and Validation of Indirect Visible Spectrophotometric Method for Doxepin and Dothiepinin Pure and the Tablet Dosage Forms Jordan Journal of Pharmaceutical Sciences 2013 Vol 6 No 1 written by Hosakere Doddarevanna Revanasiddappa and published by . This book was released on 2013 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book HPLC Methods for Recently Approved Pharmaceuticals written by George Lunn and published by John Wiley & Sons. This book was released on 2005-05-06 with total page 743 pages. Available in PDF, EPUB and Kindle. Book excerpt: An indispensable resource for busy researchers Your time is valuable-too valuable to spend hunting through the technical literature in search of the right HPLC assay techniques for your projects. With HPLC Methods for Recently Approved Pharmaceuticals, you'll quickly identify and replicate the ideal procedures for your project needs, without having to refer to original source publications. More of your time can then be spent in the lab, not the library. Covering the relevant world literature through 2003, this book picks up where Dr. Lunn's acclaimed HPLC Methods for Pharmaceutical Analysis left off. It arms you with established HPLC assay techniques for hundreds of newly approved drugs, as well as drugs for which assay methods were only recently developed. Combining detailed descriptions of procedures with specially annotated references, this practical handbook gives you: * HPLC methods for 390 commonly prescribed pharmaceutical compounds * Various procedures for each drug listed together-making it easy to mix and match for customized approaches * Methods for drugs in biological fluids and for bulk and formulated drugs * Chemical structures, molecular weights and formulas, and CAS Registry Numbers * Cross-references to The Merck Index * Retention times of other drugs that can be assayed using the same methods
Download or read book Method Validation in Pharmaceutical Analysis written by Joachim Ermer and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adopting a practical approach, the authors provide a detailed interpretation of the existing regulations (GMP, ICH), while also discussing the appropriate calculations, parameters and tests. The book thus allows readers to validate the analysis of pharmaceutical compounds while complying with both the regulations as well as the industry demands for robustness and cost effectiveness. Following an introduction to the basic parameters and tests in pharmaceutical validation, including specificity, linearity, range, precision, accuracy, detection and quantitation limits, the text focuses on a life-cycle approach to validation and the integration of validation into the whole analytical quality assurance system. The whole is rounded off with a look at future trends. With its first-hand knowledge of the industry as well as regulating bodies, this is an invaluable reference for analytical chemists, the pharmaceutical industry, pharmaceutists, QA officers, and public authorities.
Download or read book The Common Marmoset in Captivity and Biomedical Research written by Robert P. Marini and published by Academic Press. This book was released on 2018-11-19 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Common Marmoset in Captivity and Biomedical Research is the first text dedicated exclusively to this species,filling an urgent need for an encyclopedic compilation of the existing information. Sponsored by the AmericanCollege of Laboratory Animal Medicine as part of its authoritative Blue Book series, the book covers the biology,management, diseases, and clinical and research applications of this important species. The common marmoset(Callithrix jacchus) has come of age in the scientific community as a behaviorally complex, cognitively advanced,small, prolific, and easily maintained nonhuman primate with many of the advantages of larger animals, such asmacaques, but without the attendant physical and zoonotic risks. Marmosets are currently being used in diverse areas of inquiry, including vision and auditory research, infectious disease, cognitive neuroscience, behavior, reproductive biology, toxicology and drug development, and aging. Themarmoset genome has been sequenced and there is currently an intensive effort to apply gene editing technologies to the species. The creation of transgenic marmosets will provide researchers with a small nonhuman primatemodel to study a number of poorly understood disorders, like autism. Presents a complete view of the marmoset, covering their biology and management, diseases and clinical applications, and research applications Includes contributions from renowned and international authors and editors Provides the first authoritative and comprehensive treatment of marmosets in biomedical research as part of the ACLAM Series
Download or read book Handbook of Veterinary Neurology E Book written by Michael D. Lorenz and published by Elsevier Health Sciences. This book was released on 2010-12-14 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Veterinary Neurology provides quick access to vital information on neurologic conditions in a wide range of species, including canine, feline, bovine, caprine, equine, ovine, and porcine. A problem-oriented approach makes it easy to diagnose and treat neurologic problems in small and large animals. The coverage of disorders by problem, not by established disease diagnosis, emulates how animals present to the veterinary hospital and simplifies the formulation of a correct diagnosis. Within each chapter, discussions of neurologic disease include a review of the localization criteria and the diseases that can cause that problem, plus treatment and surgical techniques. Lead author Michael D. Lorenz brings decades of experience to neurologic assessment, using a diagnostic approach that requires minimal knowledge of neuroanatomy. A problem-based approach is organized by presenting sign rather than by condition, guiding you to logical conclusions regarding diagnosis and treatment. Algorithms diagram the logic necessary to localize lesions and to formulate diagnostic plans. Coverage of current diagnostic techniques includes the use of diagnostic tools, such as radiology, spinal fluid analysis, electrodiagnosis, and MR imaging. Case histories in each chapter present a problem and the results of the neurologic examination, then ask you to solve the problem by localizing the lesion, listing probable causes, and making a diagnostic plan. Answers are provided at the back of the book. A consistent format for each case history includes signalment, history, physical examination findings, and neurologic examination. A comprehensive appendix describes species and breeds that have a congenital predisposition for particular neurologic diseases. Extensive references make it easy to pursue in-depth research of more advanced topics. A companion website includes 20 narrated video clips with accompanying PowerPoint slides that correlate to the case histories in the book, covering neurologic assessment and clinical problems such as paresis of one limb, tetraparesis, stupor, seizures, ataxia of the head and limbs, and cranial nerve disorders. Two new co-authors, Jean Coates and Marc Kent, board-certified in neurology, enhance the credibility of this edition. A full-color design and numerous illustrations include enhanced images of neuroanatomy and pathology.
Download or read book Metal Nanoclusters in Catalysis and Materials Science The Issue of Size Control written by Benedetto Corain and published by Elsevier. This book was released on 2011-08-11 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal Nanoclusters in Catalysis and Materials Science: The Issue of Size Control deals with the synthesis of metal nanoclusters along all known methodologies. Physical and chemical properties of metal nanoclusters relevant to their applications in chemical processing and materials science are covered thoroughly. Special attention is given to the role of metal nanoclusters size and shape in catalytic processes and catalytic applications relevant to industrial chemical processing.An excellent text for expanding the knowledge on the chemistry and physics of metal nanoclusters. Divided in two parts; Part I deals with general aspects of the matter and Part II has to be considered a useful handbook dealing with the production of metal nanoclusters, especially from their size-control point of view. * Divided into two parts for ease of reference: general and operational * Separation of synthetic aspects, physical properties and applications* Specific attention is given to the task of metal nanoclusters size-control
Download or read book Nanostructured Materials written by T. Daniel Thangadurai and published by Springer Nature. This book was released on 2020-02-27 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the early stages of the development of nanostructures, including synthesis techniques, growth mechanisms, the physics and chemistry of nanostructured materials, various innovative characterization techniques, the need for functionalization and different functionalization methods as well as the various properties of nanostructured materials. It focuses on the applications of nanostructured materials, such as mechanical applications, nanoelectronics and microelectronic devices, nano-optics, nanophotonics and nano-optoelectronics, as well as piezoelectric, agriculture, biomedical and, environmental remediation applications, and anti-microbial and antibacterial properties. Further, it includes a chapter on nanomaterial research developments, highlighting work on the life-cycle analysis of nanostructured materials and toxicity aspects.
Download or read book Nanosensor Technologies for Environmental Monitoring written by Inamuddin and published by Springer Nature. This book was released on 2020-07-15 with total page 529 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced materials and nanotechnology is a promising, emerging field involving the use of nanoparticles to facilitate the detection of various physical and chemical parameters, including temperature, humidity, pH, metal ion, anion, small organic or inorganic molecules, gases, and biomolecules responsible for environmental issues that can lead to diseases like cancer, diabetes, osteoarthritis, bacterial infections, and brain, retinal, and cardiovascular diseases. By monitoring environmental samples and detecting these environmental issues, advanced nanotechnology in this type of sensory technology is able to improve daily quality of life. Although these sensors are commercially available for the detection of monovalent cations, anions, gases, volatile organic molecules, heavy metal ions, and toxic metal ions, many existing models require significant power and lack advanced technology for more quality selectivity and sensitivity. There is room in these sensors to optimize their selectivity, reversibility, on/off ratio, response time, and their environmental stability in real-world operating conditions. This book explores the methods for the development and design of environmentally-friendly, simple, reliable, and cost effective electrochemical nanosensors using powerful nanostructured materials. More specifically, it highlights the use of various electrochemical-based biosensor sensors involved in the detection of monovalent cations, anions, gases, volatile organic molecules, heavy metal ions, and toxic metal ions, with the ultimate goal of seeing these technologies reach market.
Download or read book Surface Modification of Nanoparticles for Targeted Drug Delivery written by Yashwant V Pathak and published by Springer. This book was released on 2019-03-11 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book is the only one to discuss various new techniques developed to enhance the application of nanoparticulate drug delivery systems using surface modification of nanoparticles. The understanding of the surface characteristics nano-particles is growing significantly with the advent of new analytical techniques. Polymer chemistry is contributing to the development of many new versatile polymers which have abilities to accommodate many different, very reactive chemical groups, and can be used as a diagnostic tool, for better targeting, for more effective therapeutic results as well as for reducing the toxic and side effects of the drugs. Surface modification of such polymeric nanoparticles has been found by many scientists to enhance the application of nanoparticles and also allows the nano particles to carry specific drug molecule and disease /tumor specific antibodies which refine and improve drug delivery. Surface Modification of Nanoparticles for Targeted Drug Delivery is a collection essential information with various applications of surface modification of nanoparticles and their disease specific applications for therapeutic purposes.
Download or read book Capillary Zone Electrophoresis written by František Foret and published by . This book was released on 1993 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Green Analytical Chemistry written by Justyna Płotka-Wasylka and published by Springer. This book was released on 2019-08-02 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book explains the principles and fundamentals of Green Analytical Chemistry (GAC) and highlights the current developments and future potential of the analytical green chemistry-oriented applications of various solutions. The book consists of sixteen chapters, including the history and milestones of GAC; issues related to teaching of green analytical chemistry and greening the university laboratories; evaluation of impact of analytical activities on the environmental and human health, direct techniques of detection, identification and determination of trace constituents; new achievements in the field of extraction of trace analytes from samples characterized by complex composition of the matrix; “green” nature of the derivatization process in analytical chemistry; passive techniques of sampling of analytes; green sorption materials used in analytical procedures; new types of solvents in the field of analytical chemistry. In addition green chromatography and related techniques, fast tests for assessment of the wide spectrum of pollutants in the different types of the medium, remote monitoring of environmental pollutants, qualitative and comparative evaluation, quantitative assessment, and future trends and perspectives are discussed. This book appeals to a wide readership of the academic and industrial researchers. In addition, it can be used in the classroom for undergraduate and graduate Ph.D. students focusing on elaboration of new analytical procedures for organic and inorganic compounds determination in different kinds of samples characterized by complex matrices composition.Jacek Namieśnik was a Professor at the Department of Analytical Chemistry, Gdańsk University of Technology, Poland. Justyna Płotka-Wasylka is a teacher and researcher at the same department.
Download or read book Drug Design and Development written by Chris Rostron and published by . This book was released on 2020-05-15 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Design and Development outlines the processes involved in the design and development of new drugs and emphasises the significance of these processes to the practice of pharmacy.
Download or read book Drug Stability and Chemical Kinetics written by Muhammad Sajid Hamid Akash and published by Springer Nature. This book was released on 2020-11-01 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively reviews drug stability and chemical kinetics: how external factors can influence the stability of drugs, and the reaction rates that trigger these effects. Explaining the important theoretical concepts of drug stability and chemical kinetics, and providing numerous examples in the form of illustrations, tables and calculations, the book helps readers gain a better understanding of the rates of reactions, order of reactions, types of degradation and how to prevent it, as well as types of stability studies. It also offers insights into the importance of the rate at which the drug is degraded and/or decomposed under various external and internal conditions, including temperature, pH, humidity and light. This book is intended for researchers, PhD students and scientists working in the field of pharmacy, pharmacology, pharmaceutical chemistry, medicinal chemistry and biopharmaceutics.
Download or read book Planar Chromatography Mass Spectrometry written by Teresa Kowalska and published by CRC Press. This book was released on 2015-11-18 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Planar Chromatography-Mass Spectrometry focuses on a relatively new approach to chemical analysis in general, and to separation science in particular. It is the first book to systemically cover the theoretical background, techniques, instrumentation, and practical applications of planar chromatography-mass spectrometry as a hyphenated tool of analy
