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Book Design and Fabrication of Integrated Plasmonic Platforms for Ultra sensitive Molecular and Biomolecular Detections

Download or read book Design and Fabrication of Integrated Plasmonic Platforms for Ultra sensitive Molecular and Biomolecular Detections written by Mohammadali Tabatabaei and published by . This book was released on 2015 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the major challenges in analytical and biological sciences is to develop a device to obtain unambiguous chemical and structural properties of a material or a probe biomolecule with high reproducibility and ultra-high sensitivity. Moreover, in addition to such a high sensitivity, other cases such as minimum intrusiveness, small amounts of analyte, and short acquisition time and high reproducibility are key parameters that can be valued in any analytical measurements. Among the promising methods to achieve such endeavor plasmon-mediated surface-enhanced spectroscopic techniques, such as surface-enhanced Raman spectroscopy (SERS), are considered as suitable options. Such techniques take advantage of the interaction between an optical field and a metallic nanostructure to magnify the electromagnetic (EM) field in the proximity of the nanostructure. This results in an amplified signal of the vibrational fingerprints of the adsorbed probe molecules onto the metallic surface. Keys to obtaining ultra-sensitive SERS measurements are the development of rationally-designed plasmonic nanostructures. Besides, a major challenge for controlled and reliable sensitive measurements of probe biomolecules on biological cells gives rise due to the intrinsic random positioning and proliferation of these cells over a substrate such as a glass coverslip. In this thesis, the rational design and development of a fluorocarbon thin film micropatterned platform is introduced for controlled programming of conventional and transfected cells proliferation over the substrate. They also provided high throughput capability of controlled neuronal network connections towards advanced imaging and sensitive detection of biomolecules of interest at nanoscale resolution. This micropatterned platform was also integrated with optimized plasmonic nanostructures fabricated by nanosphere lithography (NSL) for SERS biosensing of glycans using a Raman reporter over the positionally-controlled single cells surfaces. In addition to providing controlled plasmon-mediated measurements, the fabrications of two newly-developed 3D plasmonic nanostructures have been introduced in this thesis. These are nanopyramids arrays fabricated by NSL and arrays of nanoholes with co-registered nanocones fabricated by electron-beam lithography (EBL). These approaches have been used not only for ultra-sensitive molecular detection at the monolayer level in a variety of configurations, but also towards label-free single molecule detection at sub-femtomolar concentrations.

Book Biosurfactants for a Sustainable Future

Download or read book Biosurfactants for a Sustainable Future written by Hemen Sarma and published by John Wiley & Sons. This book was released on 2021-04-19 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biosurfactants for a Sustainable Future Explore the state-of-the-art in biosurfactant technology and its applications in environmental remediation, biomedicine, and biotechnology Biosurfactants for a Sustainable Future explores recent developments in biosurfactants and their use in a variety of cutting-edge applications. The book opens a window on the rapid development of microbiology by explaining how microbes and their products are used in advanced medical technology and in the sustainable remediation of emerging environmental contaminants. The book emphasizes the different techniques that are used for the production of biosurfactants from microorganisms and their characterization. Various aspects of biosurfactants, including structural characteristics, developments, production, bio-economics and their sustainable use in the environment and biomedicine, are addressed, and the book also presents metagenomic strategies to facilitate the discovery of novel biosurfactants producing microorganisms. Readers will benefit from the inclusion of: A thorough introduction to the state-of-the-art in biosurfactant technology, techniques, and applications An exploration of biosurfactant enhanced remediation of sediments contaminated with organics and inorganics A discussion of perspectives for biomedical and biotechnological applications of biosurfactants A review of the antiviral, antimicrobial, and antibiofilm potential of biosurfactants against multi-drug-resistant pathogens. An examination of biosurfactant-inspired control of methicillin-resistant Staphylococcus aureus Perfect for academic researchers and scientists working in the petrochemical industry, pharmaceutical industry, and in the agroindustry, Biosurfactants for a Sustainable Future will also earn a place in the libraries of scientists working in environmental biotechnology, environmental science, and biomedical engineering.

Book Label Free Biosensing

    Book Details:
  • Author : Michael J. Schöning
  • Publisher : Springer
  • Release : 2018-07-20
  • ISBN : 3319752200
  • Pages : 485 pages

Download or read book Label Free Biosensing written by Michael J. Schöning and published by Springer. This book was released on 2018-07-20 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume summarizes the state-of-the-art technologies, key advances and future trends in the field of label-free biosensing. It provides detailed insights into the different types of solid-state, label-free biosensors, their underlying transducer principles, advanced materials utilized, device-fabrication techniques and various applications. The book offers graduate students, academic researchers, and industry professionals a comprehensive source of information on all facets of label-free biosensing and the future trends in this flourishing field. Highlights of the subjects covered include label-free biosensing with: · semiconductor field-effect devices such as nanomaterial-modified capacitive electrolyte-insulator-semiconductor structures, silicon nanowire transistors, III-nitride semiconductor devices and light-addressable potentiometric sensors · impedimetric biosensors using planar and 3D electrodes · nanocavity and solid-state nanopore devices · carbon nanotube and graphene/graphene oxide biosensors · electrochemical biosensors using molecularly imprinted polymers · biomimetic sensors based on acoustic signal transduction · enzyme logic systems and digital biosensors based on the biocomputing concept · heat-transfer as a novel transducer principle · ultrasensitive surface plasmon resonance biosensors · magnetic biosensors and magnetic imaging devices

Book Nanostructured Plasmonic Interferometers for Ultrasensitive Label free Biosensing

Download or read book Nanostructured Plasmonic Interferometers for Ultrasensitive Label free Biosensing written by Yongkang Gao and published by . This book was released on 2014 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical biosensors that utilize surface plasmon resonance (SPR) technique to analyze the biomolecular interactions have been extensively explored in the last two decades and have become the gold standard for label-free biosensing. These powerful sensing tools allow fast, highly-sensitive monitoring of the interaction between biomolecules in real time, without the need for laborious fluorescent labeling, and have found widely ranging applications from biomedical diagnostics and drug discovery, to environmental sensing and food safety monitoring. However, the prism-coupling SPR geometry is complex and bulky, and has severely limited the integration of this technique into low-cost portable biomedical devices for point-of-care diagnostics and personal healthcare applications. Also, the complex prism-coupling scheme prevents the use of high numerical aperture (NA) optics to increase the spatial resolution for multi-channel, high-throughput detection in SPR imaging mode. This dissertation is focused on the design and fabrication of a promising new class of nanopatterned interferometric SPR sensors that integrate the strengths of miniaturized nanoplasmonic architectures with sensitive optical interferometry techniques to achieve bold advances in SPR biosensing. The nanosensor chips developed provide superior sensing performance comparable to conventional SPR systems, but employing a far simpler collinear optical transmission geometry, which largely facilitates system integration, miniaturization, and low-cost production. Moreover, the fabricated nanostructure-based SPR sensors feature a very small sensor footprint, allowing massive multiplexing on a chip for high-throughput detection. The successful transformation of SPR technique from bulky prism-coupling setup into this low-cost compact plasmonic platform would have a far-reaching impact on point-of-care diagnostic tools and also lead to advances in high-throughput sensing applications in proteomics, immunology, drug discovery, and fundamental cell biology research.

Book Fiber Optic Sensors and Applications

Download or read book Fiber Optic Sensors and Applications written by Swee Chuan Tjin and published by MDPI. This book was released on 2020-12-15 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Special Issue focuses on all aspects of the recent research and development related to fiber optic sensors. The recent advances in fiber-based sensing technologies have enabled both fundamental studies and a wide spectrum of applications. The goal of this Special Issue is to bring attention to the most recent results in the field of fiber optic sensors, including new mechanisms, materials, processes, and applications.

Book Nanoplasmonic Sensors

    Book Details:
  • Author : Alexandre Dmitriev
  • Publisher : Springer Science & Business Media
  • Release : 2012-07-31
  • ISBN : 1461439337
  • Pages : 394 pages

Download or read book Nanoplasmonic Sensors written by Alexandre Dmitriev and published by Springer Science & Business Media. This book was released on 2012-07-31 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compendium of the finest research in nanoplasmonic sensing done around the world in the last decade. It describes basic theoretical considerations of nanoplasmons in the dielectric environment, gives examples of the multitude of applications of nanoplasmonics in biomedical and chemical sensing, and provides an overview of future trends in optical and non-optical nanoplasmonic sensing. Specifically, readers are guided through both the fundamentals and the latest research in the two major fields nanoplasmonic sensing is applied to – bio- and chemo-sensing – then given the state-of-the-art recipes used in nanoplasmonic sensing research.

Book Surface Plasmon Resonance in Bioanalysis

Download or read book Surface Plasmon Resonance in Bioanalysis written by and published by Elsevier. This book was released on 2021-11-11 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surface Plasmon Resonance in Bioanalysis, Volume 95 in the Comprehensive Analytical Chemistry series, contains a wide range of topics on the applications and new advances of surface plasmon resonance (SPR) in bioanalysis, including Surface plasmon resonance microscopy for single-cell based drug screening, Phase-Sensitive Surface Plasmon Resonance Sensors for Highly Sensitive Bioanalysis, SPR coupled to ambient mass spectrometry, Surface Plasmon Resonance Microscopy for activity detection and imaging of single cells, SPR for water pollutant detection and biofouling control, SPR imaging for cellular analysis and detection, Progress in detection of surface palsmon resonance for biorefinery technology, and more. Additional chapters cover Long-range surface plasmon resonance and its biological sensing applications and Critical issues in clinical and biomedical applications of Surface Plasmon Resonance sensing. Provides updates on the latest applications of SPR microscopy in cell analysis Covers the latest design in SPR sensing for highly sensitive bioanalysis Presents the critical issues in clinical and biomedical applications of SPR

Book Developing Multifunctional Surface Chemistry for Plasmonic Biosensing in Complex Media

Download or read book Developing Multifunctional Surface Chemistry for Plasmonic Biosensing in Complex Media written by Fang Sun and published by . This book was released on 2016 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decades, plasmonic sensors have been explored extensively due to their ultra-sensitivity and emerged as a new generation of analytical tools. Two of the most widely used and studied plasmonic sensors are surface enhanced Raman scattering (SERS) sensors and surface plasmon resonance (SPR) sensors, which are focused in this dissertation. SERS is a phenomenon which can significantly magnify the Raman signals of the molecules adsorbed on a nanostructured metal surface for up to millions of folds and have led to the detections of single molecules. SERS can also provide chemical fingerprints representing vibrational or rotational transitions specific to the molecular structure to identify the analyte. The SPR optical sensor can enable the direct observation of molecular interaction in real-time and offer the benefits of rapid, sensitive and label-free detection of chemical and biological species. Based on these advantages such as ultra-sensitivity and molecular specificity, both of the sensors have already been used for a variety of applications ranging from chemical and biological sensing, environmental monitoring to diagnostics. However, reliable biosensing in complex biological media based on these two advanced plasmonic sensors is still very challenging due to several reasons. For example, SERS is a near-field effect; the enhancement effect decreases exponentially with increasing distance from the surface. A bare SERS-active surface lacks selectivity; anything adsorbed onto the surface can be detected. In the complex media, the background noise from interfering species could mask the signals from target analytes. In addition, nonspecific adsorption from the complex media could impede the adsorption of target analytes to SERS-active substrate surfaces. Thus, a method which can amplify the detection signals over unwanted background is highly desirable and it is also essential to introduce nonfouling modifications to protect the SERS-active surface from nonspecific adsorption. For an SPR sensor, the specificity of the SPR sensor is totally dependent on the biomolecular recognition species employed while the sensitivity depends on the amount of nonspecific binding. Thereby, the surface chemistry which can not only effectively resist nonspecific protein adsorption but also provides abundant sites for the ligand immobilization is desired. In this dissertation, we discuss the design and selection of probe molecules on the SERS surface for specific detection and signal amplification of target analytes with small Raman activity or no activity such as fructose or hydrogen ion. In addition, to overcome the protein fouling problem, we introduce a zwitterionic nonfouling surface modification to the SERS sensor. We design and synthesize a zwitterionic short thiol, which contains a carboxybetaine head group resisting the protein adsorption effectively. The CBT possesses a small Raman activity generating negligible background noise even with high packing density. To future improve the nonfouling property of the modification, we also introduce the zwitterionic poly(carboxybetaine acrylamide) (pCBAA) polymer brush on the SERS surface via surface-initiated atom transfer radical polymerization (SI-ATRP). This modification enables the SERS detection of several therapeutic drugs directly in the human undiluted plasma. For the SPR sensor, we develop a facile and stable nonfouling coating method based on the zwitterionic hydrogel. The hydrogel coating demonstrate ultra-low fouling property from the undiluted blood serum and high antibody loading capacity due to the three-dimensional structure. At last, we also propose a new method to detect the anti-PEG antibody in blood sample based on the PEG coated SPR sensor. The surface chemistry is studied and optimized to achieve an extremely low limit of detection showing better sensitivity compared with traditional ELISA detection methods. By tailoring and tuning the surface chemistry, we explore and expand the applications of the plasmonic sensor in complex media. On the one hand, we introduce the attracting and probing molecules to enhance the detection signals. And on the other hand, we modify the zwitterionic nonfouling materials on the surface of sensors to decrease the background noise and interference. With the improved signal/noise ratio, the sensitivity of sensors can be dramatically increased.

Book Nanoscience And Technology  A Collection Of Reviews From Nature Journals

Download or read book Nanoscience And Technology A Collection Of Reviews From Nature Journals written by Peter Rodgers and published by World Scientific. This book was released on 2009-08-21 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains 35 review articles on nanoscience and nanotechnology that were first published in Nature Nanotechnology, Nature Materials and a number of other Nature journals. The articles are all written by leading authorities in their field and cover a wide range of areas in nanoscience and technology, from basic research (such as single-molecule devices and new materials) through to applications (in, for example, nanomedicine and data storage).

Book Advanced Photonic Structures for Biological and Chemical Detection

Download or read book Advanced Photonic Structures for Biological and Chemical Detection written by Xudong Fan and published by Springer Science & Business Media. This book was released on 2009-08-29 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: In my career I’ve found that ‘‘thinking outside the box’’ works better if I know what’s ‘‘inside the box.’’ Dave Grusin, composer and jazz musician Different people think in different time frames: scientists think in decades, engineers think in years, and investors think in quarters. Stan Williams, Director of Quantum Science Research, Hewlett Packard Laboratories Everything can be made smaller, never mind physics; Everything can be made more ef?cient, never mind thermodynamics; Everything will be more expensive, never mind common sense. Tomas Hirschfeld, pioneer of industrial spectroscopy Integrated Analytical Systems Series Editor: Dr. Radislav A. Potyrailo, GE Global Research, Niskayuna, NY The book series Integrated Analytical Systems offers the most recent advances in all key aspects of development and applications of modern instrumentation for che- cal and biological analysis. The key development aspects include (i) innovations in sample introduction through micro- and nano?uidic designs, (ii) new types and methods of fabrication of physical transducers and ion detectors, (iii) materials for sensors that became available due to the breakthroughs in biology, combinatorial materials science, and nanotechnology, and (iv) innovative data processing and mining methodologies that provide dramatically reduced rates of false alarms.

Book Nanoplasmonics

Download or read book Nanoplasmonics written by Vasily Klimov and published by Pan Stanford. This book was released on 2014-09-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoplasmonics is one of the most important growth areas of this century. It is part of nano-optics and nanophotonics and deals with oscillations of electrons in metallic nanoparticles and nanostructures. Also, it is a multidisciplinary subject covering atomic, molecular, and solid-state physics, as well as much of chemistry. Nanoplasmonics makes it possible to combine the nanoscale properties of smart devices with their optical frequencies of operation. Nanoplasmonics presents, for the first time, both the physical principles and mathematical descriptions of main nanoplasmonic effects that now are scattered over thousands of research articles. Importantly, it contains many methods, accompanied by diagrams, for fast estimations and calculations of main properties of nanoparticles of very different shapes and their clusters. It also presents the most important applications of nanoplasmonics, including in medicine, nanolasers, electronics, perfect lenses, and invisibility cloaks.

Book WHO List of Priority Medical Devices for Cancer Management

Download or read book WHO List of Priority Medical Devices for Cancer Management written by World Health Organization and published by . This book was released on 2017-05-09 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the model list and clearing house of appropriate, basic, and priority medical devices based on the list of clinical interventions selected from clinical guidelines on prevention, screening, diagnosis, treatment, palliative care, monitoring, and end of life care. This publication addresses medical devices that can be used for the management of cancer and specifically describes medical devices for six types of cancer: breast, cervical, colorectal, leukemia, lung, and prostate. This book is intended for ministries of health, public health planners, health technology managers, disease management, researchers, policy makers, funding, and procurement agencies and support and advocacy groups for cancer patients.

Book Surface Plasmon Resonance Based Sensors

Download or read book Surface Plasmon Resonance Based Sensors written by Jiri Homola and published by Springer Science & Business Media. This book was released on 2006-08-18 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a comprehensive treatment of the field of SPR sensors, in three parts. Part I introduces principles of surface plasmon resonance bio-sensors, electromagnetic theory of surface plasmons, theory of SPR sensors and molecular interactions at sensor surfaces. Part II examines the development of SPR sensor instrumentation and functionalization methods. Part III reviews applications of SPR biosensors in the study of molecules, and in environmental monitoring, food safety and medical diagnostics.

Book Applications of Nanomaterials in Sensors and Diagnostics

Download or read book Applications of Nanomaterials in Sensors and Diagnostics written by Adisorn Tuantranont and published by Springer Science & Business Media. This book was released on 2014-07-08 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent progress in the synthesis of nanomaterials and our fundamental understanding of their properties has led to significant advances in nanomaterial-based gas, chemical and biological sensors. Leading experts around the world highlight the latest findings on a wide range of nanomaterials including nanoparticles, quantum dots, carbon nanotubes, molecularly imprinted nanostructures or plastibodies, nanometals, DNA-based structures, smart nanomaterials, nanoprobes, magnetic nanomaterials, organic molecules like phthalocyanines and porphyrins, and the most amazing novel nanomaterial, called graphene. Various sensing techniques such as nanoscaled electrochemical detection, functional nanomaterial-amplified optical assays, colorimetry, fluorescence and electrochemiluminescence, as well as biomedical diagnosis applications, e.g. for cancer and bone disease, are thoroughly reviewed and explained in detail. This volume will provide an invaluable source of information for scientists working in the field of nanomaterial-based technology as well as for advanced students in analytical chemistry, biochemistry, electrochemistry, material science, micro- and nanotechnology.

Book Plasmonics  Fundamentals and Applications

Download or read book Plasmonics Fundamentals and Applications written by Stefan Alexander Maier and published by Springer Science & Business Media. This book was released on 2007-05-16 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considered a major field of photonics, plasmonics offers the potential to confine and guide light below the diffraction limit and promises a new generation of highly miniaturized photonic devices. This book combines a comprehensive introduction with an extensive overview of the current state of the art. Coverage includes plasmon waveguides, cavities for field-enhancement, nonlinear processes and the emerging field of active plasmonics studying interactions of surface plasmons with active media.

Book Nanotechnology in Biology and Medicine

Download or read book Nanotechnology in Biology and Medicine written by Tuan Vo-Dinh and published by CRC Press. This book was released on 2017-10-03 with total page 983 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Nanotechnology in Biology and Medicine is intended to serve as an authoritative reference source for a broad audience involved in the research, teaching, learning, and practice of nanotechnology in life sciences. This technology, which is on the scale of molecules, has enabled the development of devices smaller and more efficient than anything currently available. To understand complex biological nanosystems at the cellular level, we urgently need to develop a next-generation nanotechnology tool kit. It is believed that the new advances in genetic engineering, genomics, proteomics, medicine, and biotechnology will depend on our mastering of nanotechnology in the coming decades. The integration of nanotechnology, material sciences, molecular biology, and medicine opens the possibility of detecting and manipulating atoms and molecules using nanodevices, which have the potential for a wide variety of biological research topics and medical uses at the cellular level. This book presents the most recent scientific and technological advances of nanotechnology for use in biology and medicine. Each chapter provides introductory material with an overview of the topic of interest; a description of methods, protocols, instrumentation, and applications; and a collection of published data with an extensive list of references for further details. The goal of this book is to provide a comprehensive overview of the most recent advances in instrumentation, methods, and applications in areas of nanobiotechnology, integrating interdisciplinary research and development of interest to scientists, engineers, manufacturers, teachers, and students.