Download or read book Pyridine Nucleotide Dependent Dehydrogenases written by Horst Sund and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present volume represents the proceedings of the symposium on npyridine Nucleotide-Dependent Dehydrogenases" which was held on the campus of the re cently established University of Konstanz, Germany, from September 15 to 20, 1969. The aim of the symposium was to provide a forum for discussion among the experts interested in the various aspects of pyridine nucleotide-dependent de hydrogenases and the pyridine coenzymes, so as to evaluate the state of the present knowledge and to stimulate further progress in this field. In order to facilitate discussion and personal contact it was necessary to restrict the number of participants to 90 including the invited speakers, who came from fifteen countries (Australia, Austria, Denmark, England, Finland, France, Germany, Hungary, Israel, Italy, Japan, Netherlands, Sweden, Switzerland, USA). The printed lectures in this volume differ only in minor respects from those circulated be fore the meeting. In some cases speakers presented new experimen tal material during the symposium which was added as an addendum to the papers. The discussions were not recorded. The participants were requested to provide a written report of what they considered worth including in the published re port. This, together with the answers of the speakers is presented in this vo lume. I whish to thank all the speakers and discussants for their cooperativity in preparing the manuscript. The symposium was sponsored by the International Union of Biochemistry whose President, Professor Theorell, was also present and who was acting as one of the speakers and chairmen.

Download or read book Dehydrogenases written by Rosa Angela Canuto and published by BoD – Books on Demand. This book was released on 2012-11-14 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book takes in consideration some dehydrogenases, enzymes with different functions in the cells by using different substrates, such as hydroxysteroid dehydrogenases, aldehyde dehydrogenases, glucose-6-phosphate dehydrogenase, pyruvate dehydrogenase complex, glutamate dehydrogenase, succinate dehydrogenase. They are examined from the following points of view: biochemistry, physiological functions and role in some diseases and in the development of tumours. For these reasons, the book is divided into three sections: 1. Dehydrogenases and cancer 2. Dehydrogenases and some diseases 3. Dehydrogenases and physiological role

Download or read book Dehydrogenases written by Jonathan and published by Birkhäuser. This book was released on 2013-11-21 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together lmportant work on the structure and function of the dehydrogenases requiring nicotinamide coenzymes. The structure and function of lactate dehydrogen ase, alcohol dehydrogenase, and glyceraldehyde 3-phosphate dehydrogenase are compared. These are the relatively simple oligomeric dehydrogenases for which very extensive structural and mechanistic information is available. Kinetic studies are dealt with in general terms, with selected examples. Genetic and structural relationships revealed by primary structure are discussed. General features of the specificity of dehydrogen ase reactions are described. The pyridine nucleotide - disulphide oxidoreductases exemplify a type of multicomponent enzyme complex. Lipoamide dehydrogenase, glutathione reductase, and thioredoxin reduct ase are described and compared. The fatty acid synthesizing systems of some organ isms are nonaggregated, whereas in other organisms they are multienzyme complexes containing, in animal tissues for example, two closely related multifunctional polypeptide chains. The dehydrogenase activities of the fatty acid syn thesizing systems afford many points of interest, which are described and discussed. Hydroxymethylglutaryl-CoA reductase occupies a key position in the synthesis of isoprenoid compounds, including cholesterol. It probably occurs in all forms of life; in animal cells it is a microsomal enzyme. Its properties are reviewed.

Download or read book Pyridine Nucleotide Dependent Dehydrogenases written by Horst Sund and published by Walter de Gruyter GmbH & Co KG. This book was released on 2019-10-08 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: No detailed description available for "Pyridine Nucleotide-Dependent Dehydrogenases".

Download or read book Aldehyde Dehydrogenases written by Jun Ren and published by Springer. This book was released on 2019-07-31 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers the science of ALDH enzymes in relation to chronic disease processes and the future therapeutic potentials of targeting ALDH in these processes. It thoroughly reviews the roles of ALDH family in alcohol metabolism, as well as recent findings of their emerging roles in a variety of human pathologies such as cardiovascular diseases, diabetes, obesity, stroke, cancer, liver diseases and kidney diseases. Delicate contribution of ALDH enzymes in the therapeutics against chronic diseases is also discussed. It demonstrates the unique value of targeting genetic polymorphism in ALDH enzymes in personalized medicine. The book will appeal to scientists, physicians, graduate and professional students in the fields of ALDH enzymes, alcohol metabolism, cardiometabolic and other chronic diseases. Pharmaceutical and other companies developing new tools for cardiometabolic and chronic diseases treatment will also find this a valuable resource.

Download or read book Oxidases Dehydrogenases and Related Systems written by and published by Walter de Gruyter. This book was released on 2012-12-21 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: The dynamic field of flavin and flavoprotein biochemistry has seen rapid advancement in recent years. This comprehensive two volume set provides an overview of all aspects of contemporary research in this important class of enzymes. Topics treated include flavoproteins involved in energy generation, signal transduction and electron transfer (including respiration); oxygen activation by flavoproteins; the biology and biochemistry of complex flavoproteins; flavin and flavoprotein photochemistry/photophysics as well as biotechnological applications of flavoproteins. Recent developments in this field include new structures (including those of large membrane-integral electron transfer complexes containing FMN or FAD), elucidation of the role of flavoproteins in cell signalling pathways (including both phototaxis and the circadian cycle) and important new insights into the reaction mechanisms of flavin-containing enzymes. This volume focussing on oxidases, dehydrogenases and related systems is an essential reference for all researchers in biochemistry, chemistry, photochemistry and photophysics working on flavoenzymes.

Download or read book Rare earth element biochemistry Methanol dehydrogenases and lanthanide biology written by and published by Academic Press. This book was released on 2021-04-16 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Enzymology, Volume 650 continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this new release include Biophysical methods to study lanthanide-protein interactions, Genetically encoded sensors to study lanthanide biology, Spectrophotometric methods to determine the stability constants of lanthanide-macromolecule complexes, Lanthanide-based probes for amino acid modifications, In vitro selection and application of lanthanide-dependent DNAzymes, LRET biosensors for imaging protein interactions in living cells, Synthetic Modeling of the Structure and Function of the Lanthanide-Dependent, MDH Cofactor, EPR spectroscopy of lanthanides, Macromolecular crystallography for f-element complex characterization, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series

Download or read book Carbohydrate Dehydrogenases Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 47 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrate Dehydrogenases—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Carbohydrate Dehydrogenases in a concise format. The editors have built Carbohydrate Dehydrogenases—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Carbohydrate Dehydrogenases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Carbohydrate Dehydrogenases—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Carbonyl Reductases and Pluripotent Hydroxysteroid Dehydrogenases of the Short Chain Dehydrogenase Reductase Superfamily written by Frank Hoffmann and published by diplom.de. This book was released on 2009-08-13 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inhaltsangabe:Introduction: Metabolic reduction is the counterpart to oxidative pathways and plays an important role in the phase-I metabolism of carbonyl group bearing substances. Carbonyl reduction means the formation of a hydroxy group from a reactive aldehyde or ketone moiety and is generally regarded as an inactivation or detoxification step since the resulting alcohol is easier to conjugate and to eliminate. Not only are these carbonyl-containing compounds widespread in the environment and enter the body as xenobiotics and environmental pollutants, but they can also be generated endogenously through normal catabolic oxidation and deamination reactions. Many endogenous compounds such as biogenic amines, steroids, prostaglandins and other hormones are metabolized through carbonyl intermediates. In addition, lipid peroxidation within the cell results in the production of reactive carbonyls such as acrolein, 4-hydroxynonenal, 4-oxononenal and malon-dialdehyde, while oxidative damage to DNA generates base propenals. Dietary sources of carbonyl-containing compounds are diverse and include aldehydes found in fruits as well as the breakdown product of ethanol, acetaldehyde. Pharmacologic drugs represent further sources of exposure to carbonyl-containing compounds. From the pharmacologist s point of view, carbonyl reduction has been shown to be of significance in various inactivation processes of drugs bearing a carbonyl group. On the other hand, the carbinols formed may retain therapeutic potency, thus prolonging the pharmacodynamic effect of the parent drug, or, in some instances, a compound gains activity through carbonyl reduction. From the toxicologist s point of view, carbonyl reduction plays an important role in the toxification of drugs such as daunorubicin and doxorubicin (cf. chapter 4), whereas numerous reports corroborate the concept of carbonyl-reducing enzymes being involved in detoxification processes of endogenous and xenobiotic reactive carbonyl compounds. Compared with the oxidative cytochrome P450 (CYP) system, carbonyl-reducing enzymes had, for a long time, received considerably less attention. However, the advancement of carbonyl reductase molecular biology has allowed the identification and characterization of several carbonyl-reducing enzymes, including pluripotent hydroxysteroid dehydrogenases that are involved in xenobiotic carbonyl compound metabolism, in addition to catalyzing the oxidoreduction of their physiologic [...]

Download or read book Enzymology and Molecular Biology of Carbonyl Metabolism 7 written by Henry Weiner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prior to the start of the eighth meeting, I had the good sense to ask Professor Rosa Angela Canuto of Turin, Italy if she would help me organize the ninth meeting. She quickly suggested that both she and Dr. Guiliana Muzio, also of Turin, help plan the meet ing. Each of our previous eight meetings was a unique experience for the participants. The science was always outstanding and the presentations and discussions were excellent. By moving each meeting to a different part of the world we were able to experience exciting foods and cultural aspects of the world in addition to the science. The ninth meeting was no exception. We met from June 18 to 22 in the small mountain city of Varallo, Italy, the birth place of Dr. Canuto. Holding the scientific sessions in a several-hundred-year-old converted mansion and having an afternoon trip to either Lago Maggiore or Monte Rosa made some aspects of this meeting extremely memorable. An additional unique aspect of the social portion of the meeting was our ability to invite the townspeople to share with us a concert performed in an old church. Though the social and cultural aspects of the meeting were outstanding, the pur pose of the meeting was to exchange scientific information about the status of the three enzyme systems.

Download or read book Acyl CoA Dehydrogenases Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acyl-CoA Dehydrogenases—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Acyl-CoA Dehydrogenases in a compact format. The editors have built Acyl-CoA Dehydrogenases—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Acyl-CoA Dehydrogenases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Acyl-CoA Dehydrogenases—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Complex Flavoproteins Dehydrogenases and Physical Methods written by and published by Walter de Gruyter. This book was released on 2013-08-01 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: The dynamic field of flavin and flavoprotein biochemistry has seen rapid advancement in recent years. This comprehensive two volume set provides an overview of all aspects of contemporary research in this important class of enzymes. Topics treated include flavoproteins involved in energy generation, signal transduction and electron transfer (including respiration); oxygen activation by flavoproteins; the biology and biochemistry of complex flavoproteins; flavin and flavoprotein photochemistry/photophysics as well as biotechnological applications of flavoproteins. Recent developments in this field include new structures (including those of large membrane-integral electron transfer complexes containing FMN or FAD), elucidation of the role of flavoproteins in cell signalling pathways (including both phototaxis and the circadian cycle) and important new insights into the reaction mechanisms of flavin-containing enzymes. This volume focusing on complex flavoproteins and physical methods is an essential reference for all researchers in biochemistry, chemistry, photochemistry and photophysics working on flavoenzymes.

Download or read book Enzymology and Molecular Biology of Carbonyl Metabolism 4 written by Henry Weiner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Sixth International Workshop on the Enzymology and Molecular Biology of Carbonyl Metabolism was held outside of Dublin, Ireland at the end of June, 1992. Prof. Keith Tipton, Chairman of the Biochemistry Department at Trinity College, kindly agreed to host the meeting. On behalf of all of us who attended I wish to extend our sincere thanks to the whole Tipton family for making us feel so welcome in Ireland. It has been a decade since the frrst workshop was held in Bern, Switzerland. The scope of the meetings reflected somewhat the changes that have occurred in biochemistry during the past decade. At the first meeting primarily enzymes and their properties were discussed. At this last meeting many of the talks centered on gene regulation as well as more traditional aspects of enzymology and metabolism. During the past decade site directed mutagenesis to probe for the active site of an enzyme has become part of traditional enzymology; this was virtually unheard of at our frrst meeting. Many of the presenters now used this tool to study some aspect of structure and function of one of the three carbonyl metabolizing enzymes.

Download or read book Carbohydrate Dehydrogenases Advances in Research and Application 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrate Dehydrogenases—Advances in Research and Application: 2013 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about ZZZAdditional Research in a compact format. The editors have built Carbohydrate Dehydrogenases—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Carbohydrate Dehydrogenases—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Enzymology and Molecular Biology of Carbonyl Metabolism 5 written by Henry Weiner and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the inception of these meetings in 1982, they have always been a satellite of the International Society for Biomedical Research on Alcoholism meeting. At our 1992 meeting in Dublin we learned that the next ISBRA meeting would be held in Brisbane, of all our previous meetings, I was very concerned Australia. As the scientific organizer about holding a meeting in the Southern Hemisphere for fear that many of our potential participants would not travel that far. I am pleased to say that I was proven to be incorrect. Nearly 90 scientists from a dozen countries participated at our seventh conference. At this meeting, like at all our previous ones, much new information about the three enzyme systems was presented. Of equal importance was, like at all our previous meetings, the extreme openness of the participants to discuss ideas, future directions and unpublished data. On behalf of all the participants I wish to express our sincere thanks to our Massey University colleagues for the excellent organization of this Palmerston North, New Zealand meeting. These included Kathryn Kitson, Michael Hardman, Paul Buckley, Trevor Kitson and Len Blackwell. At this meeting a few new innovations were introduced. Though posters are common at many meetings, bush walks and visits to nature preserves to see kiwi birds Our hosts were able to secure support from the International Union of Biochemistry are not.

Download or read book Alpha Keto Acid Dehydrogenase Complexes written by M.S. Patel and published by Nelson Thornes. This book was released on 1996-02-29 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: These systems have medical importance in areas ranging from defects in regulation (linked to diabetes, heart disease, obesity, nutrition defects), to inherited diseases (inborn errors, maple syrup urine disease) to acquired immune diseases (primary biliary cirrhosis).

Download or read book Knobil and Neill s Physiology of Reproduction written by Ernst Knobil and published by Gulf Professional Publishing. This book was released on 2006 with total page 1780 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 3rd edition, the first new one in ten years, includes coverage of molecular levels of detail arising from the last decade's explosion of information at this level of organismic organization. There are 5 new Associate Editors and about 2/3 of the chapters have new authors. Chapters prepared by return authors are extensively revised. Several new chapters have been added on the topic of pregnancy, reflecting the vigorous investigation of this topic during the last decade.The information covered includes both human and experimental animals; basic principels are sought, and information at the organismic and molecular levels are presented. *The leading comprehensive work on the physiology of reproduction*Edited and authored by the world's leading scientists in the field*Is a synthesis of the molecular, cellular, and organismic levels of organization*Bibliogrpahics of chapters are extensive and cover all the relevant literature