Download or read book Considerations in Conducting Bioassays written by D. R. Rosenberger and published by . This book was released on 1978 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Considerations in Conducting Bioassays written by D. R. Rosenberger and published by . This book was released on 1978 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Issues in Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 1993-02-01 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scientific basis, inference assumptions, regulatory uses, and research needs in risk assessment are considered in this two-part volume. The first part, Use of Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity, focuses on whether the maximum tolerated dose should continue to be used in carcinogenesis bioassays. The committee considers several options for modifying current bioassay procedures. The second part, Two-Stage Models of Carcinogenesis, stems from efforts to identify improved means of cancer risk assessment that have resulted in the development of a mathematical dose-response model based on a paradigm for the biologic phenomena thought to be associated with carcinogenesis.
Download or read book Bioassays with Arthropods written by Jacqueline L. Robertson and published by CRC Press. This book was released on 2017-06-26 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Imagine a statistics book for bioassays written by a statistician. Next, imagine a statistics book for bioassays written for a layman. Bioassays with Arthropods, Third Edition offers the best of both worlds by translating the terse, precise language of the statistician into language used by the laboratory scientist. The book explains the statistical basis and analysis for each kind of quantal response bioassay in just the right amount of detail. The first two editions were a great reference for designing, conducting, and interpreting bioassays: this completely revised and updated third edition will also train the laboratory scientist to be an expert in estimation of dose response curves. New in the Third Edition: Introduces four new Windows and Apple-based computer programs (PoloJR, OptiDose, PoloMixture and PoloMulti) for the analyses of binary and multiple response analyses, respectively Replaces out-of-date GLIM examples with R program samples Includes a new chapter, Population Toxicology, and takes a systems approach to bioassays Expands the coverage of invasive species and quarantine statistics Building on the foundation set by the much-cited first two editions, the authors clearly delineate applications and ideas that are exceptionally challenging for those not already familiar with their use. They lead you through the methods with such ease and organization, that you suddenly find yourself readily able to apply concepts that you never thought you would understand. To order the PoloSuite computer software described in Bioassays with Arthropods, Third Edition, use the order form found at www.leora-software.com or contact the LeOra Software Company at [email protected].
Download or read book Pesticide Bioassays W Arthropods written by Jacqueline L. Robertson and published by Springer. This book was released on 1992 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pesticide Bioassays with Arthropods is written specifically to explain the statistical bases and analyses of quantal-response bioassays in entertaining yet succinct terms that scientists can understand.
Download or read book Bioassay Techniques for Drug Development written by Atta-ur-Rahman and published by CRC Press. This book was released on 2001-10-04 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of an activity-directed isolation process is to isolate bioactive compounds which may provide structural leads of therapeutic importance. Whereas the traditional process of drug development is long and expensive, simple and rapid bioassays can serve as the starting point for drug discovery. This book presents a range of "bench top" bioassa
Download or read book Bioassays written by Donat Hader and published by Elsevier. This book was released on 2017-10-27 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioassays: Advanced Methods and Applications provides a thorough understanding of the applications of bioassays in monitoring toxicity in aquatic ecosystems. It reviews the newest tests and applications in discovering compounds and toxins in the environment, covering all suitable organisms, from bacteria, to microorganisms, to higher plants, including invertebrates and vertebrates. By learning about newer tests, water pollution control testing can be less time and labor consuming, and less expensive. This book will be helpful for anyone working in aquatic environments or those who need an introduction to ecotoxicology or bioassays, from investigators, to technicians and students. Features chapters written by internationally renowned researchers in the field, all actively involved in the development and application of bioassays Gives the reader an understanding of the advantages and deficiencies of available tests Addresses the problem of understanding the impact of toxins in an aquatic environment and how to assess them
Download or read book Selected Water Resources Abstracts written by and published by . This book was released on 1979 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Responsible Research with Biological Select Agents and Toxins written by National Research Council and published by National Academies Press. This book was released on 2010-02-12 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: The effort to understand and combat infectious diseases has, during the centuries, produced many key advances in science and medicine-including the development of vaccines, drugs, and other treatments. A subset of this research is conducted with agents that, like anthrax, not only pose a severe threat to the health of humans, plants, and animals but can also be used for ill-intended purposes. Such agents have been listed by the government as biological select agents and toxins. The 2001 anthrax letter attacks prompted the creation of new regulations aimed at increasing security for research with dangerous pathogens. The outcome of the anthrax letter investigation has raised concern about whether these measures are adequate. Responsible Research with Biological Select Agents and Toxins evaluates both the physical security of select agent laboratories and personnel reliability measures designed to ensure the trustworthiness of those with access to biological select agents and toxins. The book offers a set of guiding principles and recommended changes to minimize security risk and facilitate the productivity of research. The book recommends fostering a culture of trust and responsibility in the laboratory, engaging the community in oversight of the Select Agent Program, and enhancing the operation of the Select Agent Program.
Download or read book Manual for monitoring insecticide resistance in mosquito vectors and selecting appropriate interventions written by World Health Organization and published by World Health Organization. This book was released on 2022-06-22 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vector-borne diseases are major causes of sickness, disability and death worldwide. These diseases are caused by parasites, bacteria or viruses transmitted by various vectors, including mosquitoes, sandflies, fleas, ticks, lice and others. Insecticides form an essential part of vector control, the most widely used and effective strategy to reduce the burden of these diseases. Knowledge of vector resistance to insecticides is therefore crucial for the selection of effective vector control interventions. This document provides guidance on how to assess insecticide resistance in mosquito vectors and is aimed at field entomologists and biologists within ministries of health or partner institutions. It is also directed at programme managers and others in charge of designing and implementing vector control strategies who need to draw on resistance data to inform their decisions. Lastly, it can help researchers and the pesticide industry to assess, in a standardized way, vector resistance to compounds used in existing and new vector control products. It supersedes the “Test procedures for insecticide resistance monitoring in malaria vector mosquitoes, 2nd ed.” published in 2016.
Download or read book Field Trials of Health Interventions written by Peter G. Smith and published by Oxford University Press, USA. This book was released on 2015 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: "IEA, International Epidemiological Association, Welcome Trust."
Download or read book Conducting Biosocial Surveys written by National Research Council and published by National Academies Press. This book was released on 2010-10-02 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have seen a growing tendency for social scientists to collect biological specimens such as blood, urine, and saliva as part of large-scale household surveys. By combining biological and social data, scientists are opening up new fields of inquiry and are able for the first time to address many new questions and connections. But including biospecimens in social surveys also adds a great deal of complexity and cost to the investigator's task. Along with the usual concerns about informed consent, privacy issues, and the best ways to collect, store, and share data, researchers now face a variety of issues that are much less familiar or that appear in a new light. In particular, collecting and storing human biological materials for use in social science research raises additional legal, ethical, and social issues, as well as practical issues related to the storage, retrieval, and sharing of data. For example, acquiring biological data and linking them to social science databases requires a more complex informed consent process, the development of a biorepository, the establishment of data sharing policies, and the creation of a process for deciding how the data are going to be shared and used for secondary analysis-all of which add cost to a survey and require additional time and attention from the investigators. These issues also are likely to be unfamiliar to social scientists who have not worked with biological specimens in the past. Adding to the attraction of collecting biospecimens but also to the complexity of sharing and protecting the data is the fact that this is an era of incredibly rapid gains in our understanding of complex biological and physiological phenomena. Thus the tradeoffs between the risks and opportunities of expanding access to research data are constantly changing. Conducting Biosocial Surveys offers findings and recommendations concerning the best approaches to the collection, storage, use, and sharing of biospecimens gathered in social science surveys and the digital representations of biological data derived therefrom. It is aimed at researchers interested in carrying out such surveys, their institutions, and their funding agencies.
Download or read book Making Cancer Policy written by Mark E. Rushefsky and published by SUNY Press. This book was released on 1986-01-01 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mark Rushefsky confronts head-on the controversies surrounding federal cancer policy, within the context, however, of a balanced view of the politics and science involved. From 1976 to 1984, federal agencies such as the Consumer Product Safety Commission, the Environmental Protection Agency, the Food and Drug Administration, the Occupational Safety and Health Administration issued guidelines regulating public exposure to chemical carcinogens. These policies have engendered controversy and undergone numerous changes. Some of these are based on new scientific developments, others on new political developments. Making Cancer Policy analyzes the guidelines issued by these agencies in terms of their scientific and political environment. It addresses the issues of uncertainty in the scientific foundation of cancer policy, scientific controversies, the mixing of science and politics, and the political uses of science. This book shows just how "political" science can be.
Download or read book Techniques in Pheromone Research written by Hans E. Hummel and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Insects as a group occupy a middle ground in the biosphere between bacteria and viruses at one extreme, amphibians and mammals at the other. The size and general nature of insects present special problems to the student of entomology. For example, many commercially available instruments are geared to measure in grams, while the forces commonly encountered in studying insects are in the milligram range. Therefore, techniques developed in the study of insects or in those fields concerned with the control of insect pests are often unique. Methods for measuring things are common to all sciences. Advances sometimes depend more on how something was done than on what was measured; indeed a given field often progresses from one technique to another as new methods are discovered, developed, and modified. Just as often, some of these techniques find their way into the classroom when the problems involved have been suffi ciently ironed out to permit students to master the manipulations in a few lab oratory periods. Many specialized techniques are confined to one specific research laboratory. Although methods may be considered commonplace where they are used, in another context even the simplest procedures may save considerable time. It is the purpose of this series (1) to report new developments in methodology, (2) to reveal sources of groups who have dealt with and solved particular entomo logical problems, and (3) to describe experiments which may be applicable for use in biology laboratory co~rses.
Download or read book Heliothis Research Methods and Prospects written by Myron P. Zalucki and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heliothis ("Bull worm") species are one of the major pests of field crops worldwide, including sorghum, tomatoes, lettuce, and cotton. Pest problems have intensified over the years as the total area given to agricultural host plants has increased. This comprehensive text, written by experienced researchers, assembles biological and ecological research techniques and approaches to Heliothis management: from the fundamental question of defining genetic species to collecting, rearing, and sampling techniques for the construction of life tables; the measurement of predator impact and physiological development; the detection and measurement of behavior, migration, and diapause; population genetics and resistance. Approaches to modelling population dynamics are also explored. This book is intended for beginning research students as well as experienced workers. It will be a valuable reference for entomologists, population ecologists, and agronomists concerned with crop protection.
Download or read book A Comprehensive Guide to Toxicology in Preclinical Drug Development written by Ali S. Faqi and published by Academic Press. This book was released on 2012-11-02 with total page 904 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Comprehensive Guide to Toxicology in Preclinical Drug Development is designed for toxicologists who need a thorough understanding of the drug development process. This multi-contributed reference will provide a detailed picture of the complex and highly interrelated activities of preclinical toxicology in both small molecules and biologics --
Download or read book Small Clinical Trials written by Institute of Medicine and published by National Academies Press. This book was released on 2001-01-01 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.
