Download or read book Biochemistry and Pharmacology of Platelets written by Katherine Elliott and published by John Wiley & Sons. This book was released on 2009-09-16 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1378 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Download or read book The Platelets written by Gesina Longenecker and published by Elsevier. This book was released on 2012-12-02 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Platelets: Physiology and Pharmacology is a critical review of the basic platelet systems, methodologic critiques, and platelet involvement in major disease states. This book is composed of 20 chapters that specifically deal with the physiology and biochemistry of the platelet system, along with possibilities for, and consequences of, pharmacologic manipulation. The opening chapters examine the basic processes of platelet aggregation and adhesion. These topics are followed by discussions on the types and functions of platelet a-granule proteins; the aspects of adenine nucleotide levels, regulation, and storage; and receptors for catecholamines and consequences of their agonism. Other chapters are devoted to the metabolism of arachidonic acid, its manipulation, consequences, and metabolite receptors. The discussion then shifts to the second-messenger entities, specifically calmodulin, calcium, and cyclic adenosine monophosphate. A chapter presents the comparisons of man and commonly used laboratory animals concerning platelet behavior variability. Another chapter looks into the use and appropriateness of the use of platelets as models of neurons, with a special emphasis on serotonergic neurons. The remaining chapters contain critical reviews of platelet involvement in diabetes, hypertension and peripheral vascular disease, atherogenesis/atherosclerosis, and ischemic heart disease. These chapters also include specific techniques for platelet analysis, including lumiaggregometry, eicosanoid measurements, and serotonin uptake and release. This book is an invaluable source for pharmacologists, biochemists, researchers, and clinicians who are interested in platelet involvement in disease.
Download or read book Platelet Function Testing written by H. James Day and published by . This book was released on 1978 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Year in Hematology written by J. LoBue and published by Springer. This book was released on 2013-11-11 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Platelets written by Giovanni De Gaetano and published by Raven Press (ID). This book was released on 1978 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mechanisms of Stimulus Response Coupling in Platelets written by J. Westwick and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its inception the research area of platelet pharmacology has always been a vigorous one and it is a characteristic that new approaches to the understanding of platelet function are rapidly and thoroughly investigated. The intensity of this activity is attri butable, probably, to an appreciation by research workers in the field that a satisfactory therapeutic control of platelet function has yet to be realized. Also that if and when this problem of con trolling platelet function is achieved the benefits to clinical medicine will be immense since platelets are known to be involved in a multiplicity of events coupled within the haemostatic mechanisms and inflammatory responses. Aberrations in the behaviour of plate lets is part of the aetiology of atherosclerosis, myocardial and cerebral infarction and thrombosis. At this point in time, research in platelet function is in a particularly rapid state of flux. The recent findings of research workers active in the field and also workers investigating mechan isms of stimulus response coupling in other cells, have provided interesting insights into the generality of mechanisms involved in the function of responsive cells. One may itemize these developments as the area of cell receptor/ligand interaction, induction of cell ular response by protein phosphorylation and calcium flux. The mech anism of these latter events occurs through the activity of phospho lipase generating transient intermediates. These intermediates may act as ionophores or enzyme activators or may, in the case of eico sanoids, reinforce and make irreversible the cellular response.
Download or read book Prostaglandins Immunopharmacology written by B. B. Vargaftig and published by Elsevier. This book was released on 2013-10-22 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Pharmacology and Therapeutics, Volume 4: Prostaglandins-Immunopharmacology contains the proceedings of the 7th International Congress of Pharmacology held in Paris, France, in 1978. The papers explore advances in the understanding of prostaglandins, their immunopharmacology, and their therapeutic applications. Topics covered range from the biochemistry of prostaglandins, thromboxanes, and prostacyclin to the pharmacology of blood platelets and pharmacological approaches to enhancement of immunity. This volume is comprised of 23 chapters and opens with a discussion on the discovery of prostaglandins and their possible biological functions, including platelet aggregation and adrenergic neurotransmission. The reader is then introduced to unstable metabolites of arachidonic acid in relation to thrombosis; pharmacological interference in biotransformation of arachidonic acid; participation of prostaglandins in inflammatory pain; and factors affecting the formation and actions of cyclic AMP in blood platelets. The following chapters explore the role of thymosin and the endocrine thymus in the maintenance of immune balance; effects of thymosin fraction 5 in cancer patients; and the immunoregulatory activities of non-toxic synthetic polyribonucleotides. This book will be of interest to practitioners in biosciences, pharmacology, physiology, and medicine.
Download or read book Platelets in Biology and Pathology written by J. L. Gordon and published by North-Holland. This book was released on 1976 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Thrombosis written by H. J. Day and published by Springer. This book was released on 2013-11-22 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biochemistry of Human Diseases written by George Feuer and published by CRC Press. This book was released on 2020-04-22 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1986: This book is to help medical, pharmacy, and advanced students in science to understand the growing importance of continuously advancing biochemical concepts in human disease.
Download or read book The Platelet Amine Storage Granule written by Kenneth M. Meyers and published by CRC Press. This book was released on 1992-03-17 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Platelet Amine Storage Granule presents a comprehensive examination of the dense granule of human platelets and the development of dense granule precursors in megakaryocytes. Fundamental aspects addressed in the book include a description of the amine-nucleotide storage complex, the process of granule secretion (with focus on inositol phosphate metabolism), modulation of secretion by epinephrine, and a description of platelet storage pool disease. The book's broad coverage of the topic makes it a valuable resource to hematologists, cell biologists, platelet biologists, medical and veterinary geneticists, neurobiologists, endocrinologists, physiologists, and pharmacologists.
Download or read book Immunopharmacology Reviews written by J.W. Hadden and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunopharmacology as a field of scientific endeavor had its origins more than thirty years ago in the application of antibody-based techniques to assays of hormones and drugs in tissues and body fluids. More recently, the field has been redefined to include a primary focus on the immune system as a target of xenobiotic action. Advances in the field of immunology have made it apparent that the immune system, like other organ systems, declines in its function as a result of aging, viral infections like AIDS, and other immunotoxic influences, giving rise to secondary immunodeficiency. Deficiencyof the immune system in turn leads to infections, autoimmune diseases, and an increased incidence of certain cancers. The notion of treating the failing immune system is relatively new; however, more than a decade of research on cancer and AIDS has created the burgeoning new clinical field of immunotherapy. Immunopharmacology then stands as the preclinical and clinical science of immune manipulation. As such, like its parent field of pharmacology, it includes within its scope basic studies of immune mechanisms as they relate to the pathogenesis of inflammation and immunologic disturbances. As with pharma cology, the perspective is always a therapeutic one. Studies of immune and inflammatory processes emphasize the use of pharmacologic probes and drugs to elucidate the underlying biochemical pharmacology.
Download or read book Platelets in Thrombotic and Non Thrombotic Disorders written by Paolo Gresele and published by Cambridge University Press. This book was released on 2002-05-30 with total page 1144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Platelets have become an important research target for clinicians and basic scientists in a range of medical disciplines. This book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. It will be an essential reference for biomedical scientists and clinicians in hematology, vascular medicine, cardiology, thrombosis and related disciplines.
Download or read book Platelets and Thrombosis written by D. C. B. Mills and published by . This book was released on 1977 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Purinergic Receptors written by G. Burnstock and published by Springer Science & Business Media. This book was released on 2013-03-07 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fifty-odd years have elapsed since the first observation of the response of visceral smooth muscle to an adenine nucleotide was reported by Drury and Szent Gyorgi (1929). It is now known that purinergic receptors mediating responses to adenosine and the adenine nucleotides (AMP, ADP and ATP) are present in all types of visceral smooth muscle. Adenine itself and other endogenous purine derivatives appear to have no direct effects, or only minimal effects, on most visceral smooth muscles. Airway smooth muscle is an exception in this regard, and responds to purine bases and non-adenine nucleosides and nucleotides. Knowledge of the distribution of purinergic receptor sites on the plasma membrane of visceral musculature has grown particularly rapidly since Burnstock and his colleagues (1970) proposed that ATP, or a related adenine derivative, is the inhibitory transmitter released from non cholinergic non-adrenergic nerves present in the gut. Much evidence has been presented favoring the view that ATP is the inhibitory transmitter, and evidence to the contrary has also been put forward. The hypothesis remains controversial primarily because specific blockers of the postsynaptic purinergic site, with which the hypothesis might be tested, have not been found. Nevertheless, the numerous studies designed to investigate the purinergic nerve hypothesis have generated much information concerning the nature of the purinergic receptors in visceral smooth muscle.
