Download or read book Chemistry of Collagen Diseases written by David H. Neustadt and published by . This book was released on 1963 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Chemistry and Therapy of Collagen Diseases written by David H. Neustadt and published by . This book was released on 1963 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Chemistry and Therapy of Collagen Diseases by David H Neustadt written by David H.. Neustadt and published by . This book was released on 1963 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Collagen Superfamily and Collagenopathies written by Florence Ruggiero and published by Springer Nature. This book was released on 2021-05-15 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims at providing insights into the collagen superfamily and the remarkable diversity of collagen function within the extracellular matrix. Additionally, the mechanisms underlying collagen-related diseases such as dystrophic epidermolysis bullosa, osteogenesis imperfecta, as well as collagen-related myopathies and neurological disorders are discussed. Collagens are the most abundant extracellular matrix proteins in organisms. Their primary function is to provide structural support and strength to cells and to maintain biomechanical integrity of tissues. However, collagens can no longer be considered just as structural proteins. They can act as extracellular modulators of signaling events and serve critical regulatory roles in various cell functions during embryonic development and adult homeostasis. Furthermore, collagens are associated with a broad spectrum of heritability-related diseases known as “collagenopathies” that affect a multitude of organs and tissues including sensorial organs. The book is a useful introduction to the field for junior scientists, interested in extracellular matrix research. It is also an interesting read for advanced scientists and clinicians working on collagens and collagenopathies, giving them a broader view of the field beyond their area of specialization.

Download or read book Collagen in Health and Disease written by Jaqueline B. Weiss and published by . This book was released on 1982 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biochemistry of Collagen written by Gopalasamudram Ramachandran and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Collagen is a fascinating protein not only because of its ubiquitous occurrence in multicellular animals, but also because of its unique chemi cal structure. As the predominant constituent in bone, cartilage, skin, tendon, and tooth, it is not surprising that collagen is of interest to anatomists, biochemists, biomedical engineers, cell biologists, dermatolo gists, dental surgeons, leather chemists, orthopedic surgeons, physiologists, physicians, zoologists, and a host of others. This book was planned to provide an up-to-date comprehensive survey of all aspects of biochemistry of collagen. The recent discovery of genetically distinct collagens with tissue specificity has opened a new era in collagen biochemistry, and Karl Piez discusses this in the opening chapter on primary structure. In the next chapter, Ramachandran and Rama krishnan deal with the molecular structure of collagen, placing special emphasis on the conformational aspects of its polypeptide chains. Follow ing the consideration of primary and secondary structure of collagen, the three-dimensional arrangement of collagen molecules in the fibrils is covered by Miller in Chapter 3. Collagen is generally in the insoluble state in the living organism due to the cross-linking of individual molecules, and Tanzer describes the various aspects of this cross-linkage in Chapter 4. The biosynthesis of collagen is discussed in depth by Prockop and his colleagues.

Download or read book Chemical Investigation of Metabolites in the Urine of Patients with Collagen Diseases written by Peter John Robinson and published by . This book was released on 1961 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Immunochemistry of the Extracellular Matrix written by and published by . This book was released on 1982 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Connective Tissue and Its Heritable Disorders written by Peter M. Royce and published by John Wiley & Sons. This book was released on 2003-04-14 with total page 1201 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition of Connective Tissue and Its Heritable Disorders: Molecular, Genetic, and Medical Aspects is the definitive reference text in its field, with over 40% more pages on the nature, diagnosis, and treatment of disease than its predecessor. Collecting new research on disorders detailed in the first edition as well as on those previously excluded, editors Peter Royce and Beat Steinmann provide the most up-to-date clinical and scientific information for medical specialists treating affected individuals. Features of this revised and updated volume include detailed reviews of the clinical diagnosis, mode of inheritance, risk of recurrence, and prenatal diagnosis of each inherited connective tissue disorder; a thorough description of the morphology of connective tissues; a completely updated and revised section on the biology of the extracellular matrix; and the addition of syndromes such as craniosyntosis, and disorders of sulfate metabolism.

Download or read book Molecular Dynamics Simulations of Collagen Model Peptides written by Iwen Fu and published by . This book was released on 2015 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the structure and dynamics of the collagen triple helix is critical to un- derstanding the effect of mutations that arise in connective tissue and to understanding its interactions with receptors. Defects in triple helix domain of collagen have been associated with a number of human collagen diseases. Osteogenesis Imperfecta (OI) characterized by brittle bones affects roughly one in 10,000 individuals and results from mutations in type I collagen. The severity of the disease varies widely, ranging from mild to lethal cases. The molecular basis of the disease is still not understood. Here we integrate computational ap- proaches and NMR experiments to provide insight into the effects of variations in amino acid sequence on the conformation and dynamics of the collagen triple helix using colla- gen model peptides (CMPs), and to provide a molecular interpretation of several types of NMR experiments. Theoretical calculations of quantum mechanical NMR chemical shifts on the MD selected snapshots represent the first example of a reasonable fit of experimental data and highlight the sensitivity of the NH chemical shift to the complex dynamics of the H-bonds. The degree of inter-chain hydrogen bonding and the dynamics with different G-X-Y triplets are considered important for collagen recognition and binding sites containing disease-related mutation. A analysis of dynamics of triple helix have been studied using 15N relaxation measurements and model-free approach. This work is one of the first detailed MD studies of NMR relaxation data for proteins with high shape anisotropy. We interpret 15N relaxation measurements arising from the a variety of types of motions in the triple helical peptides. Both molecular dynamics simulations and analyses of NMR data have pointed to significant amounts of bending and twisting motions existing in the triple helical peptide, and we compare collagen-like peptides to other deformable rod-like molecules such as DNA duplexes. A Weakly Bending Rod (WBR) model is introduced to mimic the elastic properties of these flexible rod-like CMPs and provide insight into the interpretation of the relaxation data and order parameter profiles.

Download or read book The Connective Tissue written by Bernard Meyer Wagner and published by . This book was released on 1967 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecular Parameters Indicating Adaptation to Mechanical Stress in Fibrous Connective Tissue written by Stefan Milz and published by Springer Science & Business Media. This book was released on 2005-06-08 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: The connective and supportive tissues constitute a considerable amount of the biomass in human and animal organisms. The aim of this book is to contribute to the understanding of the mutual relationship between the mechanical situation of tendons and ligaments and their inner structure.

Download or read book Collagen written by Peter Fratzl and published by Springer Science & Business Media. This book was released on 2008-05-10 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Not only does this book provide a comprehensive review of current research advances in collagen structure and mechanics, it also explores this biological macromolecule’s many applications in biomaterials and tissue engineering. Readers gain an understanding of the structure and mechanical behavior of type I collagen and collagen-based tissues in vertebrates across all length scales, from the molecular (nano) to the organ (macro) level.

Download or read book The Chemistry and Reactivity of Collagen written by Karl Helmer Gustavson and published by . This book was released on 1966 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cell Biology of Extracellular Matrix written by E.D. Hay and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the ten-year interval since the first edition of this volume went to press, our knowledge of extracellular matrix (ECM) function and structure has enor mously increased. Extracellular matrix and cell-matrix interaction are now routine topics in the meetings and annual reviews sponsored by cell biology societies. Research in molecular biology has so advanced the number of known matrix molecules and the topic of gene structure and regulation that we won dered how best to incorporate the new material. For example, we deliberated over the inclusion of chapters on molecular genetics. We decided that with judicious editing we could present the recent findings in molecular biology within the same cell biology framework that was used for the first edition, using three broad headings: what is extracellular matrix, how is it made, and what does it do for cells? Maintaining control over the review of literature on the subject of ECM was not always an easy task, but we felt it was essential to production of a highly readable volume, one compact enough to serve the the student as an introduction and the investigator as a quick update on graduate the important recent discoveries. The first edition of this volume enjoyed con hope the reader finds this edition equally useful. siderable success; we D. Hay Elizabeth vii Contents Introductory Remarks 1 Elizabeth D. Hay PART I. WHAT IS EXTRACELLULAR MATRIX? Chapter 1 Collagen T. F. Linsenmayer 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2. The Collagen Molecule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2. 1. Triple-Helical Domain(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Download or read book Biochemistry of Collagens Laminins and Elastin written by Morten Karsdal and published by Academic Press. This book was released on 2016-07-29 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies. This volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologies, and describes selected modifications of proteins that result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine functions. Additionally, it highlights how this knowledge can be exploited to modulate fibrotic disease. Provides a comprehensive introduction to collagen and structural proteins Provides insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation Includes a chapter dedicated to the biomarkers of structural proteins Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states