Download or read book Make Life Visible written by Yoshiaki Toyama and published by Springer Nature. This book was released on 2019-10-02 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completelyimpossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology inthe broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. Th e second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. Th e book contains the proceedings of the 12th Uehara International Symposium 2017, “Make Life Visible” sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license.

Download or read book Voltage Gated Sodium Channels written by Peter C. Ruben and published by Springer Science & Business Media. This book was released on 2014-04-15 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.

Download or read book Molecular Genetics of Cardiac Electrophysiology written by C. Berul and published by Springer Science & Business Media. This book was released on 2000-04-30 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: The molecular basis for atrial fibrillation continues to be largely unknown, and therapy remains unchanged, aimed at controlling the heart rate and preventing systemic emboli with anticoagulation. Familial atrial fibrillation is more common than previously suspected. While atrial fibrillation is commonly associated with acquired heart disease, a significant proportion of individuals have early onset without other forms of heart disease, referred to as "lone" atrial fibrillators. It is also well recognized that atrial fibrillation occurs on a reversible or functional basis, without associated structural heart disease, such as with hyperthyroidism or of atrial fibrillation following surgery. It remains to be determined what percentage in these individuals is familial or due to a genetic predisposition. Mapping the locus for familial atrial fibrillation is the first step towards the identification of the gene. Isolation of the gene and subsequent identification of the responsible molecular genetic defect should provide a point of entry into the mechanism responsible for the familial form and the common acquired forms of the disease and eventually provide more effective therapy. We know that the ionic currents responsible for the action potential of the atrium is due to multiple channel proteins as is electrical conduction throughout the atria. Analogous to the ongoing genetic studies in patients with familial long QT syndrome, it is highly likely that defects in each of these channel proteins will be manifested in familial atrial fibrillation.

Download or read book History of Wyoming Second Edition written by T. A. Larson and published by U of Nebraska Press. This book was released on 1990-08-01 with total page 679 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The History of Wyoming" explains detailed information of territorial and state developments. This second edition also includes the post-World War II chapters containing discussion about the economy, society, culture and politics not included on the previous edition.

Download or read book Atlas of Scottish History to 1707 written by Peter G. B. McNeill and published by Scottish Medievalists and Department O Dinburgh. This book was released on 1996 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: An Atlas of Scottish History to 1707 provides a wealth of information about Scotland's history from the Roman's and Vikings onwards. With information on early Scottish place names, parish churches, acts passed during rule, Sheriffdoms, baronies, lordships, earldoms, overseas trade, linguistics, maps, diagrams, and more, the atlas pulls together information and resources to paint a picture of early Scotland. It contains not only maps, but also diagrams, plans, charts and tables covering the history of Scotland from the earliest times up to 1707, along with explanatory texts where these are necessary.

Download or read book Old Lochgelly written by Rhona Wilson and published by Stenlake Publishing. This book was released on 1998 with total page 48 pages. Available in PDF, EPUB and Kindle. Book excerpt: When the class became rowdy, my old maths teacher used to threaten us that 'Lochgelly will fly' and arguably the town's most famous son was the tawse, the story of which is included in this book. Amongst the streets featured are Bank Street, Auchterderran Road, Station Road, Motion Street and Main Road. The Minto Cottages at Brigghill are also illustrated, as is the village of Glencraig and several pits/mines, namely the Nelly Pit, the Jenny Gray Pit, Bowhill Colliery and the Brigghills Colliery.

Download or read book Geography Of Nowhere written by James Howard Kunstler and published by Simon and Schuster. This book was released on 1994-07-26 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Argues that much of what surrounds Americans is depressing, ugly, and unhealthy; and traces America's evolution from a land of village commons to a man-made landscape that ignores nature and human needs.

Download or read book On the Various Contrivances by Which British and Foreign Orchids are Fertilised by Insects written by Charles Darwin and published by London : J. Murray. This book was released on 1862 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This 1862 publication describes the flower structure of orchids and their pollination to illustrate aspects of Darwin's evolutionary theory.

Download or read book The Arrol Arroll and Arrell Families written by John Arrol and published by . This book was released on 1994 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chiefly record of the history of the Arrol family name and origins. Contains descendants of various families from Scotland. Descendants lived in Canada, Germany, England, New Zealand, Scotland, Australia, India, France, and various areas of the United States.

Download or read book The History of Blairgowrie written by John A. R. Macdonald and published by . This book was released on 1899 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Illio written by and published by . This book was released on 1911 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Ampleforth Journal written by and published by . This book was released on 1904 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book How We Lived Then written by Norman Longmate and published by Random House. This book was released on 2010-01-26 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although nearly 90% of the population of Great Britain remained civilians throughout the war, or for a large part of it, their story has so far largely gone untold. In contrast with the thousands of books on military operations, barely any have concerned themselves with the individual's experience. The problems of the ordinary family are barely ever mentioned - food rationing, clothes rationing, the black-out and air raids get little space, and everyday shortages almost none at all. This book is an attempt to redress the balance; to tell the civilian's story largely through their own recollections and in their own words.

Download or read book Chemokine Protocols written by Amanda E.I. Proudfoot and published by Humana. This book was released on 2010-11-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chemokines family of small proteins are involved in numerous b- logical processes ranging from hematopoiesis, angiogenesis, and basal l- kocyte trafficking to the extravasation and tissue infiltration of leukocytes in response to inflammatory agents, tissue damage, and bacterial or viral infection. Chemokines exert their effects through a family of seven G-protein coupled transmembrane receptors. Worldwide interest in the chemokine field surged dramatically early in 1996, with the finding that certain chemokine receptors were the elusive coreceptors, required along with CD4, for HIV infection. Today, though over 40 human chemokines have been described, the n- ber of chemokine receptors lags behind—only 17 human chemokine receptors have been identified so far. What has emerged over the years is that most chemokine receptors bind several distinct ligands, and indeed the majority of chemokines are able to bind to multiple chemokine receptors, explaining to some extent the apparent disparity in the numbers of chemokines and rec- tors. Yet in spite of the apparent redundancy in chemokine/chemokine rec- tor interactions, it is clear that in vivo, spatial, temporal, and indeed cell- and tissue-specific expression of both chemokines and their receptors are imp- tant factors in determining the precise nature of cellular infiltrates in phy- ological and pathological processes.

Download or read book Cossitt Family written by Pearl Steele Cossitt and published by . This book was released on 1925 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The People s War written by Angus Calder and published by Random House. This book was released on 2012-07-31 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second World War was, for Britain, a 'total war'; no section of society remained untouched by military conscription, air raids, the shipping crisis and the war economy. In this comprehensive and engrossing narrative Angus Calder presents not only the great events and leading figures but also the oddities and banalities of daily life on the Home Front, and in particular the parts played by ordinary people: air raid wardens and Home Guards, factory workers and farmers, housewives and pacifists. Above all this revisionist and important work reveals how, in those six years, the British people came closer to discarding their social conventions than at any time since Cromwell's republic. Winner of the John Llewellyn Rhys prize in 1970, The People’s War draws on oral testimony and a mass of neglected social documentation to question the popularised image of national unity in the fight for victory.

Download or read book National Fictions written by Geoff Hurd and published by . This book was released on 1984 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: No Marketing Blurb