Download or read book Cardiovascular Pharmacology of 5 Hydroxytryptamine written by P.R. Saxena and published by Springer. This book was released on 1990-02-28 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Serotonin and 5 HT2 Receptor Blockade in the Cardiovascular System written by Manfred Göthert and published by . This book was released on 1990 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Serotonin written by Fatima Shad Kaneez and published by BoD – Books on Demand. This book was released on 2017-07-26 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Serotonin - A Chemical Messenger Between All Types of Living Cells is a very interesting book on the most ancient neurotransmitter, hormone and trophic factor serotonin or 5-hydroxytryptamine (5-HT). This unique chemical is present in all living cells including plants and animals. This book will take us through a serene journey of the evolutionary history of serotonin and its role from man to mollusk. There are many interesting chapters incorporated in this book, including novel approaches for detecting minor metabolites of serotonin in human plasma, production and function of serotonin in cardiac cells, immuno-thrombotic effects of serotonin in platelets to the identification and localization of serotonin in the nervous system and gonad of bivalve mollusks.
Download or read book Serotonin and the Cardiovascular System written by Paul M. Vanhoutte and published by . This book was released on 1985 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drug induced Valvular Heart Disease written by Steven Droogmans and published by Nova Biomedical Books. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The notion that drugs can induce valvular heart disease (VHD) has occurred since the sixties and has received a lot of attention in recent years. Overstimulation of the serotonin 2B receptor (5-HT2B) leads to valvular fibroblast proliferation and thickening of the valvular leaflets with reduced mobility and regurgitation as a consequence. This new book focuses on different aspects of this distinct kind of valvulopathy including pathophysiology of drug-induced VHD, histopathological and echocardiographic characteristics, drugs associated with VHD, the influence of cumulative drug dose and risk factors and others.
Download or read book The Peripheral Actions of 5 hydroxytryptamine written by John R. Fozard and published by . This book was released on 1989 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to the advent of a number of new drugs with therapeutic promise, there has been an increased interest in the properties of 5-hydroxytryptamine (5-HT, serotonin). This book describes the major recent advances in this area, specifically with respect to the actions of 5-HT in the periphery. The scope is broad, covering 5-HT synthesis and catabolism, its receptors and their second messenger transduction systems, and the functional responses to 5-HT in peripheral tissues. Developments in the treatment of cardiovascular, gastrointestinal, and peripheral vascular disease are also discussed. Written by scientists actively working in the field, this book provides an extensive, authoritative, and up-to-date account of this important area of biomedical science.
Download or read book Serotonin written by Paul M. Vanhoutte and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 621 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume represents the proceedings ofthe invited lectures ofthe first International Symposium on "Serotonin from Cell Biology to Pharmacology and Therapeutics" which was held in Florence on March 29 -Aprill, 1989. This meeting, held under the co-sponsorship of the Serotonin Club and the Fondazione Giovanni Lorenzini, represents the first attempt to bring together scientists fascinated by the complexity of the action of 5-hydroxytryptamine throughout the body and in various species. Hence this volume provides the reader with the unique overview of the sources, effects, receptors, physiological actions and pathological role of Serotonin. As such it will be of interest not only to the person devoting herorhis research efforts to the study of 5-hydroxytryptamine but also to all scholars and even clinicians wanting to know how the powerful monoamine can modulate cellular functions. To accelerate the publication of these proceedings the Editors and the publishers have selected the camera ready format and have avoided a lengthy refereeing process. Hence the scientific content of, and the opinions expressed in the chapters are the sole responsibility of the authors. The Editors Milan and Houston The Editors want to thank Mrs. H. Liepman and her staff at Kluwer for the prompt and efficient handling of the manuscripts.
Download or read book 5 HT2B Receptors written by Luc Maroteaux and published by Springer Nature. This book was released on 2021-03-12 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed volume provides a comprehensive assessment of the roles played by 5-HT2B receptors in humans. These receptors have been shown to play an important role is the cardiac, intestinal, and central nervous systems as well as in bone marrow formation and growth. In this book, expert researchers present their findings on molecular and physiological/pathological aspects of 5-HT2B receptors. The molecular section includes a discussion of the genetics of 5-HT2B receptors and impulse control. The physiological section covers their role in many biological systems including the nervous system, the heart, and the lungs.
Download or read book The Serotonin Receptors written by Bryan L. Roth and published by Springer Science & Business Media. This book was released on 2008-08-17 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.
Download or read book Behavioral Pharmacology of 5 ht written by Paul Bevan and published by Psychology Press. This book was released on 2013-05-13 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews the current state of research within the behavioral pharmacology of 5-HT. The book opens exciting new approaches to the interdisciplinary study of behavior and pharmacology with special reference to ethology, endocrinology, neuroanatomy and comparative aspects of drug action, and notes new developments in therapeutic drugs of the future.
Download or read book Serotonin Receptors in Neurobiology written by Amitabha Chattopadhyay and published by CRC Press. This book was released on 2007-05-17 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of developments spanning a multitude of techniques makes this an exciting time for research in serotonin receptors. A comprehensive review of the subject from a multidisciplinary perspective, Serotonin Receptors in Neurobiology is among the first books to include information on serotonin receptor knockout studies. With contributions from l
Download or read book An Investigation of the Central Actions of 5 hydroxytryptamine on the Cardiovascular System written by D. Dalton and published by . This book was released on 1986 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Serotonin written by E. Mylecharane and published by Springer. This book was released on 2016-01-03 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: This series contains edited proceedings of the satellite symposia of the ninth IUPHAR congress held in August 1984. This volume examines the properties of serotonin and its actions.
Download or read book Neurobiology of Body Fluid Homeostasis written by Laurival Antonio De Luca Jr. and published by CRC Press. This book was released on 2013-10-01 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: A timely symposium entitled Body-Fluid Homeostasis: Transduction and Integration was held at Araraquara, São Paulo, Brazil in 2011. This meeting was convened as an official satellite of a joint gathering of the International Society for Autonomic Neuroscience (ISAN) and the American Autonomic Society (AAS) held in Buzios, Rio de Janeiro. Broad international participation at this event generated stimulating discussion among the invited speakers, leading to the publication of Neurobiology of Body Fluid Homeostasis: Transduction and Integration. Drawn from the proceedings and filled with rich examples of integrative neurobiology and regulatory physiology, this volume: Provides updated research using human and animal models for the control of bodily fluids, thirst, and salt appetite Explores neural and endocrine control of body fluid balance, arterial pressure, thermoregulation, and ingestive behavior Discusses recent developments in molecular genetics, cell biology, and behavioral plasticity Reviews key aspects of brain serotonin and steroid and peptide control of fluid consumption and arterial pressure The book highlights research conducted by leading scientists on signal transduction and sensory afferent mechanisms, molecular genetics, perinatal and adult long-term influences on regulation, central neural integrative circuitry, and autonomic/neuroendocrine effector systems. The findings discussed by the learned contributors are relevant for a basic understanding of disorders such as heat injury, hypertension, and excess salt intake. A unique reference on the neurobiology of body fluid homeostasis, this volume is certain to fuel additional research and stimulate further debate on the topic.
Download or read book Pharmacology of 5 HT6 Receptors written by Franco Borsini and published by Academic Press. This book was released on 2011 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation The serotonin 5-HT6 receptor represents a novel pharmacological target whose impact on physiopathology of CNS functions remains undetermined. Some receptor antagonists have been synthesized and they show a modulatory role in learning and memory processes and food intake.
Download or read book Pharmacology of 5 HT6 receptors Part II written by and published by Academic Press. This book was released on 2011-04-05 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: The serotonin 5-HT6 receptor represents a novel pharmacological target whose impact on physiopathology of CNS functions remains undetermined. Some receptor antagonists have been synthesized, and they show a modulatory role in learning and memory processes and food intake. The pharmacology of 5-HT6 receptor agonists is still under evaluation. However, both 5-HT6 antagonists and agonists seem to exert potential antidepressant activity. Recently, a second messenger system has been discovered. 5-HT6 receptor function is becoming more and more intriguing. Thus, the aim of the present book is to try to clarify the pharmacology of 5-HT6 receptors. Written by expert researchers Covers all published literature to date in the field of 5-HT6 receptors
Download or read book The Systemic and Regional Hemodynamic Changes Responsible for 5 ht7 Receptor Mediated Hypotension written by Bridget Mahon Seitz and published by . This book was released on 2019 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: Serotonin (5-hydroxytrypamine; 5-HT) is known to cause complex dose-dependent effects within the cardiovascular system by altering vascular resistance and arterial pressure resulting in pressor or depressor outcomes. Increased circulating levels of 5-HT has been reported in chronic cardiovascular diseases. Therefore, it is important to understand the mechanisms by which 5-HT regulates cardiovascular system function under chronic conditions. Previous work in our laboratory found low doses of infused 5-HT causes a sustain fall in arterial pressure. The focus of my work was to understand the hemodynamic mechanisms that cause 5-HT-induced hypotension. A significant finding from my work was determining the activated 5-HT7 receptor is essential in mediating the chronic fall in arterial pressure with low doses of 5-HT. Rats lacking a functional 5-HT7 receptor (pharmacologically or genetically removed) resulted in no 5-HT-induced observed depressor response. At the systemic hemodynamic level, a decrease in total peripheral resistance (TPR) during 5-HT infusion was the result of an elevation in skeletal muscle blood flow mediated by the 5-HT7 receptor, which was measured with Doppler flow probes. Additionally, administration of 5-HT infusion relaxed splanchnic veins, via 5-HT7 receptor stimulation, when measured using novel imaging methodology. An increase in vascular capacitance from splanchnic venodilation is expected to affect arterial pressure by decreasing stroke volume (SV) and cardiac output. However, both SV and CO were elevated from the start and throughout the duration of 5-HT infusion, indicating that changes in vascular capacitance were unlikely to contribute to chronic 5-HT-hypotension. Previous evidence suggested chronic (but not acute) 5-HT-induced hypotension was dependent on activation of nitric oxide synthase. However, the magnitude of the pressor response to a nitric oxide synthase inhibitor was not significantly different between the control or 5-HT infused groups, concluding 5-HT-induced nitric oxide synthase may not be contributing. Collectively, my work provides insight into the unique cardiovascular pharmacology of the 5-HT7 receptor, a member of the 5-HT receptor family whose chronic cardiovascular effects have been little studied up to now. Future work should include: characterizing the impact of 5-HT7 receptor activation by endogenous 5-HT on chronic cardiovascular diseases such as hypertension and heart failure; and evaluating whether it is possible to capitalize on the unique cardiovascular effects of 5-HT7 receptor stimulation for therapeutic purposes.
