Download or read book Cardiotonic Drugs written by Carl V. Leier and published by Marcel Dekker. This book was released on 1991 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis of Essential Drugs written by Ruben Vardanyan and published by Elsevier. This book was released on 2006-03-10 with total page 635 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Essential Drugs describes methods of synthesis, activity and implementation of diversity of all drug types and classes. With over 2300 references, mainly patent, for the methods of synthesis for over 700 drugs, along with the most widespread synonyms for these drugs, this book fills the gap that exists in the literature of drug synthesis. It provides the kind of information that will be of interest to those who work, or plan to begin work, in the areas of biologically active compounds and the synthesis of medicinal drugs. This book presents the synthesis of various groups of drugs in an order similar to that traditionally presented in a pharmacology curriculum. This was done with a very specific goal in mind – to harmonize the chemical aspects with the pharmacology curriculum in a manner useful to chemists. Practically every chapter begins with an accepted brief definition and description of a particular group of drugs, proposes their classification, and briefly explains the present model of their action. This is followed by a detailed discussion of methods for their synthesis. Of the thousands of drugs existing on the pharmaceutical market, the book mainly covers generic drugs that are included in the WHO's Essential List of Drugs. For practically all of the 700+ drugs described in the book, references (around 2350) to the methods of their synthesis are given along with the most widespread synonyms. Synthesis of Essential Drugs is an excellent handbook for chemists, biochemists, medicinal chemists, pharmacists, pharmacologists, scientists, professionals, students, university libraries, researchers, medical doctors and students, and professionals working in medicinal chemistry. * Provides a brief description of methods of synthesis, activity and implementation of all drug types* Includes synonyms* Includes over 2300 references
Download or read book Cardiotonic Drugs in Critical Settings written by 博之·田中 and published by . This book was released on 2001 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Digitalis and Other Cardiotonic Drugs written by Eli Rodin Movitt and published by . This book was released on 1949 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Digitalis and Other Cardiotonic Drugs Second Edition Revised and Enlarged written by Eli Rodin MOVITT and published by . This book was released on 1949 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardiac Glycosides written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pharmacokinetics of digitalis glycosides have been the subject of extensive re view (IISALO, 1977; ARONSON, 1980; PERRIER et ai., 1977). Research on glycoside kinetics has progressed at a rapid pace, requiring continuing reevaluation of the state of our understanding of this problem. The present article focuses on the effect of disease states (renal, gastrointestinal, thyroid, and cardiac) on the absorption, distribution, and clearance of a number of digitalis glycosides. Evidence is critically reviewed, and interpreted with respect to possible clinical implications. A. Renal Insufficiency I. Strophanthin Strophanthin disposition in renal failure has been evaluated in only two studies. KRAMER et ai. (1970) determined an elimination half-life of 14 h in normals as com pared to 60 h in anuric patients. Similar results were reported by BRASS and Pm LIPPS (1970) using tritiated strophanthin. They found a half-life value of 18 h in healthy individuals as compared to 68 h in anuric patients. The findings clearly in dicate that the elimination half-life of strophanthin is prolonged in renal failure.
Download or read book Digitalis and Other Cardiotonic Drugs written by Eli Rodin Movitt and published by . This book was released on 1946 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drug Discovery and Evaluation Pharmacological Assays written by Hans Vogel and published by Springer Science & Business Media. This book was released on 2007-10-30 with total page 2118 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of this successful reference offers both cutting-edge and classic pharmacological methods. Thoroughly revised and expanded to two volumes, it offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Every chapter has been updated, and numerous assays have been added. Each of the more than 1,000 assays comprises a detailed protocol outlining purpose and rationale, and a critical assessment of the results and their pharmacological and clinical relevance.
Download or read book Roach s Introductory Clinical Pharmacology written by Susan M. Ford and published by Lippincott Williams & Wilkins. This book was released on 2010 with total page 671 pages. Available in PDF, EPUB and Kindle. Book excerpt: This core text offers LPN/LVN students a clear, concise introduction to pharmacology, focusing on basic principles and the nurse's responsibility in drug administration. Organized by body system, the book examines pharmacologic properties and therapeutic applications of drug classes. Summary Drug Tables present generic and trade drug names, uses, adverse reactions, and usual dosage ranges. This edition has thoroughly updated drug information, a new "Pharmacology in Practice" case study feature, Nursing Alerts, Lifespan Alerts, Chronic Care Alerts, Diversity Alerts, and additional material on the nursing process. Including a FREE copy of Lippincott’s Photo Atlas of Medication Administration, a bound CD-ROM, a companion website includes an NCLEX® alternate item format tutorial, a Spanish-English audio glossary, monographs on 100 most commonly prescribed drugs, Listen and Learn, Concepts in Action animations, Watch and Learn video clips, and Dosage Calculation Quizzes. The full text is also available online. Online Tutoring powered by Smarthinking—Free online tutoring, powered by Smarthinking, gives students access to expert nursing and allied health science educators whose mission, like yours, is to achieve success. Students can access live tutoring support, critiques of written work, and other valuable tools.
Download or read book Synthetic Drugs written by Rajbir Singh and published by Mittal Publications. This book was released on 2002 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Code of Federal Regulations Title 21 Food and Drugs Pt 200 299 Revised as of April 1 2010 written by and published by Government Printing Office. This book was released on 2010-07-09 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Code of Federal Regulations is a codification of the general and permanent rules published in the Federal Register by the Executive departments and agencies of the United States Federal Government.
Download or read book Cardiac Glycosides written by G. Bodem and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: In spite of old vintage and 200 years of clinical use, digitalis remains an interesting therapeutic agent, to clinicians as well as to the pharmacologist, the biochemist, and colleagues in other diciplines of theoretic medicine. When a drug, however, has so many attractive facets, it seems proper and aJvis able for the success of a scientific meeting to focus on a number of well-defined aspects. This symposium was devoted to pharmacokinetics, drug metabolism, analytic procedures, blood level determinations, and their interpretation both for thera peutic and toxic situations. Considerable progress has been made during the last years in this area of digitalis research. The time was suitable for a critical reap praisal of facts and theories and for future planning. Our main intention was to relate analytic data and biochemical findings to clinical problems and questions. Despite the undoubtedly basic character of clinical pharmacology, it is neverthe less an applied science which should help to develop the rational basis of thera peutics. We are particularly grateful to the active participants who bore the burden of preparing presentations and - even worse - manuscripts. At the same time we are well-aware that many other active research groups would have been able to contribute in this way, but our program was limited because of the short time available. Their knowledge is included in the discussion parts of the meeting, so we hope a well-balanced description of the present state of affairs emerged in this volume.
Download or read book Drug Design written by E. J. Ariëns and published by Elsevier. This book was released on 2013-10-22 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Design, Volume X covers promising and current developments in drug design. The book discusses procedures as applied in the practice of drug design; the structural aspects of the structure-activity relationships of neuroleptics; and promising perspectives in the highly actual field of bioactive peptides. The text also describes the application of the dynamic systems analysis to the antihypertensive drug action; polymeric drug delivery systems; and the design of biocompatible polymers. The structure-activity relationships of insect repellents as a basis for the design of such agents, as well as the approaches to the multivariate data analysis in structure-activity relationships, which is an essential aspect of drug design, are also encompassed. Chemists, pharmacologists, bioengineers, and people involved in drug design and manufacture will find the book invaluable.
Download or read book Drugs written by G.L. David and published by Universities Press. This book was released on 2001-11 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drugs have played a central role in the progress of human civilizations. There are many important stages before a compound is used as a drug to treat a disease. The first stage is drug discovery; the second stage is the manufacture; and the third stage is the formulation of the drug in the form of tablets, capsules, injections and solutions Some drugs like penicillin have been discovered quite accidentally, while some plantderived drugs have been known to man since very early times;....
Download or read book Cardiac Glycosides 1785 1985 written by E. Erdmann and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: The bicentenary of William Withering's now famous medical report entitled "An Account of the Foxglove and Some of its Medical Uses" has given us the occasion to analyze the state of the art. Cardiac glycosides in 1985 are considered tobe the basis for medical treatment of myocardial failure, together with diuretics and vasodilators in the more severe cases. Nevertheless, the controversy as to their exact place in the treatment of heart failure with sinus rhythm has never ceased. Although cardiac glycosides are of unquestionable value in tachycardia caused by atrial fibrillation or atrial flutter, the chronic use of these drugs in sinus rhythm is not generally accepted. The development of tolerance has been reported. It is of interest that Withering hirnself wrote: "-let it (foxglove) be continued until it either acts on the kidneys, the stomach, the pulse, or the bowels; Iet it be stopped upon the first appearance of any of these effects, and I will maintain that the patient will not suffer from its exhibition, nor the practitioner be disappointed in any reasonable expectation. " In West Germany alone, more than three million patients (about 5% of the total population) are constantly taking cardiac glycosides. These drugs are the most prescribed medicaments in many countries. Thus, we considered it worthwhile and necessary to review in a critical way today's knowledge about the foxglove; to report new findings and to evaluate old Statements.
Download or read book Inotropic Stimulation and Myocardial Energetics written by H. Just and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inotropic stimulation of the myocardium, as well as vasodilation and diuresis as essential principles in the treatment of congestive heart failure have recently met with considerable criticism and reevaluation. It is generally agreed that unloading of the heart, either through vasodilation and/or diuresis, improves the working conditions of the dilated, failing heart. It reduces myocar dial oxygen consumption through reduction of chamber radius and, thereby, wall tension as the major determinants of myocardial oxygen consumption. Inotropic stimulation, quite in contrast, does not conserve oxygen. It rather consumes energy and that may be disadvantageous in situations of compromised oxygen supply and energy metabolism of the working myocardium. However, under conditions of suf ficient oxygen supply and metabolic support inotropic stimulation may bring about in creased pumping and subsequent improvement of myocardial failure. In recent years it could convincingly be demonstrated that vasodilation leads to symp tomatic improvement of congestive heart failure, improvement of exercise tolerance, and it prolongs life - especially in the case of ACE-inhibitors and the combination of hydra lazine with long-acting nitrates. Quite in contrast, equally beneficial effects could not be demonstrated for inotropic agents in congestive heart failure. Only for the cardiac glyco sides has it been shown that beneficial effects can be achieved, especially if atrial fibril lation with absolute arrhythmia is present. The influence of the cardiac glycosides on the latter represents an effect which is independent of the inotropic action.
Download or read book Heart Failure An Issue of Medical Clinics written by Prakash C. Deedwania and published by Elsevier Health Sciences. This book was released on 2012-10-31 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important issue of Medical Clinics provides essential updates in heart failure. The following topics are covered: epidemiology, pathophysiology, and general approach for heart failure; symptoms, signs, diagnostic studies, and prognostic significance of systolic versus diastolic heart failure; the appropriate use of biomarkers; oral versus intravenous diuretic therapy; guideline-based therapy including RAAS blockade, beta-blockade, and aldosterone antagonist, appropriate use of AICD and biventricular pacing; role of ventricular assist device; pathophysiological consideration and management approaches in acute decompensated heart failure; pathophysiology and current approaches to cardiorenal syndrome; heart failure with other comorbidities including diabetes, obesity, anemia, and cancer; heart failure and atrial fibrillation; and the role of disease management strategies in heart failure.
