Download or read book Biophysics of Dendritic Spine Morphogenesis written by Olena Marchenko and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Dendritic spines receive the majority of synaptic inputs in the mammalian central nervous system and constitute the foundation for a healthy nervous system. Cognitive and motor delays, and other symptoms of impaired neurodevelopment are associated with abnormal dendritic spine shape and densities. Understanding of spine stability and spine formation in neurodevelopmental conditions remains elusive. Spine formation is determined by the stability of its transient precursor: the dendritic filopodium. First, we aim to understand dendritic filopodium motility and stability mechanism that underlies its transition into a spine. We hypothesized that mechanical feedback among the actin retrograde flow, myosin activity, and substrate adhesion gives rise to various filopodial behaviors. We have formulated a minimal one-dimensional partial differential equation model that reproduces the range of observed motility. The model predicts the response of the system to each of these experimental perturbations, supporting the hypothesis that our actomyosin-driven mechanism controls dendritic filopodia dynamics and therefore identifies the main parameters in spine formation and stability. Spine development is deficient in Angelman (AS) and overabundant in Dup15q Syndromes as suggested by the corresponding animal models. In human cells, the phenotypic outcome and the timepoint in neurodevelopment at which the phenotype emerges, have not previously been studied. Therefore, we investigated dendritic spine morphology in Dup15q and AS human induced pluripotent stem cell (hiPSC)-derived neurons, characterizing filopodia motility, spine shape, maturation and neurite branching at different time points of development. Our findings suggest that the first phenotypic differences in Dup15q Syndrome arise during early neurodevelopment at week 7 with increased dendritic filopodia density and protrusion/retraction rates compared to control. We further show that the spine number and density are increased in Dup15q and decreased in AS. For future studies, syndrome-specific spine formation can be explored with a morphologically realistic 2-dimensional partial differential equation model of a dendritic spine solved on moving boundaries.
Download or read book Dendritic Spines from Biophysics to Neuropathology written by Menahem Segal and published by Frontiers Media SA. This book was released on 2021-03-26 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Dendritic Spines written by Rafael Yuste and published by MIT Press. This book was released on 2023-08-22 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: A leading neurobiologist explores the fundamental function of dendritic spines in neural circuits by analyzing different aspects of their biology, including structure, development, motility, and plasticity. Most neurons in the brain are covered by dendritic spines, small protrusions that arise from dendrites, covering them like leaves on a tree. But a hundred and twenty years after spines were first described by Ramón y Cajal, their function is still unclear. Dozens of different functions have been proposed, from Cajal's idea that they enhance neuronal interconnectivity to hypotheses that spines serve as plasticity machines, neuroprotective devices, or even digital logic elements. In Dendritic Spines, leading neurobiologist Rafael Yuste attempts to solve the “spine problem,” searching for the fundamental function of spines. He does this by examining many aspects of spine biology that have fascinated him over the years, including their structure, development, motility, plasticity, biophysical properties, and calcium compartmentalization. Yuste argues that we may never understand how the brain works without understanding the specific function of spines. In this book, he offers a synthesis of the information that has been gathered on spines (much of which comes from his own studies of the mammalian cortex), linking their function with the computational logic of the neuronal circuits that use them. He argues that once viewed from the circuit perspective, all the pieces of the spine puzzle fit together nicely into a single, overarching function. Yuste connects these two topics, integrating current knowledge of spines with that of key features of the circuits in which they operate. He concludes with a speculative chapter on the computational function of spines, searching for the ultimate logic of their existence in the brain and offering a proposal that is sure to stimulate discussions and drive future research.
Download or read book Dendritic Spines written by Louis R. Baylog and published by Nova Science Publishers. This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A dendritic spine (or spine) is a small membranous protrusion from a neuron's dendrite that typically receives input from a single synapse of an axon. Dendritic spines serve as a storage site for synaptic strength and help transmit electrical signals to the neuron's cell body. Most spines have a bulbous head (the spine head), and a thin neck that connects the head of the spine to the shaft of the dendrite. The dendrites of a single neuron can contain from thousands up to a few hundred thousand spines. In addition to spines providing an anatomical substrate for memory storage and synaptic transmission, they may also serve to increase the number of possible contacts between neurons. This book presents new information in this area of research.
Download or read book Dendritic spines from shape to function written by Nicolas Heck and published by Frontiers Media SA. This book was released on 2016-02-03 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: One fundamental requisite for a comprehensive view on brain function and cognition is the understanding of the neuronal network activity of the brain. Neurons are organized into complex networks, interconnected through synapses. The main sites for excitatory synapses in the brain are thin protrusions called dendritic spines that emerge from dendrites. Dendritic spines have a distinct morphology with a specific molecular organization. They are considered as subcellular compartments that constrain diffusion and influence signal processing by the neuron and, hence, spines are functional integrative units for which morphology and function are tightly coupled. The density of spines along the dendrite reflects the levels of connectivity within the neuronal network. Furthermore, the relevance of studying dendritic spines is emphasized by the observation that their morphology changes with synaptic plasticity and is altered in many psychiatric disorders. The present Research Topic deals with some of the most recent findings concerning dendritic spine structure and function, showing that, in order to understand how brain neuronal activity operates, these two factors should be regarded as being intrinsically linked.
Download or read book Molecular Mechanisms Regulating Dendritic Spine Morphology written by Lei Zhou and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In the central nervous system, chemical synapses are highly specialized junctions that are known to be critical for communication between neurons. The ability of synapses to change their physiological and structural properties, known as synaptic plasticity, is important for storing information in neural connections. Dendritic spines are small protrusions on dendrites where the majority of glutamatergic synapses form in the brain. In general, a dendritic spine has an enlarged head region that is connected to the dendritic shaft by a narrow neck. This geometry allows spines to function as individual biochemical compartments and control postsynaptic signaling events. Recent evidence indicates that structural remodeling of spines and the formation of new synaptic contacts may lead to long-term changes in synaptic function including long-term potentiation (LTP) and long-term depression (LTD). These forms of synaptic plasticity are believed to contribute to cognitive ...
Download or read book Encyclopedia of Behavioral Neuroscience written by and published by Elsevier. This book was released on 2010-06-03 with total page 1819 pages. Available in PDF, EPUB and Kindle. Book excerpt: Behavioral Neuroscientists study the behavior of animals and humans and the neurobiological and physiological processes that control it. Behavior is the ultimate function of the nervous system, and the study of it is very multidisciplinary. Disorders of behavior in humans touch millions of people’s lives significantly, and it is of paramount importance to understand pathological conditions such as addictions, anxiety, depression, schizophrenia, autism among others, in order to be able to develop new treatment possibilities. Encyclopedia of Behavioral Neuroscience is the first and only multi-volume reference to comprehensively cover the foundation knowledge in the field. This three volume work is edited by world renowned behavioral neuroscientists George F. Koob, The Scripps Research Institute, Michel Le Moal, Université Bordeaux, and Richard F. Thompson, University of Southern California and written by a premier selection of the leading scientists in their respective fields. Each section is edited by a specialist in the relevant area. The important research in all areas of Behavioral Neuroscience is covered in a total of 210 chapters on topics ranging from neuroethology and learning and memory, to behavioral disorders and psychiatric diseases. The only comprehensive Encyclopedia of Behavioral Neuroscience on the market Addresses all recent advances in the field Written and edited by an international group of leading researchers, truly representative of the behavioral neuroscience community Includes many entries on the advances in our knowledge of the neurobiological basis of complex behavioral, psychiatric, and neurological disorders Richly illustrated in full color Extensively cross referenced to serve as the go-to reference for students and researchers alike The online version features full searching, navigation, and linking functionality An essential resource for libraries serving neuroscientists, psychologists, neuropharmacologists, and psychiatrists
Download or read book Biology of the NMDA Receptor written by Antonius M. VanDongen and published by CRC Press. This book was released on 2008-10-29 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written
Download or read book Regulation of Dendritic Spine Morphogenesis and Synapse Formation by Copines written by Milos Galic and published by . This book was released on 2006 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Homeostasis of Dendritic Spines in Hippocampal CA1 Cells written by C. A. Mestrallet and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Synaptic connections in the brain respond throughout their lives to the activity of incoming neurones, adjusting their biological properties to increment activity-dependent changes but also avoid run-away excitation or complete loss of transmission. To ensure synapses remain functional when inputs change over time, compensatory mechanisms, coined homeostatic plasticity, take place either globally or locally. The correlation between synaptic strength and dendritic spine size has been clearly established, and thus imaging dendritic spines under various activity conditions has become accepted as a valid way of studying homeostatic changes of postsynaptic strength. Many neurological diseases demonstrate abnormalities of dendritic spines, directly linking their properties to the efficient functioning of the network. Understanding how dendritic spines are regulated under global changes of network activity is important to unveil clues about how to tackle those deficits in disease. Studying morphology of dendritic spines requires intensive and careful analysis, and a substantial part of this work has been dedicated to finding an appropriate way to analyse the data. Dendritic spines showed a remarkably stable density in CA1 pyramidal neurones during the second week in vitro, when treatments altering plasticity or even deafferentation failed to modify the autonomous development. However, deafferentation carried out a week later decreased the overall spine density and increased spine head size, specifically in the area that normally receives inputs from the transected axons. The strong activity of the Schaffer collateral axons in organotypic slices results in enlarged spines in the apical compared with basal dendrites. This difference between pathways was abolished by inhibition of CaMKII. Activity-dependent and homeostatic plasticities are working intricately to maintain the network efficacy. They operate at a local level in an age-dependent manner and are differentially modulated by the CaMKII or PKA pathways.
Download or read book Neuroscience in the 21st Century written by Donald W. Pfaff and published by Springer. This book was released on 2016-10-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer’s and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States’ Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century in its second edition serves as a comprehensive resource to students and researchers alike.
Download or read book Neuronal Cytoskeleton written by Hirokawa and published by CRC Press. This book was released on 1994-01-12 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the primary functions of microtubule-associated proteins (MAPs) such as MAP2 and tau in neuronal morphogenesis, as well as relationships between neuronal differentiation and the expression of neuronal intermediate filaments (nestin, alpha internexin, and neurofilament triplet proteins). It emphasizes the importance of several cytoskeletal proteins for neuronal differentiation and morphogenesis, organelle transport, and synaptic functions. The book considers the involvement of tau MAPs in the formation of paired helical filaments in Alzheimer's disease, and it examines the mechanisms of organelle transports and molecular motors such as kinesin, braindynein, and kinesin superfamily proteins. Cytoskeletal proteins involved in synaptic formation and transmitter release and new synaptic junctional-associated proteins are explored as well.
Download or read book Synaptic Tagging and Capture written by Sreedharan Sajikumar and published by Springer. This book was released on 2014-10-15 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Serves as a comprehensive introduction and overview of synaptic tagging and capture (STC) and covers the topic from molecular and cellular aspects to behavior. Circa 15 years ago the STC model was proposed to provide a conceptual basis for how short-term memories are transformed into long-term memories. Though the hypothesis remains unconfirmed due to technological limitations, the model is well consolidated and generally accepted in the field. Various researchers have investigated the cellular mechanisms for the formation of long-term memory using the STC model, but this is the first book-length treatments of STC. This volume features an introduction by Prof. Richard Morris and Prof. Cliff Abraham.
Download or read book Branching Morphogenesis written by Jamie Davies and published by Springer Science & Business Media. This book was released on 2007-03-20 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Branching morphogenesis, the creation of branched structures in the body, is a key feature of animal and plant development. This book brings together, for the first time, expert researchers working on a variety of branching systems to present a state-of-the-art view of the mechanisms that control branching morphogenesis. Systems considered range from single cells, to blood vessel and drainage duct systems to entire body plans, and approaches range from observation through experiment to detailed biophysical modelling. The result is an integrated overview of branching.
Download or read book The Computing Dendrite written by Hermann Cuntz and published by Springer Science & Business Media. This book was released on 2013-11-23 with total page 519 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuronal dendritic trees are complex structures that endow the cell with powerful computing capabilities and allow for high neural interconnectivity. Studying the function of dendritic structures has a long tradition in theoretical neuroscience, starting with the pioneering work by Wilfrid Rall in the 1950s. Recent advances in experimental techniques allow us to study dendrites with a new perspective and in greater detail. The goal of this volume is to provide a résumé of the state-of-the-art in experimental, computational, and mathematical investigations into the functions of dendrites in a variety of neural systems. The book first looks at morphological properties of dendrites and summarizes the approaches to measure dendrite morphology quantitatively and to actually generate synthetic dendrite morphologies in computer models. This morphological characterization ranges from the study of fractal principles to describe dendrite topologies, to the consequences of optimization principles for dendrite shape. Individual approaches are collected to study the aspects of dendrite shape that relate directly to underlying circuit constraints and computation. The second main theme focuses on how dendrites contribute to the computations that neurons perform. What role do dendritic morphology and the distributions of synapses and membrane properties over the dendritic tree have in determining the output of a neuron in response to its input? A wide range of studies is brought together, with topics ranging from general to system-specific phenomena—some having a strong experimental component, and others being fully theoretical. The studies come from many different neural systems and animal species ranging from invertebrates to mammals. With this broad focus, an overview is given of the diversity of mechanisms that dendrites can employ to shape neural computations.
Download or read book Neural Circuit Development and Function in the Healthy and Diseased Brain written by John Rubenstein and published by . This book was released on 2013 with total page 834 pages. Available in PDF, EPUB and Kindle. Book excerpt: The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 3 offers 40 high level articles devoted mainly to anatomical and functional development of neural circuits and neural systems, as well as those that address neurodevelopmental disorders in humans and experimental organisms. Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop Features leading experts in various subfields as Section Editors and article Authors All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship Volume 3 sections include coverage of: mechanisms that control the assembly of neural circuits in specific regions of the nervous system, multiple aspects of cognitive development, and disorders of the nervous system arising through defects in neural development
Download or read book Neurogenesis and Neural Plasticity written by Catherine Belzung and published by Springer Science & Business Media. This book was released on 2014-07-08 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume brings together authors working on a wide range of topics to provide an up to date account of the underlying mechanisms and functions of neurogenesis and synaptogenesis in the adult brain. With an increasing understanding of the role of neurogenesis and synaptogenesis it is possible to envisage improvements or novel treatments for a number of diseases and the possibility of harnessing these phenomena to reduce the impact of ageing and to provide mechanisms to repair the brain.
