Download or read book Biomolecular Forms and Functions written by Manju Bansal and published by World Scientific. This book was released on 2013 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is primarily a compilation of contributed articles representing the impact and application of Ramachandran's work on conformation analysis of biopolymers, as well as recent advances in macromolecular structural biology, involving diverse experimental and computational approaches. This volume is being published to coincide with a conference on "Biomolecular Forms and Functions: A celebration of 50 years of the Ramachandran Map" being held at the Indian Institute of Science, Bangalore, in January 2013.
Download or read book Biomolecular Forms and Functions written by Manju Bansal and published by World Scientific. This book was released on 2013 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the functions and properties of molecules in living systems requires a detailed knowledge of their three-dimensional structures and the conformational variability that allows them to adopt multiple functional forms. Interpreting biological systems in the language of three-dimensional structures is of fundamental importance and innumerable research groups around the world are working in this area. This book is a compilation of articles describing attempts at understanding the intricacies of biological systems through the structures of and interactions between their constituent molecules.
Download or read book Biomolecular Forms and Functions written by Manju Bansal and published by World Scientific. This book was released on 2012-12-13 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the functions and properties of molecules in living systems requires a detailed knowledge of their three-dimensional structures and the conformational variability that allows them to adopt multiple functional forms. Interpreting biological systems in the language of three-dimensional structures is of fundamental importance and innumerable research groups around the world are working in this area. This book is a compilation of articles describing attempts at understanding the intricacies of biological systems through the structures of and interactions between their constituent molecules. Contents:The Legacy of G N Ramachandran and the Development of Structural Biology in India (M Vijayan)The Open-Ended Intellectual Legacy of GNR (George Rose)The Ramachandran Plot and Protein Structure Validation (Roman A Laskowski, Nicholas Furnham and Janet M Thornton)Analysis of Dihedral Angle Variability in Related Protein Structures (Shekhar C Mande, Ashwani Kumar and Payel Ghosh)Multiprotein Assemblies: Modulating Cell Activity Through Targeting Protein-Protein Interfaces (Alicia P Higueruelo, Harry Jubb and Tom L Blundell)Computational Approaches for Understanding the Recognition Mechanism of Protein Complexes (M Michael Gromiha)Cold-Shock Domains — Versatile Molecular Modules for Single-Stranded RNA Binding and Remodeling (Florian Mayr and Udo Heinemann)Protein Disulfide Analysis and Design (Siddharth Patel, S Indu, C Ramakrishnan and Raghavan Varadarajan)Controlling Conformational Dynamics to Modulate Protein Function (Shahir S Rizk, Marcin Paduch and Anthony A Kossiakoff)Structural Bioinformatics Approaches for Deciphering Biosynthetic Code of Secondary Metabolites (Shradha Khater and Debasisa Mohanty)The Inherent Structure Landscape of Met–Enkephalin Determined by the MOLS Technique (N Balaji, L Ramya and N Gautham)and other papers Readership: Practicing researchers in academia and industry. Keywords:Three-Dimensional Structure;Protein Structures;Biopolymer Conformation;G N Ramachandran;Ramachandran Map Phi-Psi Plot;Nuclei Acid Structures;Macromolecular Interactions;Biomolecular Assemblies;Simulations of Biological Molecular StructuresKey Features:Authors are eminent scientists with well-cited research in structural and computational biologyThe book includes articles covering results obtained using the latest structural biology techniquesThe book covers important areas in the fields of protein folding, association, function and design
Download or read book Biomolecular Structure and Function written by Paul F. Agris and published by . This book was released on 1978 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomolecular Structure and Function ...
Download or read book Biomolecular Networks written by Luonan Chen and published by John Wiley & Sons. This book was released on 2009-06-29 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alternative techniques and tools for analyzing biomolecular networks With the recent rapid advances in molecular biology, high-throughput experimental methods have resulted in enormous amounts of data that can be used to study biomolecular networks in living organisms. With this development has come recognition of the fact that a complicated living organism cannot be fully understood by merely analyzing individual components. Rather, it is the interactions of components or biomolecular networks that are ultimately responsible for an organism's form and function. This book addresses the important need for a new set of computational tools to reveal essential biological mechanisms from a systems biology approach. Readers will get comprehensive coverage of analyzing biomolecular networks in cellular systems based on available experimental data with an emphasis on the aspects of network, system, integration, and engineering. Each topic is treated in depth with specific biological problems and novel computational methods: GENE NETWORKS—Transcriptional regulation; reconstruction of gene regulatory networks; and inference of transcriptional regulatory networks PROTEIN INTERACTION NETWORKS—Prediction of protein-protein interactions; topological structure of biomolecular networks; alignment of biomolecular networks; and network-based prediction of protein function METABOLIC NETWORKS AND SIGNALING NETWORKS—Analysis, reconstruction, and applications of metabolic networks; modeling and inference of signaling networks; and other topics and new trends In addition to theoretical results and methods, many computational software tools are referenced and available from the authors' Web sites. Biomolecular Networks is an indispensable reference for researchers and graduate students in bioinformatics, computational biology, systems biology, computer science, and applied mathematics.
Download or read book Concepts of Biology written by Samantha Fowler and published by . This book was released on 2018-01-07 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concepts of Biology is designed for the single-semester introduction to biology course for non-science majors, which for many students is their only college-level science course. As such, this course represents an important opportunity for students to develop the necessary knowledge, tools, and skills to make informed decisions as they continue with their lives. Rather than being mired down with facts and vocabulary, the typical non-science major student needs information presented in a way that is easy to read and understand. Even more importantly, the content should be meaningful. Students do much better when they understand why biology is relevant to their everyday lives. For these reasons, Concepts of Biology is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand.We also strive to show the interconnectedness of topics within this extremely broad discipline. In order to meet the needs of today's instructors and students, we maintain the overall organization and coverage found in most syllabi for this course. A strength of Concepts of Biology is that instructors can customize the book, adapting it to the approach that works best in their classroom. Concepts of Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand--and apply--key concepts.
Download or read book Molecular Simulations and Biomembranes written by Mark S. P. Sansom and published by Royal Society of Chemistry. This book was released on 2010 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: The need for information in the understanding of membrane systems has been caused by three things - an increase in computer power; methodological developments and the recent expansion in the number of researchers working on it worldwide. However, there has been no up-to-date book that covers the application of simulation methods to membrane systems directly and this book fills an important void in the market. It provides a much needed update on the current methods and applications as well as highlighting recent advances in the way computer simulation can be applied to the field of membranes and membrane proteins. The objectives are to show how simulation methods can provide an important contribution to the understanding of these systems. The scope of the book is such that it covers simulation of membranes and membrane proteins, but also covers the more recent methodological developments such as coarse-grained molecular dynamics and multiscale approaches in systems biology. Applications embrace a range of biological processes including ion channel and transport proteins. The book is wide ranging with broad coverage and a strong coupling to experimental results wherever possible, including colour illustrations to highlight particular aspects of molecular structure. With an internationally respected list of authors, its publication is timely and it will prove indispensable to a large scientific readership.
Download or read book Biomolecular Feedback Systems written by Domitilla Del Vecchio and published by Princeton University Press. This book was released on 2014-10-26 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an accessible introduction to the principles and tools for modeling, analyzing, and synthesizing biomolecular systems. It begins with modeling tools such as reaction-rate equations, reduced-order models, stochastic models, and specific models of important core processes. It then describes in detail the control and dynamical systems tools used to analyze these models. These include tools for analyzing stability of equilibria, limit cycles, robustness, and parameter uncertainty. Modeling and analysis techniques are then applied to design examples from both natural systems and synthetic biomolecular circuits. In addition, this comprehensive book addresses the problem of modular composition of synthetic circuits, the tools for analyzing the extent of modularity, and the design techniques for ensuring modular behavior. It also looks at design trade-offs, focusing on perturbations due to noise and competition for shared cellular resources. Featuring numerous exercises and illustrations throughout, Biomolecular Feedback Systems is the ideal textbook for advanced undergraduates and graduate students. For researchers, it can also serve as a self-contained reference on the feedback control techniques that can be applied to biomolecular systems. Provides a user-friendly introduction to essential concepts, tools, and applications Covers the most commonly used modeling methods Addresses the modular design problem for biomolecular systems Uses design examples from both natural systems and synthetic circuits Solutions manual (available only to professors at press.princeton.edu) An online illustration package is available to professors at press.princeton.edu
Download or read book Computational Modeling And Simulations Of Biomolecular Systems written by Benoit Roux and published by World Scientific. This book was released on 2021-08-23 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook originated from the course 'Simulation, Modeling, and Computations in Biophysics' that I have taught at the University of Chicago since 2011. The students typically came from a wide range of backgrounds, including biology, physics, chemistry, biochemistry, and mathematics, and the course was intentionally adapted for senior undergraduate students and graduate students. This is not a highly technical book dedicated to specialists. The objective is to provide a broad survey from the physical description of a complex molecular system at the most fundamental level, to the type of phenomenological models commonly used to represent the function of large biological macromolecular machines.The key conceptual elements serving as building blocks in the formulation of different levels of approximations are introduced along the way, aiming to clarify as much as possible how they are interrelated. The only assumption is a basic familiarity with simple mathematics (calculus and integrals, ordinary differential equations, matrix linear algebra, and Fourier-Laplace transforms).
Download or read book Computer Simulation of Biomolecular Systems written by W.F. van Gunsteren and published by Springer Science & Business Media. This book was released on 1997-11-30 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the third volume in this highly successful series. Since the first volume in 1989 and the second in 1993, many exciting developments have occurred in the development of simulation techniques and their application to key biological problems such as protein folding, protein structure prediction and structure-based design, and in how, by combining experimental and theoretical approaches, very large biological systems can be studied at the molecular level. This series attempts to capture that progress. Volume 3 includes contributions that highlight developments in methodology which enable longer and more realistic simulations (e.g. multiple time steps and variable reduction techniques), a study of force fields for proteins and new force field development, a novel approach to the description of molecular shape and the use of molecular shape descriptors, the study of condensed phase chemical reactions, the use of electrostatic techniques in the study of protonation, equilibria and flexible docking studies, structure refinement using experimental data (X-ray, NMR, neutron, infrared) and theoretical methods (solvation models, normal mode analysis, MD simulations, MC lattice dynamics, and knowledge-based potentials). There are several chapters that show progress in the development of methodologies for the study of folding processes, binding affinities, and the prediction of ligand-protein complexes. The chapters, contributed by experienced researchers, many of whom are leaders in their field of study, are organised to cover developments in: simulation methodology the treatment of electrostatics protein structure refinement the combined experimental and theoretical approaches to the study of very large biological systems applications and methodology involved in the study of protein folding applications and methodology associated with structure-based design.
Download or read book Biomolecular Films written by James F. Rusling and published by CRC Press. This book was released on 2003-02-26 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text examines films of biomolecules that can provide solid surfaces for catalyzing enzyme reactions, serve in biosensors and as biorecognition elements, mediate nanoparticle formation, and provide a basis for fundamental studies and applications in biomedicine and biomedical devices.
Download or read book Modeling Biomolecular Networks in Cells written by Luonan Chen and published by Springer Science & Business Media. This book was released on 2010-07-05 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modeling Biomolecular Networks in Cells shows how the interaction between the molecular components of basic living organisms can be modelled mathematically and the models used to create artificial biological entities within cells. Such forward engineering is a difficult task but the nonlinear dynamical methods espoused in this book simplify the biology so that it can be successfully understood and the synthesis of simple biological oscillators and rhythm-generators made feasible. Such simple units can then be co-ordinated using intercellular signal biomolecules. The formation of such man-made multicellular networks with a view to the production of biosensors, logic gates, new forms of integrated circuitry based on "gene-chips" and even biological computers is an important step in the design of faster and more flexible "electronics". The book also provides theoretical frameworks and tools with which to analyze the nonlinear dynamical phenomena which arise from the connection of building units in a biomolecular network.
Download or read book Dynamics Structure and Function of Biological Macromolecules written by Oleg Jardetzky and published by IOS Press. This book was released on 2001 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of articles looking at modern structural biology, summarizing the applications of physical methods - such as x-ray diffraction, high resolution nuclear magnetic resonance and molecular dynamics - to the study of protein structure and dynamics. There is a review of contemporary thoughts within the field, looking at the mechanisms of alloateric transitions and allosteric control, the transmission of information within protein structures and the role of dynamics in determining the specificity of protein - ligand interactions. There is also a look at future innovations.
Download or read book Probes and Tags to Study Biomolecular Function written by Lawrence W. Miller and published by John Wiley & Sons. This book was released on 2008-09-02 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: The only resource to systematically review current experimental methods, this handy reference enables researchers to select the best solution for their experimental problems. For each method covered, the book provides step-by-step protocols, illustrated by typical research applications. After an initial section on probing the lipid bilayer, the text moves on to discuss probing proteins -- including membrane proteins -- and nucleic acids. The first single publication to incorporate chemical markers, fluorescent probes and genetic tags allows a well-informed comparison of different solutions for the same problem in molecular analytics.
Download or read book Nuclear Magnetic Resonance written by and published by Royal Society of Chemistry. This book was released on 2015-05-12 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applications of nuclear magnetic resonance span a wide range of scientific disciplines, from physics to medicine. This series has provided an essential digest of the NMR literature for more than four decades and each volume provides unrivalled coverage of the literature on this topic. Continuous coverage on some topics such as theoretical and physical aspects of nuclear shielding is balanced by the desire for coverage on newer topics like applications in biological systems and materials science. For those wanting to become rapidly acquainted with NMR or seasoned practitioners, this is an invaluable source of current methods and applications.
Download or read book Biomolecular structure and function proceedings of Cellular Function and Molecular Structure a symposium of biophysical approaches to biological problems held at the University of Missouri Columbia May 18 20 1977 written by and published by . This book was released on 1978 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biomolecular Self Assembling Materials written by National Research Council and published by National Academies Press. This book was released on 1996-11-29 with total page 43 pages. Available in PDF, EPUB and Kindle. Book excerpt:
