Download or read book Biological Aspects of Brain Tumors written by Kazuo Tabuchi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Growth activity of brain tumors, metabolism of brain tumors, brain tumors and cytokines, drug resistance of brain tumors, oncogenes and anti-oncogenes, basic studies in brain tumor biology and therapy are presented in this book.
Download or read book Biological Aspects of Brain Tumors written by Kazuo Tabuchi and published by . This book was released on 1991-11-01 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Brain Tumors written by K.J. Zülch and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 1113 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third American edition has been completely revised and expanded, although parts of the text of the second edition have been included. I wish to acknowledge once again the excellent translation of the former two editions by Dr. ALAN B. ROTHBALLER and the late Dr. JERZY OLSZEWSKI. With this edition I have followed the general theme of the original German edition published in 1951. However, I have tried to consider modern techniques and the many new publications on the subject of brain tumors. Meanwhile, an early desire of mine has been fulfilled by the completion and publication of a classification which can be understood worldwide and hopefully be used widely, namely, the classi fication of the World Health Organization: Histological Typing of Tu mours of the Central Nervous System (1979). The classification which I used in the 1951 edition is very close to the final pattern of that accepted by the World Health Organization (WHO), since both follow the line of the BAILEY and CUSHING classifica tion of 1926/1930. To consolidate our old concepts and experiences we have reclassi fied our collection of 9000 cases with the assistance of my co-workers Dr. M. FUKUI, Dr. A. SATO. Dr. E. SCHARRER, Dr. E. SIMON, and Dr. J. SZYMAS. In the last decade two large atlases have been published, one called an Atlas of the Histology of Brain Tumors 1 (in six languages) and a second one called an Atlas of the Gross Neurosurgical Pathology 2.
Download or read book Biological Aspects of Brain Tumors written by Kazuo Tabuchi and published by . This book was released on 1991-01-01 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biology of Brain Tumour written by Michael D. Walker and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the proceedings of the Second International Symposium on Biology of Brain Tumour. The first Symposium was held in 1979 at Gardonne Riviera, Italy. This meeting was planned in order to coincide with the lOOth Anniversary of the first reported operation for glioma in London on November 25, 1884. Since the first meeting, the field of neuro-oncology has made remarkable progress in understanding both basic and clinical factors of significance to patients with brain tumor. While the earlier meeting dealt to a large extent with clinically oriented studies, this symposium was more heavily weighted toward the biology of brain tumour and improving our understanding at the physiologic, biochemical, pharmacologic, and cellular level. The meeting was divided according to scientific content into presentations and discussions as well as posters for more leisurely viewing, so as to allow the main themes of the meeting to sequentially develop. The first session dealt extensively with neuro-oncology at the molecular level and included considerable discus sion of material related to the babic biochemical milieu in which tumors originate, proliferate, and eventually destroy the brain. Classic neuropathology has been the mainstay of tumor identification and characteriza tion, however, the process of classification has become much more complex. The availability of a variety of new tools has allowed investigation into the validity of the more traditional classification systems as well as the development of newer biologically related concepts.
Download or read book Brain Tumor Invasion written by Tom Mikkelsen and published by Wiley-Liss. This book was released on 1998-05-05 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain Tumor Invasion Biological, Clinical, and Therapeutic Considerations Edited by Tom Mikkelsen Rolf Bjerkvig Ole Didrik Laerum Mark L. Rosenblum Recent advances in molecular biology have given us profound new insights into the behavior of primary brain tumors. Not only are such tumors more diffuse in their infiltration of brain tissue and therefore less amenable to surgery than brain tumors originating elsewhere in the body—it now appears that the central nervous system and the normal brain itself constitute a biological environment conducive to the uncontrolled spread of primary tumors. Brain Tumor Invasion is the first comprehensive reference devoted to the invasive behavior of primary brain tumors. It examines the biological mechanisms responsible for the increased ability of gliomas to metastasize in the central nervous system, and discusses the role of chemical carcinogens, growth factors, oncogenes, and tumor suppressors in the progression of such metastases. This book surveys the latest research in the field, reviews present and future prospects of anti-invasive brain tumor therapy, and even translates preclinical trials and other research results into potential new therapies. The material is divided into five main categories: Developmental biology and molecular neuro-oncology Pathological and clinical features of malignant brain tumors Models for the study of brain tumor invasion in vivo and in vitro Mechanisms of invasion New therapeutic strategies Brain Tumor Invasion offers dozens of maps and photographs that illustrate topics under discussion. This in-depth introduction to one of the most difficult problems in the management of brain tumors is indispensable to neuro-oncologists involved in brain tumor research and therapy. It is also useful to researchers in cancer biology, neuroscience, cell biology, and molecular genetics.
Download or read book Brain Tumors written by Davide Schiffer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 717 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analogue to the first edition, the principal characteristic of this work is its casting of pathology as the common nosographic link in the diagnosis, prognosis and treatment of brain tumours. A result of the author's many years of experience in the study of brain tumours and their pathological and clinical characteristics, the book presents different aspects of neurooncology from the perspective of pathology and its biological and clinical correlates. This new, second and enlarged volume preserves all the qualities of the first edition while further amplifying clinical applications and updating biological and pathological problems. The references have been completely revised and new chapters have been added on topics such as neuroimaging, invasion and angiogenesis. Professor Schiffer is President of the Italian Association of Neurooncology and of the Italian Association of Neuropathology.
Download or read book Brain Tumors written by Klaus Joachim Zülch and published by Springer. This book was released on 1986 with total page 732 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Central Nervous System Metastasis the Biological Basis and Clinical Considerations written by Diane Palmieri and published by Springer Science & Business Media. This book was released on 2012-12-30 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is a thorough survey of the biology and treatment of CNS metastasis, including natural history, risk factors, molecular biology, the blood-brain barrier, imaging, quality of life, surgery, chemotherapy, radiation and the future of targeted therapies.
Download or read book Brain Tumor Pathology Current Diagnostic Hotspots and Pitfalls written by Davide Schiffer and published by Springer Science & Business Media. This book was released on 2006-03-09 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is not a treatise on brain tumor pathology and nosography. It has been conceived as a help to pathologists, neuropathologists and neuro-oncologists in confronting everyday problems arising in the diagnostics of brain tumors. Today, because of scientific advances in clinical diagnosis brain tumors are operated earlier, when they are still of reduced dimensions, and with new techniques and more frequently they undergo biopsy procedures. As a consequence, surgical samples for diagnosis are of a smaller size. On the other hand, the recourse to therapies ever more selective require more and more precise identification of tumor types and grades and quite often reliance must be placed on a limited number of cells, as tumor morphological patterns are no longer available. The ever greater precision leads to an increased risk of a flawed diagnosis. The book aims to illustrate the pitfalls most frequently encountered today in the practical activity of diagnosis and also of prognosis. The initial chapters cover the distinction between infiltrating tumors and normal nervous tissue, between diffuse astrocytoma and oligodendroglioma and the identification of the malignant variant of some tumor types. Moreover, in the pathology of brain tumors, some biological processes are active which show a development over the course of time, such that in surgical samples they cannot be recognized as a whole, but only from the occurrence of limited and partial aspects. Invasion modalities, angiogenesis and apoptosis fall in this category and are discussed not in an exhaustive manner, but as stages or phases of the processes identified in the tissue. The figures do not seek to illustrate the characteristic aspects of the tumors, but only the points under discussion.This book is the result of many years of personal experience in the diagnosis of brain tumors as well as of discussions with neurosurgeons and neuro-oncologists and it aspires to contribute to solving emerging everyday problems.
Download or read book Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications written by Terry Lichtor and published by BoD – Books on Demand. This book was released on 2013-02-27 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt: A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years. In particular recent new avenues regarding the role of stem cells and microRNAs along with further understanding of the importance of angiogenesis, immunotherapy and explanations for the resistance of the tumors to chemotherapeutic agents and radiation therapy has been developed. It is hopeful that this new information will lead to efficacious treatment strategies for these tumors which remain a challenge. In this book a review of the latest information on these topics along with a variety of new therapeutic treatment strategies with an emphasis on molecular targeted therapies is provided.
Download or read book Brain Tumors written by Davide Schiffer and published by Springer. This book was released on 2013-03-09 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose and goal of this work it to present the pathology of brain tumors interpreted by its biological correlates. Furthermore, better understanding of the many oncological and neuropathological problems of brain tumors as well as better understanding of neuro-imaging prognostic problems.
Download or read book Brain Tumors written by Francis Ali-Osman and published by Springer Science & Business Media. This book was released on 2007-10-28 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exciting new developments and discoveries of the last two decades are beginning to shed light on the complex biology of brain tumors and are advancing our understa- ing of the cellular and molecular processes involved in their initiation, progression, and clinical and biological behavior. The disease process in brain tumors is quite complex and the resulting tumors are characterized by a high degree of biological and clinical diversity. Thus, despite the advances of the last two decades, prognosis for patients with malignant brain tumors remains abysmal. Significant progress in the diagnosis, treatment and, ultimately, prevention of these tumors will require both the timely h- nessing of the advances in basic and clinical brain tumor research, and a continuing concerted effort at increasing our understanding of brain tumor biology, in particular, the molecular genetic changes and perturbations of cellular pathways involved in brain oncogenesis and which drive the biological and clinical behavior of the tumors. Brain tumor diagnosis and prognosis, which is still largely based on histopathology and other clinical criteria, will, in the future, acquire a significant molecular component, with the incorporation of knowledge of genes that are mutated, over-expressed, deleted, silenced, or functionally altered in the tumors. Treatment strategies for brain tumors, rather than being empirical, will be rationally developed based on an understanding of the cellular and molecular mechanisms and targets that have been activated, suppressed, or otherwise altered.
Download or read book Human Brain and Spinal Cord Tumors From Bench to Bedside Volume 1 written by Nima Rezaei and published by Springer Nature. This book was released on 2023-01-01 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain tumors comprise about 5–9% of all human neoplasms; and interestingly the central nervous system (CNS) neoplasms are ranked among the most prevalent neoplasms of childhood as well. Besides to the morphologic and histopathologic characteristics, and as each pathologic states first starts with molecular alterations, each tumor may have its own story in the matter of activating tumorigenesis pathways and having specific molecular characteristics. Importantly, the molecular classification of tumors has been highly considered in the past few decades for taking the most appropriate therapeutic approach. On the other hand, the tumors shall have tumor-scape mechanisms preventing the immunologic system to eliminate its invasion. The failure of innate and acquired immune system to defeat tumorigenesis mechanisms would consequently result in tumor development. Interestingly, the neuro-immunologic mechanism plays a role in development of psychiatric manifestations of brain tumors as well. Taking all these to account, the different arms of innate immunity, acquired immunity, and genetics have been approached to defeat development and/or progression of such tumors. Accordingly, the activation immunotherapeutic approaches focus on activating or strengthening the anti-tumor immunologic pathways in order to assist the weakened immune system to defeat the tumor (such as Dendritic cell vaccination, DNA vaccines, peptide vaccines, viral vector-based vaccines, monoclonal antibodies, and CAR T-cell therapy). In addition to immunologic components of brain and spinal cord tumors, numerous genes and genetic pathways have been recognized to take part in tumorigenesis. Taking these non-immune genetic pathways to account, some other therapeutic approaches such as stem cell therapy and gene therapy have been developed in the new era of cancer treatment. Moreover, and besides the biologic and medical aspects of these tumors, different physical/mathematical models have been proposed to either explain or predict tumor behavior. Such models would be advantageous in developing new therapeutic modalities in pre-clinical stages and enter new eras in cancer treatment. The first book of Human Brain and Spinal Cord Tumors, Neuro-immunology and Neuro-genetics, will mainly discuss the neuro-immunology and neurogenetic pathways associated with development of brain and spinal cord tumor. After a short introduction chapter, this book will focus on the role of innate and acquired immunity on development of these tumors and then the immunotherapeutic approaches to defeat these tumorigenesis mechanisms. This book will then focus on genetic aspects of brain and spinal cord tumors and bioinformatics models to describe the behavioral patterns of these tumors, as well as associated therapeutic approaches such as stem cell therapy and gene therapy. This volume of book could be useful for experts in basic sciences, mainly geneticists and immunologists, and also physicians of different specialties, mainly neurosurgeons, neurologists, neuropathologists and neuroradiologists.
Download or read book Brain Oncology Biology diagnosis and therapy written by M. Chatel and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Meeting on Brain Oncology in Rennes was organised in honor of Jean Pecker, to pay tribute to his contribution to the development of neurological sciences and to take stock of the current state of knowledge on brain tumors, a domain in which the role of neurosurgery has been and will continue to be primordial. During the two-day conference, the major themes of brain oncology studies, both fundamental and clinical, were examined: oncogenesis, tumoral markers and immunology, metabolic and diagnosis imaging, prognostic factors and therapeutic strategies. The large number and high quality of participations resulted in a genuinely synthetic view of current advances in research, of which this book presents the essentials. We have attempted both to preserve the richness of scientific exchanges which occurred and to publish a great many oral and poster communications. The book respects the organization of conference sessions, and thus reflects the importance accorded to glial tumor studies. This may seem disproportionate given their frequency of occurrence in proportion to total numbers of intracranial tumor processes, but their gravity and quasi-total resistance to current therapeutic methods are ample justification. Moreover, this is the domain in which hopes of progress are beginning to appear, and it is becoming possible to envisage treatment based on recently established fundamental knowledge.
Download or read book Brain Tumors written by Davide Schiffer and published by Springer. This book was released on 2011-09-27 with total page 695 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analogue to the first edition, the principal characteristic of this work is its casting of pathology as the common nosographic link in the diagnosis, prognosis and treatment of brain tumours. A result of the author's many years of experience in the study of brain tumours and their pathological and clinical characteristics, the book presents different aspects of neurooncology from the perspective of pathology and its biological and clinical correlates. This new, second and enlarged volume preserves all the qualities of the first edition while further amplifying clinical applications and updating biological and pathological problems. The references have been completely revised and new chapters have been added on topics such as neuroimaging, invasion and angiogenesis. Professor Schiffer is President of the Italian Association of Neurooncology and of the Italian Association of Neuropathology.
Download or read book Gliomas written by J. Hekmatpanah and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: When I was asked by the Cancer Teaching Committee of the University of Chicago to set up a Symposium on Brain Tumors, I welcomed the opportunity to do so. But I felt that "Brain Tumors" was far too broad a subject to cover in a day and a half meeting. Furthermore, during the past decade, there have been a great many papers and symposiums on technical advancements in the treatment of benign brain tumors. On the other hand, while gliomas make up somewhere around 50% of all brain tumors, there have certainly been far fewer communications about them. For this reason I thought that it would be highly valuable to invite some of the leading investigators to share with us their experience with gliomas. The hope was to learn the current concepts about these tumors biologically and therapeutically, specifically to find out what we are doing and where we are going in these respects. Naturally all aspects could not be covered. Nevertheless, it was a widely expressed opinion by the speakers that they too learned while they came to teach. It is therefore hoped that the publication of their works and ideas through this mono graph will also be useful for the reader. Most of the manu scripts were handed in at the time of the Symposium, and a few were sent later. Except for minor editorial changes the words are entirely those of the speakers and authors.
