Download or read book Better Science Through Safety written by Gary E. Downs and published by Wiley-Blackwell. This book was released on 1981-02 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Emerging Safety Science written by Institute of Medicine and published by National Academies Press. This book was released on 2008-05-08 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the costs of new drug development have skyrocketed. The average cost of developing a new approved drug is now estimated to be $1.3 billion (DiMasi and Grabowski, 2007). At the same time, each year fewer new molecular entities (NMEs) are approved. DiMasi and Grabowski report that only 21.5 percent of the candidate drugs that enter phase I clinical testing actually make it to market. In 2007, just 17 novel drugs and 2 novel biologics were approved. In addition to the slowing rate of drug development and approval, recent years have seen a number of drugs withdrawn from the market for safety reasons. According to the Government Accountability Office (GAO), 10 drugs were withdrawn because of safety concerns between 2000 and March 2006 (GAO, 2006). Finding ways to select successful drug candidates earlier in development could save millions or even billions of dollars, reduce the costs of drugs on the market, and increase the number of new drugs with improved safety profiles that are available to patients. Emerging scientific knowledge and technologies hold the potential to enhance correct decision making for the advancement of candidate drugs. Identification of safety problems is a key reason that new drug development is stalled. Traditional methods for assessing a drug's safety prior to approval are limited in their ability to detect rare safety problems. Prior to receiving U.S. Food and Drug Administration (FDA) approval, a drug will have been tested in hundreds to thousands of patients. Generally, drugs cannot confidently be linked to safety problems until they have been tested in tens of thousands to hundreds of thousands of people. With current methods, it is unlikely that rare safety problems will be identified prior to approval. Emerging Safety Science: Workshop Summary summarizes the events and presentations of the workshop.
Download or read book Safe Science written by National Research Council and published by National Academies Press. This book was released on 2014-10-08 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent serious and sometimes fatal accidents in chemical research laboratories at United States universities have driven government agencies, professional societies, industries, and universities themselves to examine the culture of safety in research laboratories. These incidents have triggered a broader discussion of how serious incidents can be prevented in the future and how best to train researchers and emergency personnel to respond appropriately when incidents do occur. As the priority placed on safety increases, many institutions have expressed a desire to go beyond simple compliance with regulations to work toward fostering a strong, positive safety culture: affirming a constant commitment to safety throughout their institutions, while integrating safety as an essential element in the daily work of laboratory researchers. Safe Science takes on this challenge. This report examines the culture of safety in research institutions and makes recommendations for university leadership, laboratory researchers, and environmental health and safety professionals to support safety as a core value of their institutions. The report discusses ways to fulfill that commitment through prioritizing funding for safety equipment and training, as well as making safety an ongoing operational priority. A strong, positive safety culture arises not because of a set of rules but because of a constant commitment to safety throughout an organization. Such a culture supports the free exchange of safety information, emphasizes learning and improvement, and assigns greater importance to solving problems than to placing blame. High importance is assigned to safety at all times, not just when it is convenient or does not threaten personal or institutional productivity goals. Safe Science will be a guide to make the changes needed at all levels to protect students, researchers, and staff.
Download or read book Foundations of Safety Science written by Sidney Dekker and published by Routledge. This book was released on 2019-04-09 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: How are today’s ‘hearts and minds’ programs linked to a late-19th century definition of human factors as people’s moral and mental deficits? What do Heinrich’s ‘unsafe acts’ from the 1930’s have in common with the Swiss cheese model of the early 1990’s? Why was the reinvention of human factors in the 1940’s such an important event in the development of safety thinking? What makes many of our current systems so complex and impervious to Tayloristic safety interventions? ‘Foundations of Safety Science’ covers the origins of major schools of safety thinking, and traces the heritage and interlinkages of the ideas that make up safety science today. Features Offers a comprehensive overview of the theoretical foundations of safety science Provides balanced treatment of approaches since the early 20th century, showing interlinkages and cross-connections Includes an overview and key points at the beginning of each chapter and study questions at the end to support teaching use Uses an accessible style, using technical language where necessary Concentrates on the philosophical and historical traditions and assumptions that underlie all safety approaches
Download or read book Safe Science written by National Research Council (U.S.) and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent serious and sometimes fatal accidents in chemical research laboratories at United States universities have driven government agencies, professional societies, industries, and universities themselves to examine the culture of safety in research laboratories. These incidents have triggered a broader discussion of how serious incidents can be prevented in the future and how best to train researchers and emergency personnel to respond appropriately when incidents do occur. As the priority placed on safety increases, many institutions have expressed a desire to go beyond simple compliance with regulations to work toward fostering a strong, positive safety culture: affirming a constant commitment to safety throughout their institutions, while integrating safety as an essential element in the daily work of laboratory researchers. Safe Science takes on this challenge. This report examines the culture of safety in research institutions and makes recommendations for university leadership, laboratory researchers, and environmental health and safety professionals to support safety as a core value of their institutions. The report discusses ways to fulfill that commitment through prioritizing funding for safety equipment and training, as well as making safety an ongoing operational priority. A strong, positive safety culture arises not because of a set of rules but because of a constant commitment to safety throughout an organization. Such a culture supports the free exchange of safety information, emphasizes learning and improvement, and assigns greater importance to solving problems than to placing blame. High importance is assigned to safety at all times, not just when it is convenient or does not threaten personal or institutional productivity goals. Safe Science will be a guide to make the changes needed at all levels to protect students, researchers, and staff.
Download or read book Enhancing the Effectiveness of Team Science written by National Research Council and published by National Academies Press. This book was released on 2015-07-15 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past half-century has witnessed a dramatic increase in the scale and complexity of scientific research. The growing scale of science has been accompanied by a shift toward collaborative research, referred to as "team science." Scientific research is increasingly conducted by small teams and larger groups rather than individual investigators, but the challenges of collaboration can slow these teams' progress in achieving their scientific goals. How does a team-based approach work, and how can universities and research institutions support teams? Enhancing the Effectiveness of Team Science synthesizes and integrates the available research to provide guidance on assembling the science team; leadership, education and professional development for science teams and groups. It also examines institutional and organizational structures and policies to support science teams and identifies areas where further research is needed to help science teams and groups achieve their scientific and translational goals. This report offers major public policy recommendations for science research agencies and policymakers, as well as recommendations for individual scientists, disciplinary associations, and research universities. Enhancing the Effectiveness of Team Science will be of interest to university research administrators, team science leaders, science faculty, and graduate and postdoctoral students.
Download or read book From Safety to Safety Science written by Paul Swuste and published by Routledge. This book was released on 2021-11-29 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: How do accidents and disasters occur? How has knowledge of accident processes evolved? A significant improvement in safety has occurred during the past century, with the number of accidents falling spectacularly within industry, aviation and road traffic. This progress has been gradual in the context of a changing society. The improvements are partly due to a better understanding of the accident processes that ultimately lead to damage. This book shows how contemporary crises instigated the development of safety knowledge and how the safety sciences pieced their theories together by research, by experience and by taking ideas from other domains. From Safety to Safety Science details 150 years of knowledge development in the safety sciences. The authors have rigorously extracted the essence of safety knowledge development from more than 2,500 articles to provide a unique overview and insight into the background and usability of safety theories, as well as modelling how they developed and how they are used today. Extensive appendices and references provide an additional dimension to support further scholarly work in this field. The book is divided into clear time periods to make it an accessible piece of science history that will be invaluable to both new and experienced safety researchers, to safety courses and education, and to learned practitioners.
Download or read book Resources in Education written by and published by . This book was released on 1994 with total page 1008 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Monsanto Papers written by Carey Gillam and published by Island Press. This book was released on 2021-03-02 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lee Johnson was a man with simple dreams. All he wanted was a steady job and a nice home for his wife and children, something better than the hard life he knew growing up. He never imagined that he would become the face of a David-and-Goliath showdown against one of the world’s most powerful corporate giants. But a workplace accident left Lee doused in a toxic chemical and facing a deadly cancer that turned his life upside down. In 2018, the world watched as Lee was thrust to the forefront of one the most dramatic legal battles in recent history. The Monsanto Papers is the inside story of Lee Johnson’s landmark lawsuit against Monsanto. For Lee, the case was a race against the clock, with doctors predicting he wouldn’t survive long enough to take the witness stand. For the eclectic band of young, ambitious lawyers representing him, it was a matter of professional pride and personal risk, with millions of dollars and hard-earned reputations on the line. For the public at large, the lawsuit presented a question of corporate accountability. With enough money and influence, could a company endanger its customers, hide evidence, manipulate regulators, and get away with it all—for decades? Readers will be astounded by the depth of corruption uncovered, captivated by the shocking twists, and moved by Lee’s quiet determination to see justice served. With gripping narrative force that reads like fiction, The Monsanto Papers takes readers behind the scenes of a grueling legal battle, pulling back the curtain on the frailties of the American court system and the lengths to which lawyers will go to fight corporate wrongdoing.
Download or read book Chemical Safety in the Laboratory written by Stephen K. Hall and published by CRC Press. This book was released on 2018-12-19 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nothing is more important to an organization than the health and safety of its workers. The managerial effectiveness of any health and safety program is judged on the basis of how well it prevents injuries and ill health. Chemical Safety in the Laboratory provides a proven approach to implementing and maintaining an effective chemical safety program for laboratories in hospital, industrial, and educational settings. Based on 20 years of experience managing and auditing chemical safety programs, the author discusses the OSHA Laboratory Standard and the Chemical Hygiene Plan, provides guidelines for the effective use of personal protective equipment, and details chemical emergency planning and response procedures. He also outlines a 19-step decontamination procedure for emergency responders. Employee chemical exposure monitoring and victim handling procedures are among the other major topics covered in this essential guide.
Download or read book Safety Differently written by Sidney Dekker and published by CRC Press. This book was released on 2014-06-23 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of a bestseller, Safety Differently: Human Factors for a New Era is a complete update of Ten Questions About Human Error: A New View of Human Factors and System Safety. Today, the unrelenting pace of technology change and growth of complexity calls for a different kind of safety thinking. Automation and new technologies have resulted in new roles, decisions, and vulnerabilities whilst practitioners are also faced with new levels of complexity, adaptation, and constraints. It is becoming increasingly apparent that conventional approaches to safety and human factors are not equipped to cope with these challenges and that a new era in safety is necessary. In addition to new material covering changes in the field during the past decade, the book takes a new approach to discussing safety. The previous edition looked critically at the answers human factors would typically provide and compared/contrasted them with current research and insights at that time. The edition explains how to turn safety from a bureaucratic accountability back into an ethical responsibility for those who do our dangerous work, and how to embrace the human factor not as a problem to control, but as a solution to harness. See What’s in the New Edition: New approach reflects changes in the field Updated coverage of system safety and technology changes Latest human factors/ergonomics research applicable to safety Organizations, companies, and industries are faced with new demands and pressures resulting from the dynamics and nature of the modern marketplace and from the development and introduction of new technologies. This new era calls for a different kind of safety thinking, a thinking that sees people as the source of diversity, insight, creativity, and wisdom about safety, not as the source of risk that undermines an otherwise safe system. It calls for a kind of thinking that is quicker to trust people and mistrust bureaucracy, and that is more committed to actually preventing harm than to looking good. This book takes a forward-looking and assertively progressive view that prepares you to resolve current safety issues in any field.
Download or read book Occupational Health and Safety in the Care and Use of Research Animals written by Committee on Occupational Safety and Health in Research Animal Facilities and published by National Academies Press. This book was released on 1997-06-23 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Much has been written about the care of research animals. Yet little guidance has appeared on protecting the health and safety of the people who care for or use these animals. This book, an implementation handbook and companion to Guide For the Care and Use of Laboratory Animals, identifies principles for building a program and discusses the accountability of institutional leaders, managers, and employees for a program's success. It provides a detailed description of risks-- physical and chemical hazards, allergens and zoonoses, and hazards from experiments--which will serve as a continuing reference for the laboratory. The book offers specific recommendations for controlling risk through administrative procedures, facility design, engineering controls, and periodic evaluations. The volume focuses on the worker, with detailed discussions of work practices, the use of personal protective gear, and the development of an emergency response plan. This handbook will be invaluable to administrators, researchers, and employees in any animal research facility. It will also be of interest to personnel in zoos, animal shelters, and veterinary facilities.
Download or read book School Science Laboratories written by Council of State Science Supervisors (U.S.) and published by . This book was released on 1984 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Department of Housing and Urban Development and Certain Independent Agencies Appropriations for Fiscal Year 1984 written by United States. Congress. Senate. Committee on Appropriations. Subcommittee on HUD-Independent Agencies and published by . This book was released on 1983 with total page 1458 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Risk Science written by Terje Aven and published by Routledge. This book was released on 2021-09-12 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Risk science is becoming increasingly important as businesses, policymakers and public sector leaders are tasked with decision-making and investment using varying levels of knowledge and information. Risk Science: An Introduction explores the theory and practice of risk science, providing concepts and tools for understanding and acting under conditions of uncertainty. The chapters in this work cover the fundamental concepts, principles, approaches, methods and models for how to understand, assess, communicate, manage and govern risk. These topics are presented and examined in a way which details how they relate, for example, how to characterize and communicate risk with particular emphasis on reflecting uncertainties; how to distinguish risk perception and professional risk judgments; how to assess risk and guide decision-makers, especially for cases involving large uncertainties and value differences; and how to integrate risk assessment with resilience-based strategies. The text provides a variety of examples and case studies that relate to highly visible and relevant issues facing risk academics, practitioners and non-risk leaders who must make risk-related decisions. Presenting both the foundational and most recent advancements in the subject matter, this work particularly suits students of risk science courses at college and university level. The book also provides broader key reading for students and scholars in other domains, including business, engineering and public health.
Download or read book Departments of Veterans Affairs and Housing and Urban Development and Independent Agencies Appropriations for Fiscal Year 1992 written by United States. Congress. Senate. Committee on Appropriations and published by . This book was released on 1991 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Safety of Food Imports written by United States. Congress. Senate. Committee on Governmental Affairs. Permanent Subcommittee on Investigations and published by . This book was released on 1998 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt:
