Download or read book An Animal Model of Nevirapine induced Skin Rash in the Female Brown Norway Rat microform Discovery Characterization and Use to Investigate an Immune mediated Mechanism written by Jacintha M. (Jacintha Margaret) Shenton and published by Library and Archives Canada = Bibliothèque et Archives Canada. This book was released on 2005 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Idiosyncratic drug reactions (IDRs) are adverse drug reactions that don't occur in most patients at any dose, cannot be explained based on the pharmacological properties of the drug, and are unpredictable. Severe reactions can be life-threatening and may result in the withdrawal of the implicated drug from the market. Thus, these reactions pose significant problems to pharmaceutical manufacturers, government regulators, clinicians, and patients. The ultimate goal is to be able to treat, predict, and/or prevent these reactions; therefore, an understanding of the mechanism of these reactions is imperative. Currently, we believe the immune system is involved in the etiology of IDRs, but absolute proof is lacking. Mechanistic studies by way of human clinical trials are hampered by the idiosyncratic nature of these reactions. Also, in vitro studies are not very useful without parallel in vivo research. Animal models are more likely to mimic the complex pathogenesis of these reactions; however, the reactions are just as idiosyncratic in animals. Thus, practical animal models are rare. We recently discovered a new animal model of an IDR. Female Brown Norway rats treated with nevirapine (150 mg/kg/day)---a drug used to treat human immunodeficiency virus infection---develop a skin rash with similar characteristics to humans treated with nevirapine suggesting a common mechanism. Importantly, the characteristics of the reaction also implicated the immune system in the pathogenesis of the skin rash. Further studies revealed a role for T cells in the reaction as splenic T cells could adoptively transfer susceptibility to nevirapine-induced rash to naive recipients. T cell infiltrates were also observed in skin sections from nevirapine-treated rats. As for the role of CD4+ versus CD8+ T cells, it appears that CD8+ T cells are not necessary for initiation of the reaction; instead, the evidence implicates CD4+ T cells. For instance, CD4+ T cells adoptively transfer sensitivity to naive recipients (in some cases). A role for CD4+ T cells is also supported by the increased susceptibility of humans with high CD4 counts to nevirapine rash. Understanding the mechanism of nevirapine-induced cutaneous reactions may help guide the development of safer drugs or predict patients at risk.
Download or read book Retrotransposition Diversity and the Brain written by Fred H. Gage and published by Springer Science & Business Media. This book was released on 2007-12-05 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Fondation IPSEN Colloque Médecine et Recherche was devoted to the interface between the complexity of brain organization and function, the mechanisms for generating diversity and genetic mobility. The goal was to expand the current limits of research in neurobiology not only to the benefit of those interested in the cellular and molecular processes but also for the understanding of high-level cognitive functions and the understanding of complex mental diseases.
Download or read book Human Antibody Therapeutics For Viral Disease written by Scott K. Dessain and published by Springer Science & Business Media. This book was released on 2007-11-21 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the utility of human antibodies as medical therapeutics for cancer and immune diseases has been well-established, it is only beginning to be realized for the treatment of viral infectious diseases. Polyclonal immunoglobulins have long been used for some viral diseases, but they have limited potency and disease scope. Only a single humanized monoclonal antibody (pavilizumab) has been approved as a viral countermeasure.
Download or read book Dictionary of Medical Acronyms and Abbreviations written by Stanley Jablonski and published by Hanley & Belfus. This book was released on 2004-09 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dictionary lists acronyms and abbreviations occurring with a reasonable frequency in the literature of medicine and the health care professions. Abbreviations and acronyms are given in capital letters, with no punctuation, and with concise definitions. The beginning sections also include symbols, genetic symbols, and the Greek alphabet and symbols.
Download or read book Dorland s Dictionary of Medical Acronyms and Abbreviations written by Dorland and published by Elsevier Health Sciences. This book was released on 2015-07-24 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical acronyms and abbreviations offer convenience, but those countless shortcuts can often be confusing. Now a part of the popular Dorland's suite of products, this reference features thousands of terms from across various medical specialties. Its alphabetical arrangement makes for quick reference, and expanded coverage of symbols ensures they are easier to find. Effective communication plays an important role in all medical settings, so turn to this trusted volume for nearly any medical abbreviation you might encounter. - Symbols section makes it easier to locate unusual or seldom-used symbols. - Convenient alphabetical format allows you to find the entry you need more intuitively. - More than 90,000 entries and definitions. - Many new and updated entries including terminology in expanding specialties, such as Nursing; Physical, Occupational, and Speech Therapies; Transcription and Coding; Computer and Technical Fields. - New section on abbreviations to avoid, including Joint Commission abbreviations that are not to be used. - Incorporates updates suggested by the Institute for Safe Medication Practices (ISMP).
Download or read book Life Threatening Dermatoses and Emergencies in Dermatology written by Jean Revuz and published by Springer Science & Business Media. This book was released on 2009-04-17 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since extensive dermatoses can be life threatening, it is important to recognize and treat skin emergencies rapidly. This book covers all cutaneous emergencies and life threatening dermatoses, as well as true and false emergencies in the dermatologic office. It provides treatment advice for the management of major life threatening dermatoses, such as severe infections, severe drug eruptions and bullous diseases. In addition, it describes the manifestations in acutely ill patients in the ICU, as well as severe cutaneous manifestations occurring during pregnancy, after sun exposure, in cold weather, as a result of extreme poverty, and in other situations. With diagnostic clues, reader-friendly charts and clinical photographs, this clinical guide will not only benefit the hospital-based dermatologist, but will also be a helpful guide for non-dermatologists, such as ER and ICU physicians.
Download or read book AIDS written by Jad Adams and published by St Martins Press. This book was released on 1989 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book marshals the diverse and convincing arguments against the now widely accepted theory that the HIV virus is the sole and sufficient cause of AIDS.
Download or read book Bound Lives written by Rachel Sarah O'Toole and published by University of Pittsburgh Pre. This book was released on 2012-04-15 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bound Lives chronicles the lived experience of race relations in northern coastal Peru during the colonial era. Rachel Sarah O'Toole examines how Andeans and Africans negotiated and employed casta, and in doing so, constructed these racial categories. Royal and viceregal authorities separated "Indians" from "blacks" by defining each to specific labor demands. Casta categories did the work of race, yet, not all casta categories did the same type of work since Andeans, Africans, and their descendants were bound by their locations within colonialism and slavery. The secular colonial legal system clearly favored indigenous populations. Andeans were afforded greater protections as "threatened" native vassals. Despite this, in the 1640s during the rise of sugar production, Andeans were driven from their assigned colonial towns and communal property by a land privatization program. Andeans did not disappear, however; they worked as artisans, muleteers, and laborers for hire. By the late seventeenth and early eighteenth centuries, Andeans employed their legal status as Indians to defend their prerogatives to political representation that included the policing of Africans. As rural slaves, Africans often found themselves outside the bounds of secular law and subject to the judgments of local slaveholding authorities. Africans therefore developed a rhetoric of valuation within the market and claimed new kinships to protect themselves in disputes with their captors and in slave-trading negotiations. Africans countered slaveholders' claims on their time, overt supervision of their labor, and control of their rest moments by invoking customary practices. Bound Lives offers an entirely new perspective on racial identities in colonial Peru. It highlights the tenuous interactions of colonial authorities, indigenous communities, and enslaved populations and shows how the interplay between colonial law and daily practice shaped the nature of colonialism and slavery.
Download or read book Civil Censorship written by United States. Department of the Army and published by . This book was released on 1981 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Photosensitivity Diseases written by Leonard C. Harber and published by . This book was released on 1989 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fresh from the Farm 6pk written by Rigby and published by . This book was released on 2006 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Retrospective Conversion written by and published by Association of Research Libr. This book was released on 1987 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cosmetic Dermatology written by Murad Alam and published by Elsevier Health Sciences. This book was released on 2009-01-01 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This title in the Requisites in Dermatology series is the perfect resource for quick reference and rapid review in cosmetic dermatology. It succinctly presents all of the most essential clinical and foundational knowledge you need for certification, recertification, or practice. An extremely user-friendly full-color format, replete with full-color clinical photographs and other pertinent illustrations, makes it easy to locate and read up on any topic. Plus, full-text online access lets you consult the book from any computer, download all of the images, watch online lectures, and more." --Book Jacket.
Download or read book Kumba Africa written by Sampson Ejike Odum and published by iUniverse. This book was released on 2020-11-03 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: ‘KUMBA AFRICA’, is a compilation of African Short Stories written as fiction by Sampson Ejike Odum, nostalgically taking our memory back several thousands of years ago in Africa, reminding us about our past heritage. It digs deep into the traditional life style of the Africans of old, their beliefs, their leadership, their courage, their culture, their wars, their defeat and their victories long before the emergence of the white man on the soil of Africa. As a talented writer of rich resource and superior creativity, armed with in-depth knowledge of different cultures and traditions in Africa, the Author throws light on the rich cultural heritage of the people of Africa when civilization was yet unknown to the people. The book reminds the readers that the Africans of old kept their pride and still enjoyed their own lives. They celebrated victories when wars were won, enjoyed their New yam festivals and villages engaged themselves in seasonal wrestling contest etc; Early morning during harmattan season, they gathered firewood and made fire inside their small huts to hit up their bodies from the chilling cold of the harmattan. That was the Africa of old we will always remember. In Africa today, the story have changed. The people now enjoy civilized cultures made possible by the influence of the white man through his scientific and technological process. Yet there are some uncivilized places in Africa whose people haven’t tested or felt the impact of civilization. These people still maintain their ancient traditions and culture. In everything, we believe that days when people paraded barefooted in Africa to the swarmp to tap palm wine and fetch firewood from there farms are almost fading away. The huts are now gradually been replaced with houses built of blocks and beautiful roofs. Thanks to modern civilization. Donkeys and camels are no longer used for carrying heavy loads for merchants. They are now been replaced by heavy trucks and lorries. African traditional methods of healing are now been substituted by hospitals. In all these, I will always love and remember Africa, the home of my birth and must respect her cultures and traditions as an AFRICAN AUTHOR.
Download or read book Yvain written by Chretien de Troyes and published by Yale University Press. This book was released on 1987-09-10 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: A twelfth-century poem by the creator of the Arthurian romance describes the courageous exploits and triumphs of a brave lord who tries to win back his deserted wife's love
Download or read book Gender and Newsroom Cultures written by Marjan de Bruin and published by Hampton Press (NJ). This book was released on 2004 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers chapters on the dialectics of gender and newsroom culture, bringing a feminist analysis to that relation. The text aims to bring coherence and insight to a still relatively under-researched topic. The contributors come from a diverse range of geographies, approaches and contexts. Together, the chapters provide a timely intervention i the debates around gender and journalism, extending the analysis to produce a genuinely East-West, North-South set of analyses on this important topic.
Download or read book Cambridge International AS A Level Further Mathematics Coursebook written by Lee Mckelvey and published by Cambridge University Press. This book was released on 2018-08-31 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cambridge International AS & A Level Further Mathematics supports students following the 9231 syllabus. This single coursebook comprehensively covers all four modules of the syllabus and helps support students in their studies and develops their mathematical skills. Authored by experienced teachers of Further Mathematics, the coursebook provides detailed explanations and clear worked examples with practice exercises and exam-style questions. Answers are at the back of the book.
