Download or read book Age related Changes in Auditory Function of Rhesus Monkeys Macaca Mulatta written by Peter Torre (III.) and published by . This book was released on 1999 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Recalibrating Brain written by James Ryan Engall and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Age-related hearing loss is a complex auditory disorder that is associated with a gradual decline of auditory perceptions. Sound localization is one of many auditory perceptions that get impaired in the aged. While sound localization has been studied in great detail at the behavioral level in a variety of young and middle aged animals, little is known about how the neuronal processing breaks down in the aged to impair our perception acoustic space. The current set of studies presented in the forthcoming chapters is part of a series of experiments to develop a primate model of age-related hearing loss that are designed to further our understanding of both the structural and functional changes that accompany aging. In the present series of experiments, several anatomical and electrophysiological studies were designed to characterize and correlate age-related hearing loss in the rhesus macaque monkey (Macaca mulatta) to determine if the auditory system compensates for a reduction in drive from the periphery. A requisite was first to determine if rhesus monkeys experience age-related hearing loss. This was accomplished by linking changes in hearing level to distinct histopathologies in the cochlea. Age-related hearing loss was assessed by the auditory brainstem response (ABR) to clicks and pure tones across a population of rhesus macaque monkeys at the California National Primate Research Center at the University of California of Davis. Histological specimens were then randomly collected and examined for distinct histopathological changes in the cochlea. Multiple regression was used to tease apart the contributions of the observed histopathologies on ABR thresholds. Consistent with findings in humans, rhesus monkeys were found to experience progressive age-related hearing loss with a concomitant increase in the number of histopathologies in the cochlea. We found that spiral ganglion cell loss and outer hair cells loss made significant contributions to ABR threshold increases across the spectrum. At the level of the midbrain, the density of parvalbumin neurons in the inferior colliculus was found to increase with age. Interestingly, there was no direct relationship between the densities of parvalbumin cells in the inferior colliculus with the hearing ability of the monkeys. One explanation for this result is that the increase in the density of parvalbumin neurons produced a functional advantage in the processing of simple stimuli. Lastly, we collected and examined neuronal responses in A1 and CL of young and aged rhesus monkeys to investigate the role of age-related hearing loss on auditory cortical responses to spatial stimuli in azimuth. Interestingly, we found a differential increase in driven firing rates and a decrease in the efficacy of inhibition across defined periods of the neuronal response that contributed to broader spatial tuning properties in both A1 and CL of aged rhesus monkeys. These results suggest that spatial tuning may reflect a maladaptive compensatory mechanism within the central auditory system that overcompensation for changes in the periphery. Overall, the combined results of these studies suggest that the decline of auditory perceptions associated with age-related hearing loss maybe generated by the central nervous systems own mechanisms to adapt to changes in peripheral drive. It is proposed that this process is a major contributor to age-related cognitive decline.

Download or read book Handbook of Models for Human Aging written by P. Michael Conn and published by Elsevier. This book was released on 2011-04-28 with total page 1103 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. Utilizes a multidisciplinary approach Shows tricks and approaches not available in primary publications First volume of its kind to combine both methods of study for human aging and animal models Over 200 illustrations

Download or read book The Aging Auditory System written by Sandra Gordon-Salant and published by Springer Science & Business Media. This book was released on 2010-05-03 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume brings together noted scientists who study presbycusis from the perspective of complementary disciplines, for a review of the current state of knowledge on the aging auditory system. Age-related hearing loss (ARHL) is one of the top three most common chronic health conditions affecting individuals aged 65 years and older. The high prevalence of age-related hearing loss compels audiologists, otolaryngologists, and auditory neuroscientists alike to understand the neural, genetic and molecular mechanisms underlying this disorder. A comprehensive understanding of these factors is needed so that effective prevention, intervention, and rehabilitative strategies can be developed to ameliorate the myriad of behavioral manifestations.

Download or read book The Auditory Cortex written by Jeffery A. Winer and published by Springer Science & Business Media. This book was released on 2010-12-02 with total page 711 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been substantial progress in understanding the contributions of the auditory forebrain to hearing, sound localization, communication, emotive behavior, and cognition. The Auditory Cortex covers the latest knowledge about the auditory forebrain, including the auditory cortex as well as the medial geniculate body in the thalamus. This book will cover all important aspects of the auditory forebrain organization and function, integrating the auditory thalamus and cortex into a smooth, coherent whole. Volume One covers basic auditory neuroscience. It complements The Auditory Cortex, Volume 2: Integrative Neuroscience, which takes a more applied/clinical perspective.

Download or read book Cognitive Aging written by Institute of Medicine and published by National Academies Press. This book was released on 2015-07-21 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: For most Americans, staying "mentally sharp" as they age is a very high priority. Declines in memory and decision-making abilities may trigger fears of Alzheimer's disease or other neurodegenerative diseases. However, cognitive aging is a natural process that can have both positive and negative effects on cognitive function in older adults - effects that vary widely among individuals. At this point in time, when the older population is rapidly growing in the United States and across the globe, it is important to examine what is known about cognitive aging and to identify and promote actions that individuals, organizations, communities, and society can take to help older adults maintain and improve their cognitive health. Cognitive Aging assesses the public health dimensions of cognitive aging with an emphasis on definitions and terminology, epidemiology and surveillance, prevention and intervention, education of health professionals, and public awareness and education. This report makes specific recommendations for individuals to reduce the risks of cognitive decline with aging. Aging is inevitable, but there are actions that can be taken by individuals, families, communities, and society that may help to prevent or ameliorate the impact of aging on the brain, understand more about its impact, and help older adults live more fully and independent lives. Cognitive aging is not just an individual or a family or a health care system challenge. It is an issue that affects the fabric of society and requires actions by many and varied stakeholders. Cognitive Aging offers clear steps that individuals, families, communities, health care providers and systems, financial organizations, community groups, public health agencies, and others can take to promote cognitive health and to help older adults live fuller and more independent lives. Ultimately, this report calls for a societal commitment to cognitive aging as a public health issue that requires prompt action across many sectors.

Download or read book New Therapies to Prevent or Cure Auditory Disorders written by Sylvie Pucheu and published by Springer Nature. This book was released on 2020-03-25 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hearing loss is the most common form of sensory impairment in humans, affecting 360 million persons worldwide. In parallel, tinnitus disorder, the perception of a phantom sound often described as a ringing or buzzing, affects around 10–15% of the general population and interferes with daily life. Hyperacusis, defined as a hypersensitivity to moderate-intensity sounds often co-occurs with tinnitus suggesting a common mechanism of dysfunction for these two perceptual disorders. Whereas some drug candidates are in the process of being developed, nowadays no effective treatment exists to cure hearing loss and tinnitus. The topic of this book was selected with the goal of emphasizing mechanisms that induce hearing loss and tinnitus which lead the selection of promising targets for hearing disorder treatment. Hair cells (HC) are the sensory cells of the inner ear required for both auditory and vestibular functions in all vertebrates. HC are progressively lost during ageing and they are in addition sensitive to physical and acoustic traumas, infectious diseases and chemicals present in commonly used treatments such as anticancer, antimalarial or antibiotics. As adult mammals--including humans--cannot regenerate dead HC, all the possible injury could result in irreversible and permanent hearing loss. It has been shown, however, that a limited capacity to regenerate HC exists in mouse at an early stage of development. The regenerative capacity of HC then appears simply “repressed” in adult mammals, and one could expect it will be possible to re-activate it with an appropriate therapeutic approach which is still to be defined. Immune-mediated inner ear disease has been introduced and accepted as one SNHL pathophysiology; it responds to immunosuppressive therapy and is one of the few reversible forms of bilateral SNHL. Macrophages are always present in the spiral ligament of the lateral wall and are activated in response to various types of stimuli, including noise exposure, ischemia, mitochondrial damage, and surgical stress. Recent studies have also revealed another type of immune cell, called perivascular melanocyte-like macrophages (PVM/Ms), in the stria vascularis. The book will include a review of inflammatory/immune cells in the cochlear lateral wall, the pathways involved in cochlear damage and their potential as therapeutic targets. The final chapter provides an overview of current animal model of tinnitus and hyperacusis. Nowadays no effective treatment exists to cure tinnitus and hyperacusis. One major obstacle to arises from the fact that tinnitus is a subjective phenomenon, the only possible diagnosis relies on self-reports of the subjects. The main constraint of the use of animal models is the subjective character of tinnitus. This chapter describe the advancement in animal models which play an important role in revealing the underlying mechanisms and treatment for tinnitus and hyperacusis.

Download or read book Functional Neurobiology of Aging written by Patrick R. Hof and published by Elsevier. This book was released on 2001-01-11 with total page 989 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some well-known age-related neurological diseases include Parkinson's disease, Alzheimer's disease, deafness, and blindness. Even more common are the problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging continue to become more common, and conditions associated with aging need more attention by doctors and researchers. In 1991, patients over the age of 65 saw their doctors an average of eight times per year. Research funding is provided by the Neuroscience and Neuropsychology of Aging (NNA) Program, which is run by the National Institute on Aging. This book offers a comprehensive overview of all topics related to functional impairments which are related to the aging brain and nervous system. It is organized according to four general functions: movement, senses, memory, and neuroendocrine regulation. Written by the leading researchers in the field, this comprehensive work addresses both impairments associated with diseases and not associated with diseases, making it easier to understand the mechanisms involved. Functional Neurobiology of Aging is an important reference for professionals and students involved in aging research, as well as physicians who need to recognize and understand age-related impairments. Organized by function, making it easy to find and understand the material Addresses impairments both associated with diseases and not associated with diseases Written by leading researchers in the field Most comprehensive source of information on the neurobiology of aging

Download or read book Mechanisms of Dietary Restriction in Aging and Disease written by Charles V. Mobbs and published by Lulu.com. This book was released on with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1836 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Integrative Functions in the Mammalian Auditory Pathway written by Donata Oertel and published by Springer Science & Business Media. This book was released on 2002-01-17 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: A summary of how the electrical signals used to represent sounds are encoded and interpreted through the integrated roles of various nuclei. This volume builds on the information about the anatomy and physiology of the auditory pathway found in volumes 1 and 2 of the SHAR series. While the first two volumes describe the structure and function of auditory pathways, this one explains how these pathways lead to an animal's ability to localize and interpret sounds.

Download or read book Auditory neuroanatomy A sound foundation for sound processing written by Miguel A. Merchán and published by Frontiers E-books. This book was released on with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last two decades, the ever increasing pace of auditory research has generated an undreamed of knowledge about the molecular and cellular bases of hearing, the physiopathology of hearing loss, the activity of the brain evoked by sounds, and the possibilities of imaginative strategies to restore hearing. The aim of this Research Topic is to contribute to the development of auditory neuroscience by placing in an up-to-date morphological context some of the latest developments in the field. This Research Topic for Frontiers in Neuroanatomy will consist of peer-reviewed articles dealing with the development, evolution, function and plasticity of the auditory system through a broad range of anatomical approaches. Articles combining neuroanatomy with other disciplines, such as molecular biology, genetics, physiology, pharmacology, behavior, neuroimaging, clinical medicine or bioinformatics, will be considered for publication insofar as they contribute to the understanding of the structure of the auditory regions of the central nervous system. The authors of the papers published in this Research Topic will be invited to present and discuss their results during a symposium organized by the Instituto de Neurociencias of Castilla y León (INCyL), to be held in Salamanca, Spain, in 2010.

Download or read book Biotechnology in Functional Foods and Nutraceuticals written by Debasis Bagchi and published by CRC Press. This book was released on 2010-04-21 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern food biotechnology is now a billion-dollar industry, producing functional foods and nutraceuticals that offer a whole host of increased health benefits, including prevention against illness, and chronic and degenerative conditions. Written by a team of top-tier researchers and scientists from around the world, Biotechnology in Functional Foo

Download or read book Principles and Practice of Geriatric Sleep Medicine written by S. R. Pandi-Perumal and published by Cambridge University Press. This book was released on 2009-11-26 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a concise and comprehensive review of geriatric sleep medicine from a multidisciplinary viewpoint.

Download or read book The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment written by Joerg Bluemel and published by Academic Press. This book was released on 2015-03-13 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more Includes practical examples on techniques and methods to guide your daily practice Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes

Download or read book Brain Aging written by David R. Riddle and published by CRC Press. This book was released on 2007-04-19 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur

Download or read book Animal Models of Human Cognitive Aging written by Jennifer L. Bizon and published by Springer Science & Business Media. This book was released on 2008-11-12 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant improvements in lifestyle and medical science are leading to an ever increasing elderly population in the United States and other developed nations. The U.S census bureau estimates that the number of people over 65 will nearly double by 2030, and that the elderly will comprise nearly one-fifth of the world’s entire population within the next 20 years. In Animal Models of Human Cognitive Aging, Jennifer Bizon, Alisa Woods, and a panel of international authorities comprehensively discuss the use of animal models as a tool for understanding cognitive changes associated with the aging process. The book provides substantive background on the newest and most widely used animal models in studies of cognition and aging, while detailing the normal and pathological processes of brain aging of humans in relation to those models. Additional chapters comprehensively review frontal cortical deficits and executive function in primates as related to humans, and the use of transgenic modulation in mice to model Alzheimer’s and other age-related diseases. Groundbreaking and authoritative, Animal Models of Human Cognitive Aging provides a valuable resource for Neuroscientists, Gerontological Scientists and all aging medicine researchers, while serving as a primer for understanding current brain aging studies.