Download or read book Targeted Therapies for Solid Tumors written by Antonio Russo and published by Humana Press. This book was released on 2015-03-11 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides readers a comprehensive and state-of-the-art overview about the range of applications of targeted therapies for solid tumors. The sections of the book have been structured to review the oncogene addicted tumors, the pharmacology and clinical development of new molecularly targeted agents, the use of biomarkers as prognostic, predictive and surrogate endpoints, and the evaluation of tumor response and specific malignancies treated with targeted agents. The book also covers some of the newest developments in cancer therapy that are not adequately covered by any current available literature. Written by recognized experts in the field, Targeted Therapies for Solid Tumors: A Handbook for Moving Toward New Frontiers in Cancer Treatment provides a unique and valuable resource in the field of molecular oncology, both for those currently in training, and for those already in clinical or research practice.

Download or read book Topics in Anti Cancer Research written by Atta-ur Rahman and published by Bentham Science Publishers. This book was released on 2013-07-31 with total page 561 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second volume of the Patent eBook Series titled Topics in Anti-Cancer Research. The eBook includes updated chapters on topics relevant to contemporary cancer research published in the journal, Recent Patents on Anti-Cancer Drug Discovery. This volume covers scientific and patented novel chemotherapeutic agents and drugs for metastatic castration-resistant prostate cancer and Ras/ Raf /MEK/ERK pathway, P1K, AKT and mTORC1/2 inhibitors, ATPase inhibitors for cancer therapy, and sphingomyelin biosynthesis which regulates cancer cell death and growth. Other chapters also explain research on biochemical regulation i.e. cell cycle and energy metabolism, the role of genetic variations of FcγRs gamma receptors in monoclonal antibody based anti-cancer therapy and effectiveness of antiangiogenic therapy, endogenous angiogenesis inhibitors and anti-angiogenic drugs for the treatment of renal cell carcinoma, prevention of cancer by ribonucleotide reductase, anticancer activity of Erlotinib in glioblastoma and the mechanisms of action of nanodrugs and nano-sized camptothecin drugs in cancer chemotherapy. The volume also covers recent studies in the field of onconutrition. The broad range of topics covered in this second volume will be of immense interest to clinicians, scientists and R&D experts seeking new targets for the prevention of cancer, novel oncogenic biomarkers, and methods for cancer therapy.

Download or read book Small Molecules in Oncology written by Uwe M. Martens and published by Springer Science & Business. This book was released on 2014-04-22 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the progress being made will result in significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book, written by acknowledged experts, discusses in detail the most recent developments in targeted cancer therapy using small molecules. A wide range of small molecules is covered, including, in addition to tyrosine kinase inhibitors, mTOR, proteasome, and multikinase inhibitors, among others. For each molecule, aspects such as chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed.

Download or read book Current Challenges in Personalized Cancer Medicine written by Keiran Smalley and published by Academic Press. This book was released on 2012-09-26 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: For this volume of Advances in Pharmacology we have brought together some of the foremost basic science and clinical researchers to discuss some of the new frontiers in the development of targeted cancer therapy. Although still in its formative stages, the development of targeted cancer therapies has already shown incredible promise in a limited number of cancer types. As basic cancer research and drug development continues, we expect this number to grow and more patients to benefit from these exciting advances. Through better patient selection and novel strategies to manage resistance, a future can be envisaged in which cancer can be reduced to the level of a chronic, manageable disease. Brought together some of the foremost basic science and clinical researchers Part of the renowned Advances in Pharmacology Serial Discussion of some of the new frontiers in the development of targeted cancer therapy

Download or read book Inhibitors of the Ras Superfamily G proteins Part B written by and published by Academic Press. This book was released on 2013-11-07 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer, this is the second part of The Enzymes' volumes that discuss inhibitors of the Ras superfamily G-proteins. - Informs and updates on all the latest developments in the field - Contributions from leading authorities and industry experts

Download or read book The Pancreas written by Hans G. Beger and published by John Wiley & Sons. This book was released on 2018-01-05 with total page 1220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Die brandneue aktualisierte Ausgabe des wohl umfassendsten Referenzwerks zu Erkrankungen der Bauchspeicheldrüse präsentiert im Detail die neuesten Erkenntnisse zu Genetik und molekularbiologischen Hindergründen im Hinblick auf Anatomie, Physiologie, Pathologie und Pathophysiologie aller bekannten Störungen. Zum ersten Mal enthält das Werk neue Abschnitte zu wichtigen Bereichen der Autoimmunpankreatitis und gutartigen zystischen Neoplasien. Darüber hinaus bietet diese Ausgabe hochwertige Illustrationen, Zeichnungen und Röntgenaufnahmen als Schritt-für-Schritt-Anleitungen zu sämtlichen endoskopischen und chirurgischen Verfahren. Alle Bilder können für wissenschaftliche Präsentationen aus einer Bilddatenbank heruntergeladen werden. Jedes Kapitel in der 3. Auflage von The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery wurde gründlich überarbeitet und aktualisiert. Viele Veränderungen in der klinischen Praxis seit Veröffentlichung der Vorgängerversion sind nun dokumentiert. Dazu gehören neue Leitlinien für invasive und nicht-invasive Behandlungen, neue molekularbiologische Pathways zur Unterstützung klinischer Entscheidungen für die gezielte Behandlung von Bauchspeicheldrüsenkrebs, neue minimal-invasive Ansätze zur Behandlung von Erkrankungen des Pankreas und die neuesten Erkenntnisse zu neuroendokrinen periampullären Tumoren. - Das umfassendste Werk über die Bauchspeicheldrüse, mit herausragenden und klaren Leitlinien für Kliniker. - Deckt alle Erkrankungen der Bauchspeicheldrüse detailliert ab, inkl. Anatomie, Physiologie, Pathologie, Pathophysiologie, Diagnose und Management. - Vollständig aktualisiert und um neue Kapitel erweitert. - Über 500 Illustrationen zum Herunterladen. - International renommierte Herausgeber und Autoren. Die 3. Auflage von The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery ist ein wichtiges Werk für Gastroenterologen und Chirurgen für gastrointestinale Chirurgie weltweit.

Download or read book Gastrointestinal Malignancies written by David Bentrem and published by Springer. This book was released on 2016-07-27 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively summarizes the current state of knowledge on malignancies of the gastrointestinal tract. Dedicated organ-based chapters evaluate current treatments and management and provide information on incidence, etiology and biological characteristics. The state of the art in the radiologic and endoscopic staging of gastrointestinal malignancies is described, and guidance is offered on the role of interventional radiology and interventional gastroenterology in the treatment of these challenging tumors. In addition, the book explores novel and evolving treatments, including personalized systemic therapy and minimally invasive surgical and radiology techniques, and addresses patient-reported outcomes and survivorship challenges. It closes by discussing animal models of gastrointestinal malignancies and examining the significance of the Ras superfamily of GTPases. It will be of benefit to all surgeons, oncologists and other specialists who treat these malignancies, as well as to trainees looking to increase their understanding of the field.

Download or read book ECAB Adjuvant and Neoadjuvant Therapy in Gastrointestinal Cancer E Book written by Bhawna Sirohi and published by Elsevier Health Sciences. This book was released on 2014-12-11 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: ECAB Adjuvant and Neoadjuvant Therapy in Gastrointestinal Cancer - E-Book

Download or read book Management of Colorectal Cancers in Older People written by Demetris Papamichael and published by Springer Science & Business Media. This book was released on 2013-03-15 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to provide an up-to-date review of the literature in each of the major areas relating to the management of older colorectal cancers patients, and makes recommendations for best practice and future research. The authors come from a broad geographic spread including the UK, mainland Europe and North America to ensure a worldwide relevance.

Download or read book The American Cancer Society s Oncology in Practice written by The American Cancer Society and published by John Wiley & Sons. This book was released on 2018-02-09 with total page 777 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developed by the American Cancer Society this new textbook designed for a wide range of learners and practitioners comprehensively addresses all aspects of clinical management for cancer taking a balanced, authoritative and, -where possible- evidence-based stance and may be used in conjunction with the book, The American Cancer Society's Principles of Oncology: Prevention to Survivorship. Edited by leading clinicians in the field and a stellar contributor list from the US and Europe, this book is written in an easy to understand style by multidisciplinary teams of medical oncologists, radiation oncologists and other specialists, reflecting day-to-day decision-making and clinical practice. Input from pathologists, surgeons, radiologists, and other specialists is included wherever relevant and comprehensive treatment guidelines are provided by expert contributors where there is no standard recognized treatment. This book is an ideal resource for anyone seeking a practical understanding of the field of oncology.

Download or read book Colorectal Cancer written by John H. Scholefield and published by John Wiley & Sons. This book was released on 2014-02-12 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal Cancer: Diagnosis and Clinical Management provides colorectal surgeons, gastroenterologists and oncologists with an authoritative, practical guide to best practice in the diagnosis and clinical management of colorectal cancer. Covering all forms of treatment including surgery, chemotherapy and radiotherapy, it examines the various new and emerging therapies, new strategies for screening and prevention, as well as the latest guidance on the most challenging and controversial aspects of managing colorectal cancer. The authors present important information on: Controversies in adjuvant chemotherapy Long versus short course radiotherapy Minimally invasive surgery and robotics Radical colonic resection Each chapter contains key points, tips and tricks and clinical case studies to aid rapid browsing and knowledge of the basic principles, while self-assessment questions allow readers to test their clinical knowledge. With leading international surgeons, gastroenterologists and oncologists combining to offer their considerable wealth of expertise and knowledge, Colorectal Cancer is a well-balanced, indispensable resource for all those involved in colorectal cancer management.

Download or read book Surgical Treatment of Colorectal Cancer written by Nam Kyu Kim and published by Springer. This book was released on 2018-05-02 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an Asian perspective on how the treatment of colorectal cancer can be optimized and standardized in ways that take into account technological advances and the trend towards individually tailored therapy. Readers will find careful, well-illustrated descriptions of the standard surgical techniques for rectal cancer and colon cancer that have contributed to recent improvements in 5-year survival rates in the Asia-Pacific region, where the incidence of colorectal cancer has been rising alarmingly due to lifestyle changes. The vital role now being played by minimally invasive laparoscopic and robotic options receives detailed scrutiny. Extent and timing of surgery, patient safety, risk of complications, and unresolved issues are all discussed. Furthermore, the use of surgery within the context of multimodal management including chemotherapy and radiotherapy is explained and an integrated approach for stage IV and recurrent disease is described. The book will serve as a valuable reference for young surgeons who are in training, experienced practitioners who want to enhance their knowledge and skills, and all others who wish to learn about this field.

Download or read book Therapeutic Strategies in Cancer Biology and Pathology written by Gajanan V. Sherbet and published by Elsevier. This book was released on 2013-07-26 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: Currently, intensive effort is being directed toward the identification of molecular targets that can provide approaches to the development of novel therapeutic strategies in cancer management. This book focuses on metastasis-associated genes, metastasis promoter and suppressor genes, which relate specifically to behavioral alterations of cancer cells in epithelial mesenchymal transition, cancer stem cell maintenance and propagation, and to the acquisition of invasive and metastasis faculty. The function of these genes has implications for cell cycle regulation and cell proliferation and so constitute an essential element in cancer growth and dissemination. The emphasis in this book is on how appropriate these genes are as molecular targets and how practicable are the constituents of their signal transduction systems as potential candidates and how accessible they are to targeted therapy. Written in a straightforward and clear style with background information supporting the new research, this book will be useful for students and researchers in cancer therapies. - Identifies molecular targets and their accessibility for therapeutic intervention - Provides information on biological features of tumor development and dissemination - Background information provided for each topic

Download or read book Sexology for the Wise written by Omar Zaid and published by Al Ginkgo LLC. This book was released on 2022-07-29 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: This essay collection applies wide-ranging optics to myths of LGBT normality. The author compares and contrasts biological, metaphysical, psychological, moral, and social dynamics that define and delimit normal heterosexual duality with elements of the gender confused. He does this in terms that illustrate spiritual and physical absolutes that are denied yet manipulated by postmodern nihilists who serve the occult governance that institutionalizes evil. The heterosexual dyad is rigorously defended as cardinal, essential, existential, naturally hegemonic, and not the least bit ambiguous. Zaid's comprehensive acumen is both frightening and captivating. His race through the Holocene irremediably shakes and changes the reader's world view via this careful amalgamation of Religion, Theology, Scripture, History, Science, Geo-Politics, Human Nature, Magick, Philosophy, and Occult Mystery Systems. Sexology For The Wise is an intense dot-connecting narrative that crosses all bounds of taboo to reveal much we do not wish to acknowledge.

Download or read book Sarcoma An Issue of Hematology Oncology Clinics of North America written by Andrew J. Wagner and published by Elsevier Health Sciences. This book was released on 2013-10-15 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue focuses on Sarcoma in areas such as: Gastrointestinal Stromal Tumors: Risk assessment and adjuvant therapy, Gastrointestinal Stromal Tumors: Management of metastatic disease and emerging therapies, Liposarcoma, Leiomyosarcoma, Update in treatment and targets in cartilage and bone tumors, Update in treatment and targets in Ewing sarcoma, Angiosarcoma and Epithelioid Hemangioendothelioma, Emerging therapies for sarcoma, and Treatment of localized sarcomas.

Download or read book Modern GI Oncology E Book written by Shailesh V Shrikhande and published by Elsevier Health Sciences. This book was released on 2015-08-31 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern Gastrointestinal Oncology is a comprehensive and authoritative book dealing with contemporary issues in diagnosis and management of gastrointestinal cancers. The book is specially designed to update senior students, super-specialty residents, fellows and all clinicians with an interest in gastrointestinal cancers. - Interdisciplinary coverage of gastrointestinal cancer by more than 70 authors who are leading epidemiologists, researchers, gastroenterologists, surgeons, medical oncologists and radiation oncologists from all over the world - Special emphasis on controversial issues in management of gastrointestinal cancers - Dynamic and in-depth information coupled with practical guidelines to aid the busy clinician - Lucid presentation with texts, figures, updated case studies and key research questions

Download or read book Textbook of Gastrointestinal Oncology written by Suayib Yalcin and published by Springer Nature. This book was released on 2019-09-05 with total page 711 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook discusses core principles and practices in gastrointestinal oncology and covers a wide range of practice areas such as pathology and radiologic images, epidemiology, genetics, staging, multidisciplinary management of specific gastrointestinal cancer, and pathology for each primary tumor site. The comprehensive coverage makes Textbook of Gastrointestinal Oncology a useful resource for the practitioner wishing to gain a greater understanding of the principles of managing malignant gastrointestinal disease, as well as medical oncology fellows, surgeons, radiation oncologists, gastroenterologists and fellows, and residents.