Download or read book Unusual resistance to ionizing radiation of the viruses of kuru Creutzfeldt Jakob disease and scrapie written by Clarence J. Gibbs and published by . This book was released on 1979 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Unusual Resistance to Ionizing Radiation of the Viruses of Kuru Creutzfeldt Jakob Disease and Scrapie written by Clarence J. Gibbs and published by . This book was released on 1979 with total page 3 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Publication Catalog of the U S Department of Health and Human Services written by United States. Department of Health and Human Services and published by . This book was released on with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Publication Catalog of the U S Department of Health Education and Welfare written by United States. Dept. of Health, Education, and Welfare and published by . This book was released on 1979 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Monthly Catalog of United States Government Publications written by and published by . This book was released on 1979 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Monthly Catalogue United States Public Documents written by and published by . This book was released on 1979 with total page 1136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Monthly Catalog of United States Government Publications written by United States. Superintendent of Documents and published by . This book was released on 1968 with total page 1122 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Madness and Memory written by Stanley B. Prusiner and published by Yale University Press. This book was released on 2014-04-28 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this “utterly fascinating” science memoir, the Nobel Prize–winning author chronicles his revolutionary discovery of a major cause of brain diseases (The New York Times). In 1997, Stanley B. Prusiner received the Nobel Prize in Physiology or Medicine for his research on devastating brain diseases. That he was the award’s sole recipient was entirely appropriate. His struggle to identify the agent responsible for scrapie and mad cow disease in animals, and Creutzfeldt-Jakob disease in humans, had been waged largely alone, and in some cases, in the face of strenuous opposition. In Madness and Memory, Prusiner recounts the journey to his remarkable discovery of prions—infectious proteins that replicate and cause disease, but surprisingly contain no genetic material. Along the way, he sheds light on the world of contemporary science and the meticulousness and perseverance it requires. Through his telling, the agony and triumph of years of research comes to life, along with fascinating portraits of fellow scientists racing to make breakthrough discoveries. Prusiner’s hypothesis, once considered heresy, now stands as accepted science and provides a path toward conquering such pervasive scourges as Alzheimer’s, Parkinson’s, Lou Gehrig’s, and others diseases. “Madness and Memory is the story of one of the most important discoveries in recent medical history, and it is also a vivid and compelling portrait of a life in science.” —Oliver Sacks, MD, neurologist and author of Hallucinations
Download or read book NINDS at 50 written by Lewis P. Rowland and published by . This book was released on 2001 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Enigma of Slow Viruses written by Pawel P. Liberski and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scrapie, a naturally occurring neurodegenerative disease of sheep and sometimes goats, is a prototypic disease for the whole group of the subacute spongiform virus encephalopathies. Kuru was the first human disease of this type to be discovered in 1957 by Gajdusek and Zigas, and its discovery opened the whole field in the human biomedical sciences by the very realization of the fact that viruses may induce disease months or even decades after infections, and that these slow virus diseases are more compatible with classical degenerations of the nervous system than with inflammatory disorders of the brain. More than a quarter of a century since discovery of Kuru, and more than half a century following the first transmission of scrapie, the very nature of the infectious virus remains unknown. This comprehensive review covers all aspects of slow unconventional virus infections known today. It includes numerous historical data, biochemistry and molecular biology of the prion protein and its gene, the role of genetics and mutations within PrP gene, spreading and targeting of the virus, biochemistry and neurochemistry of the alterations of different neurotransmitter system and neuropathology. More than 1000 references are listed and critically analyzed; the reader can find references to all experiments and laboratory findings which has ever been done in this field. Furthermore, the book offers different view on the basic problems as for example, the nature of the scrapie agent.
Download or read book The Molecular and Genetic Basis of Neurologic and Psychiatric Disease written by Roger N. Rosenberg and published by Lippincott Williams & Wilkins. This book was released on 2008 with total page 930 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely updated for its Fourth Edition, this book is the most comprehensive, current review of the molecular and genetic basis of neurologic and psychiatric diseases. More than 120 leading experts provide a fresh, new assessment of recent molecular, genetic, and genomic advances, offer new insights into disease pathogenesis, describe the newest available therapies, and explore promising areas of therapeutic development. This edition features an updated section on psychiatric disease and expanded, updated chapters on human genomics, gene therapy, and ethical issues. Six new chapters cover congenital myasthenic syndromes, hereditary spastic paraplegia, ion channel disorders, the phakomatoses, beta-galactosidase deficiency, and prion diseases. A Neurologic Gene Map describes the chromosome locus of all the genetic diseases and their gene product where known. The fully searchable online text will be available on a companion Website. (www.rosenbergneuroandpsychdisease.com)
Download or read book The Behavioral Neurology of Dementia written by Bruce L. Miller and published by Cambridge University Press. This book was released on 2016-11-17 with total page 1310 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition of The Behavioral Neurology of Dementia provides clinicians and researchers with the latest research findings written by the leading dementia experts. With chapters ranging from cognitive evaluation to imaging, and genetics and pathology to treatment, the detailed clinical descriptions of diseases and symptoms serve not only as an educational tool for trainees, but also as an opportunity for experienced clinicians to deepen their knowledge and better serve their patients. After years of little progress, the pace of discovery has been speeding up in the last decade, and the authors distil the most valuable discoveries into clear, insightful chapters with applicable information. All the chapters from the first edition have been refreshed with new text and figures. There are new chapters on autoimmune antibody-associated encephalopathy; chronic traumatic encephalopathy; and sleep issues in dementia.
Download or read book New Research on Signal Transduction written by Bruce R. Yanson and published by Nova Publishers. This book was released on 2007 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. In such cases the chain of steps is referred to as a "signalling cascade" or a "second messenger pathway" and often results in a small stimulus eliciting a large response. Hormones and other signalling molecules may exit the sending cell by exocytosis or other means of membrane transport. The sending cell is typically of a specialised type. Its recipients may be of one type or several, as in the case of insulin, which triggers diverse and systemic effects. This book sheds new light in this exciting field of cell transportation research.
Download or read book Protein Misfolding Aggregation and Conformational Diseases written by Vladimir N. Uversky and published by Springer Science & Business Media. This book was released on 2007-05-26 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second volume continues to fill the gap in protein review and protocol literature. It does this while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. The focus of Part B is the molecular basis of differential disorders.
Download or read book Current Topics in Biomedical Research written by Reinhard Kurth and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: A select group of highly renowned scientists - among them four Nobel Prize Winners - have been asked to summarize significant developments of their ownrecent research in the life sciences at a workshop organized on the occasionof the opening of the new Paul-Ehrlich-Institut in Langen near Frankfurt/ Main. They do this in a comparative fashion evaluating similar achievements in adjacent fields. Their intellectual state-of-the-art analysis and fascinating outlook on future perspectives provides exciting and stimulating reading. The authors address areas in virology, immunology, oncology and evolution. Intelligent design of vaccines and other immunologial drugs, virus evolution and viruses as nature's engineers, pathology of chronic autoimmune and central nervous system diseases and the biology of mammary cancer belong to the topics discussed. A book easy to read for scientists, doctors and students interested in rapidly developing fields in the life sciences.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1977 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Transmissible Spongiform Encephalopathies written by Bruce W. Chesebro and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: In spite of a long history of intense investigation the transmissible spongiform encephalopathies remain a poorly understood family of neurodegenerative diseases. This group of diseases has been described in a wide variety of animal species and includes kuru, Creutzfeldt-Jakob disease, and Gerstmann-Straussler syndrome in humans, and scrapie, bovine spongiform encephalopathy, and related syndromes in ruminants and rodents. In all cases spongiform degeneration and astrocytosis are seen in specimens of brain and a filterable transmissible agent is present in the brain and some other tissues of affected individuals. However, the precise nature of this agent remains unknown. Agent infectivity, which can so far only be assayed by serial transmission to new individuals, be remarkably resistant to inactivation has been shown to by heat, chemicals, and irradiation. These properties create significant biohazard possibilities during exposure to infected tissues. Transmission between humans was originally reco gnized in the unique epidemiology of kuru in New Guinea tribesmen, and concern about transmission from animals to humans has re-emerged as a result of the current epidemic of bovine spongiform encephalopathy in dairy cattle in Great Britain. Although interspecies transmission has often been achieved experimentally, its efficiency is highly variable. There fore, the possibility of spread of bovine spongiform encephalopathy from cattle to humans or various animal populations cannot be accurately predicted at this time. This volume presents a comprehensive update of know ledge concerning the transmissible spongiform encephalo pathies.
