Download or read book Unmasking metabolic dependencies for anti cancer treatment in cancer written by Johannes Fahrmann and published by Frontiers Media SA. This book was released on 2024-05-27 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decade, our understanding of metabolism in the context of cancer has evolved greatly. It is now evident that altered cellular metabolism is an integral effector of tumorigenesis that is intricately intertwined with cell signaling as well as genetic and epigenetic regulation of diverse tumor programs. Recognizing the dysregulation of cellular metabolism as an important aspect of tumor function has offered new potential direction to seek clinical benefit by providing targets for the development of novel therapeutics. To-date, several small molecule inhibitors that target tumor or immune cell metabolism are being explored in active clinical trials as either preventive, stand-alone, or adjuvant therapies for various malignancies. Thus, identifying critical metabolic vulnerabilities in pre-neoplastic cells, cancer cells, and immune cells has direct and timely relevance for developing additional treatment and preventative strategies against cancer.
Download or read book Examining Metabolic Vulnerabilities for Cancer Therapy written by Alba Luengo and published by . This book was released on 2018 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic reprogramming is essential for cancer cells to balance energetics, maintain redox homeostasis, and synthesize biosynthetic precursors. Many chemotherapeutics that target metabolism are essential components of standard cancer treatment regimens, arguing that there is a therapeutic window to target the metabolic dependencies of cancer cells. However, the use of these drugs as cancer therapies was determined empirically, and rational approaches to directly target the metabolism of cancer cells, especially reprogrammed glucose metabolism, have proved challenging, in part because it is not well understood which metabolic processes are most important for cancer cell proliferation and survival. The goal of this dissertation is to explore metabolic pathways preferentially used by cancer cells in order to identify potential tumor dependencies that could be exploited for clinical benefit. We first determined that production of reactive byproducts is an indirect consequence of the altered glucose metabolism of cancer cells, which suggests that clinically targeting secondary effects of reprogrammed tumor metabolism could be an approach for designing novel cancer treatments. Next, we found that a molecular driver for the altered glucose metabolism of cancer cells is limited electron acceptor availability, suggesting that interventions that further restrict the oxidative capacity of tumors could also have anticancer efficacy. Finally, we interrogated the metabolic fluxes of breast cancers proliferating in different microenvironments and determined that tumors in the brain parenchyma display enhanced lipid biosynthesis, which could guide therapeutic strategies to treat cancer based on tumor site. Collectively, these studies contribute to an understanding of how the reprogrammed metabolism of cancer cells introduces targetable dependencies, with the aim of optimizing cancer therapies.
Download or read book Metabolite and Nutrient Transporters in Cancer Cell Metabolism Role in Cancer Progression and Metastasis written by Vadivel Ganapathy and published by Frontiers Media SA. This book was released on 2022-08-12 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Understanding mitochondrial dynamics and metabolic plasticity in cancer stem cells Recent advances in cancer treatment and potential therapeutic approaches written by Pramod Darvin and published by Frontiers Media SA. This book was released on 2023-06-02 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Tumor Microenvironment written by Jacinta Serpa and published by Springer Nature. This book was released on 2020-03-04 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: The way a cell undergoes malignant transformation should meet their capacity of surviving in the microenvironment of the organ where the cancer will develop. Metabolic adaptation is for sure one of the criteria that must be accomplished, driven by metabolic plasticity that allows the adaptation of cancer cells to the availability of energy and biomass sources that will sustain cell survival and proliferation. Each human organ has a particular microenvironment which depends on several cell types and in some cases also on symbiotic microorganisms. These biological partners are constantly sharing organic compounds and signaling molecules that will control mitogenesis, cell death and differentiation, accounting for the organ's function. Nevertheless, cancer cells are capable of taking advantage of this metabolic and signaling microenvironmental dynamics. In this book, we intend to present the different components of the microenvironment driving the metabolic fitness of cancer cells. The metabolic changes required for establishing a tumor in a given microenvironment and how these metabolic changes limit the response to drugs will generally be the major items addressed. It is important to mention not only aspects of the microenvironment that stimulate metabolic changes and that select better adapted tumor cells, but also how this regulation of cell plasticity is made. Thus, the signaling pathways that orchestrate and are orchestrated throughout this panoply of metabolic rearrangements will also be addressed in this book. The subjects will be presented from the conceptual point of view of the cross-cancer mechanisms and also particularizing some models that can be examples and enlightening within the different areas.
Download or read book Gene Therapy for Cancer written by Kelly K. Hunt and published by Springer Science & Business Media. This book was released on 2007-10-26 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.
Download or read book The Unfolded Protein Response in Cancer written by Robert Clarke and published by Springer. This book was released on 2019-03-01 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents state-of-the-art information on each of the arms of the unfolded protein response (UPR), how their activation/repression are regulated, integrated, and coordinated, how UPR components affect cancer cell biology and responsiveness to therapeutic interventions, and how UPR components/activities offer potentially novel targets for drug discovery, repurposing, and development. The volume will provide the most recent information on the signaling and regulation of the UPR, explore examples of how the UPR and/or specific components contribute to cancer biology, and identify and explore specific examples of potently new actionable targets for drug discovery and development from within the UPR and its regulation. Unique to the volume will be a specific focus on the UPR and its role in cancer biology, as well as a discussion of the role of the UPR in drug responses and resistance in cancer.
Download or read book Innovations for Next Generation Antibody Drug Conjugates written by Marc Damelin and published by Springer. This book was released on 2018-05-29 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.
Download or read book Multimodal Concepts for Integration of Cytotoxic Drugs written by Martin J. Brown and published by Springer Science & Business Media. This book was released on 2006-08-06 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first part of this book summarizes the rationale and the preclinical data for combined treatment with ionizing radiation and pharmaceutical agents. Individual chapters focus on forms of combined treatment, with due consideration being given to a range of drugs and to emerging combinations with small molecules and antibodies. The second part comprises a series of disease-specific chapters in which the clinical results of combined modality treatment are presented.
Download or read book Normal and Malignant Hematopoiesis written by Enrico Mihich and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: ''An exciting glance at key issues in contemporary hematopoiesis.'' -The Quarterly Review of Biology
Download or read book Special Issue on Innovative Multi Disciplinary Approaches for Precision Studies in Leukemia written by Xu Huang and published by Frontiers Media SA. This book was released on 2021-10-01 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Heat Shock Proteins in Cancer written by Stuart K. Calderwood and published by Springer Science & Business Media. This book was released on 2007-09-09 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.
Download or read book Clinical Handbook for the Management of Mood Disorders written by J. John Mann and published by Cambridge University Press. This book was released on 2013-05-09 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a one-stop evidence-based guide to the management of all types of mood disorders.
Download or read book Ionizing radiation reprograms tumor immune microenvironment by inducing immunogenic cell death written by Fei Yu and published by Frontiers Media SA. This book was released on 2023-09-25 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Juzen taiho to Shi Quan Da Bu Tang written by Haruki Yamada and published by CRC Press. This book was released on 2005-04-29 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kampo is a traditional Japanese herbal medicine that takes a holistic approach to healing. Since Kampo is currently being used for the treatment of a wide range of diseases with many reports of clinical effectiveness, it is playing an increasingly important role in Japan's modern-day health care. Juzen-taiho-to (Shi-Quan-Da-Bu-Tang): Scientific Evaluation and Clinical Applications presents a concise overview of the important Kampo formula of Juzen-taiho-to. The book describes the therapeutic indications and traditional uses of Juzen-taiho-to, followed by its taxonomy, cultivation, quality assurance, and chemical constituents and pharmacological actions of raw plant material as the component herbs. Experts in the field discuss up-to-date findings and topics associated with the pharmacology and clinical application of Juzen-taiho-to, including its important immunomodulating, anti-tumor, and anti-metastatic properties, toxicology and side effects, and other related formulations. Today, Kampo medicine is steadily gaining acceptance by Japan's national health insurance system, the medical community, and contemporary society. This book provides a comprehensive review of Juzen-taiho-to and demonstrates how Kampo and other herbal medicines are becoming the popular, practical, and preferred treatments of tomorrow.
Download or read book Anticancer Treatments and Cardiotoxicity written by Patrizio Lancellotti and published by Academic Press. This book was released on 2016-11-11 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anticancer Treatments and Cardiotoxicity: Mechanisms, Diagnostic and Therapeutic Interventions presents cutting edge research on the adverse cardiac effects of both radiotherapy and chemotherapy, brought together by leaders in the field. Cancer treatment-related cardiotoxicity is the leading cause of treatment-associated mortality in cancer survivors and is one of the most common post-treatment issues among survivors of adult cancer. Early detection of the patients prone to developing cardiotoxicity, taking in to account the type of treatment, history and other risk factors, is essential in the fight to decrease cardiotoxic mortality. This illustrated reference describes the most effective diagnostic and imaging tools to evaluate and predict the development of cardiac dysfunction for those patients undergoing cancer treatment. In addition, new guidelines on imaging for the screening and monitoring of these patients are also presented. Anticancer Treatments and Cardiotoxicity is an essential reference for those involved in the research and treatment of cardiovascular toxicity. Provides algorithms essential for the use of imaging, and biomarkers for the screening and monitoring of patients Written by world-leading experts in the field of cardiotoxicity Includes high-quality images, case studies, and test questions Describes the most effective diagnostic and imaging tools to evaluate and predict the development of cardiac dysfunction for those patients undergoing cancer treatment
Download or read book Principles and Practice of College Health written by John A. Vaughn and published by Springer Nature. This book was released on 2020-12-04 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique and comprehensive title offers state-of-the-art guidance on all of the clinical principles and practices needed in providing optimal health and well-being services for college students. Designed for college health professionals and administrators, this highly practical title is comprised of 24 chapters organized in three sections: Common Clinical Problems in College Health, Organizational and Administrative Considerations for College Health, and Population and Public Health Management on a College Campus. Section I topics include travel health services, tuberculosis, eating disorders in college health, and attention deficit hyperactivity disorder among college students, along with several other chapters. Subsequent chapters in Section II then delve into topics such as supporting the health and well-being of a diverse student population, student veterans, health science students, student safety in the clinical setting, and campus management of infectious disease outbreaks, among other topics. The book concludes with organizational considerations such as unique issues in the practice of medicine in the institutional context, situating healthcare within the broader context of wellness on campus, organizational structures of student health, funding student health services, and delivery of innovative healthcare services in college health. Developed by a renowned, multidisciplinary authorship of leaders in college health theory and practice, and coinciding with the founding of the American College Health Association 100 years ago, Principles and Practice of College Health will be of great interest to college health and well-being professionals as well as college administrators.
