Download or read book Tumor Suppressor Par 4 written by Vivek M. Rangnekar and published by Springer Nature. This book was released on 2022-01-01 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Par-4 is a naturally occurring tumor suppressor. Studies have indicated that overexpression of Par-4 selectively induces apoptosis in cancer cells while leaving normal, health, cells unaffected. Mechanisms contributing to this cancer-selective action of Par-4 have been associated with PKA activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. On the other hand, endogenous Par-4 sensitizes cells to the action of a broad range of apoptotic inducers acting via the extrinsic and intrinsic pathways. A number of binding partners of Par-4 have been identified and shown to regulate Par-4 function in cancer and other diseases, such as Alzheimer’s and major depression. Recent studies have recognized a number of natural products, dietary supplements, synthetic molecules and FDA-approved drugs that induce the secretion of Par-4 protein to cause apoptosis in primary or metastatic tumors, one of which is in clinical trials. More than 50 different laboratories worldwide are involved in Par-4 based research of this unique protein that has progressed from the bench to clinical trials. This second, companion volume will provide a comprehensive overview of Par-4’s role in cancer and other diseases. Chapters are written by leading researchers, and will be useful for a broad audience across the scientific community, particularly students and trainees, who are the next generation of scientists and clinicians to participate in new studies and discoveries on Par-4.
Download or read book Tumor Suppressor Par 4 written by Vivek M. Rangnekar and published by Springer Nature. This book was released on 2022-01-08 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Par-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar’s laboratory in prostate cancer cells undergoing apoptosis. Par-4 (later also known as PAWR) is a naturally occurring tumor suppressor. Studies have indicated that Par-4 selectively induces apoptosis in cancer cells while leaving normal, healthy, cells unaffected. Mechanisms contributing to the cancer-selective action of Par-4 have been associated with protein kinase A activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. Par-4 is downregulated, inactivated or mutated in diverse cancers. This first of two volumes will be the first on the market on the topic of Par-4, and will provide the opportunity for researchers to discuss the future direction of studies, broaden the scope of research, and contribute a more complete understanding of the molecule’s structural features, key functional domains, regulation and relevant basic and clinical/translational facets.
Download or read book The Tumor Suppressor Par 4 Regulates Hypertrophic Obesity written by Nathalia Araujo and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Novel Role for the Tumor suppressor Par 4 in Regulation of Adipogenesis and Obesity written by James Sledziona and published by . This book was released on 2018 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Investigating the Function and Regulation of Prostate Apoptosis Response 4 in Cancer written by Jeffrey Nguyen and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is a disease where normal cells proliferate uncontrollably, which can ultimately lead to significant morbidity and death. The aggressiveness and mortality of cancers vary by type: certain cancers respond well to treatment, such as pediatric leukemias, whereas pancreatic cancer and glioblastoma have a high mortality and low five-year survival. In an effort to improve current cancer therapies, I focus on elucidating the function and regulation of prostate apoptosis response-4 (Par-4) in various cancers. Par-4 is a tumor-suppressor that has been shown to induce cancer cell selective apoptosis and to sensitize cancer cells to apoptotic stimuli, such as chemotherapeutics and radiation, and therefore has therapeutic potential. In the first part of this work, I focused on studying the effect of Par-4 on cell migration, invasion, and the epithelial-mesenchymal transition in colon cancer cells. I found that ectopic expression of Par-4 inhibited both cell migration and cell invasion, while knocking down Par-4 promoted cell migration in SW480 and SW620 colon cancer cells. In addition, I found that Par-4 overexpression appeared to induce a mesenchymal-epithelial transition in SW620 cells. In the second part of this work, I sought to identify novel regulators of Par-4 and elucidate the mechanism of regulation. I identified Trim21 as a novel binding partner in colon cancer cells, and show that Trim21 overexpression in the presence of cisplatin downregulates Par-4 in colon and pancreatic cancer cell lines, and show that modulating levels of Trim21 and Par-4 affects the sensitivity of cancer cells to cisplatin. Finally, I demonstrate that Trim21 mRNA levels correlate with survival in pancreatic cancer patients, with lower Trim21 levels correlating with increased overall survival and disease-free survival and high Trim21 levels correlating with reduced disease-free survival. In the third part of this work, I sought to determine whether Par-4 could enhance the effectiveness of chemotherapeutics and small molecule drugs. I chose to focus on glioma due to the lack of effective therapeutics. I show that ectopic Par-4 expression alone is sufficient to reduce cell viability and to induce apoptosis in glioma cell lines, A172 and SNB19. Furthermore, I demonstrate that Par-4 transfected glioma cells are sensitized to 5-fluorouracil and ISC-4. Taken together, the results presented in this dissertation suggest novel roles and regulatory mechanisms of Par-4 in cancer, and provide rationale for its use in cancer treatment; as well as suggesting a novel prognostic marker for pancreatic cancer.
Download or read book TRAIL Fas Ligand TNF and TLR3 in Cancer written by Olivier Micheau and published by Springer. This book was released on 2017-07-03 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides the current understanding of death receptor's/TLR3 signaling regulation in cancer. Death receptors, including TRAIL-R1, TRAIL-R2, Fas and TNF-RI, owing to their ability to trigger apoptosis and to contribute to the elimination of cancer cells by the immune system have been considered, to variable extent, as important therapeutic targets for cancer therapy. But an increasing body of evidence suggests that some of these receptors may also contribute to tumorigenesis, or that new players such as TLR3 may be targeted for cancer therapy due to their ability to behave like death receptors.
Download or read book Investigation Into the Role of the Par 4 Tumor Suppressor Pathway in B Cell Biology and Chronic Lymphocytic Leukemia written by Joseph Thomas Greene and published by . This book was released on 2018 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Eμ-TCL1 mouse is a B cell leukemia model commonly used to test the efficacy of experimental therapeutics and interrogate the functions of oncogenes and tumor suppressors. The CLL-like disease in this mouse shares similar pathology and molecular etiology with the human variant. We therefore hypothesized that overexpression of the human isoform of Par-4 in the B cells of this mouse would impede disease progression through either an anti-proliferative or pro-apoptotic mechanism. Consistent with this hypothesis, results indicated that B cell-specific overexpression of human Par-4 reduced the rate of T Cell Leukemia/Lymphoma 1 (TCL1)-induced leukemogenesis. In addition, B cell-specific knockout of endogenous Par-4 increased the rate of TCL1-induced leukemogenesis. Par-4 activity is regulated through a variety of mechanisms, which seem to give it a pleiotropic property. It is generally thought to act as either an anti-proliferative or pro-apoptotic tumor suppressor. In our study, TCL1 mice overexpressing human Par-4 were found to harbor malignant B cell clones that proliferated at reduced rates when compared to their Par-4 wild-type (WT) littermates. This indicated that Par-4 was reducing the expansion of overexpressing cells; which we found interesting, because Par-4 overexpressing mice null for the TCL1 oncogene exhibited no phenotype when examined in various immune response assays.
Download or read book Innovative Medicine written by Kazuwa Nakao and published by Springer. This book was released on 2015-10-13 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.
Download or read book Anticancer Genes written by Stefan Grimm and published by Springer. This book was released on 2014-07-08 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the emergence of a new class of genes with a specific anticancer activity. These genes, recently defined as “Anticancer Genes”, are reviewed in individual chapters on their mode of action, the specific cell death signals they induce, and the status of attempts to translate them into clinical application. Anticancer Genes provides an overview of this nascent field, its genesis, current state, and prospect. It discusses how Anticancer Genes might lead to the identification of a repertoire of signaling pathways directed against cellular alterations that are specific for tumor cells. With contributions from experts worldwide, Anticancer Genes is an essential guide to this dynamic topic for researchers and students in cancer research, molecular medicine, pharmacology and toxicology and genetics as well as clinicians and clinical researchers interested in the therapeutic potential of this exciting new field.
Download or read book Tumor Suppressor Genes in Human Cancer written by David E. Fisher and published by Springer Science & Business Media. This book was released on 2000-10-26 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.
Download or read book Double edged swords Important factors connecting metabolic disorders and cancer development from basic research to translational applications written by Che-Pei Kung and published by Frontiers Media SA. This book was released on 2023-04-04 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Tumor Suppressor Proteins Advances in Research and Application 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor Suppressor Proteins: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Tumor Suppressor Proteins in a compact format. The editors have built Tumor Suppressor Proteins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Tumor Suppressor Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Tumor Suppressor Proteins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Signal Transduction in Cancer written by David A. Frank and published by Springer Science & Business Media. This book was released on 2002-12-31 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."
Download or read book Modulation of the Tumor Suppressor Programmed Cell Death 4 by the Protein Arginine Methyl Transferase 5 written by Matthew A. Powers and published by . This book was released on 2010 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Tumor Suppressors written by John W. Ludlow and published by R. G. Landes. This book was released on 1994 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Amazing World of IDPs in Human Diseases written by Simona Maria Monti and published by . This book was released on 2021 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is now clearly established that some proteins or protein regions are devoid of any stable secondary and/or tertiary structure under physiological conditions, but still possess fundamental biological functions. These intrinsically disordered proteins (IDPs) or regions (IDRs) have peculiar features due to their plasticity such as the capacity to bind their biological targets with high specificity and low affinity, and the possibility of interaction with numerous partners. A correlation between intrinsic disorder and various human diseases such as cancer, diabetes, amyloidoses and neurodegenerative diseases is now evident, highlighting the great importance of the topic. In this volume, we have collected recent high-quality research about IDPs and human diseases. We have selected nine papers which deal with a wide range of topics, from neurodegenerative disease to cancer, from IDR-mediated interactions to bioinformatics tools, all related to IDP peculiar features. Recent advances in the IDPs/IDRs issue are here presented, contributing to the progress of knowledge of the intrinsic disorder field in human disease.
Download or read book Context dependent Modulation of the Tumor Suppressor Programmed Cell Death 4 PDCD4 by Arginine Methylation written by Marta Marie Fay and published by . This book was released on 2013 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
