Download or read book Natural Products in Clinical Trials written by Atta-ur- Rahman and published by Bentham Science Publishers. This book was released on 2018-03-03 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural products continue to play a key role in drug development. A recent analysis of the drug market in the developed world revealed that 40% of total clinically approved drugs were either unmodified natural products or their semi-synthetic derivatives. This book series focuses on reviews of exciting new bioactive natural products that have huge potential as drugs. It highlights the everlasting importance of natural products in our lives. Each volume brings reviews contributed by eminent scientists in the field. The first volume covers the following topics: - bioactive compounds from marine invertebrates - natural product derived drugs for immunological and inflammatory diseases - clinical trials of curcumin, camptothecin, astaxanthin, and biochanin - antibacterial and antifungal drugs from natural sources - natural products as anti-HIV medicines.
Download or read book Trying Leviathan written by D. Graham Burnett and published by Princeton University Press. This book was released on 2010-01-04 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Moby-Dick, Ishmael declares, "Be it known that, waiving all argument, I take the good old fashioned ground that a whale is a fish, and call upon holy Jonah to back me." Few readers today know just how much argument Ishmael is waiving aside. In fact, Melville's antihero here takes sides in one of the great controversies of the early nineteenth century--one that ultimately had to be resolved in the courts of New York City. In Trying Leviathan, D. Graham Burnett recovers the strange story of Maurice v. Judd, an 1818 trial that pitted the new sciences of taxonomy against the then-popular--and biblically sanctioned--view that the whale was a fish. The immediate dispute was mundane: whether whale oil was fish oil and therefore subject to state inspection. But the trial fueled a sensational public debate in which nothing less than the order of nature--and how we know it--was at stake. Burnett vividly recreates the trial, during which a parade of experts--pea-coated whalemen, pompous philosophers, Jacobin lawyers--took the witness stand, brandishing books, drawings, and anatomical reports, and telling tall tales from whaling voyages. Falling in the middle of the century between Linnaeus and Darwin, the trial dramatized a revolutionary period that saw radical transformations in the understanding of the natural world. Out went comfortable biblical categories, and in came new sorting methods based on the minutiae of interior anatomy--and louche details about the sexual behaviors of God's creatures. When leviathan breached in New York in 1818, this strange beast churned both the natural and social orders--and not everyone would survive.
Download or read book Clinical Trials written by Stuart J. Pocock and published by John Wiley & Sons. This book was released on 2013-07-17 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive, unified text on the principles and practice of clinical trials presents a detailed account of how to conduct the trials. It describes the design, analysis, and interpretation of clinical trials in a non-technical manner and provides a general perspective on their historical development, current status, and future strategy. Features examples derived from the author's personal experience.
Download or read book A Fever in Salem written by Laurie M. Carlson and published by Ivan R. Dee Publisher. This book was released on 1999 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Laurie Winn Carlson offers an innovative explanation for the madness behind the Salem Witch Trials.
Download or read book Some Famous Medical Trials written by Leonard A. Parry and published by Beard Books. This book was released on 2000-09 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Clinical Trials written by Steven Piantadosi and published by John Wiley & Sons. This book was released on 2017-10-09 with total page 918 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents elements of clinical trial methods that are essential in planning, designing, conducting, analyzing, and interpreting clinical trials with the goal of improving the evidence derived from these important studies This Third Edition builds on the text’s reputation as a straightforward, detailed, and authoritative presentation of quantitative methods for clinical trials. Readers will encounter the principles of design for various types of clinical trials, and are then skillfully guided through the complete process of planning the experiment, assembling a study cohort, assessing data, and reporting results. Throughout the process, the author alerts readers to problems that may arise during the course of the trial and provides common sense solutions. All stages of therapeutic development are discussed in detail, and the methods are not restricted to a single clinical application area. The authors bases current revisions and updates on his own experience, classroom instruction, and feedback from teachers and medical and statistical professionals involved in clinical trials. The Third Edition greatly expands its coverage, ranging from statistical principles to new and provocative topics, including alternative medicine and ethics, middle development, comparative studies, and adaptive designs. At the same time, it offers more pragmatic advice for issues such as selecting outcomes, sample size, analysis, reporting, and handling allegations of misconduct. Readers familiar with the First and Second Editions will discover revamped exercise sets; an updated and extensive reference section; new material on endpoints and the developmental pipeline, among others; and revisions of numerous sections. In addition, this book: • Features accessible and broad coverage of statistical design methods—the crucial building blocks of clinical trials and medical research -- now complete with new chapters on overall development, middle development, comparative studies, and adaptive designs • Teaches readers to design clinical trials that produce valid qualitative results backed by rigorous statistical methods • Contains an introduction and summary in each chapter to reinforce key points • Includes discussion questions to stimulate critical thinking and help readers understand how they can apply their newfound knowledge • Provides extensive references to direct readers to the most recent literature, and there are numerous new or revised exercises throughout the book Clinical Trials: A Methodologic Perspective, Third Edition is a textbook accessible to advanced undergraduate students in the quantitative sciences, graduate students in public health and the life sciences, physicians training in clinical research methods, and biostatisticians and epidemiologists. This book is accompanied by downloadable files available below under the DOWNLOADS tab. These files include: MATHEMATICA program – A set of downloadable files that tracks the chapters, containing code pertaining to each. SAS PROGRAMS and DATA FILES used in the book. The following software programs, included in the downloadables, were developed by the author, Steven Piantadosi, M.D., Ph.D: RANDOMIZATION – This program generates treatment assignments for a clinical trial using blocked stratified randomization. CRM – Implements the continual reassessment methods for dose finding clinical trials. OPTIMAL – Calculates two-stage optimal phase II designs using the Simon method. POWER – This is a power and sample size program for clinical trials. Executables for installing these programs can also be found at https://risccweb.csmc.edu/biostats/. Steven Piantadosi, MD, PhD, is the Phase One Foundation Distinguished Chair and Director of the Samuel Oschin Cancer Institute, and Professor of Medicine at Cedars-Sinai Medical Center in Los Angeles, California. Dr. Piantadosi is one of the world’s leading experts in the design and analysis of clinical trials for cancer research. He has taught clinical trials methods extensively in formal courses and short venues. He has advised numerous academic programs and collaborations nationally regarding clinical trial design and conduct, and has served on external advisory boards for the National Institutes of Health and other prominent cancer programs and centers. The author of more than 260 peer-reviewed scientific articles, Dr. Piantadosi has published extensively on research results, clinical applications, and trial methodology. While his papers have contributed to many areas of oncology, he has also collaborated on diverse studies outside oncology including lung disease and degenerative neurological disease.
Download or read book The Biologist s Imagination written by William Hoffman and published by Oxford University Press, USA. This book was released on 2014 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Scholars and policymakers alike agree that innovation in the biosciences is key to future growth. The field continues to shift and expand, and it is certainly changing the way people live their lives in a variety of ways. But despite the lion's share offederal research dollars being devoted to innovation in the biosciences, the field has yet to live up to its billing as a source of economic productivity and growth. With vast untapped potential to imagine and innovate in the biosciences, adaptation of the innovative model is needed. In The Biologist's Imagination, William Hoffman and Leo Furcht examine the history of innovation in the biosciences, tracing technological innovation from the late eighteenth century to the present and placing special emphasis on how and where technology evolves. Place is key to innovation, from the early industrial age to the rise of the biotechnology industry in the second half of the twentieth century. The book uses the distinct history of bioscientific innovation to discuss current trends as they relate to medicine, agriculture, biofuels, stem-cell research, neuroscience, and more. Ultimately, Hoffman and Furcht argue that, as things currently stand, we fall short in our efforts to innovate in the biosciences; our system of innovation is itself in need of innovation. It needs to adapt to the massive changes brought about by converging technologies, globalization in higher education as well as in finance, and increases in entrepreneurship. The Biologist's Imagination is both an analysis of past models for bioscience innovation and a forward-looking, original argument for how future models should be developed"--
Download or read book The Poison Trials written by Alisha Rankin and published by University of Chicago Press. This book was released on 2021-01-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1524, Pope Clement VII gave two condemned criminals to his physician to test a promising new antidote. After each convict ate a marzipan cake poisoned with deadly aconite, one of them received the antidote, and lived—the other died in agony. In sixteenth-century Europe, this and more than a dozen other accounts of poison trials were committed to writing. Alisha Rankin tells their little-known story. At a time when poison was widely feared, the urgent need for effective cures provoked intense excitement about new drugs. As doctors created, performed, and evaluated poison trials, they devoted careful attention to method, wrote detailed experimental reports, and engaged with the problem of using human subjects for fatal tests. In reconstructing this history, Rankin reveals how the antidote trials generated extensive engagement with “experimental thinking” long before the great experimental boom of the seventeenth century and investigates how competition with lower-class healers spurred on this trend. The Poison Trials sheds welcome and timely light on the intertwined nature of medical innovations, professional rivalries, and political power.
Download or read book Reports and Documents written by United States. Congress and published by . This book was released on with total page 1974 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Bioactive Natural Products written by Steven M. Colegate and published by CRC Press. This book was released on 2007-12-14 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioactive natural products are proving to be a rich source of novel therapeutics to both protect against and combat diseases, as well as serve as lead compounds in crop protection. Following the successful format of the first edition, this volume brings together collective research from many new contributors and emphasizes the rationale behind the
Download or read book Agricultural News written by and published by . This book was released on 1912 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Learning Theory written by Nader Bshouty and published by Springer. This book was released on 2007-06-12 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 20th Annual Conference on Learning Theory, COLT 2007, held in San Diego, CA, USA in June 2007. It covers unsupervised, semisupervised and active learning, statistical learning theory, inductive inference, regularized learning, kernel methods, SVM, online and reinforcement learning, learning algorithms and limitations on learning, dimensionality reduction, as well as open problems.
Download or read book The Trials of Life A Natural History of Animal Behaviour written by David Attenborough and published by HarperCollins UK. This book was released on 2022-11-10 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third and final updated edition of David Attenborough’s classic Life trilogy. Life on Earth covered evolution, Living Planet , ecology, and now The Trials of Life tackles ethology, the study of how animals behave.
Download or read book Engineering written by and published by . This book was released on 1877 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Annual Report of the Director of the Administrative Office of the United States Courts written by United States. Administrative Office of the United States Courts and published by . This book was released on 1975 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chemistry of Natural Products written by K. Anand Solomon and published by MJP Publisher. This book was released on 2019-06-11 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural products, i.e., products from Nature, be it of plant or animal origin, plays a major role in human life. Hence their isolation and characterization of natural products will help in understanding their mode of action with reference to their biological and pharmacological activity. The book has been written with a view that it would help both students and researchers who are in their initial stages of exploration in the field of Natural product chemistry.The importance of natural products, techniques for the analysis,interpretation of the data and finally its role in health care has been dealt with. With the voluminous information available on each such topic, only the basic aspect, hopefully to elicit interest in further exploration has been discussed.
