Download or read book Clinical and Translational Science written by David Robertson and published by Academic Press. This book was released on 2016-11-25 with total page 812 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical and Translational Science: Principles of Human Research, Second Edition, is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science. Introduces novel physiological and therapeutic strategies for engaging the fastest growing scientific field in both the private sector and academic medicine Brings insights from international leaders into the discipline of clinical and translational science Addresses drug discovery, drug repurposing and development, innovative and improved approaches to go/no-go decisions in drug development, and traditional and innovative clinical trial designs

Download or read book Principles of Translational Science in Medicine written by Martin Wehling and published by Academic Press. This book was released on 2015-04-02 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine. Provides an in-depth description of novel tools for the assessment of translatability of trials to balance risk and improve projects at any given stage of product development New chapters deal with translational issues in the fastest growing population (the elderly), case studies, translatability assessment tools, and advances in nanotherapies Details IPR issues of translation, especially for public-private-partnerships Contains contributions from world leaders in translational medicine, including the former NIH director and authorities from various European regulatory institutions

Download or read book Translational Research in Traumatic Brain Injury written by Daniel Laskowitz and published by CRC Press. This book was released on 2016-04-21 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme

Download or read book The CTSA Program at NIH written by Institute of Medicine and published by National Academies Press. This book was released on 2013-10-09 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2006 the National Institutes of Health (NIH) established the Clinical and Translational Science Awards (CTSA) Program, recognizing the need for a new impetus to encourage clinical and translational research. At the time it was very difficult to translate basic and clinical research into clinical and community practice; making it difficult for individual patients and communities to receive its benefits. Since its creation the CTSA Program has expanded, with 61 sites spread across the nation's academic health centers and other institutions, hoping to provide catalysts and test beds for policies and practices that can benefit clinical and translation research organizations throughout the country. The NIH contracted with the Institute of Medicine (IOM) in 2012 to conduct a study to assess and provide recommendations on appropriateness of the CTSA Program's mission and strategic goals and whether changes were needed. The study was also address the implementation of the program by the National Center for Advancing Translational Sciences (NCATS) while exploring the CTSA's contributions in the acceleration of the development of new therapeutics. A 13-member committee was established to head this task; the committee had collective expertise in community outreach and engagement, public health and health policy, bioethics, education and training, pharmaceutical research and development, program evaluation, clinical and biomedical research, and child health research. The CTSA Program at NIH: Opportunities for Advancing Clinical and Translational Research is the result of investigations into previous program evaluations and assessments, open-session meetings and conference class, and the review of scientific literature. Overall, the committee believes that the CTSA Program is significant to the advancement of clinical and translational research through its contributions. The Program would benefit from a variety of revisions, however, to make it more efficient and effective.

Download or read book Translational Pain Research written by Lawrence Kruger and published by CRC Press. This book was released on 2009-11-24 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practical

Download or read book Research for the Public Good written by Elaine Wethington and published by Amer Psychological Assn. This book was released on 2012 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational research links scientific findings with programs and policies that improve human health and well-being. It includes research that evaluates interventions or policies for efficacy and effectiveness, as well as research that applies field experience to future development of basic theory and its applications. Although translational research has traditionally emphasised biomedical studies with one type of application (i.e., individual-level intervention to treat disease), the concept has expanded to include various sciences and many types of applications. Social and behavioural sciences now often contribute to public- and individual-level interventions that promote education, disease prevention, health care delivery, health care access, and more. This broader, more inclusive approach to translational research has gained popularity and been promoted by the National Institutes of Health, the Centers for Disease Control, medical centers, and university programs. This book demonstrates how emerging methods of translational research can be applied to important topics of interest to social and behavioural scientists. Accessible models and real-world case studies are provided to help bridge the gaps among research, policy, and practice.

Download or read book Translational Research in Breast Cancer written by Dong-Young Noh and published by Springer Nature. This book was released on 2021-05-13 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes recent advances in translational research in breast cancer and presents emerging applications of this research that promise to have meaningful impacts on diagnosis and treatment. It introduces ideas and materials derived from the clinic that have been brought to "the bench" for basic research, as well as findings that have been applied back to "the bedside". Detailed attention is devoted to breast cancer biology and cell signaling pathways and to cancer stem cell and tumor heterogeneity in breast cancer. Various patient-derived research models are discussed, and a further focus is the role of biomarkers in precision medicine for breast cancer patients. Next-generation clinical research receives detailed attention, addressing the increasingly important role of big data in breast cancer research and a wide range of other emerging developments. An entire section is also devoted to the management of women with high-risk breast cancer. Translational Research in Breast Cancer will help clinicians and scientists to optimize their collaboration in order to achieve the common goal of conquering breast cancer.

Download or read book The Journal of Laboratory and Clinical Medicine written by and published by . This book was released on 1920 with total page 836 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Translational Research in Coronary Artery Disease written by Wilbert S. Aronow and published by Academic Press. This book was released on 2015-10-29 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Research in Coronary Artery Disease: Pathophysiology to Treatment covers the entire spectrum of basic science, genetics, drug treatment, and interventions for coronary artery disease. With an emphasis on vascular biology, this reference fully explains the fundamental aspects of coronary artery disease pathophysiology. Included are important topics, including endothelial function, endothelial injury, and endothelial repair in various disease states, vascular smooth muscle function and its interaction with the endothelium, and the interrelationship between inflammatory biology and vascular function. By providing this synthesis of current research literature, this reference allows the cardiovascular scientist and practitioner to access everything they need from one source. - Provides a concise summary of recent developments in coronary and vascular research, including previously unpublished data - Summarizes in-depth discussions of the pathobiology and novel treatment strategies for coronary artery disease - Provides access to an accompanying website that contains photos and videos of noninvasive diagnostic modalities for evaluation of coronary artery disease

Download or read book Translational Research and Onco Omics Applications in the Era of Cancer Personal Genomics written by Erika Ruiz-Garcia and published by Springer Nature. This book was released on 2019-11-11 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: Being a complex disease that affects millions of people world over, cancer research has assumed great significance. Translational cancer research transforms scientific discoveries in the laboratory into clinical application to reduce incidence of cancer, morbidity and mortality. On the other hand, personalized medicine in cancer is the concept that selection of a treatment should be tailored according to the individual patient’s specific genomic characteristics, including mutations, chromosomal aberrations, protein interactions, and SNPs, and even more, taking into account the inmume system, the metabolism and maybe in the next future also the microbiome.

Download or read book Translational Regenerative Medicine written by Anthony Atala and published by Academic Press. This book was released on 2014-12-01 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Regenerative Medicine is a reference book that outlines the life cycle for effective implementation of discoveries in the dynamic field of regenerative medicine. By addressing science, technology, development, regulatory, manufacturing, intellectual property, investment, financial, and clinical aspects of the field, this work takes a holistic look at the translation of science and disseminates knowledge for practical use of regenerative medicine tools, therapeutics, and diagnostics. Incorporating contributions from leaders in the fields of translational science across academia, industry, and government, this book establishes a more fluid transition for rapid translation of research to enhance human health and well-being. Provides formulaic coverage of the landscape, process development, manufacturing, challenges, evaluation, and regulatory aspects of the most promising regenerative medicine clinical applications Covers clinical aspects of regenerative medicine related to skin, cartilage, tendons, ligaments, joints, bone, fat, muscle, vascular system, hematopoietic /immune system, peripheral nerve, central nervous system, endocrine system, ophthalmic system, auditory system, oral system, respiratory system, cardiac system, renal system, hepatic system, gastrointestinal system, genitourinary system Identifies effective, proven tools and metrics to identify and pursue clinical and commercial regenerative medicine

Download or read book From Auto to Allotransplantation written by F.-C. Wei and published by Karger Medical and Scientific Publishers. This book was released on 2016-06-28 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique publication was written by experts who have made significant contributions to the development of reconstructive microsurgery and vascularized composite allotransplantation and are likely to shape its future. The book is divided into three major sections. The first presents the state-of-the-art of autologous microsurgical reconstruction. It summarizes current achievements, highlights the shortcomings of currently available techniques, and prepares the reader for the next evolutionary step: allotransplantation. Section two is a comprehensive review of allotransplantation, from immunology to surgical techniques. Finally, for those interested in establishing a comprehensive center for vascularized composite allotransplantation, section three provides important lessons from the successful Chang Gung Vascularized Composite Allotransplantation Center. From Auto- to Allotransplantation is indeed the only up-to-date and complete reference available on the topic. Scholars and research fellows interested in transplantation will benefit greatly from this work. It is also an invaluable resource for plastic, orthopedic, hand, ENT, oromaxillofacial, and general surgeons as well as for residents.

Download or read book Shockwave Medicine written by C.-J. Wang and published by Karger Medical and Scientific Publishers. This book was released on 2018-04-05 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference work provides a detailed overview of shockwave therapy, a relatively new clinical specialty in modern medicine. It follows the evolution of Extracorporeal Shockwave Therapy (ESWT) from its initial stage as the gold standard for the disintegration of kidney stones to its regenerative effects in biological tissues. Starting with the basic principles of shockwave treatment, the book goes on to review its application in musculoskeletal disorders, including osteonecrosis of the hip, tendinopathy, fracture treatment, and treatment of sports related injuries. The application of ESWT in cardiovascular diseases is discussed. This includes preclinical and clinical applications for ischemic cardiovascular disease and effects on angiogenesis and anti-inflammation-molecular-cellular signaling pathways. The treatment of urinary diseases and erectile dysfunction by ESWT is elaborated. The book concludes with a discussion of future prospects of the shockwave therapy. Scholars and research fellows interested in shockwave medicine will benefit greatly from this work. It is also a useful clinical resource for nephrologists, urologists, cardiologists, and orthopedists.

Download or read book Pharmaceutical Medicine and Translational Clinical Research written by Divya Vohora and published by Academic Press. This book was released on 2017-11-14 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceutical Medicine and Translational Clinical Research covers clinical testing of medicines and the translation of pharmaceutical drug research into new medicines, also focusing on the need to understand the safety profile of medicine and the benefit-risk balance. Pharmacoeconomics and the social impact of healthcare on patients and public health are also featured. It is written in a clear and straightforward manner to enable rapid review and assimilation of complex information and contains reader-friendly features.As a greater understanding of these aspects is critical for students in the areas of pharmaceutical medicine, clinical research, pharmacology and pharmacy, as well as professionals working in the pharmaceutical industry, this book is an ideal resource. Includes detailed coverage of current trends and key topics in pharmaceutical medicine, including biosimilars, biobetters, super generics, and Provides a comprehensive look at current and important aspects of the science and regulation of drug and biologics discovery

Download or read book The Comprehensive Cancer Center written by Mahmoud Aljurf and published by Springer Nature. This book was released on 2021-10-28 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book provides a valuable resource for hospitals, institutions, and health authorities worldwide in their plans to set up and develop comprehensive cancer care centers. The development and implementation of a comprehensive cancer program allows for a systematic approach to evidence-based strategies of prevention, early detection, diagnosis, treatment, and palliation. Comprehensive cancer programs also provide a nexus for the running of clinical trials and implementation of novel cancer therapies with the overall aim of optimizing comprehensive and holistic care of cancer patients and providing them with the best opportunity to improve quality of life and overall survival. This book's self-contained chapter format aims to reinforce the critical importance of comprehensive cancer care centers while providing a practical guide for the essential components needed to achieve them, such as operational considerations, guidelines for best clinical inpatient and outpatient care, and research and quality management structures. Intended to be wide-ranging and applicable at a global level for both high and low income countries, this book is also instructive for regions with limited resources. The Comprehensive Cancer Center: Development, Integration, and Implementation is an essential resource for oncology physicians including hematologists, medical oncologists, radiation oncologists, surgical oncologists, and oncology nurses as well as hospitals, health departments, university authorities, governments and legislators.

Download or read book Translational Neuroimaging written by Robert A. McArthur and published by Academic Press. This book was released on 2012-10-26 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers methodical issues in human and animal neuroimaging translational research as well as detailed applied examples of the use of neuroimaging in neuropsychiatric disorders and the development of drugs for their treatment. Offering an accompanying website with illustrations and text available for further knowledge and presentations, Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment appeals to non-clinical and clinical neuroscientists working in and studying neuropsychiatric disorders and their treatment as well as providing the novice researcher or researcher outside of his/her expertise the opportunity to understand the background of translational research and the use of imaging in this field. Provides a background to translational research and the use of brain imaging in neuropsychiatric disorders.

Download or read book Progress in Molecular Biology and Translational Science written by David B. Teplow and published by Academic Press. This book was released on 2018-10-16 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Molecular Biology and Translational Science, Volume 159, provides the most topical, informative and exciting monographs available on a wide variety of research topics related to prions, viruses, bacteria and eukaryotes. The series includes in-depth knowledge on molecular biological aspects of organismal physiology, along with insights on how this knowledge may be applied to understand and ameliorate human disease. New chapters in this release discuss timely topics, such as Targeting recently deorphanized GPR83 for the treatment of infection, stress, and drug addiction, Arrestin Structure-Function, Arrestins in the Cardiovascular System, Analysis of biased agonism, and more. - Includes comprehensive coverage of molecular biology - Presents ample use of tables, diagrams, schemata, and color figures to enhance the reader's ability to rapidly grasp the information provided - Contains contributions from renowned experts in the field