Download or read book Transcriptional Regulation of Metabolic Genes by the Basic Leucine Zipper Transcription Factor Hac1ip and Nutrient Stimuli written by Vipulkumar Mohanlal Parmar and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Saccharomyces cerevisiae cells respond to nutrients in their environment by altering their metabolic and transcriptional state in order to optimise the use of available nutrients and decide which of the several developmental pathways to pursue. In the yeast S. cerevisiae, meiosis and pseudohyphal growth are two major differentiation outcomes in response to nitrogen starvation. A central component of unfolded protein response pathway, the bZIP transcription factor Hac1ip, negatively regulates meiosis and pseudohyphal growth. The present study investigates this negative regulatory mechanism at early meiotic genes by Hac1ip in nitrogen-rich conditions. Regulation of transcription by Ume6p transcriptional regulator, Rpd3p-Sin3p histone deacetylase complex and Isw2p-Itc1p chromatin remodelling complex at URS1 was also investigated here. We also tested for induction of pseudohyphal growth in diploids from SK1 genetic background in response to nitrogen starvation conditions known to induce meiosis. I constructed destabilised [beta]-galactosidase reporters expressed from URS1- CYC1-Ub-X-lacZ reporters to analyze transcriptional activity at URS1 site of early meiotic genes in nutrient rich conditions. The data presented here successfully demonstrates Hac1ip-mediated repression at URS1 sites in nitrogen-rich conditions. URS1-CYC1-Ub-X-lacZ reporters were expressed in mitotic repression machinery mutants (ume6[Delta], rpd3[Delta], sin3[Delta], isw2[Delta] and itc1[Delta]) under nitrogen rich conditions. The data presented here from these experiments not only corroborates their known role in repression at URS1 but also suggested regulation at additional sites in the minimal CYC1 promoter. Deletion of Sin3p suggested independent repression function separable from Rpd3p. Isw2p also acts independently of Itc1p at sites other than URS1. We also show that pseudohyphal growth was stimulated by non-fermentable carbon sources in sporulation efficient SK1 genetic background. The data also indicates that stimulation of pseudohyphal growth by non-fermentable carbon sources does not require respiration function or functional mitochondrial RTG pathway.
Download or read book Self and Nonself written by Carlos López-Larrea and published by Springer Science & Business Media. This book was released on 2012-03-07 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1960 Sir Frank Macfarlane Burnet received the Noble Prize in Physiology and Medicine. He titled his Nobel Lecture “Immunological Recognition of Self” emphasizing the central argument of immunological tolerance in “How does the vertebrate organism recognize self from nonself in this the immunological sense—and how did the capacity evolve.” The concept of self is linked to the concept of biological self identity. All organisms, from bacteria to higher animals, possess recognition systems to defend themselves from nonself. Even in the context of the limited number of metazoan phyla that have been studied in detail, we can now describe many of the alternative mechanism of immune recognition that have emerged at varying points in phylogeny. Two different arms—the innate and adaptive immune system—have emerged at different moments in evolution, and they are conceptually different. The ultimate goals of immune biology include reconstructing the molecular networks underlying immune processes.
Download or read book Biosorption of Heavy Metals written by Bohumil Volesky and published by CRC Press. This book was released on 1990-08-15 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: This state-of-the-art volume represents the first comprehensively written book which focuses on the new field of biosorption. This fascinating work conveys essential fundamental information and outlines the perspectives of biosorption. It summarizes the metal-sorbing properties of nonliving bacterial, fungal, and algal biomass, plus highlights relevant metal-binding mechanisms. This volume also discusses the aspects of obtaining and processing microbial biomass and metal-chelating chemicals into industrially applicable biosorbent products. Microbiologists, chemists, and engineers with an interest in new technological and scientific horizons will find this reference indispensable.
Download or read book Ant Ecology written by Lori Lach and published by Oxford University Press. This book was released on 2010 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: The incredible global diversity of ants, and their important ecological roles, mean that we cannot ignore the significance of ants in ecological systems. Ant Ecology takes the reader on a journey of discovery from the beginnings of ants many hundreds of thousands of years ago, through to the makings of present day distributions.
Download or read book Franny and Zooey written by J. D. Salinger and published by Penguin UK. This book was released on 2019-08-13 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: A sharp and poignant snapshot of the crises of youth - from the acclaimed author of The Catcher in the Rye 'Everything everybody does is so - I don't know - not wrong, or even mean, or even stupid necessarily. But just so tiny and meaningless and - sad-making. And the worst part is, if you go bohemian or something crazy like that, you're conforming just as much only in a different way.' First published in the New Yorker as two sequential stories, 'Franny' and 'Zooey' offer a dual portrait of the two youngest members of J. D. Salinger's fictional Glass family. 'Salinger's masterpiece' Guardian
Download or read book Woody Plant Communities written by T.T. Kozlowski and published by Elsevier. This book was released on 2012-12-02 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt: Water Deficits and Plant Growth, Volume VI: Woody Plant Communities focuses on the water relations of woody plants in a community context. Organized into eight chapters, this book begins with a quantitative overview of sources of water available to woody plants. Separate chapters follow that discuss the water relations of coniferous, temperate hardwood, and tropical and subtropical forests and woodlands; apple and citrus orchards; closely related woody plants; and tea plantations. For each of these plant communities, emphasis is placed on hydrological cycles; water use and transpiration; absorption of water; and effects of environmental factors on soil and plant water balance. The effects of water deficits on physiological processes; vegetative and reproductive growth; yield of harvested products; drought resistance; and cultural practices affecting plant water balance and yield are also emphasized in this book. This volume will be useful to both researchers and those involved in the practice of growing woody plants for wood and fruit crops and for esthetic values.
Download or read book Cell Cycle Regulation written by Philipp Kaldis and published by Results and Problems in Cell Differentiation. This book was released on 2006-06-26 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a state-of-the-art summary of the latest achievements in cell cycle control research with an outlook on the effect of these findings on cancer research. The chapters are written by internationally leading experts in the field. They provide an updated view on how the cell cycle is regulated in vivo, and about the involvement of cell cycle regulators in cancer.
Download or read book The Tumor Stroma written by Jai Prakash and published by CRC Press. This book was released on 2022-01-27 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: The identification of the role of tumor stroma—the tissue in the surroundings of cancer cells—in cancer development, progression, and metastasis has revolutionized the fields of cancer biology as well as cancer therapeutics. This book provides a comprehensive overview of this rapidly-evolving field including tumor stroma biology, therapeutic targets, molecular imaging, and advanced tumor stroma in vitro models. The book will serve as a handbook for graduate students, postgraduate researchers, pharmaceutical scientists, and biomedical engineers.
Download or read book Natural and Constructed Wetlands written by Jan Vymazal and published by Springer. This book was released on 2016-09-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book extends the knowledge on wetland ecosystem services based on the new research. The information combines the achievements gained in carbon sequestration, nutrient accumulation, macrophyte decomposition, wastewater treatment, global warming mitigation in constructed as well as natural wetlands across the globe. The book presents up-to-date results of ongoing research and the content of the book could be used by wetland scientists, researchers, engineers, designers, regulators, decision-makers, universities teachers, landscape engineers and landscape planners as well as by water authorities, water regulatory offices or wastewater treatment research institutions.
Download or read book Genome Stability written by Igor Kovalchuk and published by Academic Press. This book was released on 2021-07-17 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. - A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects - Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability - Contains applications of genome instability research and outcomes for human disease - Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair
