Download or read book Transcriptional and Post transcriptional Regulation of a Thyroid Hormone Responsive MRNA written by Prema Narayan and published by . This book was released on 1984 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Analysis of the Molecular Basis of Transcriptional Regulation by Thyroid Hormone and Estrogen Receptors written by Jeffrey Morse Holloway and published by . This book was released on 1992 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Post transcriptional Mechanisms in Endocrine Regulation written by K.M.J. Menon, PhD and published by Springer. This book was released on 2015-12-30 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines how post-transcriptional mechanisms control endocrine function. This includes newly identified regulatory mechanisms involved in hormone biosynthesis, control of hormone receptors and the outputs of hormone mediated signal transduction. Chapters address endocrine hormones including protein peptide/peptide, steroid, and non-steroidal hormones. The impacts of these mechanisms on disease and health are covered, providing a novel update to the scientific literature. Post-transcriptional regulatory mechanisms play an essential role in controlling dynamic gene expression. The outcome of this regulation includes control of the amount, timing, and location of protein expression. Regulation is mediated by cis-acting RNA sequences and structures and transacting RNA binding proteins and non-coding RNAs, including microRNAs. Recent advances in characterization of these regulatory factors have revealed enormous regulatory potential.
Download or read book Thyroid Hormone Regulation of Gene Expression written by G.R. Williams and published by Springer. This book was released on 1994 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the historical perspective and physiological background of the role of thyroid hormones. In both specific target tissues and during development, it provides clinical perspectives and physiological and developmental implications of the interactions between retinoid and vitamin D3 signalling pathways.
Download or read book Transcriptional and Post transcriptional Regulation written by Ghedira Kais and published by BoD – Books on Demand. This book was released on 2018-10-10 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the transcriptional and post-transcriptional gene regulations and presents a detailed portrait of many novel aspects related to highlighting the importance of key TFs in some vital biological processes, the role of certain TFs to control some infectious diseases, the role of non-coding RNAs in controlling mRNA expression, the involvement of these non-coding RNAs in diseases, and the interplay between TFs and microRNAs as key players for gene expression regulation giving a complete picture of how genes are regulated at the cellular level. The editor embarked upon this writing project entitled "Transcriptional and Post-transcriptional Regulation" to make pertinent contributions accessible to the scientific community. Hopefully, a large audience will enjoy reading and benefit from the chapters of this book.
Download or read book Gene Regulation written by David Latchman and published by Garland Science. This book was released on 2007-01-25 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene regulation is an essential process in the development and maintenance of a healthy body, and as such, is a central focus in both basic science and medical research. Gene Regulation, Fifth Edition provides the student and researcher with a clear, up-to-date description of gene regulation in eukaryotes, distilling the vast and complex primary literature into a concise overview.
Download or read book Molecular Mechanisms of Thyroid Hormone and Retinoid Receptor Transcriptional Regulation written by Anders Michael Näär and published by . This book was released on 1995 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Role of Isoform specific Transcriptional Regulation in the Molecular Mechanisms of Resistance to Thyroid Hormone Syndrome RTH written by Wei Wan and published by . This book was released on 2005 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Hormonal Control of Gene Transcription written by P. Cohen and published by Elsevier. This book was released on 2012-12-02 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past few years there have been considerable advances in our understanding of cellular control mechanisms, and current research is now linking areas of biology that were previously thought of as being quite separate. Molecular Aspects of Cellular Regulation is a series of occasional books on multidisciplinary topics which illustrate general principles of cellular regulation. Previous volumes described Recently Discovered Systems of Enzyme Regulation by Reversible Phosphorylation (Volumes 1 and 3), The Molecular Actions of Toxins and Viruses (Volume 2), Molecular Mechanisms of Transmembrane Signalling (Volume 4) and Calmodulin (Volume 5). This sixth volume, The Hormonal Control of Gene Transcription, has now been published to highlight recent important advances in our understanding of this topic which is linking two of the most active areas of current biochemical and molecular biological research (hormone action and gene transcription) and leading to the emergence of unifying concepts.
Download or read book Analysis of the Molecular Mechanisms of Isoform specific Transcriptional Regulation by Thyroid Hormone Receptors written by Zhihong Yang and published by . This book was released on 2001 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Transcriptional Regulation by Thyroid Hormone Receptor written by Elizabeth Bozena Helmer and published by . This book was released on 1994 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Negative and Positive Transcriptional Regulation by Thyroid Hormone Receptor Isoforms written by Anne Rentoumis and published by . This book was released on 1990 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Post Transcriptional Gene Regulation written by Erik Dassi and published by . This book was released on 2016 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume aims to provide the most recent advances in techniques for studying gene expression regulation at the post-transcriptional level. Post-Transcriptional Gene Regulation, Second Edition is organized in six sections describing bioinformatics approaches for studying post-transcriptional regulation, various expression profiling approaches, protein-RNA interaction and non-coding RNA investigation techniques, methods for profiling RNA modifications, and other techniques such as alternative translation initiation or polyadenylation sites determination. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Post-Transcriptional Gene Regulation, Second Edition is a versatile resource to researchers studying post-transcriptional regulation, introducing the most recent techniques and providing a comprehensive guide to their implementation.
Download or read book Molecular Analysis of Thyroid Hormone Receptors and Retinoic Acid Receptors written by Theresa Qui Phan and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Thyroid hormone receptors (TRs) and retinoic acid receptors (RARs) are members of the nuclear hormone receptor family. These ligand-regulated transcription factors bind to specific DNA sequences, called response elements, as homodimers or heterodimers with retinoid-X receptor (RXR) and regulate specific target genes. In the absence of hormone, TR and RAR repress transcription by recruiting corepressor complexes. In the presence of hormone, a coactivator complex is recruited and results in transcriptional activation. TRs and RARs are highly structurally conserved and possess very similar DNA binding domains. Despite these similarities, these receptors bind to different response elements in the genome, regulate different target genes, and control distinct physiological processes. The work presented in this dissertation identifies the DNA recognition properties of TR and RAR that account for these receptors' response element binding specificity and, subsequently, their distinct physiological responses. While response elements based on the consensus half-site are high affinity binding sites for TR and RAR, they show poor specificity. In contrast, the variations in half-site sequence, flanking sequences, and spacing found in natural TR and RAR target genes generate response elements that are bound in vitro and transcriptionally activated in vivo in a receptor-specific manner. Not all DNA sequences that bind TR or RAR efficiently in vitro are able to confer transcriptional regulation in vivo; we provide evidence that auxiliary proteins in cells may destabilize the binding of nuclear receptors to improperly spaced response elements to generate an additional layer of receptor-specific target gene recognition.
Download or read book Transcriptional Programming by Thyroid Hormone Receptor Beta Maintains Normal Cell Identity and Suppresses Tumor Growth written by Noelle Elizabeth Gillis and published by . This book was released on 2021 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: The overall incidence of thyroid cancer has more than tripled over the past several decades, as has aggressive disease and mortality. The direct relationship between thyroid disease, thyroid hormone levels, and development of thyroid cancer is incomplete. Recent meta-analyses have indicated a higher risk of thyroid cancer for patients with thyroid diseases that reflect an altered thyroid-pituitary signaling axis, which can have profound impacts on the physiology of the thyroid gland. These largely unanswered questions regarding altered thyroid hormone signaling and its consequences for thyroid tumor growth present a significant clinical challenge. This dilemma may come from a lack of understanding of the target genes and pathways regulated by the thyroid hormone receptor beta (TRß), and how those pathways respond to the presence of the ligand, thyroid hormone. This dissertation addresses the fundamental link between the loss of thyroid hormone signaling mediated by TRß and thyroid cancer. Transcriptional regulation in response to thyroid hormone is a dynamic process that maintains cellular homeostasis and identity in all tissues. In the first part of this dissertation, I propose an updated model using an integrated genomics approach to profile and characterize the cistrome of TRß, map changes in chromatin accessibility, and capture the transcriptomic changes in response to thyroid hormone in normal thyroid cells. I demonstrate that thyroid hormone promotes significant shifts in TRß genomic occupancy, which are associated with differential chromatin accessibility, and differential recruitment of chromatin remodeling complexes. These results establish selective recruitment of different chromatin remodelers to TRß binding sites, revealing novel functions in regulating chromatin accessibility and gene expression. In total, this data supports a multi-modal regulation model for TRß interaction with chromatin with at least three distinct modes defined by their T3-dependent occupancy, changes in accessibility, and differential recruitment of chromatin remodelers. Altered gene expression programming in cancer cells is often a consequence of a loss of function of cell-type specific transcriptional control mechanisms. Genetic mutations and epigenetic silencing of TRß is characteristic of thyroid, breast, and other tumors, and the loss of expression can be a marker for dedifferentiation in thyroid cancers. TRß is recognized as a tumor suppressor and a positive prognostic indicator for increased survival. In the second part of this dissertation, I demonstrate that TRß regulates critical tumor growth suppression pathways in thyroid cancer cells. Induction of TRß signaling in thyroid cancer cells results in transcriptional reprogramming, and in reduced aggressive cancer phenotypes. This analysis identified TRß regulated pathways and selected nodes as potential therapeutic targets for the most aggressive endocrine cancer, anaplastic thyroid cancer. This dissertation uncovers novel insights into thyroid hormone signaling and development of thyroid cancer, and bridges a significant gap in knowledge within the field. Taken together the studies presented there represent one of the most comprehensive profiles of TRß regulated gene expression and chromatin remodeling in normal and malignant cells
Download or read book Transcriptional and Post transcriptional Regulation written by Kais Ghedira and published by . This book was released on 2018 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the transcriptional and post-transcriptional gene regulations and presents a detailed portrait of many novel aspects related to highlighting the importance of key TFs in some vital biological processes, the role of certain TFs to control some infectious diseases, the role of non-coding RNAs in controlling mRNA expression, the involvement of these non-coding RNAs in diseases, and the interplay between TFs and microRNAs as key players for gene expression regulation giving a complete picture of how genes are regulated at the cellular level. The editor embarked upon this writing project entitled ""Transcriptional and Post-transcriptional Regulation"" to make pertinent contributions accessible to the scientific community. Hopefully, a large audience will enjoy reading and benefit from the chapters of this book.
Download or read book Thyroid Hormone Metabolism written by Georg Hennemann and published by Marcel Dekker. This book was released on 1986 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt:
