Download or read book Transarterial Chemoembolization TACE written by Pierleone Lucatelli and published by Springer Nature. This book was released on 2023-10-09 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book thoroughly presents Transarterial Chemoembolization (TACE), a procedure representing the standard of care for several clinical oncological indications. Thanks to the considerable technological advances in the available instrumentation (guidewire, microcatheter, guiding imaging modalities) as well as the different platforms utilized to perform treatment (conventional TACE, drug eluted TACE, degradable starch microsphere TACE) indication for treatment has been broadened and results significantly improved. By clearly depicting the procedure, with technical details, advantages and limitations, the book provides a unique and most updated source on TACE procedures. Clinical cases regarding crucial parts of the procedure are also provided. Expert users as well as novel clinicians interested in the most recent aspects of this interventional radiology procedure will find in this book a valuable tool and guide for their clinical routine.

Download or read book Transarterial chemoembolization for hepatocellular carcinoma patients written by and published by Frontiers Media SA. This book was released on 2024-04-09 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Transarterial Chemoembolization TACE Prior to Liver Transplantation Does it Add to Surgical Risk when Considering Marginal Grafts written by Amanda Boteon and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction:TACE is established tumour control measure in patients with hepatocellular carcinoma (HCC) prior to liver transplantation (LT). Loco-regional effects of TACE may adversely affect the technical aspects of LT, and hence implications for graft selection.Methods:Retrospective cohort study involving patients with HCC that underwent TACE before LT (TACE group) between January 2011 and December 2015. The outcome of this group was compared with patients that underwent LT for HCC but without preoperative TACE (NoTACE group). Post-transplant surgical morbidity was compared according to Clavien classification.Results:59 cases included in the TACE group were compared with 123 cases in the NoTACE group. TACE group had higher prevalence of ischaemia related native collateral damage (11.86% vs 0%; p=0.002), native hepatic artery occlusion identified at surgery (5.1% vs 0%;p=0.033) and adhesions between the necrotic tumour to adjacent structures (14.75% vs. 3.15%; p=0.005). Surgical morbidity rate was significantly higher in the TACE group considering Dindo-Clavien grade 2 complications (64.4% vs 47.2%; p=0.029), however this was not found for grade u2265 3 (45,8% vs 58,5%; p=0,105). Patients in the TACE group transplanted with grafts from donors after cardiac death had 8.7% 90-day mortality and 56.5% major complication rate compared to 6.7% and 65% for the NoTACE group (p=0.719 and p=0.475; respectively).Discussion:HCC patients undergoing TACE while in the LT waiting list may lead to complications related to the procedure experienced in the laparotomy, nevertheless it has not shown repercussions on the mortality and only partial impact at morbidity, even considering the use of marginal grafts.

Download or read book Monitoring Liver Function of Patients Undergoing Transarterial Chemoembolization TACE by a 13C Breath Test LiMAx written by Emona Barzakova and published by . This book was released on 2021* with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Hepatocellular Carcinoma written by Yujin Hoshida and published by Springer. This book was released on 2019-08-05 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.

Download or read book Liver Cancer in the Middle East written by Brian I. Carr and published by Springer Nature. This book was released on 2021-09-22 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to illuminate the causes, incidence, and treatments of Hepatocellular Carcinoma(HCC) or liver cancer in the politically important and societally diverse region of the Middle East. Taking a flexible and inclusive view, it examines the influences of geography, crops and diet, ethnicity, and local behavior on both diagnosis and outcomes of this disease. Understanding the different causes of liver cancer enables effective strategies for both prevention and early diagnosis while knowledge of the different treatment modalities, their uses and limitations, availability and costs, works to inform rational treatment provision and selection. Divided into four sections, this book considers the causes and clinical syndromes associated with HCC, provides a detailed overview of clinical HCC and treatment modalities, describes country-specific clinical HCC experience and practice, and considers future needs and the potential for HCC collaborations across the region. Liver Cancer in the Middle East is a useful resource for clinicians seeking insight into the second highest cause of death from cancer worldwide, governments planning social and medical services for their peoples, as well as for international aid agencies prioritizing donations.

Download or read book Parametric Contrast Enhanced Ultrasound Evaluation of Transarterial Chemoembolization written by Minakshi Mohanty and published by . This book was released on 2015 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work investigates quantitative contrast enhanced ultrasound (CEUS) derived blood flow parameters for evaluating chemoembolization of hepatocellular carcinoma. Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide and is becoming increasingly common. Liver transplant is the only cure with 70 percent 5 year survival rate. However, transplant requires the tumor to fall under the Milan criteria (less than 5cm or up to 3 nodules each less than 1cm) and the technique is limited by the availability of donors. Transarterial chemoembolization (TACE), currently, is a treatment option for non-resectable tumors. It involves the administration of drug eluting beads via catheter into the branch of the hepatic artery that feeds the tumor. These beads occlude the blood supply to the tumor and at the same time release chemotherapy, leading to necrosis of the tumor and reduction in its size. Presently, the effectiveness of TACE procedure is determined one month post embolization through the use of contrast enhanced magnetic resonance imaging (MRI) or computed tomography (CT) scans, by evaluating blood flow within the tumor. Early screening for effective chemoembolization with contrast-enhanced MRI has been proven ineffective due to an inability to adequately visualize the vasculature. An earlier estimation of treatment efficacy would provide clinicians more time and options for re-treatment. Additionally, a number of patients may have morbidities including renal insufficiency. These patients may develop nephrogenic systemic fibrosis, which is the necrosis of skin and the internal organs, on exposure to gadolinium (present in MRI contrast agents). This project proposes the use of contrast enhanced ultrasound (CEUS) for monitoring the effectiveness of transarterial chemoembolization. Ultrasound contrast agents are gas filled microbubbles, which are encapsulated within a thin elastic shell made of lipids. They have a diameter of 1-[mu]m. Due to their restriction to the vasculature, an absence of contrast within the tumor is expected in cases where complete embolization has been achieved. Earlier studies have shown that lack of detected agents as little as 2 days post procedure correlated with effective procedure. However, currently there is no established standard as to how many days post treatment should the follow up be conducted, or which contrast agent to use. Fourteen patients with 16 lesions scheduled for transarterial chemoembolization (TACE) of HCC using drug eluting beads provided informed consent to undergo CEUS exam prior to treatment, 2 weeks post treatment, and the morning of follow up (contrast enhanced MRI 1 month post TACE). Ultrasound was performed using a Sequoia 512 scanner with 4C1 probe (Siemens Medical Solutions, Mountain View, CA). CEUS data was acquired using Cadence Pulse Sequencing (Siemens) during bolus injection of 0.6-0.7 ml of Definity (Lantheus Medical Imaging, N. Billerica, MA). Motion compensation was performed and time intensity curves were generated on a pixel-by-pixel basis to create parametric images showing maximum signal intensity (MAX), time to peak intensity (TTP), perfusion (PER), and area under curve (AUC). These values were averaged over the tumor and expressed normalized relative to baseline. Results were then grouped by clinical diagnosis (fully treated (n=5), partially treated (n=5) or no change (n=6)) and compared at each time point. Parametric imaging was successfully performed on 10 lesions, while six were excluded due to inability to identify tumor. Significant difference was observed in the time to peak dataset 2 weeks post TACE between complete response and no response group (p=0.018). No significance was observed in maximum intensity, perfusion and area under curve dataset. In the time intensity parameters obtained 4 weeks post TACE, no significant difference was observed. In conclusion, time to peak currently appears to be a good quantitative CEUS parameter for evaluating the effectiveness of TACE treatment 2 weeks post treatment.

Download or read book Hepatobiliary Cancer written by Paul H. Sugarbaker and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: When one deals with cancer, the hepatobiliary malignancies present a chal lenge to the oncologists that can be characterized as a series of unsolved clinical and biological dilemmas. Liver metastases from colorectal and other gastrointestinal malignancies, hepatocellular carcinoma, cholangiocar cinoma, and gall bladder cancer present an array of problems but have two features in common. These are high morbidity and mortality with an overall poor result from treatment. Why is it that hepatobiliary cancer carries with it such a dismal prognosis? First of all, these diseases present, for the most part, in an advanced state. To this point in time the oncologist has had no help from early diagnosis or screening. Only the occasional patient followed by ultrasound or a tumor marker has the disease diagnosed in an asymptomatic state. By the time these diseases become symptomatic, curative treatment options have usually disappeared. Evolution has placed the liver in a protected position in order to avoid injury to the soft parenchyma. As with many other internal organs, the nerve supply is extremely limited. These two anatomic features result in a great lack of early warning signs of cancer.

Download or read book Radiotherapy of Liver Cancer written by Jinsil Seong and published by Springer. This book was released on 2022-07-02 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides up-to-date information on all aspects of radiotherapy for liver cancer, from the basic science to clinical practice. While demand for radiotherapy of liver cancer has been increasing, the guidance available to clinicians has remained limited. Radiotherapy of Liver Cancer aims to address this deficit on the basis of the best available evidence. The first two sections explain the relevant basic science and present detailed information on the available technologies and techniques, including the most recent advances. The radiotherapy strategies appropriate in different patient groups are then fully described, covering the use of ablative, adjuvant, neoadjuvant, and definitive radiotherapy, radiotherapy as a bridge to liver transplantation, and palliative radiotherapy. The final section addresses a range of specific issues of concern to the clinician. Radiotherapy of Liver Cancer will be an ideal reference for clinical radiation oncologists, radiation oncology residents, oncologists, and hepatologists.

Download or read book Encyclopedia of Cancer written by Manfred Schwab and published by Springer Science & Business Media. This book was released on 2008-09-23 with total page 3307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.

Download or read book Survival Benefit of Transarterial Chemoembolization in Patients with Metastatic Hepatocellular Carcinoma a Single Center Experience written by Dominik Bettinger and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Image Guided Interventions in Oncology written by Christos Georgiades and published by Springer Nature. This book was released on 2020-07-28 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an up-to-date and comprehensive primer on image-guided interventions for cancer. Image-guided interventional oncology is gaining popularity as it is a minimally invasive and more precisely targeted approach that both proves more effective and results in fewer side effects. This book’s aim is to provide a clinical guide to interventional oncology for the entire oncology team. Chapters are approached with the same interdisciplinary perspective that is used in the care itself, with each chapter written by an interventional radiologist with contributions from medical, surgical and/or radiation oncologists. Chapters cover the major cancers that can benefit from interventional oncology treatment (including lung, liver, kidney, and bone), as well as some of the physics and physiology behind these interventional modalities. This is an ideal guide for interventional radiologists, medical oncologists, surgical oncologists, radiation oncologists, as well as relevant trainees.

Download or read book Laser induced Interstitial Thermotherapy written by Gerhard J. Müller and published by SPIE Press. This book was released on 1995 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Hepatocellular Carcinoma written by Kelly M. McMasters and published by Springer Science & Business Media. This book was released on 2010-11-30 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatocellular Carcinoma: Targeted Therapy provides a detailed repository of the latest information regarding HCC epidemiology, diagnosis, imaging, pathology, staging, and treatment options. This volume also provides an up-to-date guide for treatment that explores not only traditional treatments, but newer investigational treatment options including, surgical resection, liver transplantation, ablation (radiofrequency, microwave), percutaneous ethanol or acetic acid injection, transarterial chemoembolization (TACE), intra-arterial radiation therapy, and systemic chemotherapy. Heptocellular Carcinoma: Targeted Therapy will be of great value to all health care professionals and trainees worldwide who have an interest in the diagnosis and treatment of HCC, including surgeons, medical oncologists, radiologists, radiation oncologists, and pathologists.

Download or read book Embolization Therapy Principles and Clinical Applications written by Marcelo Guimaraes and published by Lippincott Williams & Wilkins. This book was released on 2014-12-01 with total page 1128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Embolization procedures have grown in numbers, diversity and complexity during the last decade. During this time, there have been a number of new embolic agents and techniques developed. This book presents evidence based reviews of all the advances in the field including current devices, basic and advanced techniques, and tips and tricks. Key Features Topics included span the breadth of the embolization work performed by Interventional Radiologists, including neuro applications, trauma applications, and applications in Interventional Oncology among others A comprehensive reference covering all applications of embolotherapy Focal point of the text will be the evidence-based reviews for each topic Tips and tricks section will bring added value to this project providing clinical pearls that can be immediately incorporated into everyday clinical practice

Download or read book Colorectal Cancer Liver Metastases written by Mauro Monteiro Correia and published by Springer Nature. This book was released on 2019-12-28 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer is the third most commonly diagnosed condition in oncology, affecting around 1.23 million individuals per year, according to recent statistics. Of these patients, about 50% will develop liver metastases and approximately 20% will present a stage IV disease at diagnosis. These statistics make colorectal liver metastases (CLM) an issue of major importance in current oncology. The area of CLM is subject to great and continuous advances, as its pathophysiologic mechanisms are better understood and more therapeutic and surgical options are developed. Consequently, all professionals involved with the diagnosis, treatment and follow up of CLM should be kept up to date with the latest advances on the field, to provide high standard medical care to their patients. This book is designed to present the state-of-the-art in CLM management and, in doing so, to review the current evidence on CLM, discussing all important topics in the field. Coverage is broad and comprehensive, encompassing introductory topics (history, definitions, epidemiology, etc.), basic science subjects (molecular biology, genetics, dissemination process, etc.) and practical clinical topics (tumor behavior, diagnosis, drug therapy, radiation therapy, surgery, ablation, multidisciplinary teams, etc.). Although comprehensive on the coverage and selection of topics, each chapter is concise and objective, dissecting topics in a practical and direct format. Evidences and recommendations are included. Chapters display a brief introduction of the common knowledge, go straight to the detailed revision of the most recent years of the literature, and end with practical closing observations. This book is a tool for professionals (general and cancer surgeons, HPB surgeons, clinical oncologists, gastroenterologists and medical residents) and interns who search for a qualified and reader friendly revision on topics concerning Colorectal Cancer Liver Metastases.

Download or read book Malignant Liver Tumours Basic Concepts and Clinical Management written by F. Berr and published by Springer Science & Business Media. This book was released on 2002-11-30 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC), both increasing in incidence, have become a major topic of basic and clinical research as well as clinical practice in hepatology. Experts in the field update the current concepts on the carcinogenesis of HCC and CC such as genetic alterations in the pathways of cell cylce and apoptosis regulation, the hypothesis of dedifferentiation of hepatocytes to the malignant phenotype vs that of activation of hepatic progenitor cells incapable of maturation (maturation arrest hypothesis). In spite of an increasing number of genetic alterations described in human HCC as well as cell regulatory pathways tested in experimental HCC models, the key hits causing progression of the cell cycle in imbalance with apoptosis, tissue invasive growth and metastatic potential of cell clones still remain elusive. Very powerful genomic and proteomic techniques are promising insights into the carcinogenesis of liver malignancies that will allow more efficient therapeutic strategies. The current concepts on risk profiling, surveillance of risk groups and therapeutic strategies are evidence-based for HCC and less detailed for CC. Surveillance of risk groups improves detection of liver tumours in curable stages. Best strategies for curative treatment of HCC use neoadjuvant antitumour therapies before liver transplantation and a role is emerging for living donor-related liver transplantation. New palliative therapies for HCC are in the experimental stage with biological response modifiers, including angiogenesis inhibitors, and entering phase II clinical trials with the alpha-fetoprotein derived vaccines.