Download or read book Toxoplasma Gondii Host Interactions A Story of Immune Attack and Parasite Counterattack written by Jeroen P. J. Saeij and published by Frontiers Media SA. This book was released on 2020-08-10 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxoplasma gondii is an obligate intracellular parasite that can infect all warm-blooded animals, including an estimated ~30% of humans. It can cause severe disease in immune-suppressed individuals and in fetuses as well as blinding chorioretinitis in adults and children. Toxoplasma-innate immune system interactions determine early parasite control and activation of the adaptive immune system by the host and are therefore critical in determining host survival during the acute phase of infection. However, induction of an exaggerated inflammatory response can also lead to pathology. Only the chronic tissue cyst form of Toxoplasma is orally infectious. It is therefore critical for the parasite’s survival during the chronic phase to escape immune responses at this stage as well. Toxoplasma exists as genetically divergent strains mostly depending on geography, with the most strain diversity being found in South America. The key to Toxoplasma’s successful co-option of the host are proteins secreted from its rhoptry and dense granule secretory organelles. Rhoptry proteins (ROPs) are secreted into the host cell cytoplasm upon invasion while dense granule proteins (GRAs) are secreted once the parasite establishes itself in its parasitophorous vacuole (PV). GRAs can localize to the PV, the PV membrane, or are secreted beyond the PVM into the host cytoplasm. Many ROPs and GRAs are involved in modulating host cell signaling pathways and evasion of host immune responses and play important roles in Toxoplasma virulence. Polymorphisms in Toxoplasma’s ROPs and GRAs, likely determine how well these effectors bind to the divergent substrates in different host species, which can explain Toxoplasma strain differences in virulence in a particular host species. By studying Toxoplasma we have not only started to unravel how the parasite modulates immune responses to enhance its survival, replication, and transmission but we have also learned a lot about the immune system. Many unique mechanisms of immunity have indeed been defined using Toxoplasma and this parasite has aided our understanding of tissue-specific immune responses in the brain and intestine. This Research Topic will give a comprehensive overview of Toxoplasma-host immune response interactions. Most Toxoplasma virulence determinants to date have been established in murine systems and it is unclear how the parasite interacts with other intermediate hosts and humans. In addition, the interactions of Toxoplasma with some of the most relevant cell types during infection, including dendritic cells, neurons, intestinal epithelial cells or vascular endothelial cells, remain poorly understood.
Download or read book Metabolic Interaction in Infection written by Ricardo Silvestre and published by Springer. This book was released on 2018-04-06 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on host–pathogen interactions at the metabolic level. It explores the metabolic requirements of the infectious agents, the microbial metabolic pathways that are dedicated to circumvent host immune mechanisms as well as the molecular mechanisms by which pathogens hijack host cell metabolism for their own benefit. Finally, it provides insights on the possible clinical and immunotherapeutic applications, as well as on the available experimental and analytical methods. The contributions break new ground in understanding the metabolic crosstalk between host and pathogen.
Download or read book The Rapture of the Nerds written by Cory Doctorow and published by Macmillan. This book was released on 2012-09-04 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the two defining personalities of post-cyberpunk SF, a brilliant collaboration to rival 1987's The Difference Engine by William Gibson and Bruce Sterling
Download or read book The Emperor of All Maladies written by Siddhartha Mukherjee and published by Simon and Schuster. This book was released on 2011-08-09 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Winner of the Pulitzer Prize and a documentary from Ken Burns on PBS, this New York Times bestseller is “an extraordinary achievement” (The New Yorker)—a magnificent, profoundly humane “biography” of cancer—from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.
Download or read book Immunopathology in Toxicology and Drug Development written by George A. Parker and published by Springer. This book was released on 2017-03-28 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 2, Organ Systems, offers summaries of organ-specific immunobiology and immunopathology as well as common responses to xenobiotics. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system.
Download or read book Hugo and Russell s Pharmaceutical Microbiology written by Stephen P. Denyer and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised and updated Pharmaceutical Microbiologycontinues to provide the essential resource for the 21st centurypharmaceutical microbiologist "....a valuable resource for junior pharmacists graspingan appreciation of microbiology, microbiologists entering thepharmaceutical field, and undergraduate pharmacy students." Journal of Antimicrobial Chemotherapy ".....highly readable. The content is comprehensive, withwell-produced tables, diagrams and photographs, and is accessiblethrough the extensive index." Journal of Medical Microbiology WHY BUY THIS BOOK? Completely revised and updated to reflect the rapid pace ofchange in the teaching and practice of pharmaceuticalmicrobiology Expanded coverage of modern biotechnology, including genomicsand recombinant DNA technology Updated information on newer antimicrobial agents and theirmode of action Highly illustrated with structural formulas of organiccompounds and flow diagrams of biochemical processes
Download or read book Microbiology Demystified written by Tom Betsy and published by McGraw Hill Professional. This book was released on 2005-04-21 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a must-have supplement for pre-med, nursing, and medical science students, and anyone else wanting to improve their understanding of microbiology Utilising a unique self-teaching approach, the authors follow the syllabus of the leading textbooks and translate complex terms and concepts into an easy-to-read and understand format. Follows syllabus of leading textbooks, but translates complex terms and concepts into a format that’s easy to read and understand.Includes a 10-question quiz at the end of each chapter, and a 100-question exam at the end of the book.
Download or read book The Xavante in Transition written by Carlos E. A. Coimbra and published by University of Michigan Press. This book was released on 2004-03-25 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: DIVIlluminates the experience of a small-scale culture with large-scale change /div
Download or read book Parasitology written by Eric Loker and published by Garland Science. This book was released on 2015-03-02 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parasitology: A Conceptual Approach focuses on the conceptual basis of parasitology, with the goal of providing students with an enriched view of parasites and their biology. Concentrating on concepts will enable readers to gain a broader perspective that will increase their ability to think critically about all kinds of parasitic associations. The interfaces between the study of parasitism and prominent biological disciplines such as biodiversity, immunology, ecology, evolution, conservation biology, and disease control are highlighted. Studying individual parasites is an essential part of parasitology so Parasitology: A Conceptual Approach contains an appendix which provides a concise overview of the biology of important human and veterinary parasites. End-of-chapter questions are provided, as is an instructor manual.
Download or read book The Chinese written by and published by . This book was released on 1851 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Overcoming Liver Fluke as a Constraint to Ruminant Production in South East Asia written by R. S. Copland and published by . This book was released on 2008 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver fluke is an important internal parasite of ruminants. It debilitates livestock from a wide range of economically important species including cattle, buffalo, sheep and goats. This monograph addresses the knowledge gaps in the genetics, immunology, epidemiology and control of liver fluke disease --Website of online version, viewed 26 June, 2008.
Download or read book Oxford Handbook of Paediatrics written by Robert C. Tasker and published by Oxford University Press, USA. This book was released on 2013-01-31 with total page 1125 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully revised for the new edition, this handbook covers all significant aspects of acute and chronic paediatrics. Areas such as neonatology, surgery, genetics and congenital malformations and child protection are covered in a user-friendly and succinct style.
Download or read book HIV AIDS Care Counselling written by Alta C. Van Dyk and published by Cape Town, [Great Britain]: Pearson Education. This book was released on 2005 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: A textbook which provides care workers with practical information when dealing with HIV/AIDS. Issues addressed include the fundamental facts about the virus and its spread. principles for behavioural change, education of children, pre and post test counselling, nursing care principles and the legal and ethical aspects of HIV/AIDS.
Download or read book The Lung Microbiome written by Michael J. Cox and published by European Respiratory Society. This book was released on 2019-03-01 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studying the lung microbiome requires a specialist approach to sampling, laboratory techniques and statistical analysis. This Monograph introduces the techniques used and discusses how respiratory sampling, 16S rRNA gene sequencing, metagenomics and the application of ecological theory can be used to examine the respiratory microbiome. It examines the different components of the respiratory microbiome: viruses and fungi in addition to the more frequently studied bacteria. It also considers a range of contexts from the paediatric microbiome and how this develops to disease of all ages including asthma and chronic obstructive pulmonary disease, chronic suppurative lung diseases, interstitial lung diseases, acquired pneumonias, transplantation, cancer and HIV, and the interaction of the respiratory microbiome and the environment.
Download or read book Primate Biogeography written by Shawn M. Lehman and published by Springer Science & Business Media. This book was released on 2006-05-24 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: Primate Biogeography is a subject rarely addressed as a discipline in its own right. This comprehensive source introduces the reader to Primate Biogeography as a discipline. It highlights the many factors that may influence the distribution of primates, and reveals the wide range of approaches that are available to understanding the distribution of this order. The biogeography of primates in the past is a major component of our understanding of their evolutionary history and is an essential component of conservation biology. This book will appeal to primatologists, physical anthropologists, zoologists, and undergraduates in these areas.
Download or read book Ellie a Child s Fight Against Leukemia written by Jonathan B. Tucker and published by Holt McDougal. This book was released on 1982 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Bovine Udder and Mastitis written by Markus Sandholm and published by . This book was released on 1995 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
