Download or read book Toxicology of Contact Hypersensitivity written by Ian Kimber and published by CRC Press. This book was released on 1996-02-07 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: An analysis of allergic contact dermatitis - a common occupational health problem affecting between 5-15% of the workforce. This book considers the condition from the perspective of the toxicologist rather than the dermatologist.
Download or read book Toxicology of Contact Dermatitis written by David Basketter and published by . This book was released on 1999 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Toxicology Series Series Editors Diana Anderson, BIBRA Toxicology International, Surrey, UK Michael D Waters, Consultant, Chapel Hill, NC, USA Timothy C Marrs, Department of Health, London, UK Toxicology of Contact Dermatitis Allergy, Irritancy and Urticaria David Basketter, Unilever R&D, Safety & Environmental Assurance Centre Toxicology Unit, Bedford, UK Frank Gerberick, Proctor & Gamble, Miami Valley Laboratories, Cincinnati, OH, USA Ian Kimber, ZENECA Pharmaceuticals, Central Toxicology Laboratory, Macclesfield, UK Carolyn Willis, Department of Dermatology, Amersham Hospital, Amersham, UK The contact dermatoses represent a family of clinical conditions of the skin which affect a surprising number of people. These diseases cover skin irritation, allergic contact dermatitis (skin sensitisation) and the urticarias (both immunologic and non-immunologic). They arise from contact with chemicals at work (contact dermatitis is the major cause of occupational health problems) and from consumer contact with chemicals in the home (in cosmetics, household products, medicaments, pesticides, and so on). The aim of this book is to describe in detail the latest understanding of the pathophysiological mechanisms involved in the three main aspects of contact dermatitis (irritation, allergy and urticaria), to then encapsulate modern approaches to the evaluation of chemical hazards in this area by critically reviewing the test methodologies involved, and finally to illustrate how the risks presented may be assessed. This last point is a critical area, since methods for the identification of these hazards (at least for skin irritation and sensitisation) have been available for some years. However, the understanding of how to measure the potency of these hazards and so enable a proper risk assessment is only now becoming a more tractable and thus transparent activity. Better and more consistent risk assessments are the optimal route to the reduction of the morbidity presented by the skin disorders described in this book. This timely book is essential reading for toxicologists, dermatologists, occupational health specialists, allergologists and those with an interest in risk assessment and safety evaluation.
Download or read book Applied Dermatotoxicology written by Howard I. Maibach and published by Academic Press. This book was released on 2014-06-24 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applied Dermatotoxicology: Clinical Aspects provides concise, systematic, and state-of-the-art information on the toxicological effects of substances on skin, and recent advances in dermal toxicity testing. This book specifically addresses the clinical presentations borne out of exposure to a variety of chemicals. It begins with an overview of skin biology to provide toxicologists with a basic understanding of its anatomy and physiology. Next it presents a variety of dermatotoxicological effects, as well at the toxic agents that cause them, with color photographs to illustrate these effects. Applied Dermatotoxicology: Clinical Aspects is an essential reference for toxicologists in industry, and for those medical professionals who encounter cases of dermal exposure to toxic agents. A concise, yet inclusive review of effects of chemical exposure Includes background on basic skin biology Provides vital clinical reference for toxicologists in non-clinical settings
Download or read book Contact Dermatitis written by Peter J. Frosch and published by Springer Science & Business Media. This book was released on 2006-06-07 with total page 1127 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is an unusual event for a textbook covering such a national and international networks and the use of highly specialized field as contact dermatitis to be standardized methodology, a highly differentiated published in its fourth edition within a time period picture can now be painted; we know the major p- of 13 years. When the European and Environmental fessions at risk, as well as the influences of age and Contact Dermatitis Research Group was founded in various cofactors. This is a solid basis for preventive 1985,one of the major goals was to edit a textbook of measures. A new allergen, described in one center, high scientific standard written by renown experts can now be tested on a large scale in a short time and keep it regularly updated. The greatest danger period. If the data evaluation shows an unacceptably for a textbook is to become outdated – then it stays high rate of sensitization in the exposed population, on the bookshelf and is rarely consulted. The contin- regulatory measures will be undertaken to protect uous flow of new medicaments, the fascinating the consumer. A recent example is the “methyldib- improvements in diagnostic image analysis and ever- mo glutaronitrile story. ” changing operative procedures are the reasons for These and other issues of importance are covered considerable knowledge deficits in old textbooks, in depth in the newest edition of this textbook.
Download or read book Toxicology of Skin written by Howard I. Maibach and published by CRC Press. This book was released on 2001-03-15 with total page 573 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxic injury to the skin in the general population, and particularly in western populations, is on the increase. This is partly due to the expanding number of natural and man-made chemicals present in our everyday environment. The need for a thorough understanding of the skin, and the mechanisms of toxicity therein, has never been more pressing. Th
Download or read book Nickel and the Skin written by Howard I. Maibach and published by CRC Press. This book was released on 1989-04-30 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication serves as a guide to medical doctors and dentists in the evaluation and management of problems related to nickel allergy. The chemistry, analysis, and monitoring of nickel is explored. Recent advances in the immunology of nickel are dis-cussed. Additionally, sensitization assays for both humans and animals are presented. The clinical, genetic, and epidemiologic as-pects of nickel sensitization and nickel dermatitis are explained. Social and demographic aspects of nickel contact allergy are dis-cussed, as well as the topic of the nickel dermatitis as a pre-ventable health problem.
Download or read book Allergic Hypersensitivities Induced by Chemicals written by Regional Office Who/Europe and published by CRC Press. This book was released on 1995-11-27 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, commissioned by the World Health Organization (WHO) and written by international experts, provides consensus views on the most important issues related to allergic hypersensitivities. The text details predictive testing, diagnosis, epidemiological monitoring of intervention measures, sources of sensitizing agents, and mechanisms of action. Contributors extensively cover allergic hypersensitivity reactions of the skin and the respiratory system. They present the current knowledge on hypersensitivity reactions of the gastrointestinal tract and kidneys. Major gaps in existing information about allergic hypersensitivities are highlighted and recommendations for future research are given. Practical methods are provided for establishing preventive programs. Allergic Hypersensitivities Induced by Chemicals offers valuable information to both scientists and public health officials. This is a useful reference for health professionals in their work with allergies, allergens, and allergy sufferers.
Download or read book Allergic Contact Dermatitis written by Camilla Smith and published by CRC Press. This book was released on 2023-01-06 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: llergic Contact Dermatitis assesses the potential effects of xenobiotic metabolism and protein reactivity on toxicity. It reviews current knowledge of percutaneous absorption and skin metabolism and includes discussion of the xenobiotics themselves. It answers questions such as: How does sensitisation relate to protein reactivity and levels of metabolism? How we can identify potential hazards in food, cosmetics and pharmaceuticals etc? In a world where people are becoming increasingly aware of their allergies, this up to date one-stop reference will prove an invaluable addition to the shelves of any researcher in academia, government, regulatory bodies, public health officials and, of course, the food, cosmetics and pharmaceuticals industries will find the book to be of particular relevance.
Download or read book Nickel and the Skin written by Jurij J. Hostynek and published by CRC Press. This book was released on 2019-08-15 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published 2002, Allergic contact dermatitis from nickel is a continuing and increasing health problem. Nickel dermatitis may occur in sensitized individuals following contact with nickel-containing items such as jewelry, zippers, buttons, and other objects; by nickel leaching from implants and prostheses; and following occupational exposures. Although the most common of the health effects associated with exposure to nickel, the skin penetration of nickel and its compounds is poorly understood. Nickel and the Skin: Absorption, Immunology, Epidemiology, and Metallurgy gives an extensive, updated review of major topics and new topics, and covers material progress in the field of nickel hypersensitivity. Its content complements the mandate of NiPERA, the Nickel Producers Environmental Research Association, which is to promote the health and safety of those exposed to nickel or nickel containing products in the workplace and general environment. Many books on the toxicology of metals discuss nickel and its alloys in general terms. This one provides you with in-depth information on the causes, diagnosis, prognosis, and prevention, all in one source. Nickel and the Skin: Absorption, Immunology, Epidemiology, and Metallurgy provides a guide to the evaluation and treatment of what has become the most common cause of allergic contact dermatitis.
Download or read book Encyclopedic Reference of Immunotoxicology written by Hans-Werner Vohr and published by Springer. This book was released on 2005-06-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work provides rapid access to focused information on topics of Immunotoxicology not only for scientists and those dealing with laboratory aspects but also for lecturers and advanced students. Over 200 contributing authors – including many of the world’s top specialists – have contributed full essays on all relevant topics, supplemented by keyword definitions of related terms. Full essays are structured uniformly to provide reader-friendly information on all aspects of Immunotoxicology, including methods of testing and analysis, characteristics of substances, the regulatory environment and the relevance of these to humans. The single A–Z format of both types of entry makes this reference book very easy to use. The Encyclopedic Reference of Immunotoxicology is intended to be a comprehensive work of reference which will provide easy access to relevant information in the fast-growing field of Immunotoxicology.
Download or read book Pediatric Allergy Principles and Practice E Book written by Donald Y. M. Leung and published by Elsevier Health Sciences. This book was released on 2010-10-13 with total page 705 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pediatric Allergy supplies the comprehensive guidance you need to diagnose, manage, and treat virtually any type of allergy seen in children. Drs. Leung, Sampson, Geha, and Szefler present the new full-color second edition, with coverage of the diagnosis and management of anaphylaxis, the immune mechanisms underlying allergic disease, the latest diagnostic tests, and more. Treat the full range of pediatric allergic and immunologic diseases through clinically focused coverage relevant to both allergists and pediatricians. Understand the care and treatment of pediatric patients thanks to clinical pearls discussing the best approaches. Easily refer to appendices that list common food allergies and autoantibodies in autoimmune diseases. Apply the newest diagnostic tests available—for asthma, upper respiratory allergy, and more—and know their benefits and contraindications. Treat the allergy at its source rather than the resulting reactions through an understanding of the immune mechanisms underlying allergic diseases. Get coverage of new research that affects methods of patient treatment and discusses potential reasons for increased allergies in some individuals. Better manage potential anaphylaxis cases through analysis of contributing facts and progression of allergic disease. Effectively control asthma and monitor its progression using the new step-by-step approach. Eliminate difficulty in prescribing antibiotics thanks to coverage of drug allergies and cross-reactivity.
Download or read book Dermatotoxicology written by Hongbo Zhai and published by CRC Press. This book was released on 2004-02-25 with total page 1232 pages. Available in PDF, EPUB and Kindle. Book excerpt: For twenty-five years, Dermatotoxicology has stood as the definitive reference book in the field. A generation of toxicologists and dermatologists has consulted this volume throughout their careers, finding within it a wealth of theoretical and practical guidance. Updated and expanded to reflect the latest developments in skin toxicology, De
Download or read book Common Contact Allergens written by John McFadden and published by John Wiley & Sons. This book was released on 2020-01-21 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: How to diagnose allergic contact dermatitis, perform and interpret patch tests, and select the best treatment options Written for a broad range of dermatologic professionals, Common Contact Allergens is a straightforward and useful guide that bridges the gap between detailed reference texts and basic handbooks on contact allergy, making it an ideal addition to general dermatology practices for practical use in the office. The first section of the book leads practitioners through the steps necessary to effectively and accurately perform patch testing. This covers basic immunological knowledge, various ways in which contact allergy can present, patch test techniques, and how to diagnose allergic contact dermatitis. Giving attention to all standard allergens, the second section offers an overview of the current literature on each, with detailed analysis on determining the clinical relevance of a positive patch test reaction. This convenient companion: Offers universally applicable guidance on when and how to perform patch testing, as well as how to interpret test reactions and arrive at accurate diagnoses Characterizes allergens from the Standard 'Baseline' Series, the International Series, and the T.R.U.E. Test Series Profiles allergens such as metals, fragrances, medicaments, rubber chemicals, plant chemicals, hair and clothing dyes, excipients, and resins Contains case reports, clinical images, patch test tips, and more Features color-coded exposure templates for easy consultation Provides key pointers on how to take patient histories and handle challenging cases Introduces new concepts such as 'microhistory' and 'microexamination' Allows access to online supplementary material featuring CAS numbers, toxicology, immunology, prevalence rates, chemical structures, additional case reports, and more Common Contact Allergens is a valuable reference tool for trainee and practicing general dermatologists, dermatology nurses, occupational health physicians, allergists, and other medical professionals with an interest in dermatology.
Download or read book Irritant Dermatitis written by Ai-Lean Chew and published by Springer Science & Business Media. This book was released on 2006-06-18 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Irritant dermatitis is a common condition, accounting for a significant proportion of occupational skin disease. The recent advent of non-invasive skin bioengineering technology has accelerated dermatology research in this field. This book comprises an exhaustive reference text on irritant contact dermatitis, covering all aspects of the condition: clinical features, epidemiology, prevention and therapy, prognosis, mechanisms, pathology and regulatory issues. The book also presents novel in vitro and in vivo research techniques and findings. As irritant dermatitis affects multiple specialties, the audience for this book is wide, including clinical and investigative dermatologists, allergists, toxicologists, pharmaceutical scientists, occupational and environmental physicians, public health physicians, cosmetologists and skin bioengineers.
Download or read book Dermatotoxicology Methods written by Francis N. Marzulli and published by CRC Press. This book was released on 2019-05-07 with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work presents and evaluates methods employed to identify the potential of certain types of chemicals to adversely affect the skin. A variety of test methods are included such as tests for skin penetration, metabolism, irritation, the skin immune system, photo effects, skin cancer, and topical effects of retinoids and depigmenting chemicals. Tests for chemicals that affect the reproductive and nervous system are also included. Both animal and human tests that have been standardised and tests that are under development and employ animal alternatives are addressed in this book. Besides different testing methods, a rationale for accepting non-animal models and a review of some regulatory agency discussions about animal alternative tests are included.
Download or read book Drug Hypersensitivity written by Werner J. Pichler and published by Karger Medical and Scientific Publishers. This book was released on 2007-01-01 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Approaches the phenomenon of drug hypersensitivity in a comprehensive manner. Besides epidemiological aspects, it addresses the immunological mechanisms underlying these complicated reactions which go far beyond the IgE-mediated drug allergies also considered in this book. The book also covers clinical manifestations and new diagnostic methods, and introduces some recetly established animal models. Many topics are treated from multiple perspectives, and the 33 chapters are thoroughly cross-referenced.
Download or read book Skin Sensitization in Chemical Risk Assessment written by World Health Organization and published by World Health Organization. This book was released on 2008 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Harmonization Project Document presents the conclusions of an IPCS Workshop on Skin Sensitization in Chemical Risk Assessment. The workshop focused on the question of methods for dose-response assessment, to evaluate the relative ability of a chemical to induce sensitization in the skin, and hence inform risk assessment for humans. In addition this publication includes a series of short articles on this topic by leading experts in the field. The conclusions of the workshop cover such aspects as the nature and utility for risk assessment of the data produced by non-animal test methods (such as quantitative structure-activity relationships), in vitro testing approaches, animal test methods, and epidemiological studies. While traditional animal test methods used for identification and regulation of skin sensitizers have focused on determining whether or not a substance is a sensitizer, this report describes the use of tests for deriving more informative potency information. This book will be useful to toxicologists, researchers, regulatory authorities and industry.
