Download or read book Animal Models in Toxicology written by Shayne C. Gad and published by CRC Press. This book was released on 2006-10-30 with total page 950 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reflecting more than a decade's worth of changes, Animal Models in Toxicology, Second Edition is a practical guide to the common statistical problems encountered in toxicology and the methodologies that are available to solve them. The book presents a historical review of the use of animal models and an overview of broad considerations of me
Download or read book In Vitro Toxicology Second Edition written by Shayne C. Gad and published by CRC Press. This book was released on 2000-11-02 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicology has made tremendous strides in the sophistication of the models used to identify and understand the mechanisms of agents that can harm or kill humand and other higher organisms. Non-animals or in vitro models started to gain significant use in the 1960s. As a result of the increased concern over animal welfare, economic factors, and the need for greater sensitivity and understanding of mechanisms, interest in in vitro^n models has risen. This volume demonstrates that there now exists a broad range of in vitro models for use in either identifying or understanding most forms of toxicity. The availability of in vitro models spans both the full range of endpoints (irritation, sensitization, lethality, mutagenicity, and devlopmental toxicity) and the full spectrum of target organ systems (skin, eye, heart, liver, kidney, nervous system, etc.). Chapters are devoted to each of these speciality areas from a perspective of presenting the principal models and their uses and limitations. Chapters that overview the principles involved in the general selection and use of models, and that address the issues of safety concerns and regulatory acceptance of these methods are also included.
Download or read book Scientific Frontiers in Developmental Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2000-12-21 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Download or read book Toxicology and Experimental Models Volume 5 written by Y Hagihara (Ed) and published by . This book was released on 1982 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Experimental and Comparative Toxicology written by Charles E. Cornelius and published by Elsevier. This book was released on 2013-10-22 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental and Comparative Toxicology, Volume 31 aims to explore some of the potentially important and crucial areas in experimental toxicology. The book discusses tumor promoters and genotoxic chemicals in short-term testing for carcinogenicity, as well as the significance of preneoplastic liver lesions in experimental animals. The text also describes the factors known to be associated with increased risk of liver neoplasia as a human disease, and the extent to which it is known that the same factors have a similar effect in laboratory animals. Neurobehavioral toxicology; immunotoxicology; and the endocrine system as the target in experimental toxicology are also considered. The book further tackles the uses of gamma-glutamyltransferase in experimental toxicology, as well as the predictive value of ocular irritation tests. Toxicologists, biochemists, pathologists, and those involved in preventive medicine and community health will find the text invaluable.
Download or read book Toxicology and Experimental Models written by H. Yoshida and published by Elsevier. This book was released on 2013-10-22 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Pharmacology and Therapeutics II, Volume 5: Toxicology and Experimental Models is the fifth of a six-volume compilation of the scientific papers of invited speakers of the Eighth International Congress of Pharmacology. Organized into six parts, this book begins by elucidating the rational interpretation of species and strain differences in toxicity for the prediction of risk to man. Subsequent parts discuss the chemical interactions resulting in liver and kidney injury; the role of heme synthesis and degradation in predicting drug toxicity; and delayed toxic effects of pre- and perinatal drug exposure. Other chapters describe models of experimental peptic ulcers and therapeutic agents and models and quality control of laboratory animals.
Download or read book Toxicology experimental models written by and published by . This book was released on 1982 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Invertebrates written by Marcelo Larramendy and published by BoD – Books on Demand. This book was released on 2016-02-10 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited book, Invertebrates-Experimental Models in Toxicity Screening, is intended to provide an overview of the use of conventional and nonconventional invertebrate species as experimental models for the study of different toxicological aspects induced by environmental pollutants in both aquatic and terrestrial ecosystems. Furthermore, it is hoped that the information in the present book will be of value to those directly engaged in the handling and use of environmental pollutants and that this book will continue to meet the expectations and needs of all interested in the different aspects of toxicity screening.
Download or read book Animal Models in Toxicology Third Edition written by Shayne C. Gad and published by CRC Press. This book was released on 2015-08-05 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal Models in Toxicology is a single-source reference for the use of animal models in toxicology. Chapters cover nine species used in toxicology and experimental biology. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provides an excellent introductory "course" along with guidance to the literature for a more detailed understanding. This edition includes five new chapters. The first of these provides specific and detailed guidance on the humane, efficient, and effective performance of necropsies for laboratory animals. Other new chapters discuss new technologies available for laboratory animal research—imaging technologies, use of telemetry in animal studies, transgenic animal models, and immunology endpoint for assessment. Also provided is an overview of the increasingly complex laws and regulations that govern how laboratory animals are obtained, maintained, and utilized. A helpful appendix provides a quick guide to commercial sources of laboratory animals.
Download or read book Toxicology and Experimental Models written by Hiroshi Yoshida and published by . This book was released on 1982 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Pharmacology and Therapeutics II, Volume 5: Toxicology and Experimental Models is the fifth of a six-volume compilation of the scientific papers of invited speakers of the Eighth International Congress of Pharmacology. Organized into six parts, this book begins by elucidating the rational interpretation of species and strain differences in toxicity for the prediction of risk to man. Subsequent parts discuss the chemical interactions resulting in liver and kidney injury; the role of heme synthesis and degradation in predicting drug toxicity; and delayed toxic effects of pre- and per.
Download or read book Animal Models in Toxicology Second Edition written by Shayne C. Gad and published by CRC Press. This book was released on 2006-10-30 with total page 952 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reflecting more than a decade’s worth of changes, Animal Models in Toxicology, Second Edition is a practical guide to the common statistical problems encountered in toxicology and the methodologies that are available to solve them. The book presents a historical review of the use of animal models and an overview of broad considerations of metabolism and relevance used in toxicology. Individual chapters covering the eight major species used in toxicology and experimental biology form the core of the book. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provide an excellent introductory “course” along with guidance to the literature for more detailed understanding. The book goes on to make the case for a range of species not commonly used for safety assessment studies but which may provide useful alternative models for some specific endpoints. The chapter authors discuss special considerations regarding the evaluation and interpretation of the clinical pathology of the eight major model species as well as how to select a model species and how to extrapolate the results to humans. They detail potential pitfalls and situations that cause either human or model to be significantly more sensitive than the other or totally irrelevant to each other. The book concludes with an overview of the increasingly complex laws and regulations that govern how laboratory animals are obtained, maintained, and utilized, and an appendix that provides a quick guide to commercial sources of laboratory animals.
Download or read book EXPERIMENTAL MODEL SYSTEMS IN TOXICOLOGY AND THEIR SIGNIFICANCE IN MAN PROCEEDINGS OF A MEETING OF THE EUROPEAN SOCIETY FOR THE STUDY OF DRUG TOXICITY written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Experimental Model Systems in Toxicology and Their Significance in Man written by European Society for the Study of Drug Toxicity. Meeting and published by . This book was released on 1974 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Experimental Model Systems in Toxicology and Their Significance in Man written by W. A. M. Duncan and published by . This book was released on 1974 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Experimental Model System in Toxicology and Their Significance in Man written by European Society for the Study of Drug Toxicity. Symposium and published by . This book was released on 1974 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Pharmacology and Therapeutics II Toxicology experimental models written by and published by . This book was released on 1982 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advancing Disease Modeling in Animal Based Research in Support of Precision Medicine written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-06-29 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: Precision medicine is focused on the individual and will require the rapid and accurate identification and prioritization of causative factors of disease. To move forward and accelerate the delivery of the anticipated benefits of precision medicine, developing predictable, reproducible, and reliable animal models will be essential. In order to explore the topic of animal-based research and its relevance to precision medicine, the National Academies of Sciences, Engineering, and Medicine convened a 2-day workshop on October 5 and 6, 2017. The workshop was designed to focus on the development, implementation, and interpretation of model organisms to advance and accelerate the field of precision medicine. Participants examined the extent to which next-generation animal models, designed using patient data and phenotyping platforms targeted to reveal and inform disease mechanisms, will be essential to the successful implementation of precision medicine. This publication summarizes the presentations and discussions from the workshop.
