Download or read book Tissue Perfusion Quantification Using Magnetic Resonance Imaging and Contrast Media written by Jean-Paul Vallée and published by . This book was released on 1999 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cette thèse décrit une approche originale de mesure de la perfusion tissulaire basée sur l'imagerie par résonance magnétique (IRM) et l'injection intraveineuse de produits de contraste. Les grands principes de la technique d'IRM ainsi que les différentes classes de produits de contraste sont passés en revue. Puis, les séquences d'impulsions RF utilisées pour la mesure de la perfusion tissulaire sont étudiées, suivies des méthodes de conversion du signal en concentration de produit de contraste. Enfin, la dernière partie présente deux classes de modèles permettant de mesurer la perfusion tissulaire à partir des courbes de transit obtenues avec l'IRM qui ont été développées durant cette thèse. La méthode proposée dans cette thèse démontre qu'il est possible de mesurer d'une manière non invasive par IRM le débit de perfusion tissulaire ainsi que cela a été vérifié dans quelques situations cliniques.
Download or read book Perfusion Imaging in Clinical Practice written by Farhood Saremi and published by Lippincott Williams & Wilkins. This book was released on 2015-05-22 with total page 1810 pages. Available in PDF, EPUB and Kindle. Book excerpt: Make optimal use of all the latest clinical applications of perfusion imaging! Perfusion Imaging is the first comprehensive resource that encompasses every facet of this important and rapidly advancing area of diagnostic imaging. Authored by an elite cadre of leading perfusion imaging authorities, this clinical reference offers balanced multimodality perspectives to deliver a well-rounded understanding of clinical issues and diagnoses, with a focus on practical clinical applications. In short, Perfusion Imaging provides the expert guidance you need to take advantage of the full capabilities of this powerful diagnostic tool.
Download or read book Interrogating Tissue Perfusion and Oxygenation Using Dynamic Magnetic Resonance Imaging and Quantitative Susceptibility Mapping written by Bo Xu and published by . This book was released on 2014 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic resonance imaging (MRI) is a widely used non-invasive imaging technique, with rich contrast for interrogation of tissue physiology and pathology. MRI can be used to examine hemodynamic conditions like perfusion and oxygenation qualitatively and quantitatively. This dissertation reports new techniques that employ dynamic imaging and quantitative susceptibility mapping (QSM) to overcome technical challenges for improved MRI perfusion imaging and oxygenation quantification. Perfusion imaging after gadolinium contrast agent administration is a common clinical practice, where dynamic MRI technique is used to track contrast bolus. It is desirable to have high temporal resolution to capture blood dynamics, as well as high spatial resolution to depict small lesions. Unfortunately, these requirements are limited by hardware and physiological conditions. In this dissertation, a dynamic MRI technique was realized, using fast spiral acquisition and a constrained image reconstruction algorithm, to achieve high temporal-spatial resolution for liver perfusion imaging. Tissue susceptibility provides unique contrast in MRI. Recent development of QSM technique has been applied in various clinical applications. In this dissertation, the dynamic imaging method was extended to multi-echo acquisition and combined with QSM to map gadolinium contrast agent concentration during the first passage for cerebral perfusion mapping. Blood oxygenation is determined by the amount of deoxyhemoglobin in red blood cell. Magnetic susceptibility of deoxyhemoglobin is a source of MR contrast for imaging oxygenation. This dissertation reports correction schemes in both data acquisition and image reconstruction of QSM for improved blood oxygenation quantification.
Download or read book Quantitative Magnetic Resonance Imaging written by Nicole Seiberlich and published by Academic Press. This book was released on 2020-11-18 with total page 1094 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative Magnetic Resonance Imaging is a 'go-to' reference for methods and applications of quantitative magnetic resonance imaging, with specific sections on Relaxometry, Perfusion, and Diffusion. Each section will start with an explanation of the basic techniques for mapping the tissue property in question, including a description of the challenges that arise when using these basic approaches. For properties which can be measured in multiple ways, each of these basic methods will be described in separate chapters. Following the basics, a chapter in each section presents more advanced and recently proposed techniques for quantitative tissue property mapping, with a concluding chapter on clinical applications. The reader will learn: - The basic physics behind tissue property mapping - How to implement basic pulse sequences for the quantitative measurement of tissue properties - The strengths and limitations to the basic and more rapid methods for mapping the magnetic relaxation properties T1, T2, and T2* - The pros and cons for different approaches to mapping perfusion - The methods of Diffusion-weighted imaging and how this approach can be used to generate diffusion tensor - maps and more complex representations of diffusion - How flow, magneto-electric tissue property, fat fraction, exchange, elastography, and temperature mapping are performed - How fast imaging approaches including parallel imaging, compressed sensing, and Magnetic Resonance - Fingerprinting can be used to accelerate or improve tissue property mapping schemes - How tissue property mapping is used clinically in different organs - Structured to cater for MRI researchers and graduate students with a wide variety of backgrounds - Explains basic methods for quantitatively measuring tissue properties with MRI - including T1, T2, perfusion, diffusion, fat and iron fraction, elastography, flow, susceptibility - enabling the implementation of pulse sequences to perform measurements - Shows the limitations of the techniques and explains the challenges to the clinical adoption of these traditional methods, presenting the latest research in rapid quantitative imaging which has the possibility to tackle these challenges - Each section contains a chapter explaining the basics of novel ideas for quantitative mapping, such as compressed sensing and Magnetic Resonance Fingerprinting-based approaches
Download or read book Measuring Perfusion with Magnetic Resonance Imaging Using Novel Data Acquisition and Reconstruction Strategies written by Katherine L Wright and published by . This book was released on 2015 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue perfusion is an important metric that can provide valuable information for disease diagnosis, treatment planning, and treatment follow-up. MRI can quantify perfusion both with and without Gd-based contrast agents, and can provide spatially-localized perfusion maps. However, these techniques are rarely used in the clinical environment. The works in this thesis focused on providing novel data acquisition and/or reconstruction techniques to overcome limitations in DCE MRI and ASL in order to provide clinically-viable perfusion exams.There are three main projects that will be described in this thesis. First, a simultaneous 3D magnetic resonance angiography and perfusion (MRAP) exam is proposed and is demonstrated in the distal lower extremities. Second, a 3D non-Cartesian parallel imaging method is described and used to achieve a low-dose, 3D, high spatiotemporal resolution renal DCE MRI exam that is acquired without breath-holding. Finally, a novel approach to ASL is proposed using the Magnetic Resonance Fingerprinting framework to simultaneously quantify perfusion, transit time, and tissue T1 in a single, efficient acquisition.
Download or read book Nuclear Cardiology written by Barry L. Zaret and published by . This book was released on 1999 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: This latest edition of NUCLEAR CARDIOLOGY provides up-to-the-minute information on current and future uses of radionuclides in imaging diagnosis of the heart. Thoroughly revised and updated, it contains practical information on radiopharmaceuticals, tracer kinetics, instrumentation, ventricular function, perfusion, acute ischemic syndrome, viability, and metabolic images, as well as a discussion of the role of nuclear cardiology in a changing health care system. Practitioners in nuclear medicine, radiology, and cardiology will benefit from having current information on a wide range of topics in one focused reference. Provides highly detailed and comprehensive information in one convenient resource Includes more than 600 images and illustrations to aid comprehension Incorporates the knowledge of internationally recognized authors who are experts in the field Discusses a broad spectrum of nuclear cardiology applications to help you gain a better perspective on contemporary cardiac nuclear medicine
Download or read book Magnetic Resonance Imaging in Tissue Engineering written by Mrignayani Kotecha and published by John Wiley & Sons. This book was released on 2017-03-06 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic Resonance Imaging in Tissue Engineering provides a unique overview of the field of non-invasive MRI assessment of tissue engineering and regenerative medicine Establish a dialogue between the tissue-engineering scientists and imaging experts and serves as a guide for tissue engineers and biomaterial developers alike Provides comprehensive details of magnetic resonance imaging (MRI) techniques used to assess a variety of engineered and regenerating tissues and organs Covers cell-based therapies, engineered cartilage, bone, meniscus, tendon, ligaments, cardiovascular, liver and bladder tissue engineering and regeneration assessed by MRI Includes a chapter on oxygen imaging method that predominantly is used for assessing hypoxia in solid tumors for improving radiation therapy but has the ability to provide information on design strategies and cellular viability in tissue engineering regenerative medicine
Download or read book In Vivo Tissue Perfusion Measurements in the Rat by Means of Magnetic Resonance Imaging and Application of a Macromolecular Contrast Agent written by Birgitte Helene Pedersen and published by . This book was released on 1993 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Measuring Resting Cerebral Perfusion using Magnetic Resonance Imaging MRI written by James Duffin and published by Frontiers Media SA. This book was released on 2024-07-12 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: The acquisition of resting cerebral perfusion measures using magnetic resonance imaging (MRI) is one of the assessments of cerebrovascular health used to discern how well patients are coping with anatomical changes such as stenosis, and other factors impacting the supply of blood flow to the brain. Perfusion measures may be obtained using several MRI based techniques including arterial spin labeling (ASL) and dynamic contrast enhanced methods that rely on injected contrast agents such as gadolinium. Recently hypoxia-induced changes in deoxyhemoglobin have been used as a non-invasive contrast agent, measuring the resulting changes in blood oxygen dependent (BOLD) signals with MRI. With each approach, the means through which voxel-wise cerebral perfusion information is derived differs, leading to the development a variety of analysis methods in recent studies. This Research Topic is intended to attract manuscripts that advance the use of resting cerebral perfusion measures in clinical assessments of cerebrovascular health. In pursuit of this aim a better understanding of several aspects are needed.
Download or read book Quantitative Perfusion MRI written by Hai-Ling Margaret Cheng and published by Elsevier. This book was released on 2023-08-22 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative Perfusion MRI: Techniques, Applications, and Practical Considerations, Volume 11 clearly and carefully explains the basic theory and MRI techniques for quantifying perfusion non-invasively in deep tissue, covering all aspects of perfusion imaging, from acquisition requirements to selection of contrast agents and appropriate pharmacokinetic models and for reliable quantification in different diseases and tissue types. Specifically, this book enables the reader to understand what microvascular functional parameters can be measured with perfusion MRI, learn the basic techniques to measure perfusion in different organs, apply the appropriate perfusion MRI technique to the organ of interest, and much more. This complete reference on quantitative perfusion MRI is highly suitable for both early and experienced researchers, graduate students and clinicians wishing to understand how quantitative perfusion MRI can apply to their application area of interest. - Provides a one-stop resource for students and early and experienced researchers on all aspects of quantitative perfusion MRI as written by experts in the field - Explains basic theory and MRI techniques - Presents a strong focus on the practical considerations that can make or break perfusion MRI - Includes applications in oncology, cardiology, neurology and body imaging
Download or read book Quantification of Contrast Kinetics in Clinical Imaging written by Massimo Mischi and published by Springer. This book was released on 2018-11-02 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive survey of the pharmacokinetic models used for the quantitative interpretation of contrast-enhanced imaging. It discusses all the available imaging technologies and the problems related to the calibration of the imaging system and accuracy of the estimated physiological parameters. Enhancing imaging modalities using contrast agents has opened up new opportunities for going beyond morphological information and enabling minimally invasive assessment of tissue and organ functionality down to the molecular level. In combination with mathematical modeling of the contrast agent kinetics, contrast- enhanced imaging has the potential to provide clinically valuable additional information by estimating quantitative physiological parameters. The book presents the broad spectrum of diagnostic possibilities provided by quantitative contrast-enhanced imaging, with a particular focus on cardiology and oncology, as well as novel developments in the area of quantitative molecular imaging along with their potential clinical applications. Given the variety of available techniques, the choice of the appropriate imaging modality and the most suitable pharmacokinetic model is often challenging. As such, the book provides a valuable technical guide for researchers, clinical scientists, and experts in the field who wish to better understand and properly apply tracer-kinetic modeling for quantitative contrast-enhanced imaging.
Download or read book Progress in Brain Research written by J. P. Schadé and published by . This book was released on 1963 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book MRI from Picture to Proton written by Donald W. McRobbie and published by Cambridge University Press. This book was released on 2017-04-13 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: MR is a powerful modality. At its most advanced, it can be used not just to image anatomy and pathology, but to investigate organ function, to probe in vivo chemistry, and even to visualise the brain thinking. However, clinicians, technologists and scientists struggle with the study of the subject. The result is sometimes an obscurity of understanding, or a dilution of scientific truth, resulting in misconceptions. This is why MRI from Picture to Proton has achieved its reputation for practical clarity. MR is introduced as a tool, with coverage starting from the images, equipment and scanning protocols and traced back towards the underlying physics theory. With new content on quantitative MRI, MR safety, multi-band excitation, Dixon imaging, MR elastography and advanced pulse sequences, and with additional supportive materials available on the book's website, this new edition is completely revised and updated to reflect the best use of modern MR technology.
Download or read book Quantifying Morphology and Physiology of the Human Body Using MRI written by L. Tugan Muftuler and published by CRC Press. This book was released on 2013-05-02 with total page 529 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the medical imaging field, clinicians and researchers are increasingly moving from the qualitative assessment of printed images to the quantitative evaluation of digital images since the quantitative techniques often improve diagnostic accuracy and complement clinical assessments by providing objective criteria. Despite this growing interest, the field lacks a comprehensive body of knowledge. Filling the need for a complete manual on these novel techniques, Quantifying Morphology and Physiology of the Human Body Using MRI presents a wide range of quantitative MRI techniques to study the morphology and physiology of the whole body, from the brain to musculoskeletal systems. Illustrating the growing importance of quantitative MRI, the book delivers an indispensable reference for readers who would like to explore in vivo MRI techniques to quantify changes in the morphology and physiology of tissues caused by various disease mechanisms. With internationally renowned experts sharing their insight on the latest developments, the book goes beyond conventional MRI contrast mechanisms to include new techniques that measure electromagnetic and mechanical properties of tissues. Each chapter offers comprehensive information on data acquisition, processing, and analysis techniques as well as clinical applications. The text organizes the techniques based on their primary use either in the brain or the body. Some of the techniques, such as diffusion-weighted imaging and diffusion tensor imaging, span several application areas, including brain imaging, cancer imaging, and musculoskeletal imaging. The book also covers up-and-coming quantitative techniques that explore tissue properties other than the presence of protons (or other MRI-observable nuclei) and their interactions with their environment. These novel techniques provide unique information about the electromagnetic and mechanical properties of tissues and introduce new frontiers of study into disease mechanisms.
Download or read book Brain Neurotrauma written by Firas H. Kobeissy and published by CRC Press. This book was released on 2015-02-25 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.
Download or read book Cardiac and Renal Perfusion Quantification Using Magnetic Resonance Imaging written by Jean-Paul Vallée and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Signal Processing Tools of MRI Perfusion weighted Imaging Data Analysis written by and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In dynamic susceptibility contrast (DSC) magnetic resonance (MR) approaches, by injecting a bolus of paramagnetic contrast agent intravenously, the measured MR signal is converted to a concentration time course to estimate hemodynamic parameters like cerebral blood flow (CBF), cerebral blood volume (CBV) and mean transit time (MTT). Before estimating hemodynamic parameters, recirculation effects need to be removed by a gamma-variate fit of the concentration curve. In this dissertation, however, it has been found and demonstrated by simulation that fitting may not discern recirculation from the first-pass in case of cerebral ischemia. A new methodology using temporal independent component analysis (ICA) to remove recirculation in both normal and ischemic brain tissues while preserving the first-pass is therefore proposed. This should improve hemodynamics accuracy particularly in ischemic lesions. In DSC MR approaches, bolus delays between the arterial input function (AIF) and tissue curves may induce significant CBF quantification error. Our second contribution is using ICA to estimate bolus arrival time for each 5x5 region of interest (ROI) throughout the brain parenchyma. A global AIF measured from a major artery can then be shifted in accordance to define a local AIF for each ROI. The bolus delay may therefore be minimized, and the general shape of the AIF is preserved. This should improve the flow quantification. Transfer function has been widely used to characterize an unknown system. In DSC MR approaches, vascular transfer function (VTF) represents the probability density function of the vascular transit time. Our third contribution is to propose a new tool to estimate intracranial VTF non-invasively. This should provide an alternative means of assessing tissue perfusion status, particularly in patients with cerebrovascular diseases. Bolus dispersion between the AIF and tissue curves may induce flow quantification error, which cannot be minimized without the kno.
