Download or read book Three Dimensional Near infrared Optical Imaging Using Ultrasound Guidance for Breast Cancer Detection and Diagnosis written by Minming Huang and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation focuses on the study of three-dimensional near-infrared (NIR) imaging reconstruction using ultrasound localization for breast cancer detection and diagnosis. With the 3D NIR forward model for reflection geometry built and investigated, successful reconstruction of both absorption and scattering coefficients has been obtained and evaluated using both a phantom study and initial clinic data. In this work, we first introduce a dual mesh optical reconstruction method with depth correction using a priori ultrasound information. It can significantly improve the reconstructed absorption distributions in deeper target layers. Clinical results have shown improved correlation between reconstructed total hemoglobin concentrations and the histological micorvessel density counts. Next, a combined Tikhonov regularization and dual mesh scheme based on finite element method (FEM) is proposed to solve the inter-parameter cross talk between the scattering coefficient and absorption coefficient. In this approach, the optimal regularization factor is given by the standard L-curve. Different regularization factors have been assigned to the target region and non-target region to incorporate the priori target information from the co-registered ultrasound images. Both phantom experiments and clinic examples have shown that this new approach has the ability to reconstruct the absorption and diffusion coefficients simultaneously, and the reconstructed target absorption and diffusion maps have no depth dependence effect. Finally, a simple two-layer model is generated and studied to solve a clinical issue related to the chest wall, which is a mixture of bones and muscles. For small breasts, the chest wall appears within 2–3 cm distance from the skin surface. As a result, the simple one layer model is not accurate. Furthermore, for some cases, there is also an obvious chest wall mismatch between the reference site and lesion site. To solve this clinical issue, a simplified two-layer model is generated and a fitting method is adopted to estimate the optical properties of both layers. Then a correction method is applied to correct for the chest wall mismatch between the lesion site and reference site. With this scheme, phantom targets located on top of the chest wall phantom layer can be reconstructed with good contrast and resolution.
Download or read book Three Dimensonal Near infrared Optical Imaging Using Ultrasound Guidance for Breast Cancer Detection and Diagnosis written by Minming Huang and published by . This book was released on 2005 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Three dimensional Ultrasound Imaging and Its Applications in Combined Near infrared Optical Imaging and Co registered Photoacoustic Imaging written by Puyun Guo and published by . This book was released on 2007 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation focuses on three-dimensional (3-D) ultrasound and its applications as an adjunct modality for biomedical optical imaging.
Download or read book Mammography and Beyond written by National Research Council and published by National Academies Press. This book was released on 2001-07-23 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each year more than 180,000 new cases of breast cancer are diagnosed in women in the U.S. If cancer is detected when small and local, treatment options are less dangerous, intrusive, and costly-and more likely to lead to a cure. Yet those simple facts belie the complexity of developing and disseminating acceptable techniques for breast cancer diagnosis. Even the most exciting new technologies remain clouded with uncertainty. Mammography and Beyond provides a comprehensive and up-to-date perspective on the state of breast cancer screening and diagnosis and recommends steps for developing the most reliable breast cancer detection methods possible. This book reviews the dramatic expansion of breast cancer awareness and screening, examining the capabilities and limitations of current and emerging technologies for breast cancer detection and their effectiveness at actually reducing deaths. The committee discusses issues including national policy toward breast cancer detection, roles of public and private agencies, problems in determining the success of a technique, availability of detection methods to specific populations of women, women's experience during the detection process, cost-benefit analyses, and more. Examining current practices and specifying research and other needs, Mammography and Beyond will be an indispensable resource to policy makers, public health officials, medical practitioners, researchers, women's health advocates, and concerned women and their families.
Download or read book Breast Cancer Diagnosis Using Ultrasound and Diffusive Light written by and published by . This book was released on 2001 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: We have developed a novel near-infrared optical technique with ultrasound localization. During the last year, we have made significant progress on using our technique to improve breast cancer diagnosis. Initial results with a group of biopsied patients have shown that early stage invasive cancers present two-fold greater total hemoglobin concentration than fibroadenomas and benign lesions. Initial results of advanced cancers have shown good correlation between cancer angiogenesis distributions imaged by the hybrid imaging technique and histological microvessel density counts. We believe our unique has a great potential to improve current practice on breast cancer diagnosis and monitor treatment responses of advanced cancers.
Download or read book 3D Near Infrared Diffuse Wave Imaging With Ultrasound Localization written by and published by . This book was released on 2005 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: This proposal is focused on the three-dimensional NIR imaging reconstruction using ultrasound localization for cancer detection and diagnosis. During the reported period, we have achieved simultaneous reconstruction of optical absorption and scattering coefficients of heterogeneities using a dual-mesh scheme based on finite element method, and introduced a new simple two-layer model to correct diffusive wave distortion caused by underlying chest wall of patients.
Download or read book Time Resolved and Spectroscopic Three Dimensional Optical Breast Tomography written by and published by . This book was released on 2009 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of the research project, "Time-Resolved and Spectroscopic Three-Dimensional Optical Breast Tomography," was to develop a safe and affordable breast cancer detection modality that uses noninvasive near-infrared (NIR) light for imaging and diagnosing tumors in human breast with high resolution and specificity. In order to realize that goal three different approaches were developed. These are Optical Tomography using Independent Component Analysis (OPTICA), Round Trip Matrix (RTM) approach, and Center of Intensity Time Gated Imaging (CITGI). OPTICA is the most developed of these approaches. It has been demonstrated that OPTICA can detect, obtain the threedimensional location information and cross-section images of small absorbing, scattering, and fluorescent targets in model media, and tumor(s) in realistic model breast with considerable accuracy. Further accomplishments include development of a forward model for determining the backscattered polarized light intensity distribution, and initial development of a technique to determine scattering coefficient, absorption coefficient, and anisotropy factor (g) of breast tissue specimens. Besides detection and localization of tumors in breast, these results may have potential applications in optical biopsy, and lumpectomy. The graduate student supported by the project received his Ph. D., adding another scientist to the ongoing fight against breast cancer.
Download or read book Optical Imaging of Breast Cancers written by Yan Xu and published by . This book was released on 2013 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ultrasound guided Optical Techniques for Cancer Diagnosis written by Atahar Kamal Mostafa and published by . This book was released on 2019 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: Worldwide, breast cancer is the most common cancer among women. In the United States alone, the American cancer society has estimated there will be 271,270 new breast cancer cases in 2019, and 42,260 lives will be lost to the disease. Ultrasound (US), mammography, and magnetic resonance imaging (MRI) are regularly used for breast cancer diagnosis and therapy monitoring. However, they sometimes fail to diagnose breast cancer effectively. These shortcomings have motivated researchers to explore new modalities. One of these modalities, diffuse optical tomography (DOT), utilizes near-infrared (NIR) light to reveal the optical properties of tissue. NIR-based DOT images the contrast between a suspected lesion's location and the background tissue, caused by the higher NIR absorption of the hemoglobin which characterizes tumors. The limitation of high light scattering inside tissue is minimized by using ultrasound image to find the tumor location.This thesis focuses on developing a compact, low-cost ultrasound guided diffuse optical tomography imaging system and on improving optical image reconstruction by extracting the tumor's location and size from co-registered ultrasound images. Several electronic components have been redesigned and optimized to save space and cost and to improve the user experience. In terms of software and algorithm development, manual extraction of tumor information from ultrasound images has been replaced by using a semi-automated ultrasound image segmentation algorithm that reduces the optical image reconstruction time and operator dependency. This system and algorithm have been validated with phantom and clinical data and have demonstrated their efficacy. An ongoing clinical trial will continue to gather more patient data to improve the robustness of the imaging algorithm.Another part of this research focuses on ovarian cancer diagnosis. Ovarian cancer is the most deadly of all gynecological cancers, with a less than 50% five-year survival rate. This cancer can evolve without any noticeable symptom, which makes it difficult to diagnose in an early stage. Although ultrasound-guided photoacoustic tomography (PAT) has demonstrated potential for early detection of ovarian cancer, clinical studies have been very limited due to the lack of robust PAT systems.In this research, we have customized a commercial ultrasound system to obtain real-time co-registered PAT and US images. This system was validated with several phantom studies before use in a clinical trial. PAT and US raw data from 30 ovarian cancer patients was used to extract spectral and statistical features for training and testing classifiers for automatic diagnosis. For some challenging cases, the region of interest selection was improved by reconstructing co-registered Doppler images. This study will be continued in order to obtain quantitative tissue properties using US-guided PAT.
Download or read book Developing Technologies for Early Detection of Breast Cancer written by National Research Council and published by National Academies Press. This book was released on 2000-07-06 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt: In November 1999, the Institute of Medicine, in consultation with the Commission on Life Sciences, the Commission on Physical Sciences, Mathematics, and Applications, and the Board on Science, Technology and Economic Policy launched a one year study on technologies for early detection of breast cancer. The committee was asked to examine technologies under development for early breast cancer detection, and to scrutinize the process of medical technology development, adoption, and dissemination. The committee is gathering information on these topics for its report in a number of ways, including two public workshops that bring in outside expertise. The first workshop on "Developing Technologies for Early Breast Cancer Detection" was held in Washington DC in February 2000. The content of the presentations at the workshop is summarized here. A second workshop, which will focus on the process of technology development and adoption, will be held in Washington, DC on June 19-20. A formal report on these topics, including conclusions and recommendations, will be prepared by the committee upon completion of the one-year study.
Download or read book Three Dimensional Near Infrared Imaging of Pathophysiological Changes Within the Breast written by and published by . This book was released on 2008 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: Near Infrared optical imaging is a non-invasive and non-ionizing medical imaging technique that can image functional properties of biological tissue using Near Infrared (NIR) light. Due to the dominance of scattering of light in tissue, modeling of light propagation in tissue requires advanced computational methods. This project was aimed to develop novel computational methods that will lead to use of optical imaging in a routine clinical setting. As a part of this work, an optimization of computational parameters for the existing methods was performed. A novel algorithm which includes noise characteristics of the instruments was also developed to get an optimal estimate of breast tissue optical properties. New methods for effectively using Magnetic resonance image information in NIR image reconstruction procedure were also developed to improve the total outcome of NIR functional images of breast. Optical image reconstruction methods that improve the computational efficiency by a factor of 10 for three-dimensional optical imaging were also developed.
Download or read book Dynamic Digital Optical Tomography for Cancer Imaging and Therapy Monitoring written by Molly Flexman and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Diffuse optical tomography is a non-invasive imaging technique that uses near-infrared light to create three-dimensional images of tissue. This dissertation presents the design and validation of an instrument for rapid optical imaging using digital detection techniques. In addition to a detailed description of the instrument, three studies are presented: a clinical study detecting breast cancer using dynamic optical imaging; a pre-clinical study monitoring early tumor response to anti-angiogenic therapy; and a clinical study monitoring individual patient response to neoadjuvant chemotherapy. These studies show that diffuse optical tomography is a valuable imaging modality that can play an important role in cancer detection and treatment.
Download or read book Evaluation of Near infrared Contrast Agents for Cancer Detection Using Optical Imaging Techniques written by Akram Abuteen and published by . This book was released on 2016 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Improving the Light Quantification of Near Infrared NIR Diffused Light Optical Tomography with Ultrasound Localization written by Yasaman Ardeshirpour and published by . This book was released on 2010 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Methods for Improving the Reconstruction of Diffuse Optical Tomography for Breast Cancer Detection written by Murad Mohsen Althobaiti and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Three Dimensional Reconstruction Algorithm for Imaging Pathophysiological Signals Within Breast Tissue Using Near Infrared Light written by and published by . This book was released on 2006 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical tomography is a non-invasive imaging technique that can image properties of biological tissue using Near Infrared light. Under this program, this technique has been used to characterize breast tissue in healthy volunteers as well as detecting tumor in patients. Image reconstruction models and algorithms have been developed, under this program, which incorporates inherent wavelength dependant a-priori information (spectral) as well as concurrently measured MRI structural information (spatial) to show that the quantitative and qualitative accuracy can be dramatically improved. Three dimensional models have been developed that will allow the use of correct size and shape of the breast being imaged showing that image artifacts can be eliminated by the correct assumptions about the model of the breast. Novel models have also been developed that will account for otherwise ignored Refractive Index (RI) distribution of breast tissue, and the results indicate that providing the RI distribution of breast tissue is not extremely heterogeneous, the impact on reconstructed artifacts is minimal.
Download or read book Breast Cancer Screening Using Photonic Technology written by and published by . This book was released on 2003 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt: The research carried out on this project was aimed at developing noninvasive optical detection and diagnostic methods for breast cancer. The approaches that were developed and pursued include: (a) time-sliced near-infrared (NIR) two dimensional (2-D) transillumination imaging for direct imaging of tumors, and generating data with robust information content for 3-D image reconstruction; (b) spectroscopic 2-D NIR transillumination imaging for exploring the diagnostic potential of optical approach; (c) derivation of analytical solutions of radiative transport equation (RTE) and development of inversion algorithms for reconstruction of 3-D tomographic images using a sequence of time-sliced 2-D images. Results of direct imaging measurements on ex vivo tumor and normal tissues were compared with biopsy, pathology, and nuclear magnetic resonance results for validation. Images recorded with earlier temporal slices of transmitted light were found to highlight cancerous tissues while those recorded with later slices accentuated normal fibrous tissues. Spectroscopic imaging experiments show that the ratio, R of light intensity transmitted through the cancerous tissue to that through the corresponding normal tissue exhibit a wavelength dependent variation that has the potential to be used as a useful parameter for cancer identification. Analytical solutions of RTE enable more complete description of light transport through tissue and forward models based on these solutions promise more accurate and agile 3-D image reconstruction schemes.
