Download or read book Therapeutic Locus and Mechanism of Bleomycin Action written by Anil Thomas Abraham and published by . This book was released on 2000 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Dissertation Abstracts International written by and published by . This book was released on 2000 with total page 846 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book American Doctoral Dissertations written by and published by . This book was released on 1999 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Goodman and Gilman s The Pharmacological Basis of Therapeutics 14th Edition written by Laurence Brunton and published by McGraw Hill Professional. This book was released on 2022-11-04 with total page 1664 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Doody's Core Title for 2023! The landmark pharmacology reference—updated to reflect the latest research and developments in the field For more than 50 years, Goodman & Gilman’s: The Pharmacological Basis of Therapeutics has represented the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. The text's careful balance of basic science and clinical applications has guided thousands of health care practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing and treating disease. This Fourteenth Edition includes five new chapters, 600+ illustrations, and important content from 53 new contributors. More than a textbook, Goodman & Gilman’s is a working template for the effective and rational prescribing of drugs in daily practice. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, Fourteenth Edition features: Five NEW chapters on: -Pharmacovigilance -The blood-brain barrier -Cannabis -Antibodies, immune checkpoint inhibitors, CAR-T cells, and other biological agents -Gastrointestinal microbiome and drug response Expanded coverage of the use of genetic polymorphisms in designing appropriate therapies Revised and expanded chapter on pharmacodynamics and the molecular mechanisms of drug action 600+ color illustrations Drug Fact Tables summarizing clinical pharmacology Content Outline and Abbreviation List at the beginning of each chapter 50 NEW figures on mechanism of drug actions 53 NEW contributors NEW online updates

Download or read book Current Medicinal Chemistry written by and published by . This book was released on 1995-06 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book DNA and RNA Cleavers and Chemotherapy of Cancer and Viral Diseases written by B. Meunier and published by Springer. This book was released on 1996-03-31 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: The September 1995 proceedings papers represent an increased research activity in the area of designing drugs that cleave DNA and RNA with sequence-specificity to use the resulting compounds as therapeutic agents in the treatment of cancer and viral diseases. The conference focused on bringing together scientists working in particular areas of this research, providing an overview of DNA cleavage by enediyn molecules, bleomycin paradigms of DNA cleavers based on metal complexes, site specific DNA cleavage, mechanism of oxidative DNA cleavage, RNA cleavage by RNase H, and hydrolysis of RNA by ribozymes and metal complexes. Annotation copyright by Book News, Inc., Portland, OR

Download or read book RNA Binding Antibiotics written by Renée Schroeder and published by CRC Press. This book was released on 2000-10 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past several years have seen a fundamental change in our perception of RNA. RNA was once regarded as a passive mediator of genetic information in mRNA and tRNA or as a mere scaffold for proteins in the ribosome. But the discovery of catalytic RNA, the development of SELEX, and dramatic improvements in RNA structure analysis have rather demonstrated that RNA is a highly versatile and dynamic molecule. Our increased understanding of the important role RNA plays in most, if not all, cellular processes has lead to the awareness that RNA represents a potential and prominent target for therapeutic intervention. On one hand, nature has "invented" an innumerable amount of small compounds which bind to RNA and modulate its function, on the other hand, the design and preparation of RNA molecules with defined properties is now within reach. This volume covers RNAs with known or proposed catalytic activity or functional importance whose behavior is affected by antibiotics. These include the peptidyl transferase and the decoding activities of the ribosome and the cleavage activities of several catalytic RNAs. Detailed discussion of the wide-spread effects of the tetracyclines, of the peptide antibiotic viomycin and of bleomycin on RNAs are presented. SELEX has provided a wealth of antibiotic-binding RNAs which are amenable to NMR structure determination. Detailed biophysical analyses on antibiotic-RNA interactions, and the design and synthesis of novel aminoglycosides suggest strategies for the pharmaceutical exploitation of RNA-binding drugs. On the verge of losing the battle against bacteria, which are acquiring resistance genes against all used antibiotics, it is mandatory to find new therapeutics. RNA-binding antibiotics are not only therapeutically valuable, they play a major role in the deciphering of RNA function and stimulate evolutionary thoughts about the origin of life.

Download or read book Questions and Answers in Pain Medicine written by Michael Suer and published by Springer Nature. This book was released on 2021-02-24 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a practical and comprehensive review of pain medicine in a clear and easy to apply question and answer format. Divided by topic, the book includes Q&As on Pain Basics, Psychology, Common Pain Syndromes, Medications, Pain Management in Special Populations and Interventional Pain. It is intended as a guide for residents and fellows and is written in such a manner to provide instantaneous feedback on correct answer choice and explanation for self-evaluation while preparing for written board examinations. Questions and Answers in Pain Medicine: A Guide to Board Exams fulfills the need for a resource that is similar to the Accreditation Council for Graduate Medical Education (ACGME) board examination in the US as well as international equivalents. It utilizes a fully Q&A approach which is how many students prefer to study. Written by a physician who has recently passed the ACGME written board exam and the founder of a pain management fellowship program for nearly 20 years, the authors provide valuable insight for successfully undertaking board examinations in pain medicine.

Download or read book Molecular Aspects of Human Disease written by John W. Gorrod and published by . This book was released on 1989 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Medicinal Chemistry of Anticancer Drugs written by Carmen Avendaño and published by Elsevier. This book was released on 2015-06-11 with total page 767 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature

Download or read book Multi Drug Resistance in Cancer written by Jun Zhou and published by Humana Press. This book was released on 2012-08-09 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemotherapy is one of the major treatment options for cancer patients; however, the efficacy of chemotherapeutic management of cancer is severely limited by multidrug resistance, in that cancer cells become simultaneously resistant to many structurally and mechanistically unrelated drugs. In the past three decades, a number of mechanisms by which cancer cells acquire multidrug resistance have been discovered. In addition, the development of agents or strategies to overcome resistance has been the subject of intense study. This book contains comprehensive and up-to-date reviews of multidrug resistance mechanisms, from over-expression of ATP-binding cassette drug transporters such as P-glycoprotein, multidrug resistance-associated proteins, and breast cancer resistance p- tein to the drug ratio-dependent antagonism and the paradigm of cancer stem cells. The book also includes strategies to overcome multidrug resistance, from the development of compounds that inhibit drug transporter function to the modulation of transporter expression. In addition, this book contains techniques for the detection and imaging of drug transporters, methods for the investigation of drug resistance in animal models, and strategies to evaluate the efficacy of resistance reversal agents. The book intends to provide a state-of-the-art collection of reviews and methods for both basic and clinician investigators who are interested in cancer multidrug resistance mechanisms and reversal strategies. Tianjin, China Jun Zhou v Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix 1 Multidrug Resistance in Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Bruce C. Baguley 2 Multidrug Resistance in Oncology and Beyond: From Imaging of Drug Efflux Pumps to Cellular Drug Targets . . . . . . . . . . . . . . . . . . . . . . . . . .

Download or read book Anticancer Agents from Natural Products written by Gordon M. Cragg and published by CRC Press. This book was released on 2005-06-13 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants, marine organisms, and microorganisms have evolved complex chemical defense and signaling systems that are designed to protect them from predators and provide other biological benefits. These organisms thus produce substances containing novel chemotypes that may have beneficial effects for humans. As collection methods improve and new screen

Download or read book Symposium on Clinical Pharmacology written by William A. Creasey and published by Elsevier. This book was released on 2013-10-22 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Symposium on Clinical Pharmacology reviews advances in clinical pharmacology, with emphasis on how to materially improve the efficacy of cancer chemotherapy. Topics range from absorption, protein binding, distribution, and excretion of antineoplastic drugs to factors affecting the biotransformation and activity of antitumor drugs. The transport of tumor-inhibitory agents across cell membranes is also examined, together with factors influencing drug selectivity and the mechanisms of clinical drug resistance. This volume is comprised of 23 chapters and begins with a brief summary of the different kinds of pharmacokinetic models and how detailed kinetic investigations of a drug in animals may provide further insight into modes of its clinical use. The next chapter considers the chief factors in determining the effective concentration of a drug at a receptor site as well as the duration and intensity of drug effect, citing antineoplastic agents as examples. The role of enzymatic activation and inactivation in drug selectivity is also discussed, along with the general mechanisms of clinical resistance to cancer chemotherapy; biochemical and pharmacological principles of combination chemotherapy; and the reaction and effects of nitrosoureas. This book will be of interest to clinicians, pharmacologists, and biochemists.

Download or read book Human Tumor Antigens and Specific Tumor Therapy written by Malcolm S. Mitchell and published by . This book was released on 1989 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1997 with total page 1850 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Anticarcinogenesis and Radiation Protection 2 written by O.F. Nygaard and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: The dramatic decrease in the incidence of stomach cancer in industrialized countries during the past 50 years, which is yet to be fully explained, and the observation that carcinogenesis in laboratory animals can be inhibited by antioxidants, retinoids, and caloric restriction, among other influences, challenge us to press on in the search for practical means to prevent cancer. It is in relation to this goal that the studies summarized in this book have special significance. This book is based on the invited and contributed papers presented at the Third Internationai Conference on Anticarcinogenesis and Radiation Protection, held on October 15-21, 1989, in Dubrovnik, Yugoslavia. They cover a broad range of investigations into the mechanisms and inhibition of carcinogenesis. In keeping with recent advances in our understanding of the importance of oncogenes and tumor-suppressor genes in carcinogenesis, many of the reports focus on mutations and related changes at the level of DNA. At the same time, however, other reports deal with nutritional, immunological, endocrinological, and epidemiological aspects. In all, the various reports address carcinogenesis and its inhibition at virtually every level of biological organization. Included in this compendium are timely reviews of diverse and promising research strategies for cancer prevention, as pursued by investigators in different parts of the world. The Organizers of the Conference are grateful to the many scientists who have contributed to the volume, as well as to the sponsors of the Conference, without whose generous support this book would not have been possible.

Download or read book Targeting DNA Repair and the DNA Damage Response Beyond the Standard PI3 Kinase like Kinases written by John J. Turchi and published by Frontiers Media SA. This book was released on 2022-11-09 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: