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Download or read book Cancer Evolution written by Charles Swanton and published by Perspectives Cshl. This book was released on 2017 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor progression is driven by mutations that confer growth advantages to different subpopulations of cancer cells. As a tumor grows, these subpopulations expand, accumulate new mutations, and are subjected to selective pressures from the environment, including anticancer interventions. This process, termed clonal evolution, can lead to the emergence of therapy-resistant tumors and poses a major challenge for cancer eradication efforts. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managing and treating it. The contributors review efforts to characterize the subclonal architecture and dynamics of tumors, understand the roles of chromosomal instability, driver mutations, and mutation order, and determine how cancer cells respond to selective pressures imposed by anticancer agents, immune cells, and other components of the tumor microenvironment. They compare cancer evolution to organismal evolution and describe how ecological theories and mathematical models are being used to understand the complex dynamics between a tumor and its microenvironment during cancer progression. The authors also discuss improved methods to monitor tumor evolution (e.g., liquid biopsies) and the development of more effective strategies for managing and treating cancers (e.g., immunotherapies). This volume will therefore serve as a vital reference for all cancer biologists as well as anyone seeking to improve clinical outcomes for patients with cancer.

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Download or read book Human Adult Stem Cells written by John Masters and published by Springer. This book was released on 2009-06-04 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of volume 7 of Human Cell Culture is to provide clear and precise methods for growing primary cultures of adult stem cells from various human tissues and describe culture conditions in which these adult stem cells differentiate along their respective lineages. The book will be of value to biomedical scientists and of special interest to stem cell biologists and tissue engineers. Each chapter is written by experts actively involved in growing human adult stem cells.

Download or read book American Civil Military Relations written by Suzanne C. Nielsen and published by Johns Hopkins University Press+ORM. This book was released on 2009-10-05 with total page 649 pages. Available in PDF, EPUB and Kindle. Book excerpt: American Civil-Military Relations offers the first comprehensive assessment of the subject since the publication of Samuel P. Huntington’s The Soldier and the State. Using this seminal work as a point of departure, experts in the fields of political science, history, and sociology ask what has been learned and what more needs to be investigated in the relationship between civilian and military sectors in the 21st century. Leading scholars—such as Richard Betts, Risa Brooks, James Burk, Michael Desch, Peter Feaver, Richard Kohn, Williamson Murray, and David Segal—discuss key issues, including: • changes in officer education since the end of the Cold War • shifting conceptions of military expertise in response to evolving operational and strategic requirements • increased military involvement in high-level politics • the domestic and international contexts of U.S. civil-military relations. The first section of the book provides contrasting perspectives of American civil-military relations within the last five decades. The next section addresses Huntington’s conception of societal and functional imperatives and their influence on the civil-military relationship. Following sections examine relationships between military and civilian leaders and describe the norms and practices that should guide those interactions. What is clear from the essays in this volume is that the line between civil and military expertise and responsibility is not that sharply drawn, and perhaps given the increasing complexity of international security issues, it should not be. When forming national security policy, the editors conclude, civilian and military leaders need to maintain a respectful and engaged dialogue. Essential reading for those interested in civil-military relations, U.S. politics, and national security policy.