Download or read book The Total Synthesis of Kalihinol C and Related Natural Products written by Ryan D. White and published by . This book was released on 2003 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2006 with total page 860 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comprehensive Organic Synthesis written by and published by Newnes. This book was released on 2014-02-14 with total page 9815 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Comprehensive Organic Synthesis—winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers—builds upon the highly respected first edition in drawing together the new common themes that underlie the many disparate areas of organic chemistry. These themes support effective and efficient synthetic strategies, thus providing a comprehensive overview of this important discipline. Fully revised and updated, this new set forms an essential reference work for all those seeking information on the solution of synthetic problems, whether they are experienced practitioners or chemists whose major interests lie outside organic synthesis. In addition, synthetic chemists requiring the essential facts in new areas, as well as students completely new to the field, will find Comprehensive Organic Synthesis, Second Edition, Nine Volume Set an invaluable source, providing an authoritative overview of core concepts. Winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers Contains more than170 articles across nine volumes, including detailed analysis of core topics such as bonds, oxidation, and reduction Includes more than10,000 schemes and images Fully revised and updated; important growth areas—including combinatorial chemistry, new technological, industrial, and green chemistry developments—are covered extensively
Download or read book Recent Applications of Selected Name Reactions in the Total Synthesis of Alkaloids written by Majid M. Heravi and published by Elsevier. This book was released on 2021-06-12 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Applications of Selected Name Reactions in the Total Synthesis of Alkaloids includes comprehensive coverage of name reactions in the synthesis of alkaloids. This book highlights the synthesis of various alkaloids using special name reactions including the Diels-Alder, Friedel-Crafts, Heck, Mannich, Pauson-Khand, Pictet-Spengler, Sonogashira and Suzuki reactions. In this book, some selected name reactions in the total synthesis of alkaloids are covered, as they can be used as the key step/steps in the synthesis of different alkaloids exhibiting various biological activities. All chapters include an introduction, history and mechanism of the name reaction, and present the origin of the natural product and its known biological activities. The pathway to total synthesis is visually illustrated, and the focus is on the step in which a name reaction is applied. Chemists working in the area of synthetic organic chemistry will find this reference useful, as well as those working to develop novel methodologies for the synthesis of natural products in both academia and industry. This book is also beneficial to biologists, pharmacists and botanists. Includes an introduction of alkaloids, their origins and biological properties Features the applications of special name reactions as the key step in the total synthesis of featured alkaloids Covers the pathway for the synthesis of alkaloids from commercially available or easily accessible starting materials by using at least one name reaction to achieve the desired target products
Download or read book Total Synthesis of Chrysophaentin F and Approaches to Related Natural Products written by Rebecca Frances Matters and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Total Synthesis of Indole Alkaloids written by Junpei Matsuoka and published by Springer Nature. This book was released on 2020-09-18 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores efficient syntheses of indole alkaloids based on gold-catalyzed cascade cyclizations, presenting two strategies for total synthesis of these natural products based on gold-catalyzed reactions of conjugated diyne or ynamide. The book first describes the total and formal synthesis of dictyodendrins A–F based on direct construction of the pyrrolo[2,3-c]carbazole core using the gold-catalyzed annulation of azido-diynes and protected pyrrole. This synthetic strategy features late-stage functionalization of the pyrrolo[2,3-c]carbazole scaffold at several positions and allows diverse access to dictyodendrins and their derivatives. Secondly, the book discusses the formal synthesis of vindorosine based on the pyrrolo[2,3-d]carbazole construction using the gold-catalyzed cascade cyclization of ynamide. Importantly, the reaction using a chiral gold complex provides the optically active pyrrolo[2,3-d]carbazole. This strategy facilitates the rapid construction of the pyrrolocarbazole core structure of aspidosperma and related alkaloids, including vindorosine. These methodologies can accelerate the medicinal application of pyrrolocarbazole-type alkaloids and related compounds.
Download or read book Studies Toward the Total Synthesis of chartelline C and platensimycin written by Evan Adam Hecker and published by . This book was released on 2008 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: Herein is described our work towards the total synthesis of the marine natural product (")-chartelline C and the potent antibiotic ( - )-platensimycin. Part 1 relates the (")-chartelline C project. The first chapter reviews (")-chartelline C's isolation, biogeneity, and previously reported studies relevant to the area. Chapter 2 tells of our contributions including the development of a convergent, regioselective assembly of an indole-imidazole compound en route to the natural product. Chapter 3 includes the experimental details of this work and the characterization of previously unreported compounds. Part 2 recounts the ( - )-platensimycin research project. Chapter 4 discusses the importance of the natural product and the relevant previous research reported. Chapter 5 describes our efforts in this area, culminating in the stereoselective synthesis of an intermediate closely related to a known compound, which was converted to the natural product. Chapter 6 includes the experimental details of this work and the characterization of previously unreported compounds.
Download or read book Directory of Graduate Research written by American Chemical Society. Committee on Professional Training and published by . This book was released on 2005 with total page 1932 pages. Available in PDF, EPUB and Kindle. Book excerpt: Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.
Download or read book The Total Synthesis of Three Natural Products written by Ranil Dion Guneratne and published by . This book was released on 1987 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Total Synthesis of Haliclonacyclamine C written by Brian Joseph Smith and published by . This book was released on 2010 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Directed Toward the Total Synthesis of Natural Products and Their Analogs written by Dennis Joseph Golob and published by . This book was released on 1979 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Total Synthesis of Kealiinines A C Kealiiquinone 2 deoxy 2 aminokealiquinone and Study Towards Total Synthesis of Spirocalcaridines A B written by Jayanta Kumar Das and published by . This book was released on 2019 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our group is mainly interested in the total synthesis of imidazole-containing alkaloids along with other kinds of alkaloids. A new family of imidazole alkaloids, the Leucetta alkaloids, is a group of 60 or so 2-aminoimidazole natural products found in marine sponges, which have received substantial attention recently because of their challenging structures and strong biological activities. Over the past few years, our laboratory has developed several synthetic methods for the total synthesis of 2-aminoimidazole alkaloids using site-selective functionalization of polyhaloimidazoles. By using this basic synthetic strategy, the development of high yielding and protecting group-free total syntheses of the reported structures of the Leucetta alkaloids kealiinine A-C has been accomplished. In addition to the challenging syntheses of these molecules, the spectroscopic data for the natural occurring and synthetic materials did not match. Extensive spectroscopic analysis (HMQC, ROESY) unequivocally supported the structures of the synthetic materials which were further corroborated by X-ray crystallography. On the other hand the chromatographic properties of the synthetic and natural materials were consistant, suggesting that impurities in the natural materials caused the mismatch of the spectroscopic data. A second set of targets was accessed using a biosynthetic guided strategy according to which, kealiinine C would serve as a precursor to kealiiquinone and 2-deoxy-2-aminokealiiquinone. The synthesis of both alkaloids was completed from a late stage intermediate in the kealiinine C synthesis by oxidation of the C-ring. Although the first total synthesis of kealiiquinone was accomplished by Ohta et al. in 1995, the current method was protecting group-free and required only 6 steps in comparison to 12 steps by the Japanese group. The first total synthesis of the 2-amino congener 2-deoxy-2-aminokealiiquinone was also accomplished. After successful syntheses of these naphthimidazole natural products, the cytotoxicity of these alkaloids along with several precursors and intermediates was examined. Several of these natural products and their intermediate compounds showed potential anti-cancer activity when subjected to in vitro testing against a breast cancer cell line (MCF7) using a MTT growth assay. Currently, in the study toward the total synthesis of spirocalcaridine A and B, an yneguanidine intermediate has been synthesized by using a three-component coupling as a key reaction en route to the desired products. The core structure of spirocalcaridines was furnished through a diacetoxyiodobenzene assisted concerted spirocyclization of the yne-guanidine molecule. Further studies are on going to improve the poor yield and selectivity of the above transformation and consequently allowing the completion of the total synthesis of spirocalcaridines A-B.
Download or read book Studies Towards Total Synthesis of Polyketide Natural Products and Alkaloids written by Anastasia Hager and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies in Natural Products Chemistry written by Atta-ur Rahman and published by Elsevier. This book was released on 2017-04-21 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies in Natural Products Chemistry, Volume 53, covers the synthesis, testing, and recording of the medicinal properties of natural products, providing cutting-edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis, and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry that are discussed and highlighted in this series. Focuses on the chemistry of bioactive natural products Contains contributions by leading authorities in the field Presents sources of new pharmacophores
Download or read book Total Syntheses of Indole Alkaloids and Determination of the Electrophilicity of Benzyne and Related Intermediates written by Lucas Morrill and published by . This book was released on 2019 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation encompasses several projects pertaining to natural product total synthesis, reaction methodology development, and kinetic studies. The total synthesis of natural products continues to be a fruitful area of research in organic chemistry. The successful completion of a total synthesis endeavor not only affirms ambitious route designs, but can also allow access to significant amounts of biologically-active compounds. Given that natural product structures inspire the development of new agrochemicals and pharmaceuticals, their syntheses are a worthwhile endeavor. Also, the development of new reaction methodologies and the understanding of fundamental reactivities of many intermediates remain important areas of research. Chapter One offers a current perspective on the field of natural product total synthesis. Alhough historically viewed as a highly competitive field, several recent examples show the growing spirit of collaboration in total synthesis. By forming alliances with chemists in other fields, industries, or laboratories, total synthesis chemists have made many breakthroughs that would arguably not be possible if working independently. Chapters Two and Three describe our laboratory's total syntheses of several bioactive akuammiline alkaloids, including strictamine, 2(S)-cathafoline, akuammiline, -akuammigine, and 10-demethoxynorvincorine. Our strategic approach to the natural products focused on the use of a modern variant of a classic reaction, the Fischer indolization reaction, to install several rings and the common quaternary center found in each target. This strategy allowed for the first total syntheses of akuammilines bearing the methanoquinolizidine core and those that also bear vicinal quaternary centers. In addition, rearrangements of the methanoquinolizidine core were developed that allowed us to access pyrrolidinoindoline-containing akuammilines. Chapter Four describes a series of kinetic studies used to determine the electrophilicity parameter of benzyne and related aryne intermediates. Arynes are a family of strained intermediates whose existence has been postulated for over 100 years. Recent advances have confirmed their existence and proven their synthetic utility. An advanced knowledge of their reactivity thus far has remained elusive. Our laboratory employed the diffusion clock method to measure the rates of reaction between several arynes and a variety of different nucleophilic reaction partners. The result allowed for the first quantification of the electrophilicity of these strained intermediates and should influence synthetic planning in the future. Chapter Five includes a study in the development of reaction methodology. Utilizing a variant of the Fischer Indolization reaction, our laboratory discovered a general method for making aza-indoline structures. This methodology was applied in the synthesis of derivatives of akuammiline alkaloids and Alzheimer's therapeutic molecules. In addition, a predictive computational model of reactivity was derived.
Download or read book Total Synthesis of Natural Products written by Peter Somfai and published by . This book was released on 1987 with total page 79 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Approaches to the Total Synthesis of Alkaloid Natural Products Via Intramolecular Pericyclic Reactions written by Susan Yoshiko Tamura and published by . This book was released on 1983 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt:
