Download or read book The Structural Basis of Visual Arrestin Function in Rod Photoreceptor Cells written by Susan M. Hanson and published by . This book was released on 2005 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Structural Basis of Arrestin Functions written by Vsevolod V. Gurevich and published by Springer. This book was released on 2017-05-24 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume summarizes our current understanding of the structural basis of the functions of arrestin family of proteins. Arrestins were first discovered as key players in the desensitization of G protein-coupled receptors (GPCRs). Recent studies showed that arrestins are important signal transducers in their own right, organizing multi-protein complexes and scaffolding numerous signaling cascades that regulate cell proliferation, differentiation, and apoptotic death. Here arrestin functions are described primarily from the structural prospective. The book covers basal structure of arrestin proteins, receptor binding-induced conformational changes in arrestins, as well as the structure of “pre-activated” mutants. Particular focus is on the arrestin elements interacting with numerous binding partners, GPCRs and cytoplasmic signaling proteins. We expect that this information and insights will help to understand and exploit the phenomenon of signaling bias, which is a new promising direction in drug discovery. The chapters are written by the world-class specialists in the field, mostly the people who actually contributed the data discussed. The book gives coherent historical prospective and describes the most recent findings. The book would be particularly useful for scientists in academia and industry working in the fields of pharmacology, cell biology, structural biology, and drug discovery. We expect that the focus on the molecular basis of protein-protein interactions would help to develop novel tools for engaging this important type of targets for research and therapeutic purposes.
Download or read book Photoreceptor Cells written by Paul A. Hargrave and published by Academic Press. This book was released on 2013-10-22 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Photoreceptor Cells, Volume 15 covers the advances in the study of photoreceptor cells. The book discusses biochemical, cell and structural biological, and molecular biological techniques needed for the study of photoreceptor cells. The text also describes the methods for observing the structure of photoreceptor cells and for studying their metabolism. The procedures for photoreceptor cell isolation are also considered. The book further tackles the preparation of proteins involved in rod cell metabolism, with particular emphasis on proteins of the visual transduction cascade. The text also encompasses the application of molecular biological techniques for the examination of molecular components of the visual system and their structure, distribution, and function. Neuroscientists, ophthalmologists, biochemists, and people involved in the study of photoreceptor cells will find the book invaluable.
Download or read book Rhodopsins and Phototransduction written by Ikuo Takeuchi and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brings together key new results of interdisciplinary collaborations among various research fields on rhodopsin including the photoreceptive mechanism of rhodopsins, the molecular mechanism of the visual transduction process, visual processes in the retina and other transduction processes in the retina and brain. The structures of the rhodopsin molecule are studied in the fields of protein chemistry, molecular biology, organic chemistry and structural biology; the ultra fast reactions of the retinal protein are studied in physics, biophysics, physical chemistry, organic chemistry and photobiology; the phototransduction in retinal proteins and visual cells are studied in biophysics, biochemistry, biophysical chemistry and photobiology; and the localization in the tissues is studied in anatomy and histochemistry. The diversity of visual systems in various animals is studied in zoology and comparative biochemistry.
Download or read book Webvision written by Helga Kolb and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Structures and Functions of Retinal Proteins written by Jean-Louis Rigaud and published by John Libbey Eurotext. This book was released on 1992 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of the 5th International Conference on Retinal Proteins was to present the findings of the interdisciplinary fields where photochemical, biophysical, molecular biology and physiological aspects are intimately linked. This title covers nearly all the presentations given during this symposium.
Download or read book Arrestins written by Vsevolod V. Gurevich and published by Academic Press. This book was released on 2022-03-20 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arrestins: Structure and Function in Vision and Beyond examines the structural basis of the function of arrestin proteins in the brain. Linking basic, translational and clinical research, this volume begins with history and basic signaling principles and then expands to the use of proteins as potential therapeutic targets. Multiple cellular activities are detailed, including activation, signaling, GPCR endocytosis, and ERK signaling, with chapters examining both visual and non-visual arrestins. Experts in their respective fields are featured throughout, making this book essential reading for anyone who wants to explore the basic science underlying these signaling proteins. 2023 PROSE Awards - Winner: Finalist: Biomedicine and Neuroscience: Association of American Publishers Links basic, translational and clinical research on arrestin and GPCR signaling proteins in the nervous system Features chapters on arrestins' vital signaling functions in brain health Includes unique sections on their use as potential therapeutic targets Covers both vision and non-vision arrestins Provides an overview for scientists new to the study of GPCRs and arrestins
Download or read book Molecular Mechanisms in Visual Transduction written by D.G. Stavenga and published by Elsevier. This book was released on 2000-11-30 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular mechanisms in visual transduction is presently one of the most intensely studied areas in the field of signal transduction research in biological cells. Because the sense of vision plays a primary role in animal biology, and thus has been subject to long evolutionary development, the molecular and cellular mechanisms underlying vision have a high degree of sensitivity and versatility. The aims of visual transduction research are firstto determine which molecules participate, and then to understand how they act in concert to produce the exquisite electrical responses of the photoreceptor cells.Since the 1940s [1] we have known that rod vision begins with the capture of a quantum of energy, a photon, by a visual pigment molecule, rhodopsin. As the function of photon absorption is to convert the visual pigment molecule into a G-protein activating state, the structural details of the visual pigments must beexplained from the perspective of their role in activating their specific G-proteins. Thus, Chapters 1-3 of this Handbook extensively cover the physico-chemical molecular characteristics of the vertebrate rhodopsins. Following photoconversion and G-protein activation, the phototransduction cascade leads to modifications of the population of closed and open ion channels in the photoreceptor plasma membrane, and thereby to the electrical response. The nature of the channels of vertebrate photoreceptors is examined in Chapter 4, and Chapter 5 integrates the present body of knowledge of the activation steps in the cascade into a quantitative framework. Once the phototransduction cascade is activated, it must be subsequently silenced. The various molecular mechanisms participating in inactivation aretreated in Chapters 1-4 and especially Chapter 5. Molecular biology is now an indispensable tool in signal transduction studies. Numerous vertebrate (Chapter 6) and invertebrate (Chapter 7) visual pigments have been characterized and cloned. The genetics and evolutionary aspects of this great subfamily of G-protein activating receptors are intriguing as they present a natural probe for the intimate relationship between structure and function of the visual pigments. Understanding the spectral characteristics from the molecular composition can be expected to
Download or read book Vertebrate Photoreceptors written by Takahisa Furukawa and published by Springer Science & Business Media. This book was released on 2014-04-15 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a series of comprehensive views on various important aspects of vertebrate photoreceptors. The vertebrate retina is a tissue that provides unique experimental advantages to neuroscientists. Photoreceptor neurons are abundant in this tissue and they are readily identifiable and easily isolated. These features make them an outstanding model for studying neuronal mechanisms of signal transduction, adaptation, synaptic transmission, development, differentiation, diseases and regeneration. Thanks to recent advances in genetic analysis, it also is possible to link biochemical and physiological investigations to understand the molecular mechanisms of vertebrate photoreceptors within a functioning retina in a living animal. Photoreceptors are the most deeply studied sensory receptor cells, but readers will find that many important questions remain. We still do not know how photoreceptors, visual pigments and their signaling pathways evolved, how they were generated and how they are maintained. This book will make clear what is known and what is not known. The chapters are selected from fields of studies that have contributed to a broad understanding of the birth, development, structure, function and death of photoreceptor neurons. The underlying common word in all of the chapters that is used to describe these mechanisms is “molecule”. Only with this word can we understand how these highly specific neurons function and survive. It is challenging for even the foremost researchers to cover all aspects of the subject. Understanding photoreceptors from several different points of view that share a molecular perspective will provide readers with a useful interdisciplinary perspective.
Download or read book Anatomy Ocular physiology Biochemistry and genetics Pathology Microbiology Immunology Growth and senescence Optics Therapeutics Lasers and instrument technology Basic biostatistical and epidemiological terms written by Louise Bye and published by OUP Oxford. This book was released on 2013-05-23 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: An indispensable and fully comprehensive textbook, this covers the basic sciences in ophthalmology and is the only book you need to pass the FRCOphth Part 1 exam.
Download or read book Ryan s Retina E Book written by Charles P. Wilkinson and published by Elsevier Health Sciences. This book was released on 2017-04-17 with total page 2893 pages. Available in PDF, EPUB and Kindle. Book excerpt: The undisputed gold standard text in the field, Ryan's Retina is your award-winning choice for the most current, authoritative information on new technologies, surgical approaches, scientific advances and diagnostic and therapeutic options for retinal diseases and disorders. Packed with timely updates throughout, new illustrations, and a dedicated team of editors who extend Dr. Ryan’s legacy in retina, this outstanding 6th Edition is a must-have reference for retinal specialists, ophthalmologists, and fellows in training. Offers the most comprehensive content available on retina, balancing the latest scientific research and clinical correlations, covering everything you need to know on retinal diagnosis, treatment, development, structure, function, and pathophysiology. Provides a truly global perspective from five highly esteemed section editors and more than 350 other world authorities from across Europe, Asia, Australasia, and the Americas. Bullets Includes new chapters on widefield imaging, intraoperative OCT imaging, medical management of diabetes mellitus and age-related macular degeneration, and senile retinoschisis. Includes more than 1,150 brand-new illustrations, scans, and photographs throughout. Covers the explosion of new imaging options across optical coherence tomography (OCT), fundus imaging, and autofluorescence imaging, including a greatly expanded OCT imaging chapter that features crucial information on OCT-Angiography (OCT-A). Presents new pharmacotherapy data and the latest approaches in anti-VEGF therapy for age-related macular degeneration, diabetic retinopathy, and venous occlusive disease. Features an expanded online video library highlighting the latest surgical techniques and new coverage of complications of vitreoretinal surgery. Contains thorough content updates in every area of retina, including advanced imaging technologies, gene therapy, inflammation and immune responses, white dot syndromes, epigenetic mechanisms, transplantation frontiers to improve retinal function, macular hole, myopic eye disease, ocular trauma, drug delivery to the posterior segment, advances in macular surgery, vitrectomy and complex retinal detachment, tumors, and retinal genetics and biology. Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.
Download or read book Neurotransmitter Release written by Hugo J. Bellen and published by Oxford University Press, USA. This book was released on 1999 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the reader with background information on neurotransmitter release. Emphasis is placed on the rationale by which proteins are assigned specific functions rather than just providing facts about function.
Download or read book The Molecular Biology of Arrestins written by and published by Academic Press. This book was released on 2013-06-10 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: This special volume of Progress in Molecular Biology and Translational Science focuses on the molecular biology of arrestins, with contributions from leaders in the field. Arrestins have emerged as central players in the regulation of many facets of G protein-coupled receptor signaling. This volume covers a variety of topics with reviews written by experts in the field. Contributions from leading authorities Informs and updates on all the latest developments in the field
Download or read book Genetic Diseases of the Eye written by Elias I. Traboulsi, MD and published by Oxford University Press. This book was released on 2011-06-01 with total page 940 pages. Available in PDF, EPUB and Kindle. Book excerpt: This highly anticipated new edition brings together an expert group of authors to provide a comprehensive, systematic resource on genetic diseases of the eye. This richly illustrated title covers areas such as: malformations; refractive errors, the cornea, glaucoma and cataracts; retina and the optic nerve; eye movement disorders, and systemic disease of the eye. The new edition remains grounded in a sound clinical approach to the patient with a genetic disease that affects the eye. Oxford Genetics is a comprehensive, cross-searchable collection of resources offering quick and easy access to Oxford University Press's prestigious genetics texts. Joining Oxford Medicine Online these resources offer students, specialists and clinical researchers the best quality content in an easy-to-access format. Online only benefits include downloading images and figures to PowerPoint and downloading chapters to PDF.
Download or read book Enzyme Structure and Mechanism written by Alan Fersht and published by . This book was released on 1985-01-01 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second edition of this biological reference aimed at undergraduates and graduates. The book covers the structure and mechanism of enzymes, creating a guide to the current understanding of enzymology.
Download or read book Clinical Anatomy and Physiology of the Visual System written by Lee Ann Remington and published by Butterworth-Heinemann. This book was released on 2012 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Originally published: Clinical anatomy of the visual system / Lee Ann Remington; with a contribution by Eileen C. McGill.
Download or read book The First Steps in Seeing written by Robert W. Rodieck and published by Sinauer Associates Incorporated. This book was released on 1998-01-01 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: The First Steps in Seeing is about the eyes, and how they capture an image and convert it to the neural messages that ultimately result in visual experience. A full appreciation of how the eyes work is rooted in diverse areas of science-optics; biochemistry and photochemistry; molecular biology, cell biology, neurobiology, and evolutionary biology; psychology and psychophysics. The findings related to vision from any one of these fields are not difficult to understand in themselves, but, in order to be clear and precise, each discipline has developed its own set of words and conceptual relations-in effect, its own language-and for those wanting a broad introduction to vision these separate languages can present more of an impediment to understanding than an aid. However, what lies beneath these words usually has a beautiful simplicity, and it is the aim of The First Steps in Seeing to describe how we see in a manner that is understandable to all. In this book, the use of technical terms is restricted, and several hundred full-color illustrations ensure that the terms that are used are associated with a picture, icon, or graph that visually expresses their meaning. Experimental findings have been recast in terms of the natural world whenever possible, and broad themes bring together lines of thought that are often treated separately. Fourteen main chapters form a "thread" that tells the main scientific story and can be read without specialized knowedge or reliance on other sources. This thread is linked to fourteen discussions which explore certain crucial topics in greater depth. Notes link the material presented in the thread and in the special topics discussions to important review articles and seminal research papers. The First Steps in Seeing is an innovative, authoritative work that belongs in the library of anyone with an interest in visual perception.
