Download or read book The Selected Papers of Denis Noble CBE FRS written by Denis Noble and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a scientific and philosophical autobiography written around a collection of Denis Noble's most significant papers. It traces a remarkable journey from na ve reductionism to a rigorous systems approach to living systems. It is rigorous because Denis Noble was one of the first biologists to construct computer models of cells and organs of the body. His theoretical work is entirely mathematically based, with no room for ambiguity. Far from the denigration of the systems approach as holistic 'hand-waving', his work is now regarded by pharmaceutical companies and regulators as the gold standard of modelling in the development of new medication. Systems Biology is an idea in search of a definition. This book explains why this is true: it is an approach rather than a subject. Denis Noble's work is one of the clearest examples of the systems approach in practice since it reveals the nature of some of the forms of downward causation in multilevel analysis. The story will delight readers who like to see how scientific controversy is resolved, since many of the developments described in each chapter were highly controversial when they occurred.
Download or read book The Music of Life written by Denis Noble and published by OUP Oxford. This book was released on 2008-02-14 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: What is Life? Decades of research have resulted in the full mapping of the human genome - three billion pairs of code whose functions are only now being understood. The gene's eye view of life, advocated by evolutionary biology, sees living bodies as mere vehicles for the replication of the genetic codes. But for a physiologist, working with the living organism, the view is a very different one. Denis Noble is a world renowned physiologist, and sets out an alternative view to the question - one that becomes deeply significant in terms of the living, breathing organism. The genome is not life itself. Noble argues that far from genes building organisms, they should be seen as prisoners of the organism. The view of life presented in this little, modern, post-genome project reflection on the nature of life, is that of the systems biologist: to understand what life is, we must view it at a variety of different levels, all interacting with each other in a complex web. It is that emergent web, full of feedback between levels, from the gene to the wider environment, that is life. It is a kind of music. Including stories from Noble's own research experience, his work on the heartbeat, musical metaphors, and elements of linguistics and Chinese culture, this very personal and at times deeply lyrical book sets out the systems biology view of life.
Download or read book Virtual You written by Peter Coveney and published by Princeton University Press. This book was released on 2023-03-28 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: The visionary science behind the digital human twins that will enhance our health and our future Virtual You is a panoramic account of efforts by scientists around the world to build digital twins of human beings, from cells and tissues to organs and whole bodies. These virtual copies will usher in a new era of personalized medicine, one in which your digital twin can help predict your risk of disease, participate in virtual drug trials, shed light on the diet and lifestyle changes that are best for you, and help identify therapies to enhance your well-being and extend your lifespan—but thorny challenges remain. In this deeply illuminating book, Peter Coveney and Roger Highfield reveal what it will take to build a virtual, functional copy of a person in five steps. Along the way, they take you on a fantastic voyage through the complexity of the human body, describing the latest scientific and technological advances—from multiscale modeling to extraordinary new forms of computing—that will make “virtual you” a reality, while also considering the ethical questions inherent to realizing truly predictive medicine. With an incisive foreword by Nobel Prize–winning biologist Venki Ramakrishnan, Virtual You is science at its most astounding, showing how our virtual twins and even whole populations of virtual humans promise to transform our health and our lives in the coming decades.
Download or read book Animal Locomotion written by Malcolm S. Gordon and published by CRC Press. This book was released on 2017-05-25 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal Locomotion: Physical Principles and Adaptations is a professional-level, state of the art review and reference summarizing the current understanding of macroscopic metazoan animal movement. The comparative biophysics, biomechanics and bioengineering of swimming, flying and terrestrial locomotion are placed in contemporary frameworks of biodiversity, evolutionary process, and modern research methods, including mathematical analysis. The intended primary audience is advanced-level students and researchers primarily interested in and trained in mathematics, physical sciences and engineering. Although not encyclopedic in its coverage, anyone interested in organismal biology, functional morphology, organ systems and ecological physiology, physiological ecology, molecular biology, molecular genetics and systems biology should find this book useful.
Download or read book Lavoisier written by Jean-Pierre Poirier and published by University of Pennsylvania Press. This book was released on 1998 with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: Originally published in French in 1993 (Editions Pygmalion/Gerard Watelet, Paris), and expanded and revised for this translation. The founder of modern chemistry, Lavoisier (1743-1794) was active on commisions connected with agriculture, gunpowder, banking, and finance, and was ultimately executed during the Reign of Terror. This biography recounts Lavoisier's scientific accomplishments and his role in the chemical revolution and early history of organic chemistry and physiology; but it is in the examination of his political and economic activities and accomplishments that it breaks new ground. Annotation copyrighted by Book News, Inc., Portland, OR
Download or read book Dance to the Tune of Life written by Denis Noble and published by Cambridge University Press. This book was released on 2017 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book formulates a relativistic theory of biology, challenging the common gene-centred view of organisms.
Download or read book Clive written by C. Brad Faught and published by Potomac Books, Inc.. This book was released on 2013-01-31 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: Robert Clive (1725–1774), later Baron Clive of Plassey, is widely considered the founder of British India. He arrived in Madras as a clerk for the East India Company in 1744. Through timely promotion and a clear affinity for military leadership, he proceeded to consolidate the company's commercial and territorial position in South India before doing the same in the northeast in Bengal. In 1757 company troops under his command defeated the Nawab of Bengal at the Battle of Plassey. This victory set in motion the East India Company's ascendancy over much of India and eventual development into the world's largest transnational trading company at the time. This paved the way for the 1857 creation of the British Raj, which would last for another ninety years. Clive is a fascinating and important historical figure: a lowly company employee who rose to great heights; an informally trained military commander who led company and local Indian troops to a series of stirring victories over local rivals who were supported by the French; a grasping politician who used his great wealth to secure a prominent social position; and, finally, a hounded society notable who, plagued by illness, allegedly took his own life. No one in the early days of the British ventures in India was as well known or as controversial as Clive. Today, when empire and globalism are witnessed and talked about with ease, Clive's position as both a servant of the East India Company and an agent of imperialism makes him a surprisingly resonant figure.
Download or read book Multilevel Organization and Functional Integration in Organisms written by Etienne Roux and published by Frontiers Media SA. This book was released on 2021-03-09 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Afghan Peace Talks written by James Shinn and published by Rand Corporation. This book was released on 2011-08-09 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of a negotiated peace in Afghanistan has been firmly embraced by most of the potential parties to a treaty. However, arriving at an agreement about the sequencing, timing, and prioritization of peace terms is likely to be difficult, given the divergence in the parties' interests and objectives. The U.S. objective in these negotiations should be a stable and peaceful Afghanistan that neither hosts nor collaborates with terrorists.
Download or read book Understanding John Dewey written by James Campbell and published by Open Court Publishing. This book was released on 1995 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dewey is the most influential of American social thinkers, and his stock is now rising once more among professional philosophers. Yet there has heretofore been no adequate, readable survey of the full range of Dewey's thought. After an introduction situating Dewey in the context of American social and intellectual history, Professor Campbell devotes Part I to Dewey's general philosophical perspective as it considers humans and their natural home. Three aspects of human nature are most prominent in Dewey's thinking: humans as evolutionary emergents, as essentially social beings, and as problem solvers. Part II examines Dewey's social vision, taking his ethical views as the starting point. Underlying all of Dewey's efforts at social reconstruction are certain assumptions about cooperative enquiry as a social method, assumptions which Campbell explains and clarifies before evaluating various criticisms of Dewey's ideas. The final chapter discusses Dewey's views on religion.
Download or read book Against the Mainstream written by George Gerbner and published by Peter Lang Incorporated, International Academic Publishers. This book was released on 2002 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: George Gerbner has been recognized as one of the most influential and prolific media scholars for over four decades. In this text, Morgan (communication, U. of Massachusetts/Amherst) brings together for the first time an extensive collection of Gerbner's writings. Forty-five selections are grouped into sections on Gerbner's early theories about communication, education and the media, early studies of media institutions and content, the theory and method of Cultural Indicators, Gerbner's key writings about violence, samples of Gerbner's Cultural Indicator studies on a variety of topics, and critical studies and opinion pieces on a variety of topics. No subject index. Annotation copyrighted by Book News, Inc., Portland, OR
Download or read book Speaking My Mind written by Ronald Reagan and published by Simon and Schuster. This book was released on 2004-08 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most important speeches of America's "Great Communicator": Here, in his own words, is the record of Ronald Reagan's remarkable political career and historic eight-year presidency.
Download or read book Systems Medicine written by and published by Academic Press. This book was released on 2020-08-24 with total page 1571 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technological advances in generated molecular and cell biological data are transforming biomedical research. Sequencing, multi-omics and imaging technologies are likely to have deep impact on the future of medical practice. In parallel to technological developments, methodologies to gather, integrate, visualize and analyze heterogeneous and large-scale data sets are needed to develop new approaches for diagnosis, prognosis and therapy. Systems Medicine: Integrative, Qualitative and Computational Approaches is an innovative, interdisciplinary and integrative approach that extends the concept of systems biology and the unprecedented insights that computational methods and mathematical modeling offer of the interactions and network behavior of complex biological systems, to novel clinically relevant applications for the design of more successful prognostic, diagnostic and therapeutic approaches. This 3 volume work features 132 entries from renowned experts in the fields and covers the tools, methods, algorithms and data analysis workflows used for integrating and analyzing multi-dimensional data routinely generated in clinical settings with the aim of providing medical practitioners with robust clinical decision support systems. Importantly the work delves into the applications of systems medicine in areas such as tumor systems biology, metabolic and cardiovascular diseases as well as immunology and infectious diseases amongst others. This is a fundamental resource for biomedical students and researchers as well as medical practitioners who need to need to adopt advances in computational tools and methods into the clinical practice. Encyclopedic coverage: ‘one-stop’ resource for access to information written by world-leading scholars in the field of Systems Biology and Systems Medicine, with easy cross-referencing of related articles to promote understanding and further research Authoritative: the whole work is authored and edited by recognized experts in the field, with a range of different expertise, ensuring a high quality standard Digitally innovative: Hyperlinked references and further readings, cross-references and diagrams/images will allow readers to easily navigate a wealth of information
Download or read book Du Bois s Dialectics written by Reiland Rabaka and published by Lexington Books. This book was released on 2009 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: With chapters that undertake ideological critiques of education, religion, the politics of reparations, and the problematics of black radical politics in contemporary culture and society, Du Bois's Dialectics employs Du Bois as its critical theoretical point of departure and demonstrates his (and Africana Studies') contributions to, as well as contemporary critical theory's connections to, critical pedagogy, sociology of religion, and reparations theory. Rabaka offers the first critical theoretical treatment of the W. E. B. Du Bois-Booker T. Washington debate, which lucidly highlights Du Bois's transition from a bourgeois black liberal to a black radical and revolutionary democratic socialist.
Download or read book Exosomes written by Larry Edelstein and published by Academic Press. This book was released on 2019-10-16 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exosomes: A Clinical Compendium is a comprehensive and authoritative account of exosomes in the context of biomarkers, diagnostics, and therapeutics across a wide spectrum of medical disciplines, as well as their role in cell-cell communication. It is intended to serve as a reference source for clinicians, physicians, and research scientists who wish to gain insight into the most recent advances in this rapidly growing field. The exosome revolution may well be the greatest advance in physiology and medicine since antibiotics. The discovery of their epigenetic role in intercellular signaling in virtually all tissues is a major breakthrough in our understanding of how cells function. Provides readers with a broad and timely overview of exosomes in health and disease, closing with a thought-provoking chapter on transgenerational inheritance, Darwin and Lamarck. Summarizes the most recent laboratory and clinical findings on exosomes across numerous medical disciplines, thereby offering readers a broad-ranging and solid foundation for prospective investigative efforts Twenty-one chapters authored by a global team of peer-acknowledged experts, each representing a key medical disciplineProvides readers with a broad and timely overview of exosomes in health and disease, closing
Download or read book Entrepreneurial Decision Making written by R. J. Mitchellette and published by Xlibris Corporation. This book was released on 2008-11-07 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: RETHINK, RETOOL AND REENGINEER YOUR CAREER This book is an entrepreneurial feasibility examination exercise divided into two essential parts with the fi rst part directed toward your decision to become an entrepreneur including numerous case studies followed by a trait and personality self-assessment chapter to determine your entrepreneurial potential and a chapter on venture selection. The second part of the book is devoted to building your body of knowledge on the key subjects that you will need to be successful, such as business plan preparation and presentation, marketing, capital formation, securities compliance, and exit strategies. The book also contains numerous graphs and fl ow charts of all the chronological stages of the entrepreneurial journey. You should fi nish this book with the knowledge that you have the right stuff to begin your entrepreneurial journey or the wisdom to pursue other life choices. For more information, please visit www.newventurecoach.org
Download or read book Citizen Newhouse written by Carol Felsenthal and published by Seven Stories Press. This book was released on 2011-01-04 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: An acclaimed biographer takes on one of the world's most elusive media moguls in Citizen Newhouse. The harvest of four years and over 400 interviews, Carol Felsenthal's book is an unauthorized investigative biography that paints a tough yet even-handed portrait. Here is the father, Sam Newhouse, who developed a formula for creating newspaper monopolies in small metropolitan markets and turned it into a huge family fortune. And the sons: Si in the magazine business, with his crown jewels, The New Yorker, Vanity Fair, and Vogue, and Donald, who runs the family's newspaper and cable television companies. Focusing on Si's life and career, Citizen Newhouse takes the measure of one of America's most powerful yet unexamined figures. Felsenthal shows how Si's quirky behavior as a shy and awkward outsider has had a far-reaching impact on the properties he owns, affecting—and in the opinion of some, compromising—the quality of the Newhouse "product" across the country and the world. Felsenthal shines a light on the breathtaking changes that have taken place among Si’s top editors, and the fabulous perks available to members of this elite. She also lays bare the role played by Roy Cohn in the affairs of both father and son. Citizen Newhouse provides a fascinating account of powerful and glamorous lives—and their impact on the newspapers and magazines we read every day.
