Download or read book The role of tumor associated macrophages in tumor progression written by Bernd Kaina and published by Frontiers Media SA. This book was released on 2023-06-01 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Inflammation and Cancer written by Bharat B. Aggarwal and published by Springer. This book was released on 2014-05-12 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
Download or read book Tumour Associated Macrophages written by Toby Lawrence and published by Springer Science & Business Media. This book was released on 2011-10-06 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: The subject of Tumour-Associated Macrophages is of interest in the cancer research community, and this book promises to be among the first to discuss a definitive theory on the role of macrophage in tumor development.
Download or read book Cancer Immunotherapy written by Alberto Mantovani and published by Elsevier Inc. Chapters. This book was released on 2013-06-04 with total page 43 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor development and progression are strongly linked to inflammation and macrophage infiltration is a major component of the inflammatory reactions associated with neoplasia. Plasticity is a hallmark of mononuclear phagocytes, which undergo polarized diverse forms of activation. Metabolic adaptation is a key component of macrophage plasticity and polarization, instrumental to their function in homeostasis, immunity and inflammation. Tumor-associated macrophages (TAM) and related immature myeloid suppressor cells generally have properties of an M2-like population. TAM produce growth factors, have immunoregulatory and immunosuppressive activity, stimulate angiogenesis and provide tissue remodeling, invasion and metastasis. Thus, TAM are a key component of cancer-promoting inflammatory reactions.
Download or read book Approaching Complex Diseases written by Mariano Bizzarri and published by Springer Nature. This book was released on 2020-04-17 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.
Download or read book The Link Between Inflammation and Cancer written by Angus G. Dalgleish and published by Springer Science & Business Media. This book was released on 2006-03-05 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: A link between inflammation and cancer has been established many years ago, yet it is only recently that the potential significance of this connection has become apparent. Although several examples of chronic inflammatory conditions, often induced by persistent irritation and/or infection, developing into cancer have been known for some time, there has been a notable resistance to contemplate the possibility that this association may apply in a causative way to other cancers. Examples for such progression from chronic inflammation to cancer are colon carcinoma developing with increased frequency in patients with ulcerative colitis, and the increased incidence of bladder cancer in patients suffering from chronic Schistosoma infection. Inflammation and cancer have been recognized to be linked in another context for many years, i.e., with regards to pathologies resembling chronic lacerations or 'wounds that do not heal.' More recently, the immunology of wound healing has given us clues as to the mechanistic link between inflammation and cancer, in as much as wounds and chronic inflammation turn off local cell-mediated immune responses and switch on growth factor release as well the growth of new blood vessels - angiogenesis. Both of these are features of most types of tumours, which suggest that tumours may require an immunologically shielded milieu and a growth factor-rich environment.
Download or read book The Recruitment of Tumor associated Macrophages and Their Role in Tumor Growth written by Lei Zhang and published by . This book was released on 1997 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chemokines and Cancer written by Barrett Rollins and published by Springer Science & Business Media. This book was released on 1999-04-09 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemokines and Cancer synthesizes a state-of-the-art understanding of the role that chemokines and their receptors play in the pathophysiology of malignancy. It examines the influence of chemokines on a broad array of malignant cells, including their effects on such intrinsic properties as growth and movement, as well as exploring their influence on the host's response to a growing tumor. The authors also demonstrate the physiological consequences of chemokine expression and suggest how chemokines can be used to regulate tumor growth in vivo, including their direct effects on tumor growth, on tumor destruction by host inflammatory cells, and on tumor angiogenesis. The only book available that relates chemokines to cancer, Chemokines and Cancer holds out the promise of novel therapeutic approaches to malignancy through the manipulation of chemokines and/or their receptors.
Download or read book Tumor Immunology and Immunotherapy written by Robert C. Rees and published by Oxford University Press, USA. This book was released on 2014 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor immunology and immunotherapy provides a comprehensive account of cancer immunity and immunotherapy. Examining recent results, current areas of interest and the specific issues that are affecting the research and development of vaccines, this book provides insight into how these problems may be overcome as viewed by leaders in the field.
Download or read book Macrophages written by Hridayesh Prakash and published by BoD – Books on Demand. This book was released on 2021-02-24 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a collection of chapters that discuss methodologies, resources, and technologies by dedicated authors. This book has addressed the significance of macrophages in infectious disease, tumor metabolism, and muscular disorders. All chapters have focused on the fate of differentiated macrophages and discussed molecular pathways that are important for the pathologic role of macrophages. I am confident that our readers will find this book useful in designing immune mediated strategies for managing various diseases that this book is based on.
Download or read book Tumour Associated Macrophages written by and published by . This book was released on 2011-10-06 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Download or read book Genetic Analysis of Specialized Tumor Associated Macrophages and Tumor Associated Fibroblast written by Jeff Anderson and published by . This book was released on 2008 with total page 34 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Tumor associated macrophages (TAMs) perform various task that are essential for tumor growth, angiogenesis, metastasis, and tumor invasion. Growth factors, chemokines, cytokines and the extra cellular matrix in the tumor microenvironments signal the TAMs to perform these tasks. The tumor microenvironment is not homogeneous and can be classified into several distinct regions such as sites of tumor invasion, perivascular, hypoxic and stromal regions. Each of these sites likely has different cytokines and signaling molecules in their microenvironment that might signal and direct the function of TAMs. The purpose of this project is to isolate and analyze TAMs from distinct tumor regions to gain a better understanding of the mechanism behind the specialized role of these TAMs. As a first step towards this goal, micro array analysis was conducted on flow sorted TAMs and developmental macrophages expressing yellow fluorescence protein (YFP). Micro array data from age matched developmental macrophages was compared to TAMS from early, premalignant stage of breast cancer, and late stage metastatic breast cancer to find the genes which were upregulated in TAMs versus developmental macrophages, and in late stage TAMs versus TAMs from the earlier premalignant stage of breast cancer. From this list of genes upregulated in TAMs, candidate cell surface macrophage markers that could be used to classify TAMs based on there association with one of the distinct tumor microenvironments was selected. These candidate markers will be used to visualize macrophages associated with different regions within the tumor microenvironment using immuno-staining of tumor sections. In preliminary work, CD16 was selected as one potential candidate gene that was upregulated late in tumor development compared to earlier stages. Immunostaining indicated CD16 was expressed on a set of macrophages near blood vessels near the tumors, but not in macrophages located within tumors. Further evaluation of these markers would facilitate isolation of different subsets of macrophages within tumor and understanding the function of these macrophages in tumor microenvironment. Another major cell group involved in all the changes in the tumor microenvironment discussed is the fibroblast. Originally the fibroblast inhibits the growth of the tumor. However through natural selection tumors evolve to change the microenvironment and like wise the function the fibroblast are performing to aid in tumor progression rather than suppress tumor progression. These fibroblast reprogrammed by the tumor cells are called tumor associated fibroblast TAFs. TAFs aid in tumor progression by angiogenesis, immune suppression, and matrix remodeling, providing growth and anti apoptotic factors and aid in metastasis by recruiting TAMs. A key gene involved with this is IKK. It is our hypothesis that ablating IKK in the fibroblast will lead to a reduction of tumor growth.
Download or read book Tumor Associated Macrophages Reprogramming written by Jiao Peng and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Tumor associated macrophages reprogramming: the role of TGF-beta/TLR7 and adiponectin" by Jiao, Peng, 彭佼, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Tumor-associated macrophages (TAMs) play a key role in the escape of tumor cells from immune surveillance. "Re-programming" TAMs to switch from a M2 to a M1-type phenotype and thereby restore tumor specific immune responses that are protective continues stimulate considerable scientific interest in the field of tumor biology. The aims of this study focus on: 1) to identify the inhibition of TGF-β signaling in combination with TLR7 ligation could re-program the phenotype of TAMs and increase their tumoricidal activities; 2) to investigate that adiponectin (APN) deficiency can promote TAMs polarization towards a M1-like phenotype and reduce tumor progression in murine sarcoma model. TGF-β plays a multi-functional role in tumor development including modulating the biological activity of both the tumor and TAMs. In a TAM/tumor cell co-culture system in which both cells were isolated from murine sarcoma model, I found inhibition of TGF-β signaling with TGF-β receptor I inhibitor in combination with TLR7 ligation could re-program TAMs to the M1-like type, evidenced by: 1) up-regulating the expression of M1-like type marker iNOS, CD80 and MHCII in TAMs; 2) down-regulating the expression of VEGF and CD31 to suppress angiogenesis; 3) increasing tumoricidal activity of TAMs and inducing tumor cells apoptosis and 4) elevating infiltration of inflammatory immune cells 〖CD4〗 DEGREES+,〖 CD8〗 DEGREES+ T cells and neutrophils in tumor mass. Mechanistically, it was also found that combination treatment could enhance NF-кB activation through up-regulating TRAF6 expression and increasing NF-кB nuclear translocation. APN, anti-inflammatory adipokine, has been shown to promote macrophage polarization to a M2 type in vitro. In the present study, APN and TAMs have high expression in infantile rhabdomyosarcoma, particularly in its malignant subtype. The study was then extended to investigate the effect of APN on TAMs polarization by murine MN/MCA1 sarcoma model. The results showed that exogenous APN had no direct effect on MN/MCA1 proliferation but tumor size was sharply reduced in 〖apn〗 DEGREES(-/-) mice compared to their wild type counterparts. Next, my study demonstrates that the accumulation of TAMs in 〖apn〗 DEGREES(-/-) mice was reduced correlated to down-regulation of serum MCP-1. Furthermore, TAMs showed a M1-like phenotype with a marked increase in the 〖MHCII 〗 DEGREEShighpopulation. Quantitative PCR analysis indicated that iNOS was increased, whereas the M2 markers IL-10 and YM1 were decreased. Increased TNF-α and reduced IL-10 were also observed in the serum and TAMs of 〖apn〗 DEGREES(-/-) mice. In addition, APN deficiency increased frequency of CD4+, CD8+ T cells and NK cells in the tumors and down-regulated MMP-9 and collagen to suppress tumor metastasis. Moreover, p-p38 was sharply decreased in TAMs of 〖apn〗 DEGREES(-/-) mice and adoption of p38 MAPK inhibitor could significantly reduce tumor size and increase MHCII expression in wild type mice, which suggested that APN regulated p38 MAPK signaling pathway may involve in TAMs polarization. In summary, the present study indicated the plasticity of TAMs which could be re-programmed depending on the alteration of microenvironment. Either inhibition of TGF-β in combination with TLR7 ligation or reducing APN in TAMs could polarize TAMs towards a M1-like type to restrict tumor progression. Subjects: Mac
Download or read book Interaction of Immune and Cancer Cells written by Magdalena Klink and published by Springer Nature. This book was released on 2022-02-14 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now, it its second edition, this book summarizes the role of immune cells in tumor suppression and progression. It describes in detail why tumor cells can survive and spread in spite of the antitumor response of immune cells. Since immunotherapy is an attractive approach to cancer therapy, this book also provides information on the two main strategies: monoclonal antibodies and adaptive T cell immunotherapy, with a focus on recent human clinical trials. A newly added chapter also focuses on the role of Natural Killer cells in tumor progression. The book provides a state-of-the-art, comprehensive overview of immune cells in cancer and is an indispensable resource for researchers and practitioners working or lecturing in the field of cancer research and immunology.
Download or read book Translocator Protein TSPO written by Giovanni Natile and published by MDPI. This book was released on 2018-03-05 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Translocator Protein (TSPO)" that was published in IJMS
Download or read book Systems Biology of Cancer written by Sam Thiagalingam and published by Cambridge University Press. This book was released on 2015-04-09 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.
